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NASA NTRS2001

Chronic mitral regurgitation and Doppler estimation of left ventricular filling pressures in patients with heart failure

Previous studies relating Doppler parameters and pulmonary capillary wedge pressures (PCWP) typically exclude patients with severe mitral regurgitation (MR). We evaluated the effects of varying degrees of chronic MR on the Doppler estimation of PCWP. PCWP and mitral Doppler profiles were obtained in 88 patients (mean age 55 +/- 8 years) with severe left ventricular (LV) dysfunction (mean ejection fraction 23% +/- 5%). Patients were classified by severity of MR. Patients with severe MR had greater left atrial areas, LV end-diastolic volumes, and mean PCWPs and lower ejection fractions (each P <.01). In patients with mild MR, multiple echocardiographic parameters correlated with PCWP; however, with worsening MR, only deceleration time strongly related to PCWP. From stepwise multivariate analysis, deceleration time was the best independent predictor of PCWP overall, and it was the only predictor in patients with moderate or severe MR. Doppler-derived early mitral deceleration time reliably predicts PCWP in patients with severe LV dysfunction irrespective of degree of MR.

NASA Discipline Cardiopulmonary↗

NASA NTRS2001

Solid Hydrogen Particles Analyzed for Atomic Fuels

Solid hydrogen particles have been selected as a means of storing atomic propellants in future launch vehicles (refs. 1 to 2). In preparation for this, hydrogen particle formation in liquid helium was tested experimentally. These experiments were conducted to visually characterize the particles and to observe their formation and molecular transformations (aging) while in liquid helium. The particle sizes, molecular transformations, and agglomeration times were estimated from video image analyses. The experiments were conducted at the NASA Glenn Research Center in the Supplemental Multilayer Insulation Research Facility (SMIRF, ref. 3). The facility has a vacuum tank, into which the experimental setup was placed. The vacuum tank prevented heat leaks and subsequent boiloff of the liquid helium, and the supporting systems maintained the temperature and pressure of the liquid helium bath where the solid particles were created. As the operation of the apparatus was developed, the hydrogen particles were easily visualized. The figures (ref. 1) show images from the experimental runs. The first image shows the initial particle freezing, and the second image shows the particles after the small particles have agglomerated. The particles finally all clump, but stick together loosely. The solid particles tended to agglomerate within a maximum of 11 min, and the agglomerate was very weak. Because the hydrogen particles are buoyant in the helium, the agglomerate tends to compact itself into a flat pancake on the surface of the helium. This pancake agglomerate is easily broken apart by reducing the pressure above the liquid. The weak agglomerate implies that the particles can be used as a gelling agent for the liquid helium, as well as a storage medium for atomic boron, carbon, or hydrogen. The smallest particle sizes that resulted from the initial freezing experiments were about 1.8 mm. About 50 percent of the particles formed were between 1.8 to 4.6 mm in diameter. These very small particle sizes are encouraging for future formation experiments, where simpler operations will reduce the costs of production.

Palaszewski, Bryan A.↗

NASA NTRS2020

A New Look at the Environmental Conditions Favorable to Secondary Ice Production

This study attempts a new identification of mechanisms of secondary ice production (SIP) based on the observation of small faceted ice crystals (hexagonal plates or columns) with typical sizes smaller than 100µm. Due to their young age, such small ice crystals can be used as tracers for identifying the conditions for SIP. Observations reported here were conducted in oceanic tropical mesoscale convective systems (MCSs) and midlatitude frontal clouds in the temperature range from 0 to −15◦C and heavily seeded by aged ice particles. It was found that in both MCSs and frontal clouds, SIP was observed right above the melting layer and extended to higher altitudes with colder temperatures. The roles of six possible mechanisms to generate the SIP particles are assessed using additional observations. In most observed SIP cases, small secondary ice particles spatially correlated with liquid-phase, vertical updrafts and aged rimed ice particles. However, in many cases, neither graupel nor liquid drops were observed in the SIP regions, and therefore, the conditions for an active Hallett–Mossop process were not met. In many cases, large concentrations of small pristine ice particles were observed right above the melting layer, starting at temperatures as warm as −0.5◦C. It is proposed that the initiation of SIP above the melting layer is stimulated by the recirculation of large liquid drops through the melting layer with convective turbulent updrafts. After re-entering a super cooled environment above the melting layer, they impact with aged ice, freeze, and shatter. The size of the splinters generated during SIP was estimated as 10µm or less. A principal conclusion of this work is that only the freezing drop-shattering mechanism could be clearly supported by the airborne in situ observations.

Korolev, Alexei↗

DOE OSTI2023

A Hybrid Physics-Based, Data-Driven Approach to Model Damage Accumulation in Corrosion of Polymeric Adhesives

The degradation of polymeric adhesives in dissimilar joints is a menace to electric and structural components of the automotive industry. In polymeric adhesives, failure often occurs due to damage accumulated from discrete environmental sources—thermal degradation, oxidation, hydrolysis, radiation, and moisture—that are combined with progressive damage mechanisms, such as aging and fatigue. Because most damage mechanisms that lead to degradation act in parallel, the estimation of the lifetime of a polymeric material becomes a significant reliability issue, no study currently exists that can simultaneously consider even two of these phenomena. Most current efforts are directed toward a single-phenomenon, single-model approach in which a model is developed to cover one specific damage mechanism. While this approach is advantageous in exploring single mechanisms, it is strongly inconclusive for degradation that occurs by multiple damage mechanisms. Our team plans to take a fresh perspective by designing a hybrid constitutive/data-driven approach that allows models of different damage mechanisms to be integrated into one model and then used to explore the degradation-induced failure of polymeric adhesives. The theoretical-computational part of this work is divided into four research components as described in the Approach section below.

36 MATERIALS SCIENCE↗

DOE OSTI2022

Prevalence of Americans reporting a family history of cancer indicative of increased cancer risk: Estimates from the 2015 National Health Interview Survey

The collection and evaluation of family health history in a clinical setting presents an opportunity to discuss cancer risk, tailor cancer screening recommendations, and identify people with an increased risk of carrying a pathogenic variant who may benefit from referral to genetic counseling and testing. National recommendations for breast and colorectal cancer screening indicate that men and women who have a first-degree relative affected with these types of cancers may benefit from talking to a healthcare provider about starting screening at an earlier age and other options for cancer prevention. The prevalence of reporting a first-degree relative who had cancer was assessed among adult respondents of the 2015 National Health Interview Survey who had never had cancer themselves (n = 27,999). We found 35.6% of adults reported having at least one first-degree relative with cancer at any site. Significant differences in reporting a family history of cancer were observed by sex, age, race/ethnicity, educational attainment, and census region. Nearly 5% of women under age 50 and 2.5% of adults under age 50 had at least one first-degree relative with breast cancer or colorectal cancer, respectively. We estimated that 5.8% of women had a family history of breast or ovarian cancer that may indicate increased genetic risk. A third of U.S. adults who have never had cancer report a family history of cancer in a first-degree relative. Furthermore, this finding underscores the importance of using family history to inform discussions about cancer risk and screening options between healthcare providers and their patients.

60 APPLIED LIFE SCIENCES↗

NASA NTRS1985

Tectonic determinations of lithospheric thickness on Ganymede and Callisto

The concept of the Maxwell time of a viscoelastic material (4.5) is used in conjunction with calculated thermal profiles to evaluate the significance of tectonic estimates of lithospheric thickness. Thermal lithospheric thicknesses provide fundamental constraints on planetary thermal histories that complement the constraints provided by dateable surface deposits of endogenic origin. Lithospheric constraints are of particular value on the icy satellites where our understanding of both rheology and surface ages is considerably poorer than it is for the terrestrial planets. Certain extensional tectonic features can and have been used to estimate lithospheric thicknesses on Ganymede and Callisto. These estimates, however, refer to the depth of the elastic lithosphere defined by the zone of brittle failure. The relation between the elastic lithosphere and the thermal lithosphere (generally defined by the zone of conductive heat transport) is not straightforward, because the depth of brittle failure depends not only on the thermal profile, but also on rheology and strain rate (or the characteristic time over which stresses build towards failure). Characteristic time considerations are not trivial in this context because stresses generating brittle failure on the icy satellites may be produced by impacts, with characteristic times of seconds to days, or by geologic processes with time scales of hundreds of millions of years.

Croft, S. K.↗

DOE OSTI2014

The impact of chromospheric activity on observed initial mass functions

Using recently established empirical calibrations for the impact of chromospheric activity on the radii, effective temperatures, and estimated masses of active low-mass stars and brown dwarfs, we reassess the shape of the initial mass function (IMF) across the stellar/substellar boundary in the Upper Sco star-forming region (age ∼ 5-10 Myr). We adjust the observed effective temperatures to warmer values using the observed strength of the chromospheric Hα emission, and redetermine the estimated masses of objects using pre-main-sequence evolutionary tracks in the H-R diagram. The effect of the activity-adjusted temperatures is to shift the objects to higher masses by 3%-100%. While the slope of the resulting IMF at substellar masses is not strongly changed, the peak of the IMF does shift from ≈0.06 to ≈0.11 M {sub ☉}. Moreover, for objects with masses ≲ 0.2 M {sub ☉}, the ratio of brown dwarfs to stars changes from ∼80% to ∼33%. These results suggest that activity corrections are essential for studies of the substellar mass function, if the masses are estimated from spectral types or from effective temperatures.

79 ASTRONOMY AND ASTROPHYSICS↗

NASA NTRS2020

REQUIEM-2D Methodology: Spatially Resolved Stellar Populations of Massive Lensed Quiescent Galaxies from Hubble Space Telescope 2D Grism Spectroscopy

We present a novel Bayesian methodology to jointly model photometry and deep Hubble Space Telescope 2D grism spectroscopy of high-redshift galaxies. Our requiem2d code measures both unresolved and resolved stellar populations, ages, and star formation histories (SFHs) for the ongoing REsolving QUIEscent Magnified (REQUIEM) Galaxies Survey, which targets strong gravitationally lensed quiescent galaxies at z ∼ 2. We test the accuracy of requiem2d using a simulated sample of massive galaxies at z ∼ 2 from the Illustris cosmological simulation and find that we recover the general trends in SFH and median stellar ages. We further present a pilot study for the REQUIEM Galaxies Survey: MRG-S0851, a quintuply imaged, massive (log M ⁎ / M ʘ = 11.02 ± 0.04) red galaxy at z = 1.883 ± 0.001. With an estimated gravitational magnification of µ = 5.7 - 0.2 + 0.4, we sample the stellar populations on 0.6 kpc physical size bins. The global mass-weighted median age is constrained to be 1.8 - 0.2 + 0.3 Gyr, and our spatially resolved analysis reveals that MRG-S0851 has a flat age gradient in the inner 3 kpc core after taking into account the subtle effects of dust and metallicity on age measurements, favoring an early formation scenario. The analysis for the full REQUIEM-2D sample will be presented in a forthcoming paper with a beta release of the requiem2d code.

Strong gravitational lensing↗

NASA NTRS2013

Direct Imaging of a Cold Jovian Exoplanet in Orbit around the Sun-Like Star GJ 504

Several exoplanets have recently been imaged at wide separations of >10 AU from their parent stars. These span a limited range of ages (<50 Myr) and atmospheric properties, with temperatures of 800-1800 K and very red colors (J −H > 0.5 mag), implying thick cloud covers. Furthermore, substantial model uncertainties exist at these young ages due to the unknown initial conditions at formation, which can lead to an order of magnitude of uncertainty in the modeled planet mass. Here, we report the direct imaging discovery of a Jovian exoplanet around the Sun-like star GJ 504, detected as part of the SEEDS survey. The system is older than all other known directly-imaged planets; as a result, its estimated mass remains in the planetary regime independent of uncertainties related to choices of initial conditions in the exoplanet modeling. Using the most common exoplanet cooling model, and given the system age of 160(+350/−60) Myr, GJ 504 b has an estimated mass of 4(+4.5/−1.0) Jupiter masses, among the lowest of directly imaged planets. Its projected separation of 43.5 AU exceeds the typical outer boundary of approx.. 30 AU predicted for the core accretion mechanism. GJ 504 b is also significantly cooler (510(+30/−20) K)) and has a bluer color (J − H = −0.23 mag) than previously imaged exoplanets, suggesting a largely cloud-free atmosphere accessible to spectroscopic characterization. Thus, it has the potential of providing novel insights into the origins of giant planets, as well as their atmospheric properties.

exoplanets↗

DOE OSTI2026

Surface Reconstruction in Hydrated Amphiphilic Block Copolymer Thin Films Probed by Fluid Cell Atomic Force Microscopy

In many thin film materials, nuanced interplays of interfacial energies control the surface morphology and rearrangement. This work evaluates polymer−solvent interactions and solvent-driven surface reconstructions via ex situ and in situ fluid cell Atomic Force Microscopy (fc-AFM) analysis of amphiphilic block copolymer (BCP) thin films upon exposure to deionized (DI) water. We examine the differences in surface morphology, whole-film swelling, and force response in thin films of polystyrene-block-poly(ethylene oxide) (PS-b-PEO) and polystyrene- block-poly[(allyl glycidyl ether)-co-(ethylene oxide)] (PS-b- P[AGE-co-EO]) processed into standing-up cylinder morphologies perpendicular to a silicon substrate (⊥C). Using Amplitude Modulation AFM (AM-AFM) and Amplitude-Phase Distance (APD) force spectroscopy, this work probes the mechanoresponsive nature of the dynamic surface layers of these films, unveiling surface layer stratification and surface chain rearrangement via minimal tip−sample stimulation. To help rationalize the observed reconfigurations, the energetic driving forces were estimated using the harmonic mean approximations of interfacial energies. Given the nonionizable nature of the minority P(AGE-co-EO) block and the energetic driving forces for chain mobility, this work shows how the elimination of unfavorable PS−water interfaces drives chain rearrangement and coverage of the PS surface by chains of the hydrophilic block. This work highlights considerations for increasing the heterogeneity and complexity of BCP thin films via random blocks and how those changes to local interfacial energies may drive larger scale film morphology reconstructions, with broader implications for tuning interface hydrophilicity.

Copolymers↗

DOE OSTI2018

Exploring the observational constraints on the simulation of brown carbon

Organic aerosols (OA) that strongly absorb solar radiation in the near-UV are referred to as brown carbon (BrC). The sources, evolution, and optical properties of BrC remain highly uncertain and contribute significantly to uncertainty in the estimate of the global direct radiative effect (DRE) of aerosols. Previous modeling studies of BrC optical properties and DRE have been unable to fully evaluate model performance due to the lack of direct measurements of BrC absorption. In this study, we develop a global model simulation (GEOS-Chem) of BrC and test it against BrC absorption measurements from two aircraft campaigns in the continental US (SEAC 4 RS and DC3). To the best of our knowledge, this is the first study to compare simulated BrC absorption with direct aircraft measurements. We show that BrC absorption properties estimated based on previous laboratory measurements agree with the aircraft measurements of freshly emitted BrC absorption but overestimate aged BrC absorption. In addition, applying a photochemical scheme to simulate bleaching/degradation of BrC improves model skill. The airborne observations are therefore consistent with a mass absorption coefficient (MAC) of freshly emitted biomass burning OA of 1.33 m 2 g -1 at 365 nm coupled with a 1-day whitening e-folding time. Using the GEOS-Chem chemical transport model integrated with the RRTMG radiative transfer model, we estimate that the top-of-the-atmosphere all-sky direct radiative effect (DRE) of OA is -0.344 Wm -2 , 10 % higher than that without consideration of BrC absorption. Therefore, our best estimate of the absorption DRE of BrC is +0.048 Wm -2 . We suggest that the DRE of BrC has been overestimated previously due to the lack of observational constraints from direct measurements and omission of the effects of photochemical whitening.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

NASA NTRS2012

Technical Evaluation of the NASA Model for Cancer Risk to Astronauts Due to Space Radiation

At the request of NASA, the National Research Council's (NRC's) Committee for Evaluation of Space Radiation Cancer Risk Model reviewed a number of changes that NASA proposes to make to its model for estimating the risk of radiation-induced cancer in astronauts. The NASA model in current use was last updated in 2005, and the proposed model would incorporate recent research directed at improving the quantification and understanding of the health risks posed by the space radiation environment. NASA's proposed model is defined by the 2011 NASA report Space Radiation Cancer Risk Projections and Uncertainties 2010 (Cucinotta et al., 2011). The committee's evaluation is based primarily on this source, which is referred to hereafter as the 2011 NASA report, with mention of specific sections or tables cited more formally as Cucinotta et al. (2011). The overall process for estimating cancer risks due to low linear energy transfer (LET) radiation exposure has been fully described in reports by a number of organizations. They include, more recently: (1) The "BEIR VII Phase 2" report from the NRC's Committee on Biological Effects of Ionizing Radiation (BEIR) (NRC, 2006); (2) Studies of Radiation and Cancer from the United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR, 2006), (3) The 2007 Recommendations of the International Commission on Radiological Protection (ICRP), ICRP Publication 103 (ICRP, 2007); and (4) The Environmental Protection Agency s (EPA s) report EPA Radiogenic Cancer Risk Models and Projections for the U.S. Population (EPA, 2011). The approaches described in the reports from all of these expert groups are quite similar. NASA's proposed space radiation cancer risk assessment model calculates, as its main output, age- and gender-specific risk of exposure-induced death (REID) for use in the estimation of mission and astronaut-specific cancer risk. The model also calculates the associated uncertainties in REID. The general approach for estimating risk and uncertainty in the proposed model is broadly similar to that used for the current (2005) NASA model and is based on recommendations by the National Council on Radiation Protection and Measurements (NCRP, 2000, 2006). However, NASA's proposed model has significant changes with respect to the following: the integration of new findings and methods into its components by taking into account newer epidemiological data and analyses, new radiobiological data indicating that quality factors differ for leukemia and solid cancers, an improved method for specifying quality factors in terms of radiation track structure concepts as opposed to the previous approach based on linear energy transfer, the development of a new solar particle event (SPE) model, and the updates to galactic cosmic ray (GCR) and shielding transport models. The newer epidemiological information includes updates to the cancer incidence rates from the life span study (LSS) of the Japanese atomic bomb survivors (Preston et al., 2007), transferred to the U.S. population and converted to cancer mortality rates from U.S. population statistics. In addition, the proposed model provides an alternative analysis applicable to lifetime never-smokers (NSs). Details of the uncertainty analysis in the model have also been updated and revised. NASA's proposed model and associated uncertainties are complex in their formulation and as such require a very clear and precise set of descriptions. The committee found the 2011 NASA report challenging to review largely because of the lack of clarity in the model descriptions and derivation of the various parameters used. The committee requested some clarifications from NASA throughout its review and was able to resolve many, but not all, of the ambiguities in the written description.

Source record↗

DOE OSTI2015

HO x radical chemistry in oxidation flow reactors with low-pressure mercury lamps systematically examined by modeling

Oxidation flow reactors (OFRs) using OH produced from low-pressure Hg lamps at 254 nm (OFR254) or both 185 and 254 nm (OFR185) are commonly used in atmospheric chemistry and other fields. OFR254 requires the addition of externally formed O 3 since OH is formed from O 3 photolysis, while OFR185 does not since O 2 can be photolyzed to produce O 3 , and OH can also be formed from H 2 O photolysis. In this study, we use a plug-flow kinetic model to investigate OFR properties under a very wide range of conditions applicable to both field and laboratory studies. We show that the radical chemistry in OFRs can be characterized as a function of UV light intensity, H 2 O concentration, and total external OH reactivity (OHR ext , e.g., from volatile organic compounds (VOCs), NO x , and SO 2 ). OH exposure is decreased by added external OH reactivity. OFR185 is especially sensitive to this effect at low UV intensity due to low primary OH production. OFR254 can be more resilient against OH suppression at high injected O 3 (e.g., 70 ppm), as a larger primary OH source from O 3 , as well as enhanced recycling of HO 2 to OH, make external perturbations to the radical chemistry less significant. However if the external OH reactivity in OFR254 is much larger than OH reactivity from injected O 3 , OH suppression can reach 2 orders of magnitude. For a typical input of 7 ppm O 3 (OHR O 3 = 10 s −1 ), 10-fold OH suppression is observed at OHR ext ~ 100 s −1 , which is similar or lower than used in many laboratory studies. The range of modeled OH suppression for literature experiments is consistent with the measured values except for those with isoprene. The finding on OH suppression may have important implications for the interpretation of past laboratory studies, as applying OH exp measurements acquired under different conditions could lead to over a 1-order-of-magnitude error in the estimated OH exp . The uncertainties of key model outputs due to uncertainty in all rate constants and absorption cross-sections in the model are within ±25 % for OH exposure and within ±60 % for other parameters. These uncertainties are small relative to the dynamic range of outputs. Uncertainty analysis shows that most of the uncertainty is contributed by photolysis rates of O 3 , O 2 , and H 2 O and reactions of OH and HO 2 with themselves or with some abundant species, i.e., O 3 and H 2 O 2 . OH exp calculated from direct integration and estimated from SO 2 decay in the model with laminar and measured residence time distributions (RTDs) are generally within a factor of 2 from the plug-flow OH exp . However, in the models with RTDs, OH exp estimated from SO 2 is systematically lower than directly integrated OH exp in the case of significant SO 2 consumption. We thus recommended using OH exp estimated from the decay of the species under study when possible, to obtain the most appropriate information on photochemical aging in the OFR. Using HO x -recycling vs. destructive external OH reactivity only leads to small changes in OH exp under most conditions. Changing the identity (rate constant) of external OH reactants can result in substantial changes in OH exp due to different reductions in OH suppression as the reactant is consumed. We also report two equations for estimating OH exposure in OFR254. We find that the equation estimating OH exp from measured O 3 consumption performs better than an alternative equation that does not use it, and thus recommend measuring both input and output O 3 concentrations in OFR254 experiments. This study contributes to establishing a firm and systematic understanding of the gas-phase HO x and O x chemistry in these reactors, and enables better experiment planning and interpretation as well as improved design of future reactors.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

DOE OSTI2015

No Keplerian disk >10 AU around the protostar B335: Magnetic braking or young age?

We have conducted Atacama Large Millimeter/Submillimeter Array (ALMA) cycle 2 observations in the 1.3 mm continuum and in the C{sup 18}O (2–1) and SO (5{sub 6}–4{sub 5}) lines at a resolution of ∼0.″3 toward the Class 0 protostar B335. The 1.3 mm continuum, C{sup 18}O, and SO emission all show central compact components with sizes of ∼40–180 AU within more extended components. The C{sup 18}O component shows signs of infalling and rotational motion. By fitting simple kinematic models to the C{sup 18}O data, the protostellar mass is estimated to be 0.05 M{sub ⊙}. The specific angular momentum, on a 100 AU scale, is (4.3 ± 0.5) × 10{sup −5} km s{sup −1} pc. A similar specific angular momentum, (3–5) × 10{sup −5} km s{sup −1} pc, is measured on a 10 AU scale from the velocity gradient observed in the central SO component, and there is no clear sign of an infalling motion in the SO emission. By comparing the infalling and rotational motion, our ALMA results suggest that the observed rotational motion has not yet reached Keplerian velocity neither on a 100 AU nor even on a 10 AU scale. Consequently, the radius of the Keplerian disk in B335 (if present) is expected to be 1–3 AU. The expected disk radius in B335 is one to two orders of magnitude smaller than those of observed Keplerian disks around other Class 0 protostars. Based on the observed infalling and rotational motion from 0.1 pc to inner 100 AU scales, there are two possible scenarios to explain the presence of such a small Keplerian disk in B335: magnetic braking and young age. If our finding is the consequence of magnetic braking, ∼50% of the angular momentum of the infalling material within a 1000 AU scale might have been removed, and the magnetic field strength on a 1000 AU scale is estimated to be ∼200 μG. If it is young age, the infalling radius in B335 is estimated to be ∼2700 AU, corresponding to a collapsing timescale of ∼5 × 10{sup 4} years.

79 ASTRONOMY AND ASTROPHYSICS↗

NASA NTRS2003

Measuring sleep habits without using a diary: the sleep timing questionnaire

STUDY OBJECTIVES: To develop a single-administration instrument yielding equivalent measures of sleep to those obtained from a formal (2-week) sleep diary. DESIGN & SETTING: A single-administration Sleep riming Questionnaire (STQ) is described (and reproduced in the Appendix). Test-retest reliability was examined in 40 subjects who were given the STQ on two occasions separated by less than 1 year. Convergent validity was measured both by comparing STO-derived measures with objective measures derived from wrist actigraphy (n=23) and by comparing STQ-derived measures with other subjective measures derived from a detailed 2-week sleep diary in two nonoverlapping samples (n=101, 93). Correlations of STQ measures with age and momingness-eveningness (chronotype) were also examined. SUBJECTS: The analyses used sample sizes of 40, 23, 101, and 93 (both genders, overall age range 20y-89y). Most subjects were healthy volunteers; some Study 4 subjects were patients (enrolled in research protocols). RESULTS: Test-retest reliability for the STQ was demonstrated for estimates of bedtime (r = 0.705, p < 0.001) and waketime (r = 0.826, p < 0.001). Convergent validity using wrist actigraphy was demonstrated by correlations of 0.592 (p < 0.005) for bedtime, and of 0.769 (p < 0.001) for waketime. Diary studies indicated STQ bedtime and waketime data to be highly correlated (at about 0.8) with those obtained from a formal 2-week sleep diary. The STQ also provided data on estimated sleep latency and wake after sleep onset (WASO), which correlated reliably (at about 0.7) with average nightly ratings of these variables from a 2-week sleep diary. Mean estimated values of sleep latency and WASO from the two instruments were within 1 minute of each other. ST-derived bedtimes and waketimes correlated with both age and chronotype in the expected direction (older subjects earlier, morning types earlier). CONCLUSION: The STQ may be a reliable valid measure of sleep timing that could provide a time-efficient alternative to traditional sleep diaries.

Validation Studies↗

NASA NTRS2016

Discordant K-Ar and Young Exposure Dates for the Windjana Sandstone, Kimberley, Gale Crater, Mars

K-Ar and noble gas surface exposure age measurements were carried out on the Windjana sandstone, Kimberley region, Gale Crater, Mars, by using the Sample Analysis at Mars instrument on the Curiosity rover. The sandstone is unusually rich in sanidine, as determined by CheMin X-ray diffraction, contributing to the high K2O concentration of 3.09 +/- 0.20 wt % measured by Alpha-Particle X-ray Spectrometer analysis. A sandstone aliquot heated to approximately 915 C yielded a K-Ar age of 627 +/- 50 Ma. Reheating this aliquot yielded no additional Ar. A second aliquot heated in the same way yielded a much higher K-Ar age of 1710 +/- 110 Ma. These data suggest incomplete Ar extraction from a rock with a K-Ar age older than 1710 Ma. Incomplete extraction at approximately 900 C is not surprising for a rock with a large fraction of K carried by Ar-retentive K-feldspar. Likely, variability in the exact temperature achieved by the sample from run to run, uncertainties in sample mass estimation, and possible mineral fractionation during transport and storage prior to analysis may contribute to these discrepant data. Cosmic ray exposure ages from He-3 and Ne-21 in the two aliquots are minimum values given the possibility of incomplete extraction. However, the general similarity between the He-3 (57 +/- 49 and 18 +/- 32 Ma, mean 30 Ma) and Ne-21 (2 +/- 32 and 83 +/- 24 Ma, mean 54 Ma) exposure ages provides no evidence for underextraction. The implied erosion rate at the Kimberley location is similar to that reported at the nearby Yellowknife Bay outcrop.

K-Ar↗

DOE OSTI2022

Diabetes and hypertension are related to amyloid-beta burden in the population-based Rotterdam Study

Abstract Higher vascular disease burden increases the likelihood of developing dementia, including Alzheimer’s disease. Better understanding the association between vascular risk factors and Alzheimer’s disease pathology at the predementia stage is critical for developing effective strategies to delay cognitive decline. In this work, we estimated the impact of six vascular risk factors on the presence and severity of in vivo measured brain amyloid-beta (Aβ) plaques in participants from the population-based Rotterdam Study. Vascular risk factors (hypertension, hypercholesterolaemia, diabetes, obesity, physical inactivity and smoking) were assessed 13 (2004–2008) and 7 years (2009–2014) prior to 18F-florbetaben PET (2018–2021) in 635 dementia-free participants. Vascular risk factors were associated with binary amyloid PET status or continuous PET readouts (standard uptake value ratios, SUVrs) using logistic and linear regression models, respectively, adjusted for age, sex, education, APOE4 risk allele count and time between vascular risk and PET assessment. Participants’ mean age at time of amyloid PET was 69 years (range: 60–90), 325 (51.2%) were women and 190 (29.9%) carried at least one APOE4 risk allele. The adjusted prevalence estimates of an amyloid-positive PET status markedly increased with age [12.8% (95% CI 11.6; 14) in 60–69 years versus 35% (36; 40.8) in 80–89 years age groups] and APOE4 allele count [9.7% (8.8; 10.6) in non-carriers versus 38.4% (36; 40.8) to 60.4% (54; 66.8) in carriers of one or two risk allele(s)]. Diabetes 7 years prior to PET assessment was associated with a higher risk of a positive amyloid status [odds ratio (95% CI) = 3.68 (1.76; 7.61), P < 0.001] and higher standard uptake value ratios, indicating more severe Aβ pathology [standardized beta = 0.40 (0.17; 0.64), P = 0.001]. Hypertension was associated with higher SUVr values in APOE4 carriers (mean SUVr difference of 0.09), but not in non-carriers (mean SUVr difference 0.02; P = 0.005). In contrast, hypercholesterolaemia was related to lower SUVr values in APOE4 carriers (mean SUVr difference −0.06), but not in non-carriers (mean SUVr difference 0.02). Obesity, physical inactivity and smoking were not related to amyloid PET measures. The current findings suggest a contribution of diabetes, hypertension and hypercholesterolaemia to the pathophysiology of Alzheimer’s disease in a general population of older non-demented adults. As these conditions respond well to lifestyle modification and drug treatment, further research should focus on the preventative effect of early risk management on the development of Alzheimer’s disease neuropathology.

van Arendonk, Joyce (ORCID:0000000172941633)↗

DOE OSTI2022

Validation of earthquake ground-motion models in southern California, USA, using precariously balanced rocks

Accurate estimates of earthquake ground shaking rely on uncertain ground-motion models derived from limited instrumental recordings of historical earthquakes. A critical issue is that there is currently no method to empirically validate the resultant ground-motion estimates of these models at the timescale of rare, large earthquakes; this lack of validation causes great uncertainty in ground-motion estimates. Here, we address this issue and validate ground-motion estimates for southern California utilizing the unexceeded ground motions recorded by 20 precariously balanced rocks. We used cosmogenic 10Be exposure dating to model the age of the precariously balanced rocks, which ranged from ca. 1 ka to ca. 50 ka, and calculated their probability of toppling at different ground-motion levels. With this rock data, we then validated the earthquake ground motions estimated by the Uniform California Earthquake Rupture Forecast, Version 3 (UCERF3) seismic-source characterization and the Next Generation Attenuation (NGA)-West2 ground-motion models. We found that no ground-motion model estimated levels of earthquake ground shaking consistent with the observed continued existence of all 20 precariously balanced rocks. The ground-motion model I14 estimated ground-motion levels that were inconsistent with the most rocks; therefore, I14 was invalidated and removed. At a 2475 year mean return period, the removal of this invalid ground-motion model resulted in a 2−7% reduction in the mean and a 10−36% reduction in the 5th−95th fractile uncertainty of the ground-motion estimates. Our findings demonstrate the value of empirical data from precariously balanced rocks as a validation tool for removing invalid ground-motion models and, in turn, reducing the uncertainty in earthquake ground-motion estimates.

Geology↗