Search NASA⌕ Search

SEARCH · Search NASA

Results for “Experimental evolution”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 847 records · Page 47

Tuning site-specific dynamics to drive allosteric activation in a pneumococcal zinc uptake regulator

MarR (multiple antibiotic resistance repressor) family proteins are bacterial repressors that regulate transcription in response to a wide range of chemical signals. Although specific features of MarR family function have been described, the role of atomic motions in MarRs remains unexplored thus limiting insights into the evolution of allostery in this ubiquitous family of repressors. Here, we provide the first experimental evidence that internal dynamics play a crucial functional role in MarR proteins. Streptococcus pneumoniae AdcR (adhesin-competence repressor) regulates ZnII homeostasis and ZnII functions as an allosteric activator of DNA binding. ZnII coordination triggers a transition from somewhat independent domains to a more compact structure. We identify residues that impact allosteric activation on the basis of ZnII-induced perturbations of atomic motions over a wide range of timescales. These findings appear to reconcile the distinct allosteric mechanisms proposed for other MarRs and highlight the importance of conformational dynamics in biological regulation.

Capdevila, Daiana A.↗

Chemical evolution of dense clouds

Attention is given to chemical processes which could determine the molecular composition of the cloud during the several stages of its evolution, taking into account thermal reactions at the relatively high interstellar densities expected during the processes. The origin of the observed molecules is discussed together with questions of molecular evolution during collapse of the cloud and the role of organic molecules in planetary chemical evolution. A number of experiments are also considered along with the application of the experimental results to cloud equilibrium problems.

Chapelle, E. W.↗

Experimenters' reference based upon Skylab experiment management

The methods and techniques for experiment development and integration that evolved during the Skylab Program are described to facilitate transferring this experience to experimenters in future manned space programs. Management responsibilities and the sequential process of experiment evolution from initial concept through definition, development, integration, operation and postflight analysis are outlined and amplified, as appropriate. Emphasis is placed on specific lessons learned on Skylab that are worthy of consideration by future programs.

Source record↗

MSFC Skylab experimenter's reference

The methods and techniques for experiment development and integration that evolved during the Skylab Program are described to facilitate transferring this experience to experimenters in future manned space programs. Management responsibilities and the sequential process of experiment evolution from initial concept through definition, development, integration, operation and postflight analysis are outlined in the main text and amplified, as appropriate, in appendixes. Emphasis is placed on specific lessons learned on Skylab that are worthy of consideration by future programs.

Source record↗

Evolution of the Solar System

The origin and evolution of the solar system are analyzed. Physical processes are first discussed, followed by experimental studies of plasma-solid reactions and chemical and mineralogical analyses of meteorites and lunar and terrestrial samples.

Alfven, H.↗

OH emission intensity measurements during the 1969 NASA Airborne Auroral Expedition

Absolute intensity measurements of the (8, 6) OH band obtained during 10 flights of the December 1969 NASA Auroral Airborne Expedition are presented. Nightglow intensities higher by a factor of 2 than the usual values are recorded during flights 8, 14, and 15. The OH variations are compared with the evolution of the green line and O2(1 Delta g) emissions measured by other experimenters on board the aircraft. Before sunrise the twilight variations of OH down to a solar depression angle of 5 deg show a rapid decrease. A theoretical prediction of the OH, O I 5577 A, and O2(1 Delta g) emissions is evaluated by means of an extensive time-dependent oxygen-hydrogen model of the 25- to 150-km region. Twilight decrease of the OH emission is interpreted in terms of mesospheric ozone photodissociation. Nighttime variations of the emissions may be reproduced if modifications of the dynamic regime are introduced into the model.

Moreels, G.↗

Exobiology science objectives at a lunar base

Five general categories of experimentation on the moon are reviewed which would provide important scientific information about chemical evolution and the origin and early evolution of life. Attention is given to: (1) chemical analyses of samples for products of prebiotic evolution, (2) analysis of crater records and understanding the implications for the origin and evolution of life on earth, (3) exposure of microbes and organics to the space environment, (4) collection of cosmic dust particles and analysis of volatiles and organics, and (5) observations of planetary environments and the interstellar medium to determine the nature and extent of chemical evolution.

Devincenzi, Donald L.↗

Probabilistic Approaches: Composite Design

Probabilistic composite design is described in terms of a computational simulation. This simulation tracks probabilistically the composite design evolution from constituent materials, fabrication process through composite mechanics, and structural component. Comparisons with experimental data are provided to illustrate selection of probabilistic design allowables, test methods/specimen guidelines, and identification of in situ versus pristine strength. For example, results show that: in situ fiber tensile strength is 90 percent of its pristine strength; flat-wise long-tapered specimens are most suitable for setting ply tensile strength allowables; a composite radome can be designed with a reliability of 0.999999; and laminate fatigue exhibits wide spread scatter at 90 percent cyclic-stress to static-strength ratios.

Chamis, Christos C.↗

Self-Similar Compressible Free Vortices

Lie group methods are used to find both exact and numerical similarity solutions for compressible perturbations to all incompressible, two-dimensional, axisymmetric vortex reference flow. The reference flow vorticity satisfies an eigenvalue problem for which the solutions are a set of two-dimensional, self-similar, incompressible vortices. These solutions are augmented by deriving a conserved quantity for each eigenvalue, and identifying a Lie group which leaves the reference flow equations invariant. The partial differential equations governing the compressible perturbations to these reference flows are also invariant under the action of the same group. The similarity variables found with this group are used to determine the decay rates of the velocities and thermodynamic variables in the self-similar flows, and to reduce the governing partial differential equations to a set of ordinary differential equations. The ODE's are solved analytically and numerically for a Taylor vortex reference flow, and numerically for an Oseen vortex reference flow. The solutions are used to examine the dependencies of the temperature, density, entropy, dissipation and radial velocity on the Prandtl number. Also, experimental data on compressible free vortex flow are compared to the analytical results, the evolution of vortices from initial states which are not self-similar is discussed, and the energy transfer in a slightly-compressible vortex is considered.

vonEllenrieder, Karl↗

Probabilistic Composite Design

Probabilistic composite design is described in terms of a computational simulation. This simulation tracks probabilistically the composite design evolution from constituent materials, fabrication process, through composite mechanics and structural components. Comparisons with experimental data are provided to illustrate selection of probabilistic design allowables, test methods/specimen guidelines, and identification of in situ versus pristine strength, For example, results show that: in situ fiber tensile strength is 90% of its pristine strength; flat-wise long-tapered specimens are most suitable for setting ply tensile strength allowables: a composite radome can be designed with a reliability of 0.999999; and laminate fatigue exhibits wide-spread scatter at 90% cyclic-stress to static-strength ratios.

Chamis, Christos C.↗

Hardware Evolution of Analog Speed Controllers for a DC Motor

This viewgraph presentation provides information on the design of analog speed controllers for DC motors on aerospace systems. The presentation includes an overview of controller evolution, evolvable controller configuration, an emphasis on proportion integral (PI) controllers, schematic diagrams, and experimental results.

Gwaltney, David A.↗

MECHANICAL CLASSIFICATION OF CARBON FIBERS FROM RAMAN AND X-RAY SCATTERING

Carbon fibers for application are produced from a wide variety of precursor phases and exhibit a broad range of mechanical characteristics that result from variations in the manufacturing process [1]. Raman spectroscopy, a nondestructive and potentially high-throughput tool, is highly sensitive to a host of phenomena in carbon-based materials [2]. Carbon fibers used in applications are naturally delineated along lines of macroscopic strength properties, and control of the macroscopic strength properties is well understood to be linked to the manufacturing process and ultimate firing temperature of the carbon fibers. Consequently, there are numerous characterizations of spectroscopic observables connected to macroscopic properties of carbon fibers, particularly to optimize production by attempting to quantify signatory changes in fibers [3]. Here we are specifically concerned with the evolution of spectroscopic data collected from carbon fibers as they connect to bulk mechanical properties as a baseline for studying spectral evolution under temperature and strain application. To this end, we present correlative results of experimental studies investigating the ability to connect the macroscopic properties of carbon fibers with microscopic observables across a broad range of macroscopic values.

Niedziela, Jennifer↗

Coupled neutronics, thermochemistry, corrosion modeling and sensitivity analyses for isotopic evolution in molten salt reactors

This study presents a computational methodology for analyzing isotopic evolution and associated uncertainties in molten salt reactors (MSRs), focusing on both fluoride- and chloride-based fuel salts. The primary goal is to enhance the understanding of isotopic behavior in MSRs and provide data to support future experimental efforts. The methodology integrates transport-coupled depletion calculations using OpenMC, equilibrium thermodynamics modeling with Thermochimica, and a corrosion model. Sensitivity analyses are performed to evaluate the impact of power density, air ingress, and humidity content on isotopic evolution in MSR concepts. This study examines representative F- and Cl-based MSR designs, highlighting the dominant influence of power density on isotopic composition, which significantly affects isotope production and depletion rates, accounting for approximately 76% of the observed variance in element concentration. Air ingress and humidity content also affect the redox potential, solubility of heavier elements, and corrosion rates, thereby altering the expected isotopic evolution in the reactor. On average, air ingress accounts for around 17% of the variance in element concentrations, while humidity explains the remaining 7%. These variances differ significantly from element to element, depending on the element’s role in depletion, redox potential evolution, and galvanic corrosion. The findings indicate that power density, air ingress, and humidity content are all critical factors for optimizing reactor design and operational strategies. Furthermore, the study provides expected ranges for key impurities in the fuel salt, which are crucial for guiding future experimental studies and refining MSR designs. Finally, this study demonstrates the importance of modeling depletion coupled with the evolution of redox potential and chemical interactions in MSR fuel salts.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

Ancient origins of allosteric activation in a Ser-Thr kinase

A myriad of cellular events are regulated by allostery; therefore, evolution of this process is of fundamental interest. Here, we use ancestral sequence reconstruction to resurrect ancestors of two colocalizing proteins, Aurora A kinase and its allosteric activator TPX2 (targeting protein for Xklp2), to experimentally characterize the evolutionary path of allosteric activation. Autophosphorylation of the activation loop is the most ancient activation mechanism; it is fully developed in the oldest kinase ancestor and has remained stable over 1 billion years of evolution. As the microtubule-associated protein TPX2 appeared, efficient kinase binding to TPX2 evolved, likely owing to increased fitness by virtue of colocalization. Subsequently, TPX2-mediated allosteric kinase regulation gradually evolved. Surprisingly, evolution of this regulation is encoded in the kinase and did not arise by a dominating mechanism of coevolution.

Science & Technology - Other Topics↗

Continuous-variable quantum Boltzmann machine

Here, we propose a continuous-variable quantum Boltzmann machine (CVQBM) using a powerful energy-based neural network. It can be realized experimentally on a continuous-variable (CV) photonic quantum computer. We used a CV quantum imaginary time evolution (QITE) algorithm to prepare the essential thermal state and then designed the CVQBM to proficiently generate continuous probability distributions. We applied our method to both classical and quantum data. Using real-world classical data, such as synthetic-aperture radar (SAR) images, we generated probability distributions. For quantum data, we used the output of CV quantum circuits. We obtained high fidelity and low Kullback–Leibler (KL) divergence showing that our CVQBM learns distributions from given data well and generates data sampling from that distribution efficiently. We also discussed the experimental feasibility of our proposed CVQBM. Our method can be applied to a wide range of real-world problems by choosing an appropriate target distribution (corresponding to, e.g., SAR images, medical images, and risk management in finance). Moreover, our CVQBM is versatile and could be programmed to perform tasks beyond generation, such as anomaly detection.

SAR images↗

Mode-evolution-based ultra-broadband polarization beam splitter using adiabatically tapered extreme skin-depth waveguide

We present an ultra-broadband silicon photonic polarization beam splitter (PBS) using adiabatically tapered extreme skin-depth (eskid) waveguides. Highly anisotropic metamaterial claddings of the eskid waveguides suppress the crosstalk of transverse-electric (TE) mode, while the large birefringence of the eskid waveguide efficiently cross-couples the transverse-magnetic (TM) mode. Two eskid waveguides are adiabatically tapered to smoothly translate TM mode to the coupled port via mode evolution while keeping the TE mode in the through port. The tapered cross-section of the eskid PBS was designed numerically, achieving a large bandwidth at 1400–1650 nm with extinction ratios > <#comment/> 20 d B . We experimentally demonstrated the tapered-eskid PBS and confirmed its broad bandwidth at 1490–1640 nm, limited by laser bandwidth. With its mode evolution, the tapered-eskid PBS is tolerant to fabrication imperfections and should be crucial for controlling polarizations in photonic circuits.

Mia, Md Borhan (ORCID:0000000320851331)↗

The origin, transport, and evolution of ash in engine particulate filters

Engine particulate filters have been widely applied across the world to control engine exhaust particulate matter (or particulate number) emissions. With increasing vehicle mileage, ash accumulation deteriorates vehicle fuel economy and complicates on-board control. Extending filter service life with ash loading has significant economic and environmental impacts. Many studies have been conducted in characterizing ash accumulation and evaluating its impacts on filter performance. However, comprehensive reviews covering all the key issues in the field are rather rare. This paper reviews the extensive prior research on filter ash, and not only summarizes the experimental observations but also elucidates the fundamental mechanisms. The review covers the areas of ash origin, accumulation, transport, evolution, and artificial acceleration methods. The previously reported data of ash properties is compiled and analyzed. Furthermore, the advantages and disadvantages of ash acceleration approaches are also discussed in detail. Based on the cumulative understanding, a few potential ways to improve ash management are discussed in this paper. In summary, the present work systematically reviews the previous observations and understanding of ash aging in particulate filters and identifies areas that need further research, which can be useful guidance for future studies.

42 ENGINEERING↗

Evolution of the Reactor Antineutrino Flux and Spectrum at Daya Bay

Here, the Daya Bay experiment has observed correlations between reactor core fuel evolution and changes in the reactor antineutrino flux and energy spectrum. Four antineutrino detectors in two experimental halls were used to identify 2.2 million inverse beta decays (IBDs) over 1230 days spanning multiple fuel cycles for each of six 2.9 GW th reactor cores at the Daya Bay and Ling Ao nuclear power plants. Using detector data spanning effective 239 Pu fission fractions F 239 from 0.25 to 0.35, Daya Bay measures an average IBD yield ¯σf of (5.90±0.13)×10 –43 cm 2 /fission and a fuel-dependent variation in the IBD yield, dσ f /dF 239 , of (–1.86±0.18)×10 –43 cm 2 /fission. This observation rejects the hypothesis of a constant antineutrino flux as a function of the 239 Pu fission fraction at 10 standard deviations. The variation in IBD yield is found to be energy dependent, rejecting the hypothesis of a constant antineutrino energy spectrum at 5.1 standard deviations. While measurements of the evolution in the IBD spectrum show general agreement with predictions from recent reactor models, the measured evolution in total IBD yield disagrees with recent predictions at 3.1σ. This discrepancy indicates that an overall deficit in the measured flux with respect to predictions does not result from equal fractional deficits from the primary fission isotopes 235 U, 239 Pu, 238 U, and 241 Pu. Based on measured IBD yield variations, yields of (6.17±0.17) and (4.27±0.26)×10 –43 cm 2 /fission have been determined for the two dominant fission parent isotopes 235 U and 239 Pu. A 7.8% discrepancy between the observed and predicted 235 U yields suggests that this isotope may be the primary contributor to the reactor antineutrino anomaly.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗