Coupled Flow, Transport, and Biogeochemistry Subsurface Modeling to Inform Arctic Methane Emission Predictions
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Version of previously released anthropogenic SO2 and BC emissions data re-generated with no seasonality for use in the Emissions-MIP model inter-comparison project.
Glioblastoma multiforme (GBM) is the most aggressive glioma of the primary central nervous system. Due to the lack of effective treatment options, the prognosis for patients remains bleak. Fibroblast activation protein alpha (FAP), a 170 kDa type II transmembrane serine protease was observed to be expressed on glioma cells and within the glioma tumor microenvironment. To understand the utility of targeting FAP in this tumor type, the immuno-PET radiopharmaceutical [ 89 Zr]Zr-Df-Bz-F19 mAb was prepared and Lindmo analysis was used for its in vitro evaluation using the U87MG cell line, which expresses FAP endogenously. Lindmo analysis revealed an association constant (K a ) of 10 -8 M -1 and an immunoreactivity of 52%. Biodistribution studies in U87MG tumor-bearing mice revealed increasing radiotracer retention in tumors over time, leading to average tumor-to-muscle ratios of 3.1, 7.3, 7.2, and 8.3 at 2, 24, 48 and 72 h, respectively. Small animal PET corroborated the biodistribution studies; tumor-to-muscle ratios at 2, 24, 48, and 72 h were 2.0, 5.0, 6.1 and 7.8, respectively. Autoradiography demonstrated accumulated activity throughout the interior of FAP + tumors, while sequential tumor sections stained positively for FAP expression. Conversely, FAP - tissues retained minimal radioactivity and were negative for FAP expression by immunohistochemistry. These results demonstrate FAP as a promising biomarker that may be exploited to diagnose and potentially treat GBM and other neuroepithelial cancers.
Abstract The rapid neutron capture process ( r -process) is one of the main mechanisms whereby elements heavier than iron are synthesized, and is entirely responsible for the natural production of the actinides. Kilonova emissions are modeled as being largely powered by the radioactive decay of species synthesized via the r -process. Given that the r -process occurs far from nuclear stability, unmeasured beta-decay rates play an essential role in setting the timescale for the r -process. In an effort to better understand the sensitivity of kilonova modeling to different theoretical global beta-decay descriptions, we incorporate these into nucleosynthesis calculations. We compare the results of these calculations and highlight differences in kilonova nuclear energy generation and light-curve predictions, as well as final abundances and their implications for nuclear cosmochronometry. We investigate scenarios where differences in beta-decay rates are responsible for increased nuclear heating on timescales of days that propagates into a significantly increased average bolometric luminosity between 1 and 10 days post-merger. We identify key nuclei, both measured and unmeasured, whose decay rates directly impact nuclear heating generation on timescales responsible for light-curve evolution. We also find that uncertainties in beta-decay rates significantly impact age estimates from cosmochronometry.
We investigate the origin of the elliptical ring structure observed in the images of the supermassive black hole M87*, aiming to disentangle contributions from gravitational, astrophysical, and imaging effects. Leveraging the enhanced capabilities of the Event Horizon Telescope (EHT)'s 2018 array, including improved (u,v)-coverage from the Greenland Telescope, we measured the ring's ellipticity using five independent imaging methods, obtaining a consistent average value of τ = 0.08−0.02+0.03 with a position angle of ξ = 50.1−7.6+6.2 degrees. To interpret this measurement, we compared it to general relativistic magnetohydrodynamic (GRMHD) simulations spanning a wide range of physical parameters including the thermal or nonthermal electron distribution function, spins, and ion-to-electron temperature ratios in both low- and high-density regions. We find no statistically significant correlation between spin and ellipticity in GRMHD images. Instead, we identify a correlation between ellipticity and the fraction of non-ring emission, particularly in nonthermal models and models with higher jet emission. These results indicate that the ellipticity measured from the M87* emission structure is consistent with that expected from simulations of turbulent accretion flows around black holes, where it is dominated by astrophysical effects rather than gravitational ones. Future high-resolution imaging, including space very long baseline interferometry and long-term monitoring, will be essential to isolate gravitational signatures from astrophysical effects.Key words: accretion, accretion disks / black hole physics / gravitation / galaxies: active** These authors have contributed equally to this work.*** NASA Hubble Fellowship Program, Einstein Fellow.† Deceased.
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Jupiter far IR emission spectra models, examining atmospheric composition, temperature and structure
Computer program predicts, from readily available meteorological data, concentration and dosage fields downwind from ground-level and elevated sources of toxic fuel emissions. Mathematical model is applicable to hot plume rise from industrial stacks and should also be of interest to air pollution meteorologists.
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Thermal and nonthermal O(1D) number density profiles are calculated. The two populations are assumed to be coupled by a thermalization cross-section which determines the loss and production in the nonthermal and thermal populations, respectively. The sources, sinks and transport of the two populations are used to model volume emission rate profiles at 6300 A. The 6300 A brightness measured by the Visible Airglow Experiment is then used to establish the presence of the nonthermal population and to determine the thermalization cross-section.
It is shown that the presence of grains distributed throughout either disk or spherical galaxies can lead to detectable far-infrared sources. In particular, an elliptical such as NGC 4278 with an appreciable amount of neutral gas should be easily detectable with the Infrared Astronomical Satellite (IRAS) if it has a dust-to-gas ratio similar to the value in the solar neighborhood. A disk should be detectable at 100 Mpc with IRAS. Also, disks may emit most of their energy longward of 100 microns; this could be important for estimating the mass-to-light ratios of these galaxies.
After assessing the theory of cluster gas with polytropic equations of state, and discussing the prediction of local polytropic indices in the gas distribution, attention is given to the consequences of modifying the equation of state by thermal cooling in the central regions of the cluster. It is suggested that, if the equation of state can be understood locally, an attempt may be made at (1) predicting the X-ray luminosities of the clusters at distant cosmological epochs and (2) measuring the evolution of the cluster's potential, through observation of the evolution of X-ray luminosity and surface brightness.
Photometry of S106 at 50 and 100 microns, as well as its mapping with 35 arcsec resolution and a search for a nearby H2O maser source at 2 and 10 microns, have yielded data that are consistent with a 900 pc distance and an O9 (ZAMS) spectral type for a single, central exciting star. The correlation of dust temperature with optical emission, and anticorrelation of dust optical depth with optical emission, support models of S106 which envision an exciting star surrounded by a dusty disk having very low optical extinction along its approximately north-south axis. A local maximum in the dust column density was found to the west of the optical nebula, near the position of an H2O maser, although no local near- or far-IR flux maximum was detected.
Progress is reported in modeling cometary emission in the 18-cm OH transition with specific application and predictions for Comet Halley. Radiative transfer is also being studied in rough and porous media. The kinematics of the cold, dark interstellar cloud Li34N were examined, and CO monitoring of Venus and Mars continues. Analysis of 3.4 mm maps of the lunar surface shows thermal anomalies associated with such surface features as the Crater Copernicus, Mare Imbrium, Mare Nubium, Mare Serenitatis, and Mare Tranquillatis.
The thermal cyclotron emission from model dipole magnetic loops is computed. It is shown that a simple, isothermal dipole loop can show a great deal of spatial and polarization structure at microwave frequencies. This structure is sensitive to the observation frequency and angle of observation. Two qualitatively distinct microwave loop structures can be distinguished: (1) 'thin loop,' observed as a string of independent microwave peaks, corresponding to different harmonics of the local electron gyrofrequency; and (2) 'thick loop,' the harmonics are merged, so that a more continuous microwave structure is observed. It is shown that the presence of an external plasma can result in a change in the observed mode of polarization along one leg of a loop, without a change in the sign of the line-of-sight magnetic field. Models such as these, along with high-resolution microwave and related observations, can provide an excellent diagnostic of the magnetic and plasma properties of coronal loops.
Various methods outlined for indirect planetary detection would greatly benefit (in some cases require) the determination of the planetary orbital plane, which is theoretically equivalent to the stellar equatorial plane. Determining the stellar space orientation, therefore, would greatly benefit extrasolar planetary detection. Stellar rotation periods determined from short-term variations in Ca II H and K sunspot emission are utilized together with both stellar radii measurements and Doppler-broadened spectral line profiles to get the stellar inclination to the line of sight. The clocklike on-the-plane-of-the-sky component determination utilizes the concentration of sunspot-associated plage areas at central stellar latitudes when viewed in Ca II H or K emission. One can perform Ca II H and K emission speckle interferometry to measure the clocklike angle of this stellar Ca II H and K emission band, modeling it as an elliptical intensity distribution. Both components should be determinable to within 10 deg for at least the resolvable fifth magnitude stars.