Reaction and power conversion system design integration for earth orbital application.
Design integration of reactor, shielding and power conversion systems for manned earth orbital station
MANNED ORBITAL SPACE STATION /MOSS/↗
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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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A review of several propulsion integration features applicable to supersonic-cruise fighter aircraft
A brief review has been made of the propulsion integration features which may impact the design of a supersonic cruise fighter type aircraft. The data used for this study were obtained from several investigations conducted in the Langley 16-foot transonic and 4 by 4 foot supersonic pressure wind tunnels. Results of this study show: (1) that for conventional nozzle installations, contradictory design guidelines exist between subsonic and supersonic flight condition, (2) that substantial drag penalties can be incurred by use of dry power nozzles during supersonic cruise; and (3) that a new and unique concept, the nonaxisymmetric nozzle, offers the potential for solving many of the current propulsion installation problems.
Berrier, B. L.↗
A hybrid finite element-spectral boundary integral approach: Applications to dynamic rupture modeling in unbounded domains
The finite element method (FEM) and the spectral boundary integral method (SBI) have both been widely used in the study of dynamic rupture simulations along a weak interface. Here, we present a hybrid method that combines FEM and SBI through the consistent exchange of displacement and traction boundary conditions, thereby benefiting from the flexibility of FEM in handling problems with nonlinearities or small-scale heterogeneities and from the superior performance and accuracy of SBI. We validate the hybrid method using a benchmark problem from the Southern California Earthquake Center's dynamic rupture simulation validation exercises.We further demonstrate the capability and computational efficiency of the hybrid scheme for resolving off-fault heterogeneities by studying a 2D in-plane shear crack in two different settings: one where the crack is embedded in a high-velocity zone and another where it is embedded in a low-velocity zone. Finally, we discuss the potential of the hybrid method for addressing a wide range of problems in geophysics and engineering.
58 GEOSCIENCES↗
Multiview Incomplete Knowledge Graph Integration with application to cross-institutional EHR data harmonization
Objective: The growing availability of electronic health records (EHR) data opens opportunities for integrative analysis of multi-institutional EHR to produce generalizable knowledge. A key barrier to such integrative analyses is the lack of semantic interoperability across different institutions due to coding differences. We propose a Multiview Incomplete Knowledge Graph Integration (MIKGI) algorithm to integrate information from multiple sources with partially overlapping EHR concept codes to enable translations between healthcare systems. Methods: The MIKGI algorithm combines knowledge graph information from (i) embeddings trained from the co-occurrence patterns of medical codes within each EHR system and (ii) semantic embeddings of the textual strings of all medical codes obtained from the Self-Aligning Pretrained BERT (SAPBERT) algorithm. Due to the heterogeneity in the coding across healthcare systems, each EHR source provides partial coverage of the available codes. MIKGI synthesizes the incomplete knowledge graphs derived from these multi-source embeddings by minimizing a spherical loss function that combines the pairwise directional similarities of embeddings computed from all available sources. MIKGI outputs harmonized semantic embedding vectors for all EHR codes, which improves the quality of the embeddings and enables direct assessment of both similarity and relatedness between any pair of codes from multiple healthcare systems. Results: With EHR co-occurrence data from Veteran Affairs (VA) healthcare and Mass General Brigham (MGB), MIKGI algorithm produces high quality embeddings for a variety of downstream tasks including detecting known similar or related entity pairs and mapping VA local codes to the relevant EHR codes used at MGB. Based on the cosine similarity of the MIKGI trained embeddings, the AUC was 0.918 for detecting similar entity pairs and 0.809 for detecting related pairs. For cross-institutional medical code mapping, the top 1 and top 5 accuracy were 91.0% and 97.5% when mapping medication codes at VA to RxNorm medication codes at MGB; 59.1% and 75.8% when mapping VA local laboratory codes to LOINC hierarchy. When trained with 500 labels, the lab code mapping attained top 1 and 5 accuracy at 77.7% and 87.9%. MIKGI also attained best performance in selecting VA local lab codes for desired laboratory tests and COVID-19 related features for COVID EHR studies. Compared to existing methods, MIKGI attained the most robust performance with accuracy the highest or near the highest across all tasks. Conclusions: The proposed MIKGI algorithm can effectively integrate incomplete summary data from biomedical text and EHR data to generate harmonized embeddings for EHR codes for knowledge graph modeling and cross-institutional translation of EHR codes.
Zhou, Doudou↗
An Integrated Platform for Mission Performance: Goddard Space Flight Center's Meta Information System
Successful management of NASA Goddard Space Flight Centers portfolio of mission projects (i.e. spacecraft, spacecraft instruments / subsystems, and ground systems) depends upon numerous processes, data and information resources coming together throughout the life-cycle of the projects to enable sound decision-making, risk reduction, conformance with requirements and continual improvement. In the summer of 2012, GSFC SMA management recognized that the set of legacy data systems used to support the SMA mission and responsibilities at GSFC were not effective, integrated nor on par with best practices. Accordingly, GSFC SMA management launched a project to transform the GSFC electronic management system to create and deploy an integrated, state-of-the-market information system for process performance, data management and analytics that is currently operating in support of GSFC overall mission performance. The information system, known as Meta, provides controlled, process-based applications, integrated data management, and analytics for a robust set of integrated applications. Since the inception of the project, a lean, award-winning SMA project team has thus far designed, configured and managed the system to serve as an integrated platform for 18 applications that support key processes for GSFC and the Science Mission Directorate at NASA headquarters, such as internal Management System assessments, Supplier Assessments, Supplier Research & Analysis, Problem Reporting for in-house mission projects, On-orbit Anomaly Reporting for GSFC-operated spacecraft, GSFC Project Life-Cycle Reviews, Risk Management and Reporting, and SMA Project Team Reporting. The system has experienced steady growth in utilization with 1,917 users (NASA employees and support contractor personnel) and 44 gigabytes of data and related files managed by the system as of the end of April 2018. Overall, Meta has achieved increasing levels of process management and real-time data / information integration to enable improved process performance, richer analytics and informed decision-making. This paper will present and examine the need, goals, approach and design driving the management and operation of the Meta information system and its ongoing growth as an integrated platform for advancing NASA mission performance.
Integration↗
Application of integrated fluid-thermal-structural analysis methods
Hypersonic vehicles operate in a hostile aerothermal environment which has a significant impact on their aerothermostructural performance. Significant coupling occurs between the aerodynamic flow field, structural heat transfer, and structural response creating a multidisciplinary interaction. Interfacing state-of-the-art disciplinary analysis methods is not efficient, hence interdisciplinary analysis methods integrated into a single aerothermostructural analyzer are needed. The NASA Langley Research Center is developing such methods in an analyzer called LIFTS (Langley Integrated Fluid-Thermal-Structural) analyzer. The evolution and status of LIFTS is reviewed and illustrated through applications.
Wieting, Allan R.↗
Application of integrated fluid-thermal structural analysis methods
Hypersonic vehicles operate in a hostile aerothermal environment which has a significant impact on their aerothermostructural performance. Significant coupling occurs between the aerodynamic flow field, structural heat transfer, and structural response creating a multidisciplinary interaction. Interfacing state-of-the-art disciplinary analysis methods are not efficient, hence interdisciplinary analysis methods integrated into a single aerothermostructural analyzer are needed. The NASA Langley Research Center is developing such methods in an analyzer called LIFTS (Langley Integrated Fluid-Thermal-Structural) analyzer. The evolution and status of LIFTS is reviewed and illustrated through applications.
Wieting, Allan R.↗
Development of a Genome-Scale Metabolic Model of Clostridium thermocellum and Its Applications for Integration of Multi-Omics Datasets and Computational Strain Design
Solving environmental and social challenges such as climate change requires a shift from our current non-renewable manufacturing model to a sustainable bioeconomy. To lower carbon emissions in the production of fuels and chemicals, plant biomass feedstocks can replace petroleum using microorganisms as biocatalysts. The anaerobic thermophile Clostridium thermocellum is a promising bacterium for bioconversion due to its capability to efficiently degrade lignocellulosic biomass. However, the complex metabolism of C. thermocellum is not fully understood, hindering metabolic engineering to achieve high titers, rates, and yields of targeted molecules. In this study, we developed an updated genome-scale metabolic model of C. thermocellum that accounts for recent metabolic findings, has improved prediction accuracy, and is standard-conformant to ensure easy reproducibility. We illustrated two applications of the developed model. We first formulated a multi-omics integration protocol and used it to understand redox metabolism and potential bottlenecks in biofuel (e.g., ethanol) production in C. thermocellum. Second, we used the metabolic model to design modular cells for efficient production of alcohols and esters with broad applications as flavors, fragrances, solvents, and fuels. The proposed designs not only feature intuitive push-and-pull metabolic engineering strategies, but also present novel manipulations around important central metabolic branch-points. We anticipate the developed genome-scale metabolic model will provide a useful tool for system analysis of C. thermocellum metabolism to fundamentally understand its physiology and guide metabolic engineering strategies to rapidly generate modular production strains for effective biosynthesis of biofuels and biochemicals from lignocellulosic biomass.
59 BASIC BIOLOGICAL SCIENCES↗
An efficient computational method for solving nonlinear stochastic Itô integral equations: Application for stochastic problems in physics
Because of the nonlinearity, closed-form solutions of many important stochastic functional equations are virtually impossible to obtain. Thus, numerical solutions are a viable alternative. In this paper, a new computational method based on the generalized hat basis functions together with their stochastic operational matrix of Itô-integration is proposed for solving nonlinear stochastic Itô integral equations in large intervals. In the proposed method, a new technique for computing nonlinear terms in such problems is presented. The main advantage of the proposed method is that it transforms problems under consideration into nonlinear systems of algebraic equations which can be simply solved. Error analysis of the proposed method is investigated and also the efficiency of this method is shown on some concrete examples. The obtained results reveal that the proposed method is very accurate and efficient. As two useful applications, the proposed method is applied to obtain approximate solutions of the stochastic population growth models and stochastic pendulum problem.
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
The Application of Integrated Knowledge-based Systems for the Biomedical Risk Assessment Intelligent Network (BRAIN)
One of NASA's goals for long duration space flight is to maintain acceptable levels of crew health, safety, and performance. One way of meeting this goal is through the Biomedical Risk Assessment Intelligent Network (BRAIN), an integrated network of both human and computer elements. The BRAIN will function as an advisor to flight surgeons by assessing the risk of in-flight biomedical problems and recommending appropriate countermeasures. This paper describes the joint effort among various NASA elements to develop BRAIN and an Infectious Disease Risk Assessment (IDRA) prototype. The implementation of this effort addresses the technological aspects of the following: (1) knowledge acquisition; (2) integration of IDRA components; (3) use of expert systems to automate the biomedical prediction process; (4) development of a user-friendly interface; and (5) integration of the IDRA prototype and Exercise Countermeasures Intelligent System (ExerCISys). Because the C Language, CLIPS (the C Language Integrated Production System), and the X-Window System were portable and easily integrated, they were chosen as the tools for the initial IDRA prototype. The feasibility was tested by developing an IDRA prototype that predicts the individual risk of influenza. The application of knowledge-based systems to risk assessment is of great market value to the medical technology industry.
Loftin, Karin C.↗
Space-Based Sensor Web for Earth Science Applications: An Integrated Architecture for Providing Societal Benefits
There is a significant interest in the Earth Science research and user remote sensing community to substantially increase the number of useful observations relative to the current frequency of collection. The obvious reason for such a push is to improve the temporal, spectral, and spatial coverage of the area(s) under investigation. However, there is little analysis available in terms of the benefits, costs and the optimal set of sensors needed to make the necessary observations. Classic observing system solutions may no longer be applicable because of their point design philosophy. Instead, a new intelligent data collection system paradigm employing both reactive and proactive measurement strategies with adaptability to the dynamics of the phenomena should be developed. This is a complex problem that should be carefully studied and balanced across various boundaries including: science, modeling, applications, and technology. Modeling plays a crucial role in making useful predictions about naturally occurring or human-induced phenomena In particular, modeling can serve to mitigate the potentially deleterious impacts a phenomenon may have on human life, property, and the economy. This is especially significant when one is interested in learning about the dynamics of, for example, the spread of forest fires, regional to large-scale air quality issues, the spread of the harmful invasive species, or the atmospheric transport of volcanic plumes and ash. This paper identifies and examines these challenging issues and presents architectural alternatives for an integrated sensor web to provide observing scenarios driving the requisite dynamic spatial, spectral, and temporal characteristics to address these key application areas. A special emphasis is placed on the observing systems and its operational aspects in serving the multiple users and stakeholders in providing societal benefits. We also address how such systems will take advantage of technological advancement in small spacecraft and emerging information technologies, and how sensor web options may be realized and made affordable. Specialized detector subsystems and precision flying techniques may still require substantial innovation, development time and cost: we have presented the considerations for these issues. Finally, data and information gathering and compression techniques are also briefly described.
Habib, Shahid↗
Energy efficient transport technology: Program summary and bibliography
The Energy Efficient Transport (EET) Program began in 1976 as an element of the NASA Aircraft Energy Efficiency (ACEE) Program. The EET Program and the results of various applications of advanced aerodynamics and active controls technology (ACT) as applicable to future subsonic transport aircraft are discussed. Advanced aerodynamics research areas included high aspect ratio supercritical wings, winglets, advanced high lift devices, natural laminar flow airfoils, hybrid laminar flow control, nacelle aerodynamic and inertial loads, propulsion/airframe integration (e.g., long duct nacelles) and wing and empennage surface coatings. In depth analytical/trade studies, numerous wind tunnel tests, and several flight tests were conducted. Improved computational methodology was also developed. The active control functions considered were maneuver load control, gust load alleviation, flutter mode control, angle of attack limiting, and pitch augmented stability. Current and advanced active control laws were synthesized and alternative control system architectures were developed and analyzed. Integrated application and fly by wire implementation of the active control functions were design requirements in one major subprogram. Additional EET research included interdisciplinary technology applications, integrated energy management, handling qualities investigations, reliability calculations, and economic evaluations related to fuel savings and cost of ownership of the selected improvements.
Middleton, D. B.↗
Piezoresistive Characteristics of Silicon Carbide for Integrated Sensor Applications
Successful ubiquitous deployment of advanced reactors will depend to a large extent on the development of high-performance materials and sensors. Recently, there has been increasing interest in advanced reactors operating at very high temperatures (greater than 700 °C) and using molten salts as the primary coolant. In such reactor systems, temperature and pressure measurements are conducted using standard legacy thermocouples and pressure measurement technologies, both of which suffer from resolution issues, inaccuracies, and drift under harsh operating temperature and radiation conditions. We report on the structural, electrical, and mechanical characteristics of SiC materials and devices for the development of an integrated monolithic sensor unit capable of simultaneously monitoring temperature, pressure and flow in molten salt reactors, while at the same time exhibiting significant improvements in resolution, accuracy and signal-to-noise ratio.Wide bandgap and chemical inertness of SiC make it suitable for harsh environment sensor applications. We report on the development of a SiC pressure sensor exploiting its piezoresistive properties. Attempts have been made to fabricate thermally stable pressure sensor through doping induced high gauge factor. Both implanted and in-situ doped SiC wafers are being investigated to analyze the impact of dopant type and concentration on the piezoresistive characteristics. The microstructure, composition, and electrical conductivity of SiC samples have been analyzed to find optimum dopant incorporation and activation conditions. The mechanical measurements are being conducted on SiC beams with photolithographically defined surface piezoresistors to establish gauge factor for high performance sensors that can operate at temperatures beyond the limits of conventional silicon CMOS materials and devices.
Joshi, Pooran↗
A Comparative Evaluation and Selection of High-Temperature Heat Exchangers for Application to Integrated Energy Systems
The following report aims to create a refined and well-structured method for comparatively evaluating heat exchanger technologies for integrated energy systems that caters customers’ specific needs while meeting engineering requirements. For the evaluation, this study elevates previous evaluation metrics, enhances the knowledge base via literature and market surveys, and identifies the figures of merit with robust rationales to enhance the quality of decisions made throughout the proposed heat exchanger evaluation process. The heat exchanger designs evaluated as part of the case study are shell and tube heat exchangers, printed circuit heat exchangers, plate heat exchangers, spiral heat exchangers, and heat pipe heat exchangers. The information presented in this report is meant for industries interested in making a preliminary screening process to identify the most suitable heat exchanger design for their application of interest.
42 ENGINEERING↗
A Comparative Evaluation and Selection of High-Temperature Heat Exchangers for Application to Integrated Energy Systems
The following report aims to create a refined and well-structured method for comparatively evaluating heat exchanger technologies for integrated energy systems that caters customers’ specific needs while meeting engineering requirements. For the evaluation, this study elevates previous evaluation metrics, enhances the knowledge base via literature and market surveys, and identifies the figures of merit with robust rationales to enhance the quality of decisions made throughout the proposed heat exchanger evaluation process. The heat exchanger designs evaluated as part of the case study are shell and tube heat exchangers, printed circuit heat exchangers, plate heat exchangers, spiral heat exchangers, and heat pipe heat exchangers. The information presented in this report is meant for industries interested in making a preliminary screening process to identify the most suitable heat exchanger design for their application of interest.
42 - ENGINEERING↗
Application of integrated structural analysis to the high speed civil transport
The Integrated Structural Analysis (ISA) system was developed in response to the need to define lightweight structures early in the design process for military aircraft. The objective of the ISA system is to permit rapid development of an optimized skin and big-bones structure that insures that the requirements of strength, dynamics, loads, and weight are met. While the system was originally developed for fighter aircraft, it is applicable to commercial transports or any other structures. The design requirements dictate the structural arrangement and sizing limitations to be imposed.
Saff, C. R.↗
Data for "Discovery, Characterization, and Application of Chromosomal Integration Sites in the Hyperthermophilic Archaeon Sulfolobus islandicus"
Sulfolobus islandicus , an emerging archaeal model organism, offers unique advantages for metabolic engineering and synthetic biology applications owing to its ability to thrive in extreme environments. Although several genetic tools have been established for this organism, the lack of well-characterized chromosomal integration sites has limited its potential as a cellular factory. Here, we systematically identified and characterized 13 artificial CRISPR RNAs targeting eight integration sites in S. islandicus using the CRISPR-COPIES pipeline and a multi-omics-informed computational workflow. We leveraged the endogenous CRISPR-Cas system to integrate the reporter gene lacS and validated heterologous expression through a β-galactosidase assay, revealing significant positional effects. As a proof of concept, we utilized these sites to genetically manipulate lipid ether composition by overexpressing glycerol dibiphytanyl glycerol tetraether (GDGT) ring synthase B (GrsB). This study expands the genetic toolbox for S. islandicus and advances its potential as a robust platform for archaeal synthetic biology and industrial biotechnology.
AI/ML↗
Photonic integration for UV to IR applications
Photonic integration opens the potential to reduce size, power, and cost of applications normally relegated to table- and rack-sized systems. Today, a wide range of precision, high-end, ultra-sensitive, communication and computation, and measurement and scientific applications, including atomic clocks, quantum communications, processing, and high resolution spectroscopy, are ready to make the leap from the lab to the chip. However, many of these applications operate at wavelengths not accessible to the silicon on insulator-based silicon photonics integration platform due to absorption, power handling, unwanted nonlinearities, and other factors. Next generation photonic integration will require ultra-wideband photonic circuit platforms that scale from the ultraviolet to the infrared and that offer a rich set of linear and nonlinear circuit functions as well as low loss and high power handling capabilities. This article provides an assessment of the field in ultra-wideband photonic waveguides to bring power efficient, ultra-high performance systems to the chip-scale and enable compact transformative precision measurement, signal processing, computation, and communication techniques.
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗