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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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3,303 records · Page 49

Specific Bacterial Taxa and Their Metabolite, DHPS, May Be Linked to Gut Dyshomeostasis in Patients with Alzheimer’s Disease, Parkinson’s Disease, and Amyotrophic Lateral Sclerosis

Background: Neurodegenerative diseases (NDDs) are multifactorial disorders frequently associated with gut dysbiosis, oxidative stress, and inflammation; however, the pathophysiological mechanisms remain poorly understood. Methods: Using untargeted mass spectrometry-based metabolomics and 16S sequencing of human stool, we investigated bacterial and metabolic dyshomeostasis in the gut microbiome associated with early disease stages across three NDDs—amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s disease (PD)—and healthy controls (HC). Results: We discovered a previously unrecognized link between a microbial-derived metabolite with an unknown role in human physiology, 2,3-dihydroxypropane-1-sulfonate (DHPS), and gut dysbiosis in NDDs. DHPS was downregulated in AD, ALS, and PD, while bacteria involved in DHPS metabolism, Eubacterium and Desulfovibrio, were increased in all disease cohorts. Additionally, select taxa within the Clostridia class had strong negative correlations to DHPS, suggesting a potential role in DHPS metabolism. A catabolic product of DHPS is hydrogen sulfide, and when in excess, it is known to promote inflammation, oxidative stress, mitochondrial damage, and gut dysbiosis, known hallmarks of NDDs. Conclusions: These findings suggest that cryptic sulfur metabolism via DHPS is a potential missing link in our current understanding of gut dysbiosis associated with NDD onset and progression. As this was a hypothesis generating study, more work is needed to elucidate the role of DHPS in gut dysbiosis and neurodegenerative diseases.

Nutrition & Dietetics

Impact of Advances in Anion Exchange Membranes and Ionomers on Alkaline Fuel Cells

Abstract The operation of low‐temperature electrochemical energy conversion systems (fuel cells, electrolyzers) at high pH values is of perennial interest due to the possibility of moving away from expensive platinum group metal catalysts and reducing cost. Historically, the anion exchange membranes (AEMs) and ionomers have been hampered by performance (ionic conductivity, mechanical strength) and chemical stability issues. In this context, select developments over the past decade in alternate AEM chemistries, water management methods, and production of membrane electrode assemblies (MEAs) that have enabled a significant leap in performance of alkaline fuel cells are examined. These developments are linked to performance improvements in alkaline H 2 /O 2 fuel cells and also consider developments in alkaline fuel cells using nitrogen‐containing fuels (ammonia, hydrazine), carbon‐containing fuels (alcohols, glycols), and boron‐containing fuels (sodium borohydride, ammonia borane). Finally, current challenges and bottlenecks are identified, and potential solutions are proposed.

Chemistry

Coupled, Transient Simulations of the Interaction Between Power and Secondary Flowpaths in Gas Turbines

This paper presents a coupled analysis of the interaction between mainpath and secondary flowpaths in gas turbines using transient simulations. Some of the topics include: 1) Need for Coupled Analysis; 2) Primary-Secondary Coupling Schematic; 3) Secondary Flow Requirement; 4) Objectives of Present Methodology; 5) Current Methodologies Recap; 6) Proposed Coupled Code Methodology; 7) Description of SCISEAL Code; 8) Description of Turbo Code; 9) Code Coupling/Interface Issues; and 10) Current Interface Strategy. This paper is presented in viewgraph form.

M M Athavale

Feedstock Choices for Advancing the Bioeconomy in the US and Policy Implications

Biomass feedstocks will be critical for scaling up the bioeconomy in the United States to meet multiple demands for biofuels, sustainable aviation fuel, bioproducts, and biochemicals. There is a wide range of choices of feedstocks, including a variety of dedicated energy crops and crop residues. There are substantial differences in the yields, costs of production, and carbon intensity of these feedstocks and for each feedstock across locations. These feedstocks also differ in the trade-offs they offer among multiple environmental impacts. We discuss the economic factors that will influence the production of these feedstocks and the implications of alternative biofuel and low-carbon policies for the mix of feedstocks that will be incentivized.

Khanna, Madhu (ORCID:0000000349944451)

Change Detection Analysis in Urban and Suburban Areas Using Landsat Thematic Mapper data: Case of Huntsville, Alabama

Two Landsat Thematic Mapper (TM) images, from July 1984 and July 1992, were used to identify land use/cover changes in the urban and suburban fringe of the city of Huntsville, Alabama. Image difference was the technique used to quantify the change between the two dates. The eight-year period showed a 16% change, mainly from agricultural lands to urban areas generated by the settlement of industrial, commercial, and residential areas. Visual analysis of the change map (i.e., difference image) supported this phenomenon by showing that most changes were occurring in the vicinity of the major roads and highways across the city.

Dana Kuan

Commercial and Industrial Energy Procurement in Nigeria: A Consumer's Guidebook

Across Africa, countries have incorporated a variety of new energy sources into their energy mix to account for increasing demand. In Nigeria, electricity consumption per capita has grown nearly 50% in the past 20 years. To address rising demand for energy in Nigeria, the country has passed several recent policies and regulations aimed at increasing energy generation across the country, improving the country's transmission infrastructure, and ensuring that electricity reliably reaches end users, including commercial and industrial (C&I) customers. This guidebook is designed for C&I customers in Nigeria to use in the consideration of procuring such onsite, captive energy systems to supplement their energy needs. Each section of this guidebook touches on a step of the procurement process and details the relevant stakeholders, processes, and data needed to make decisions during that step.

14 SOLAR ENERGY

The Telecommunications and Data Acquisition Progress Report 42-74

This publication reports on developments in programs managed by JPL's office of Telecommunications and Data Acquisition (TDA). In space communications, radio navigation, radio science, and ground based radio astronomy, it reports on activities of the Deep Space Network (DSN) and its associated Ground Communications Facility (GCF) in planning, in supporting research and technology, in implementation and in operations. In geodynamics, the publication reports on the application of radio interferometry at microwave frequencies for geodynamic measurements. This publication also reports on implementation and operations for searching the microwave spectrum.

E C Posner

Horseshoe Asteroids and Quasi-satellites in Earth-like Orbits

Newly found asteroid 2003 YN107 is the first and only known current quasi-satellite (QS) of the Earth. Asteroid 2002 AA29 is in a horseshoe orbit (HS) but has periods of QS behavior. Both asteroids closely follow Earth s orbit. 2002 AA29 has inclination i is approximately 11 degrees while for 2003 YN107 i<5 degrees, making the most Earth-like orbit known. 2003 YN107, 2002 AA29, and other Earth-resonant objects in less Earthlike orbits, form an important new class of co-orbital bodies with interesting dynamics and are the best targets for sample return missions to asteroids.

M Connors

Radiation-Resistant Ti/BN Coatings: Insights From 171 Days Exposure to Space Radiation and Atomic Oxygen in Low Orbit

Atmospheric Plasma Spray (APS) and Vacuum Plasma Spray (VPS) techniques were used to develop Ti/2 vol.% hBN coatings, for extreme space environments and tested aboard the International Space Station as part of the MISSE-17 (Materials International Space Station Experiments) program. The coatings were exposed to atomic oxygen, space radiation, and low-orbit thermal cycling. VPS coatings showed a 56% increase in microhardness, a 26% rise in elastic modulus, minimal porosity and crack density changes compared to APS coatings. The change in mechanical properties is attributed to the formation of TiO, TiO₂ and TiN from nitrogen retention, alongside radiation-induced dislocations, which enhanced surface hardening. The oxidation of titanium led to the formation of TiO and TiO₂, while boron nitride was retained and underwent transmutation in VPS coatings. XPS and EDS analyses confirmed the enhanced space-environment resistance of VPS coatings, making them ideal for long-term spacecraft protection in lunar and Martian conditions.

Abhijith Kunneparambil Sukumaran

Impact of Inertia, Friction, and Backlash upon Force Control in Telemanipulation

The mechanical behavior of master controllers of telemanipulators has been a concern of both designers and implementors of telerobotic systems. In general, the literature recommends that telemanipulator systems be constructed that minimize inertia, friction, and backlash in an effort to improve telemanipulative performance. For the most part, these recommendations are founded upon theoretical analysis or simply intuition. Although these recommendations are not challenged on their merit, the material results are measured of building and fielding telemanipulators that possess less than ideal mechanical behaviors. Experiments are described in which forces in a mechanical system with human input are evaluated as a function of mechanical characteristics such as inertia, friction, and backlash. Results indicate that the ability of the human to maintain gripping forces was relatively unaffected by dynamic characteristics in the range studied, suggesting that telemanipulator design in this range should be based on task level force control requirements rather than human factors.

Neil A Duffie