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Exploration Medical Capability Clinical Decision Support Use Cases for CDSS Test Bed

Long-duration, deep-space exploration missions present significant challenges to crew health and performance. These challenges include the individual and combined effects of microgravity, radiation exposure, isolation, limited resources (mass, volume, power, data, and crew time), limited options for evacuation, and those associated with delayed or constrained communications. Each of these challenges necessitates greater degrees of crew autonomy as our distance from Earth increases. Specifically, as communication delays intensify - and evacuation capability diminishes the further we explore space - the unqualified need for Earth-independent medical operations focused on autonomous diagnosis, treatment and prevention will become key to mission continuation and success. This need will be especially true should a crewmember become ill or injured wherein treatment and disposition “in-situ” ultimately falls to the crew itself to determine. To augment the requisite knowledge, skills, and abilities (KSAs) of a time-constrained exploration mission crew operating under stressful conditions, combatting fatigue, and facing a potential medical crisis, a robust clinical decision support system (CDSS) is a probable solution. A CDSS would facilitate, guide, and inform Earth-independent medical operations while assisting crewmembers through various clinical presentations. The CDSS would allow crewmembers to take advantage of pre-mission training tied to the in-flight/in-mission use of pre-planned protocols that offer both a range of diagnostic options and “just-in-time” (refamiliarization) training and assistance. CDSS will expand such capabilities by improving the utility and effectiveness of various available diagnostic, treatment, and health maintenance tools, techniques, and measures.

ExMC↗

A Simulation Base Investigation of High Latency Space Systems Operations

NASA's human space program has developed considerable experience with near Earth space operations. Although NASA has experience with deep space robotic missions, NASA has little substantive experience with human deep space operations. Even in the Apollo program, the missions lasted only a few weeks and the communication latencies were on the order of seconds. Human missions beyond the relatively close confines of the Earth-Moon system will involve missions with durations measured in months and communications latencies measured in minutes. To minimize crew risk and to maximize mission success, NASA needs to develop a better understanding of the implications of these types of mission durations and communication latencies on vehicle design, mission design and flight controller interaction with the crew. To begin to address these needs, NASA performed a study using a physics-based subsystem simulation to investigate the interactions between spacecraft crew and a ground-based mission control center for vehicle subsystem operations across long communication delays. The simulation, built with a subsystem modeling tool developed at NASA's Johnson Space Center, models the life support system of a Mars transit vehicle. The simulation contains models of the cabin atmosphere and pressure control system, electrical power system, drinking and waste water systems, internal and external thermal control systems, and crew metabolic functions. The simulation has three interfaces: 1) a real-time crew interface that can be use to monitor and control the vehicle subsystems; 2) a mission control center interface with data transport delays up to 15 minutes each way; 3) a real-time simulation test conductor interface that can be use to insert subsystem malfunctions and observe the interactions between the crew, ground, and simulated vehicle. The study was conducted at the 21st NASA Extreme Environment Mission Operations (NEEMO) mission between July 18th and Aug 3rd of year 2016. The NEEMO mission provides ideal conditions for this study with crew in the loop, an active control center, and real-time flow of high latency communications and data. NEEMO crew and ground support will work through procedures including activation of the transit vehicle power system, opening the hatch between the transit vehicle and a Mars ascent vehicle, transferring simulated crewmembers between vehicles, overcoming subsystem malfunctions, sending simulated crewmember on extra-vehicular activities, and other housekeeping activities. This study is enhancing the understanding of high latency operations and the advantages and disadvantages of different communication methods. It is also providing results that will help improve the design of simulation interfaces and inform the design of Mars transit vehicles.

Li, Zu Qun↗

Human System Risk Management - Tools of our Trade

The risk of infectious disease to select individuals has historically been difficult to predict in either spaceflight or on Earth with health care efforts relying on broad-based prevention and post-infection treatment. Over the past 10 years, quantitative microbial risk assessment evaluations have evolved to formalize the assessment process and quantify the risk. This process of hazard identification, exposure assessment, dose-response assessment, and risk characterization has been applied by the water and food safety industries to address the public health impacts associated with the occurrence of and human exposure to pathogens in water and food for the development of preventive strategies for microbial disease. NASA is currently investigating the feasibility of using these techniques to better understand the risks to astronauts and refine their microbiological requirements. To assess these techniques, NASA began an evaluation of the potable water system on the International Space Station to determine how the microbial risk from water consumption during flight differed from terrestrial sources, such as municipal water systems. The ultimate goal of this work is to optimize microbial requirements which would minimize unnecessary cargo and use of crew time, while still protecting the health of the crew. Successful demonstration of this risk assessment framework with the water system holds the potential to maximize the use of available resources during spaceflight missions and facilitate investigations into the evaluation of other routes of infection, such as through the spaceflight foods system.

Ott, C. Mark↗

Clinical Decision Support - Concepts of Operation

We are entering a new era in space exploration to return to the moon and explore Mars. Crew members operating independently during long duration space exploration missions will require a clinical decision support system (CDSS) to increase autonomy by augmenting their knowledge, skills and abilities in different scenarios. Significant changes to in-flight and habitat medical care due to constraints on mass, volume, power, crew time and medical evacuation capabilities are needed to increase crew autonomy and self-reliance in decision making and task performance. The Exploration Medical Capability (ExMC) Element of the Human Research Program (HRP) pushes the boundary of space medical systems to advance the care of astronauts on future exploration missions beyond low Earth orbit by identifying and testing next-generation medical care and crew health maintenance technologies. Clinical decision support (CDS) presents knowledge and data in a context aware manner to augment a crew members’ knowledge, skills and abilities during the process of observation, orientation, decisions and action. A comprehensive crew health and performance CDSS is required to augment crew capability and will be used in different scenarios for several reasons. In general, the CDSS’s role is to assist the crew in prevention, detection, diagnosis and treatment of crew health and performance related conditions that may arise in exploration spaceflight. For example, CDSS would assist a high acuity scenario such as a heart attack by supplying clear instructions, vital signs and treatment reminders. A lower severity scenario such as kidney stone risk could interface to vehicle systems and display more complex predictive data during a diagnosis. A CDSS needs to contribute to successful missions by maintaining a high performing crew who can potentially exhibit countless medical conditions related to derangements from the space environment (sleep, cognition, nutrition and exercise) as well as conditions intrinsic to humans anywhere. While supporting the crew’s ability to make sound clinical decisions is desirable in any mission, it is essential for exploration missions with significant communication delays, no evacuation capability, and extended exposure to the flight environment. Such missions correspond with medical Level of Care V (LOC V), the highest level specified in NASA-STD-3001. The project focuses on CDS implementation research to derive requirements for LOC V, where the need for increased autonomy results in new practices and the inclusion of non-clinical data, such as vehicle environmental measures and physical exercise results, from other human and vehicle domains and advanced analytics. The CDS project describes how the CDSS is intended to be used by defining concepts of operations (ConOps). The process to derive ConOps focuses on increased autonomy that reduces the likelihood and consequences of accepted medical conditions. These crew health and performance inputs are grouped by common datasets and analysis models. Use cases are derived to research new clinical scenarios, architectural development and workflows. Implementation research is conducted with protypes to inform assumptions and derive requirements. The project also establishes how externally developed analysis and approaches can be added to expand a clinical decision support system and thus highlight how a comprehensive system can be globally developed with collaborators. This presentation will cover example scenarios from the CDS ConOps and the method to derive them. One example scenario will be CDSS alerting an increased kidney stone risk during a mission, with diagnosis and treatment options provided during the intervention.

clinical decision support↗

Clinical Decision Support - Concepts of Operation

We are entering a new era in space exploration to return to the moon and explore Mars. Crew members operating independently during long duration space exploration missions will require a clinical decision support system (CDSS) to increase autonomy by augmenting their knowledge, skills and abilities in different scenarios. Significant changes to in-flight and habitat medical care due to constraints on mass, volume, power, crew time and medical evacuation capabilities are needed to increase crew autonomy and self-reliance in decision making and task performance. The Exploration Medical Capability (ExMC) Element of the Human Research Program (HRP) pushes the boundary of space medical systems to advance the care of astronauts on future exploration missions beyond low Earth orbit by identifying and testing next-generation medical care and crew health maintenance technologies. Clinical decision support (CDS) presents knowledge and data in a context aware manner to augment a crew members’ knowledge, skills and abilities during the process of observation, orientation, decisions and action. A comprehensive crew health and performance CDSS is required to augment crew capability and will be used in different scenarios for several reasons. In general, the CDSS’s role is to assist the crew in prevention, detection, diagnosis and treatment of crew health and performance related conditions that may arise in exploration spaceflight. For example, CDSS would assist a high acuity scenario such as a heart attack by supplying clear instructions, vital signs and treatment reminders. A lower severity scenario such as kidney stone risk could interface to vehicle systems and display more complex predictive data during a diagnosis. A CDSS needs to contribute to successful missions by maintaining a high performing crew who can potentially exhibit countless medical conditions related to derangements from the space environment (sleep, cognition, nutrition and exercise) as well as conditions intrinsic to humans anywhere. While supporting the crew’s ability to make sound clinical decisions is desirable in any mission, it is essential for exploration missions with significant communication delays, no evacuation capability, and extended exposure to the flight environment. Such missions correspond with medical Level of Care V (LOC V), the highest level specified in NASA-STD-3001. The project focuses on CDS implementation research to derive requirements for LOC V, where the need for increased autonomy results in new practices and the inclusion of non-clinical data, such as vehicle environmental measures and physical exercise results, from other human and vehicle domains and advanced analytics. The CDS project describes how the CDSS is intended to be used by defining concepts of operations (ConOps). The process to derive ConOps focuses on increased autonomy that reduces the likelihood and consequences of accepted medical conditions. These crew health and performance inputs are grouped by common datasets and analysis models. Use cases are derived to research new clinical scenarios, architectural development and workflows. Implementation research is conducted with protypes to inform assumptions and derive requirements. The project also establishes how externally developed analysis and approaches can be added to expand a clinical decision support system and thus highlight how a comprehensive system can be globally developed with collaborators. This presentation will cover example scenarios from the CDS ConOps and the method to derive them. One example scenario will be CDSS alerting an increased kidney stone risk during a mission, with diagnosis and treatment options provided during the intervention.

clinical decision support↗

A Tool for the Automated Collection of Space Utilization Data: Three Dimensional Space Utilization Monitor

Space Human Factors and Habitability (SHFH) Element within the Human Research Program (HRP), in collaboration with the Behavioral Health and Performance (BHP) Element, is conducting research regarding Net Habitable Volume (NHV), the internal volume within a spacecraft or habitat that is available to crew for required activities, as well as layout and accommodations within that volume. NASA is looking for innovative methods to unobtrusively collect NHV data without impacting crew time. Data required includes metrics such as location and orientation of crew, volume used to complete tasks, internal translation paths, flow of work, and task completion times. In less constrained environments methods for collecting such data exist yet many are obtrusive and require significant post‐processing. Example technologies used in terrestrial settings include infrared (IR) retro‐reflective marker based motion capture, GPS sensor tracking, inertial tracking, and multiple camera filmography. However due to constraints of space operations many such methods are infeasible, such as inertial tracking systems which typically rely upon a gravity vector to normalize sensor readings, and traditional IR systems which are large and require extensive calibration. However multiple technologies have not yet been applied to space operations for these explicit purposes. Two of these include 3‐Dimensional Radio Frequency Identification Real‐Time Localization Systems (3D RFID‐RTLS) and depth imaging systems which allow for 3D motion capture and volumetric scanning (such as those using IR‐depth cameras like the Microsoft Kinect or Light Detection and Ranging / Light‐Radar systems, referred to as LIDAR).

Vos, Gordon A.↗

A Tool for the Automated Collection of Space Utilization Data: Three Dimensional Space Utilization Monitor

Space Human Factors and Habitability (SHFH) Element within the Human Research Program (HRP) and the Behavioral Health and Performance (BHP) Element are conducting research regarding Net Habitable Volume (NHV), the internal volume within a spacecraft or habitat that is available to crew for required activities, as well as layout and accommodations within the volume. NASA needs methods to unobtrusively collect NHV data without impacting crew time. Data required includes metrics such as location and orientation of crew, volume used to complete tasks, internal translation paths, flow of work, and task completion times. In less constrained environments methods exist yet many are obtrusive and require significant post-processing. Examplesused in terrestrial settings include infrared (IR) retro-reflective marker based motion capture, GPS sensor tracking, inertial tracking, and multi-camera methods Due to constraints of space operations many such methods are infeasible. Inertial tracking systems typically rely upon a gravity vector to normalize sensor readings,and traditional IR systems are large and require extensive calibration. However, multiple technologies have not been applied to space operations for these purposes. Two of these include: 3D Radio Frequency Identification Real-Time Localization Systems (3D RFID-RTLS) Depth imaging systems which allow for 3D motion capture and volumetric scanning (such as those using IR-depth cameras like the Microsoft Kinect or Light Detection and Ranging / Light-Radar systems, referred to as LIDAR)

Vos, Gordon A.↗

A Simulation Based Investigation of High Latency Space Systems Operations

This study was the first in a series of planned tests to use physics-based subsystem simulations to investigate the interactions between a spacecraft's crew and a ground-based mission control center for vehicle subsystem operations across long communication delays. The simulation models the life support system of a deep space habitat. It contains models of an environmental control and life support system, an electrical power system, an active thermal control systems, and crew metabolic functions. The simulation has three interfaces: 1) a real-time crew interface that can be use to monitor and control the subsystems; 2) a mission control center interface with data transport delays up to 15 minute each way; and 3) a real-time simulation test conductor interface used to insert subsystem malfunctions and observe the interactions between the crew, ground, and simulated vehicle. The study was conducted at the 21st NASA Extreme Environment Mission Operations (NEEMO) mission. The NEEMO crew and ground support team performed a number of relevant deep space mission scenarios that included both nominal activities and activities with system malfunctions. While this initial test sequence was focused on test infrastructure and procedures development, the data collected in the study already indicate that long communication delays have notable impacts on the operation of deep space systems. For future human missions beyond cis-lunar, NASA will need to design systems and support tools to meet these challenges. These will be used to train the crew to handle critical malfunctions on their own, to predict malfunctions and assist with vehicle operations. Subsequent more detailed and involved studies will be conducted to continue advancing NASA's understanding of space systems operations across long communications delays.

Li, Zu Qun↗

A Simulation Based Investigation of High Latency Space Systems Operations

This study was the first in a series of planned tests to use physics-based subsystem simulations to investigate the interactions between a spacecraft's crew and a ground-based mission control center for vehicle subsystem operations across long communication delays. The simulation models the life support system of a deep space habitat. It contains models of an environmental control and life support system, an electrical power system, an active thermal control system, and crew metabolic functions. The simulation has three interfaces: 1) a real-time crew interface that can be use to monitor and control the subsystems; 2) a mission control center interface with data transport delays up to 15 minute each way; and 3) a real-time simulation test conductor interface used to insert subsystem malfunctions and observe the interactions between the crew, ground, and simulated vehicle. The study was conducted at the 21st NASA Extreme Environment Mission Operations (NEEMO) mission. The NEEMO crew and ground support team performed a number of relevant deep space mission scenarios that included both nominal activities and activities with system malfunctions. While this initial test sequence was focused on test infrastructure and procedures development, the data collected in the study already indicate that long communication delays have notable impacts on the operation of deep space systems. For future human missions beyond cis-lunar, NASA will need to design systems and support tools to meet these challenges. These will be used to train the crew to handle critical malfunctions on their own, to predict malfunctions, and to assist with vehicle operations. Subsequent more detailed and involved studies will be conducted to continue advancing NASA's understanding of space systems operations across long communications delays.

Li, Zu Qun↗

Space processing in early Shuttle missions

The paper first reviews potential scientific and commercial benefits of space processing, and discusses roles of ground laboratory, sounding rocket, and Shuttle/Spacelab experimentation in carrying out space processing programs. Benefits which have been identified in such processes as containerless melting/solidification, electrophoresis, crystal growing, etc., and using such specific materials as tungsten, isoenzymes, single crystal silicon ribbon are utilized as specific examples in the above discussion. As a result, the paper identifies spectrum of specific objectives and implementation approaches for Shuttle/Spacelab experimentation. The paper then reviews currently planned Shuttle/Spacelab payload accommodations and traffic model. Finally, the paper matches experimentation approaches with Shuttle/Spacelab plans, and derives a possible schedule of missions in the 1979-1982 time frame using configurations with a high degree of automation where crew time for experiment involvement is limited.

Bloom, H. L.↗

Assured Crew Return Capability Architecture

The fundamental elements of the spacecraft Assured Crew Return Capability (ACRC) are discussed. These elements are access, response time, crew transfer, and the availability of landing sites. The use of an embedded operations concept identified as an essential element of the ACRC architecture. Several rescue assets are identified and evaluated as primary elements of an overall ACRC architecture. The investigation results lead to the following conclusions: optimum on-orbit rescue capability is provided by a rescue system integral to the operational vehicle; ground based rescue provides the most practical coverage for stranded transportation vehicles; and due to infrequent and unexpected use of ACRC, crew operations must be kept simple.

J W Craig↗

The Utility of a Small Pressurized Rover with Suit Ports for Lunar Exploration: A Geologist's Perspective

Rover trade study: As summarized recently, mission simulations at Black Point Lava Flow (Arizona) that included realistic extravehicular activity (EVA) tasking, accurate traverse timelines, and an in-loop science CAPCOM (or SciCOM) showed that a small pressurized rover (SPR) was a better mobility asset than an unpressurized rover (UPR). Traverses within the SPR were easier on crew than spending an entire day in a spacesuit, enhancing crew productivity at each station. The SPR, named Lunar Electric Rover (LER), and sometimes called the Space Exploration Vehicle (SEV), could also provide shelter during a suit malfunction, radiation event, or medical emergency that might occur on the Moon. Intravehicular activity (IVA) capabilities: From within the vehicle, crew could describe and photo-document distant features during drives between stations, as well as in the near-field, directly in front of the LER, providing an ability to begin EVA planning on approach to each outcrop prior to egress. The vehicle can rotate 360º without any lateral movement, providing views in all directions. It has high-visibility windows, a ForeCam, AftCam, port and starboard cameras, docking cameras, and a GigaPan camera. EVA capabilities: To reduce timeline, mass, and volumetric overhead, rapid egress and ingress were envisioned, replacing an airlock with lower cabin pressure than on the International Space Station and suit ports on the aft cabin wall [2]. When needed for closer inspection and sample collecting, crew could egress in about 10 minutes through suit ports. Crew use SuitCams for additional photo-documentation, transmit mobile observations verbally, and collect surface materials. Typical simulations involved 3 to 4 EVA stations/day and 2 to 3 hr/day of boots on the ground. This allowed crew to explore a far larger territory, with more complex geological and in situ resource utilization (ISRU) features, than would a single, longer-duration EVA at one location, while also minimizing crew time in a spacesuit. Additionally, the vehicle could be driven with crew locked into the suit ports. This approach could involve a driver in the cockpit with a suited crewmember in a suit port, or the vehicle could be driven from the aft deck with both crewmembers in their suit ports. This approach was used when distances between stops were short enough that vehicle ingress and egress were less efficient than remaining in the suits and driving. Utility of suit ports: The advantages of suit ports were clearly demonstrated in those field-based trade studies. To illustrate those advantages further, consider the consequences of a SPR without suit ports at the Apollo 17 landing site. At that site, the crew's second EVA was an approximately 18 km loop conducted in a UPR, called the Lunar Roving Vehicle (LRV), in 7 hr 36 min 56 s. The traverse was composed of 5 formal stations, plus 8 additional LRV stations where crew made brief scientific stops. In a scenario involving a SPR without suit ports, crew would go EVA through an airlock and probably be limited to a single EVA per day. In that case, crew could drive the SPR ~9 km from the landing site to station 2, go EVA, and complete station 2 tasks. However, to conduct station 3 tasks, the crew would then need to walk approximately 3 km to station 3, while ground control in Houston tele-robotically drives the LER to station 3. A walk of approximately 3 km is possible, as that is what the Apollo 14 crew did before LRVs were deployed, but it is a lengthy and potentially grueling EVA. Assuming crew completes station 3 tasks, they would likely need to re-enter the SPR, ending the day's EVA, and return to the landing site. They would not be able to walk the additional distances to stations 4 and 5 (the latter being about 6 km from station 3). Thus, crew in an SPR without suit ports would require two days to accomplish the same tasks Apollo 17 crew completed in a single day. If a future crew is involved in long duration traverses on the lunar surface, the deployment of a vehicle with suit ports would probably be a better solution.

Kring, David A.↗

On-Board Training for US Payloads

The International Space Station (ISS) crew follows a training rotation schedule that puts them in the United States about every three months for a three-month training window. While in the US, the crew receives training on both ISS systems and payloads. Crew time is limited, and system training takes priority over payload training. For most flights, there is sufficient time to train all systems and payloads. As more payloads are flown, training time becomes a more precious resource. Less training time requires payload developers (PDs) to develop alternatives to traditional ground training. To ensure their payloads have sufficient training to achieve their scientific goals, some PDs have developed on-board trainers (OBTs). These OBTs are used to train the crew when no or limited ground time is available. These lessons are also available on-orbit to refresh the crew about their ground training, if it was available. There are many types of OBT media, such as on-board computer based training (OCBT), video/photo lessons, or hardware simulators. The On-Board Training Working Group (OBTWG) and Courseware Development Working Group (CDWG) are responsible for developing the requirements for the different types of media.

Murphy, Benjamin↗

The Role of Space Medicine in Management of Risk in Spaceflight

The purpose of Space Medicine is to ensure mission success by providing quality and comprehensive health care throughout all mission phases to optimize crew health and performance and to prevent negative long-term health consequences. Space flight presents additional hazards and associated risks to crew health, performance, and safety. With an extended human presence in space it is expected that illness and injury will occur on orbit, which may present a significant threat to crew health and performance and to mission success. Maintaining crew health, safety and performance and preventing illness and injury are high priorities necessary for mission success and agency goals. Space flight health care should meet the standards of practice of evidence based clinical medicine. The function of Space Medicine is expected to meet the agency goals as stated in the 1998 NASA Strategic Plan and the priorities established by the Critical Path Roadmap Project. The Critical Path Roadmap Project is an integrated NASA cross-disciplinary strategy to assess, understand, mitigate, and manage the risks associated with long-term exposure to the space flight environment. The evidence based approach to space medicine should be standardized, objective process yielding expected results and establishing clinical practice standards while balancing individual risk with mission (programmatic) risk. The ability to methodically apply available knowledge and expertise to individual and mission health issues will ensure appropriate priorities are assigned and resources are allocated. NASA Space Medicine risk management process is a combined clinical and engineering approach. Competition for weight, power, volume, cost, and crew time must be balanced in making decisions about the care of individual crew with competing agency resources.

Clark, Jonathan B.↗

Cognitive Functioning in Space Exploration Missions: A Human Requirement

Solving cognitive issues in the exploration missions will require implementing results from both Human Behavior and Performance, and Space Human Factors Engineering. Operational and research cognitive requirements need to reflect a coordinated management approach with appropriate oversight and guidance from NASA headquarters. First, this paper will discuss one proposed management method that would combine the resources of Space Medicine and Space Human Factors Engineering at JSC, other NASA agencies, the National Space Biomedical Research Institute, Wyle Labs, and other academic or industrial partners. The proposed management is based on a Human Centered Design that advocates full acceptance of the human as a system equal to other systems. Like other systems, the human is a system with many subsystems, each of which has strengths and limitations. Second, this paper will suggest ways to inform exploration policy about what is needed for optimal cognitive functioning of the astronaut crew, as well as requirements to ensure necessary assessment and intervention strategies for the human system if human limitations are reached. Assessment strategies will include clinical evaluation and fitness-to-perform evaluations. Clinical intervention tools and procedures will be available to the astronaut and space flight physician. Cognitive performance will be supported through systematic function allocation, task design, training, and scheduling. Human factors requirements and guidelines will lead to well-designed information displays and retrieval systems that reduce crew time and errors. Means of capturing process, design, and operational requirements to ensure crew performance will be discussed. Third, this paper will describe the current plan of action, and future challenges to be resolved before a lunar or Mars expedition. The presentation will include a proposed management plan for research, involvement of various organizations, and a timetable of deliverables.

Fiedler, Edan↗

Mission Possible: BioMedical Experiments on the Space Shuttle

Biomedical research, both applied and basic, was conducted on every Shuttle mission from 1981 to 2011. The Space Shuttle Program enabled NASA investigators and researchers from around the world to address fundamental issues concerning living and working effectively in space. Operationally focused occupational health investigations and tests were given priority by the Shuttle crew and Shuttle Program management for the resolution of acute health issues caused by the rigors of spaceflight. The challenges of research on the Shuttle included: limited up and return mass, limited power, limited crew time, and requirements for containment of hazards. The sheer capacity of the Shuttle for crew and equipment was unsurpassed by any other launch and entry vehicle and the Shuttle Program provided more opportunity for human research than any program before or since. To take advantage of this opportunity, life sciences research programs learned how to: streamline the complicated process of integrating experiments aboard the Shuttle, design experiments and hardware within operational constraints, and integrate requirements between different experiments and with operational countermeasures. We learned how to take advantage of commercial-off-the-shelf hardware and developed a hardware certification process with the flexibility to allow for design changes between flights. We learned the importance of end-to-end testing for experiment hardware with humans-in-the-loop. Most importantly, we learned that the Shuttle Program provided an excellent platform for conducting human research and for developing the systems that are now used to optimize research on the International Space Station. This presentation will include a review of the types of experiments and medical tests flown on the Shuttle and the processes that were used to manifest and conduct the experiments. Learning Objective: This paper provides a description of the challenges related to launching and implementing biomedical experiments aboard the Space Shuttle.

Bopp, E.↗

Space shuttle/mesoscale lightning experiment

A payload integration plan (PIP) is now being developed with Johnson Space Center integration personnel which covers management, structural thermal, electrical power/avionics, training, ground operations, safety requirements, etc., in support of this experiment. If a Shuttle flight can be identified, researchers hope to conduct the experiment in the late summer or fall of 1985. Some preliminary TV lightning data has been collected by Shuttle crews on 41D and 51D and researchers are doing an analysis of it. Additional flights will be conducted to obtain data on Mesoscale Lightning Observations. Researchers will continue to study how to improve the data collection using the onboard TV cameras. By more interaction with the crews who have used the TV camera to obtain TV of lightning, they are planning to optimize the crew time and have better TV camera operations management to produce more useful data. As the crews are better trained in the use of the gain control settings and/or camera iris operations, the quality of the TV data will be improved.

Vaughan, O. H., Jr.↗

NASA’s Strategic Analysis Cycle 2021 (SAC21) Human Mars Architecture

The National Aeronautics and Space Administration’s (NASA) Mars Architecture Team (MAT) was challenged to develop a mission architecture capable of transporting humans to the surface of Mars and back as fast—and as soon—as practical. This challenge represented a significant departure from previous approaches that minimized Earth-launched mass and maximized in-space transportation efficiency, often resulting in roundtrip missions of three years or more in duration. In the interest of crew health, MAT’s cross-Agency team of subject matter experts was challenged to develop an architecture capable of shortening crew time away from Earth to about two years. MAT was given specific mission constraints, such as number of crew, as well as mandates to minimize surface infrastructure as much as possible and to incorporate nuclear transportation options. The resulting MAT-developed concept, referred to here as the Strategic Analysis Cycle 2021 (SAC21) architecture, leverages Artemis elements and emerging commercial capabilities for cargo and logistics launches, and features a hybrid Nuclear Electric Propulsion (NEP)/Chemical transportation system able to complete the 1.8 billion kilometer round-trip journey to Mars and back in 760 to 850 days transit time for the 2039 Earth departure opportunity. Three Mars Descent Systems (MDS), each capable of landing about 25 metric tons of useful cargo on the surface of Mars, would be pre-deployed in advance of crew departure from Earth; two of these MDS’s would deliver a partially fueled Mars Ascent Vehicle (MAV), a fission power system, surface mobility, and additional MAV propellant. To minimize surface infrastructure, only two of the four Mars crew would descend and live in an MDS-landed pressurized rover, exploring the martian surface for 30 martian days, or sols, before returning to Mars orbit aboard their MAV and rejoining the other two crew on the Deep Space Transport for the Earth return voyage. Specifics of many of these architecture elements are detailed in separate technical publications; this paper outlines the end-to-end integrated architecture performance and concept of operations, including synergies with Artemis lunar architecture elements. It is important to note that NASA does not have a formal human Mars program and no decisions have been made; the architecture described here is intended to fill in an often-overlooked corner of the trade space, helping to complete the menu of options available to decision-makers as they chart the course for humans to Mars.

exploration↗