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NASA NTRS2023

Automated Fluidics Device for Extraction and Quantification of miRNA Biomarkers From Blood

Radiation Assessment DuRing Exposure And long-Duration Spaceflight (RADREADS) demonstrates space-compatible point-of-care technology for quantitative biological monitoring of blood miRNA biomarkers in response to long-term low dose radiation exposure. This individualized monitoring approach will inform targeted treatment strategies to maximize medical resource utilization by accounting for individual susceptibility to radiation-related illnesses. As human spaceflight progresses beyond Earth’s magnetic shielding, radiation exposure poses a significant risk to astronaut health and safety. Extended operation in this environment comes with an increased risk of radiation exposure, leading to higher risks of radiation sickness, cancer, central nervous system effects, and degenerative diseases. While conventional physical dosimetry techniques capture radiation dose, individualistic susceptibility to radiation damage is varied. Multiple characteristics, including age, body weight, sex, genetics, and immune status, have been found to influence radiosensitivity (Liu et al. 2011, and Bouffler 2016). This differential response necessitates individualized monitoring and targeted treatment strategies to maximize medical resource utilization; however, a practical diagnostic platform for quantifying long-term, low dose radiation-induced tissue damage does not currently exist. MicroRNAs (miRNAs) are a class of small, non-coding RNAs that regulate gene expression by mediating the degradation of messenger RNA. The levels of particular miRNAs are influenced by biological processes such as inflammation and serve as biomarkers for a variety of conditions including cancer (Singh et al. 2017). MicroRNAs are found in various bodily fluids and are amenable to collection via liquid biopsies, providing a minimally invasive and easily quantifiable readout for a variety of radiosensitive reporters. A preliminary signature of 15 spaceflight sensitive miRNA has been identified in rodent and human studies, including miR-21-5p, miR-24-3p, miR-92a-3p, miR-17-5p, miR-16a-3p, miR-34a-3p, and miR-223-3p. These targets generally increased expression with radiation dose and linear energy transfer, though variation between individuals is not yet described. Current gaps in the field include a lack of understanding of longitudinal biological responses to long-term, low dose radiation exposure and the absence of space-compatible point-of-care technology for quantitative biological monitoring. In this body of work, we aim to develop an automated bleed-to-read system to process whole blood for the detection of miRNA biomarkers in order to monitor individualistic responses to radiation exposure. This will be achieved via separating serum (or plasma) from whole blood, followed by extraction, amplification, and quantification of the miRNA using a RT-qPCR reaction. Previously, the WetLab-2 hardware enabled execution of a RT-qPCR reaction aboard ISS; however, it is a manual system that requires crew manipulation and bulky components (Parra et al. 2017). To address these issues, automated fluid handling hardware was developed for each stage of sample preparation. Extraction of total RNA is achieved by sequentially pumping reagents through an off-the-shelf nucleic acid binding column (miRNeasy Serum/Plasma Advanced Kit, Qiagen). This approach eliminates several manual pipetting and centrifuging steps and limits the use of toxic chemicals commonly found in other sample processing techniques. The resulting elution will then be automatically dispensed for RT-qPCR analysis using a compact rotary qPCR (Mic qPCR Cycler, Bio Molecular Systems) that will improve spaceflight compatibility by removing bubbles from the detection region, another challenge highlighted by WetLab-2 (Parra et al. 2017). Efforts are also being made to simplify the RT-qPCR reaction to a 1-step air-dryable mix to improve long-term reagent stability at room temperature and reduce system complexity. By automating the RT-qPCR processes via microfluidic manipulation, RADREADS will reduce crewmember hands-on time and enable the personalized detection of radiation-induced tissue damage during long duration missions. Minimally invasive, longitudinal monitoring of individual’s response to radiation exposure will inform how the physiological system responds to long-term low dose space radiation and enables development of targeted countermeasures by the medical team. Ultimately, this portable technology will require minimal technical expertise and can also be used to monitor miRNA biomarkers associated with other diseases.

Tristen Head↗

NASA NTRS2006

Space-based Networking Technology Developments in the Interplanetary Network Directorate Information Technology Program

Described recent development of communications protocols, services, and associated tools targeted to reduce risk, reduce cost and increase efficiency of IND infrastructure and supported mission operations. Space-based networking technologies developed were: a) Provide differentiated quality of service (QoS) that will give precedence to traffic that users have selected as having the greatest importance and/or time-criticality; b) Improve the total value of information to users through the use of QoS prioritization techniques; c) Increase operational flexibility and improve command-response turnaround; d) Enable new class of networked and collaborative science missions; e) Simplify applications interfaces to communications services; and f) Reduce risk and cost from a common object model and automated scheduling and communications protocols. Technologies are described in three general areas: communications scheduling, middleware, and protocols. Additionally developed simulation environment, which provides comprehensive, quantitative understanding of the technologies performance within overall, evolving architecture, as well as ability to refine & optimize specific components.

scheduling↗

NASA NTRS1997

Computer based imaging and analysis of root gravitropism

Two key issues in studies of the nature of the gravitropic response in roots have been the determination of the precise pattern of differential elongation responsible for downward bending and the identification of the cells that show the initial motor response. The main approach for examining patterns of differential growth during root gravitropic curvature has been to apply markers to the root surface and photograph the root at regular intervals during gravitropic curvature. Although these studies have provided valuable information on the characteristics of the gravitropic motor response in roots, their labor intensive nature limits sample size and discourages both high frequency of sampling and depth of analysis of surface expansion data. In this brief review we describe the development of computer-based video analysis systems for automated measurement of root growth and shape change and discuss some key features of the root gravitropic response that have been revealed using this methodology. We summarize the capabilities of several new pieces of software designed to measure growth and shape changes in graviresponding roots and describe recent progress in developing analysis systems for studying the small, but experimentally popular, primary roots of Arabidopsis. A key finding revealed by such studies is that the initial gravitropic response of roots of maize and Arabidopsis occurs in the distal elongation zone (DEZ) near the root apical meristem, not in the main elongation zone. Another finding is that the initiation of rapid elongation in the DEZ following gravistimulation appears to be related to rapid membrane potential changes in this region of the root. These observations have provided the incentive for ongoing studies examining possible links between potential growth modifying factors (auxin, calcium, protons) and gravistimulated changes in membrane potential and growth patterns in the DEZ.

NASA Discipline Plant Biology↗

NASA NTRS1993

Modelling the Shuttle Remote Manipulator System: Another flexible model

High fidelity elastic system modeling algorithms are discussed. The particular system studied is the Space Shuttle Remote Manipulator System (RMS) undergoing full articulated motion. The model incorporates flexibility via a methodology the author has been developing. The technique is based in variational principles, so rigorous boundary condition generation and weak formulations for the associated partial differential equations are realized, yet the analyst need not integrate by parts. The methodology is formulated using vector-dyad notation with minimal use of tensor notation, therefore the technique is believed to be affable to practicing engineers. The objectives of this work are as follows: (1) determine the efficacy of the modeling method; and (2) determine if the method affords an analyst advantages in the overall modeling and simulation task. Generated out of necessity were Mathematica algorithms that quasi-automate the modeling procedure and simulation development. The project was divided into sections as follows: (1) model development of a simplified manipulator; (2) model development of the full-freedom RMS including a flexible movable base on a six degree of freedom orbiter (a rigid-body is attached to the manipulator end-effector); (3) simulation development for item 2; and (4) comparison to the currently used model of the flexible RMS in the Structures and Mechanics Division of NASA JSC. At the time of the writing of this report, items 3 and 4 above were not complete.

Barhorst, Alan A.↗

NASA NTRS1976

DSN research and technology support

The activities of the Venus Station (DSS 13) and the Microwave Test Facility (MTF) during the period April 19 through June 13, 1976, are discussed and progress noted. Continuing reliability testing and computer program refinement of the remote controlled, unattended automated pulsar observing station is noted, along with routine observations of 17 pulsars. Radar observations of a geostationary satellite are reported, along with the routine automatic testing of the stability of the DSS 13 maser-receiving system. Additional testing of thermal characteristics of semiflexible coaxial cables is reported, along with phase stabilization measurements thereon. Routine support of the planetary radio astronomy experiment, with 43.25 hours of observations of Jupiter and various radio calibration sources, is reported, along with 18.75 hours of differential VLBI observations in conjunction with Australia, DSS 43. Modifications of the clock synchronization winterization system are reported, along with a discussion of the activities of the DSN High-Power Transmitter Maintenance Facility.

Jackson, E. B.↗

NASA NTRS2016

Using VSWIR Microimaging Spectroscopy to Explore the Mineralogical Diversity of HED Meteorites

We use VSWIR microimaging spectroscopy to survey the spectral diversity of HED meteorites at 80-µm/pixel spatial scale. Our goal in this work is both to explore the emerging capabilities of microimaging VSWIR spectroscopy, and to contribute to understanding the petrologic diversity of the HED suite and the evolution of Vesta. Using a combination of manual and automated hyperspectral classification techniques, we identify four major classes of materials based on VSWIR absorptions that include pyroxene, olivine, Fe-bearing feldspars, and glass-bearing/featureless materials. Results show microimaging spectroscopy is an effective method for rapidly and non-destructively characterizing small compositional variations of meteorite samples and for locating rare phases for possible follow-up investigation. Future work will include incorporating SEM/EDS results to quantify sources of spectral variability and placing observations within a broader geologic framework of the differentiation and evolution of Vesta.

Fraeman, Abigail A↗

NASA NTRS1993

Automated fiber placement composite manufacturing: The mission at MSFC's Productivity Enhancement Complex

Automated fiber placement is a manufacturing process used for producing complex composite structures. It is a notable leap to the state-of-the-art in technology for automated composite manufacturing. The fiber placement capability was established at the Marshall Space Flight Center's (MSFC) Productivity Enhancement Complex in 1992 in collaboration with Thiokol Corporation to provide materials and processes research and development, and to fabricate components for many of the Center's Programs. The Fiber Placement System (FPX) was developed as a distinct solution to problems inherent to other automated composite manufacturing systems. This equipment provides unique capabilities to build composite parts in complex 3-D shapes with concave and other asymmetrical configurations. Components with complex geometries and localized reinforcements usually require labor intensive efforts resulting in expensive, less reproducible components; the fiber placement system has the features necessary to overcome these conditions. The mechanical systems of the equipment have the motion characteristics of a filament winder and the fiber lay-up attributes of a tape laying machine, with the additional capabilities of differential tow payout speeds, compaction and cut-restart to selectively place the correct number of fibers where the design dictates. This capability will produce a repeatable process resulting in lower cost and improved quality and reliability.

Vickers, John H.↗

NASA NTRS2019

Assessing Dual-Polarization Radar Estimates of Extreme Rainfall During Hurricane Harvey

Hurricane Harvey hit the Texas Gulf Coast as a major hurricane on 25 August 2017 before exiting the state as a tropical storm on 29 August 2017. Left in its wake was historic flooding, with some locations measuring more than 60 in. (150 cm) of rain over a 5-day period. The WSR-88D radar (KHGX) maintained operations for the entirety of the event. Rain gauge data from the Harris County Flood Warning System (HCFWS) was used for validation with the full radar dataset to retrieve daily and event-total precipitation estimates for the period 25–29 August2017. The KHGX precipitation estimates were then compared with the HCFWS gauges. Three different hybrid polarimetric rainfall retrievals were used, along with attenuation-based retrieval that employs the radar-observed differential propagation. An advantage of using a attenuation-based retrieval is its immunity to partial beam blockage and calibration errors in reflectivity and differential reflectivity. All of the retrievals are susceptible to changes in the observed drop size distribution (DSD). No in situ DSD data were available over the study area, so changes in the DSD were interpreted by examining the observed radar data. We examined the parameter space of two key values in the attenuation retrieval to test the sensitivity of the rain retrieval. Selecting a value ofa50.015 andb50.600 provided the best overall results, relative to the gauges, but more work needs to be done to develop an automated technique to account for changes in the ambient DSD.

David Billings Wolff↗

NASA NTRS2019

Assessing Dual-Polarization Radar Estimates of Extreme Rainfall During Hurricane Harvey

Hurricane Harvey hit the Texas Gulf Coast as a major hurricane on August 25, 2017 before exiting the state as a tropical storm on August 29, 2017. Left in its wake was historic flooding, with some locations measuring more than 60 inches of rain over a five-day period. The WSR-88D radar (KHGX) maintained operations for the entirety of the event. Rain gauge data from the Harris County Flood Warning System (HCFWS) was used for validation with the full radar data set to retrieve daily and event-total precipitation estimates for the period August 25-29, 2017. The KHGX precipitation estimates were then compared to the HCFWS gauges. Three different hybrid polarimetric rainfall retrievals were used, along with attenuation-based retrieval that employs the radar-observed differential propagation. An advantage of using a attenuation-based retrieval is its immunity to partial beam blockage and calibration errors in reflectivity and differential reflectivity. All of the retrievals are susceptible to changes in the observed Drop Size Distribution (DSD). No in situ DSD data were available over the study area, so changes in the DSD were interpreted by examining the observed radar data. We examined the parameter space of two key values in the attenuation retrieval to test the sensitivity of the rain retrieval. Selecting a value of α=0.015 and β=0.600 and β=0.625 provided the best overall results, relative to the gauges, but more work needs to be done to develop an automated technique to account for changes in the ambient DSD.

David B Wolff↗

NASA NTRSDate not supplied

Identifying Human Factors Research for Unmanned Aircraft Systems and Advanced Air Mobility

This paper identifies some of the key human factors (HF) challenges when integrating Unmanned Aircraft Systems (UAS) and Advanced Air Mobility (AAM) into the civil airspace. Unique HF considerations—those which are derived from the key differentiating aspects of UAS/AAM compared to conventional aviation—are the primary basis for identifying HF research opportunities. By identifying what makes UAS and AAM fundamentally different from conventional aviation, from a human integration perspective, HF research can be targeted to effectively inform best practices, standards, policy, guidance, and regulations associated with aircraft and air traffic systems and operations. HF research areas are discussed within the following topic areas: Sustained low-altitude operations; loss of natural sensing; novel aircraft; novel operations; link management and lost link; link performance; distributed pilot teams; and increased automation. The identified research descriptions are intended to serve as illustrative examples of what research is fundamental, and why. They are not intended to prescribe, prioritize or exclude research.

AAM↗

NASA NTRSDate not supplied

Identifying Human Factors Research for Unmanned Aircraft Systems (UAS) and Advanced Air Mobility (AAM)

AAM↗

NASA NTRS1990

Recognition of 3-D symmetric objects from range images in automated assembly tasks

A new technique is presented for the three dimensional recognition of symmetric objects from range images. Beginning from the implicit representation of quadrics, a set of ten coefficients is determined for symmetric objects like spheres, cones, cylinders, ellipsoids, and parallelepipeds. Instead of using these ten coefficients trying to fit them to smooth surfaces (patches) based on the traditional way of determining curvatures, a new approach based on two dimensional geometry is used. For each symmetric object, a unique set of two dimensional curves is obtained from the various angles at which the object is intersected with a plane. Using the same ten coefficients obtained earlier and based on the discriminant method, each of these curves is classified as a parabola, circle, ellipse, or hyperbola. Each symmetric object is found to possess a unique set of these two dimensional curves whereby it can be differentiated from the others. It is shown that instead of using the three dimensional discriminant which involves evaluation of the rank of its matrix, it is sufficient to use the two dimensional discriminant which only requires three arithmetic operations.

Alvertos, Nicolas↗

NASA NTRS2002

New Boundary Constraints for Elliptic Systems used in Grid Generation Problems

This paper discusses new boundary constraints for elliptic partial differential equations as used in grid generation problems in generalized curvilinear coordinate systems. These constraints, based on the principle of local conservation of thermal energy in the vicinity of the boundaries, are derived using the Green's Theorem. They uniquely determine the so called decay parameters in the source terms of these elliptic systems. These constraints' are designed for boundary clustered grids where large gradients in physical quantities need to be resolved adequately. It is observed that the present formulation also works satisfactorily for mild clustering. Therefore, a closure for the decay parameter specification for elliptic grid generation problems has been provided resulting in a fully automated elliptic grid generation technique. Thus, there is no need for a parametric study of these decay parameters since the new constraints fix them uniquely. It is also shown that for Neumann type boundary conditions, these boundary constraints uniquely determine the solution to the internal elliptic problem thus eliminating the non-uniqueness of the solution of an internal Neumann boundary value grid generation problem.

Kaul, Upender K.↗

NASA NTRS2011

Experimental and Modeling Studies of the Combustion Characteristics of Conventional and Alternative Jet Fuels. Final Report

The objectives of this project have been to develop a comprehensive set of fundamental data regarding the combustion behavior of jet fuels and appropriately associated model fuels. Based on the fundamental study results, an auxiliary objective was to identify differentiating characteristics of molecular fuel components that can be used to explain different fuel behavior and that may ultimately be used in the planning and design of optimal fuel-production processes. The fuels studied in this project were Fischer-Tropsch (F-T) fuels and biomass-derived jet fuels that meet certain specifications of currently used jet propulsion applications. Prior to this project, there were no systematic experimental flame data available for such fuels. One of the key goals has been to generate such data, and to use this data in developing and verifying effective kinetic models. The models have then been reduced through automated means to enable multidimensional simulation of the combustion characteristics of such fuels in real combustors. Such reliable kinetic models, validated against fundamental data derived from laminar flames using idealized flow models, are key to the development and design of optimal combustors and fuels. The models provide direct information about the relative contribution of different molecular constituents to the fuel performance and can be used to assess both combustion and emissions characteristics.

Meeks, Ellen↗

NASA NTRS2001

A New Kind of Curing

A new curing method using automated tape placement (ATP) with electron beam (EB), or e-beam, produces a combination known as in situ e-beam curing. Through a Small Business Innovation Research (SBIR) contract from NASA's Marshall Space Flight Center, Science Research Laboratory, Inc., created the in situ e-beam curing technique, which uses a low-energy electron beam gun to cure various composite materials. One important benefit is the technique's utilization of room temperature curing, which lessens the chance of mismatching the thermal expansion coefficients of different materials. For instance, metals and composites will expand at different rates when heated, but the low-energy e-beam gun reduces the expansion differential. Using a low-energy gun also results in less x-ray shielding, significantly reduced capital costs, reduced facility space, and increased processing capabilities for larger parts. However, using a low-energy gun also means that each tape layer is treated individually because the gun can penetrate only one layer at a time. The e-beam gun emits lower energy x-rays, which are more easily shielded than those emitted by previous guns. The low-energy system is relatively portable due to its light weight and small size. The gun weighs about 70 pounds and can be easily mounted on a robotic arm or an ATP head.

Source record↗

NASA NTRS2006

Saving Space and Time: The Tractor That Einstein Built

In 1984, NASA initiated the Gravity Probe B (GP-B) program to test two unverified predictions of Albert Einstein s theory of general relativity, hypotheses about the ways space, time, light, and gravity relate to each other. To test these predictions, the Space Agency and researchers at Stanford University developed an experiment that would check, with extreme precision, tiny changes in the spin direction of four gyroscopes contained in an Earth satellite orbiting at a 400-mile altitude directly over the Earth s poles. When the program first began, the researchers assessed using Global Positioning System (GPS) technology to control the attitude of the GP-B spacecraft accurately. At that time, the best GPS receivers could only provide accuracy to nearly 1 meter, but the GP-B spacecraft required a system 100 times more accurate. To address this concern, researchers at Stanford designed high-performance, attitude-determining hardware that used GPS signals, perfecting a high-precision form of GPS called Carrier-Phase Differential GPS that could provide continuous real-time position, velocity, time, and attitude sensor information for all axes of a vehicle. The researchers came to the realization that controlling the GP-B spacecraft with this new system was essentially no different than controlling an airplane. Their thinking took a new direction: If this technology proved successful, the airlines and the Federal Aviation Administration (FAA) were ready commercial markets. They set out to test the new technology, the "Integrity Beacon Landing System," using it to automatically land a commercial Boeing 737 over 100 times successfully through Real-Time Kinematic (RTK) GPS technology. The thinking of the researchers shifted again, from automatically landing aircraft, to automating precision farming and construction equipment.

Source record↗

NASA NTRS2002

Elliptic Grid Generation of Spiral-Bevel Pinion Gear Typical of OH-58 Helicopter Transmission

This paper discusses the source term treatment in the numerical solution of elliptic partial differential equations for an interior grid generation problem in generalized curvilinear coordinates. The geometry considered is that of a planar cross-section of a generic spiral-bevel gear tooth typical of a pinion in the OH-58 helicopter transmission. The source terms used are appropriate for an interior grid domain where all the boundaries are prescribed via a combination of Dirichlet and Neumann boundary conditions. New constraints based on the Green's Theorem are derived which uniquely determine the coefficients in the source terms. These constraints are designed for boundary clustered grids where gradients in physical quantities need to be resolved adequately. However, it is seen that the present formulation works satisfactorily for mild clustering also. Thus, a fully automated elliptic grid generation technique is made possible where there is no need for a parametric study of these parameters since the new relations fix these free parameters uniquely.

Kaul, Upender K.↗

NASA NTRS2007

Spherical Cryogenic Hydrogen Tank Preliminary Design Trade Studies

A structural analysis, sizing optimization, and weight prediction study was performed by Collier Research Corporation and NASA Glenn on a spherical cryogenic hydrogen tank. The tank consisted of an inner and outer wall separated by a vacuum for thermal insulation purposes. HyperSizer (Collier Research and Development Corporation), a commercial automated structural analysis and sizing software package was used to design the lightest feasible tank for a given overall size and thermomechanical loading environment. Weight trade studies were completed for different panel concepts and metallic and composite material systems. Extensive failure analyses were performed for each combination of dimensional variables, materials, and layups to establish the structural integrity of tank designs. Detailed stress and strain fields were computed from operational temperature changes and pressure loads. The inner tank wall is sized by the resulting biaxial tensile stresses which cause it to be strength driven, and leads to an optimum panel concept that need not be stiffened. Conversely, the outer tank wall is sized by a biaxial compressive stress field, induced by the pressure differential between atmospheric pressure and the vacuum between the tanks, thereby causing the design to be stability driven and thus stiffened to prevent buckling. Induced thermal stresses become a major sizing driver when a composite or hybrid composite/metallic material systems are used for the inner tank wall for purposes such as liners to contain the fuel and reduce hydrogen permeation.

Arnold, Steven M.↗