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NASA NTRS2004

Pharmacotherapeutic Aspects of Space Medicine

Medications are used for a wide variety of indications during space flight. For example, astronauts have taken drugs in flight to ameliorate or prevent symptoms of space motion sickness, headache, sleeplessness, backache, nasal congestion, and constipation. Russian cosmonauts reportedly take medications to prevent metabolic disturbances of the myocardium and intestinal flora, and to optimize their work capacity. Although the discomfort associated with some acute responses to microgravity (e.g., space motion sickness) is expected to diminish with length of time in flight, other responses that have delayed onset (e.g., maintaining nutritional status, bone and muscle strength, and perhaps immune response) may affect health and quality of life during longer missions. Therefore, as the duration of space flights increases, the need for treatment with medications is expected to increase accordingly. Medications carried on Space Shuttle missions have varied somewhat from flight to flight, depending on the individual needs of the crewmembers. Medications use during Shuttle flights seems to be more prevalent than during earlier programs, perhaps because drugs are provided in easy-to-use forms. In fact, nearly all medications taken to date have been ingested orally in tablet form. However, given that the oral route may not be ideal for those suffering motion-sickness symptoms, intramuscular and intranasal preparations are being tested. For example, intramuscular administration of promethazine hydrochloride (Phenergan(Registered TradeMark)) has been reported to be more effective in alleviating motion-sickness symptoms. The difficulties involved in conducting definitive studies of drug efficacy during U.S. space flights have been compounded by the absence of a systematic approach to determining which drugs were taken by whom and under what circumstances. The use of some drugs in space has been less efficacious than expected. The onset, intensity, and duration of the response produced by any drug depend upon rates of absorption, distribution, metabolism, and elimination of the drug; space flight-induced changes in blood flow and the function of the gastrointestinal (GI) tract, liver, or kidneys may alter these processes. Another important aspect of clinical efficacy of medications in space is the stability of pharmaceuticals. As the U.S. space program is moving toward extended Space Shuttle flights and beyond, to space station missions and planetary explorations, understanding how space flight affects organ systems and clinical pharmacology is necessary to optimize pharmacotherapeutics in space and ensure adequate safety and health of crewmembers.

Putcha, Lakshmi↗
NASA NTRS1972

Long range planning for the development of space flight emergency systems.

The importance of long-range planning for space flight emergency systems is pointed out. Factors in emergency systems planning are considered, giving attention to some of the mission classes which have to be taken into account. Examples of the hazards in space flight include fire, decompression, mechanical structure failures, radiation, collision, and meteoroid penetration. The criteria for rescue vehicles are examined together with aspects regarding the conduction of rescue missions. Future space flight programs are discussed, taking into consideration low earth orbit space stations, geosynchronous orbit space stations, lunar operations, manned planetary missions, future space flight vehicles, the space shuttle, special purpose space vehicles, and a reusable nuclear shuttle.

Bolger, P. H.↗
NASA NTRSDate not supplied

What You Need to Know about Planetary Protection Categorization for Your Mission

Planetary protection mission categorization helps to define the risk posture for requirements definition and implementation practices on space flight projects with planetary protection considerations. NASA has recently updated it’s planetary protection policy (NPR 8715.24), and with the update comes a major change in how the planetary protection categorization process is performed for NASA missions. Previously, projects would request the NASA Planetary Protection Officer (PPO) provide a categorization letter documenting the planetary protection category assigned to the proposed mission. Under the new policy the project manager (PM) proposes the planetary protection category for their mission. Depending on the level of the category, the PPO either concurs or recommends concurrence to the Chief of Safety and Mission Assurance (SMA) before forwarding to the Mission Directorate Associate Administrator (MDAA) for final approval prior to the system requirements review (SRR). But what topics must be considered for categorization? This presentation will provide key considerations for planetary protection mission categorization including the target solar system body to be explored, the trajectory to get to the target body, and the operations to be performed at the target body. Additional unique scenarios such as secondary and auxiliary payloads, encountering other solar system bodies on the way to the target body, and sample return missions will also be discussed to share lessons learned from missions that have been through the new categorization process.

Elaine Seasly↗
NASA NTRS2008

"50 Cents, 50 Years": Finding the Value of the Space Program on the Back of a Quarter

Brief presentation highlighting the accomplishments of NASA upon its 50th anniversary. NASA's first manned space flight, voyage to the moon, planetary exploration, space station construction, international cooperation, space habitat construction and the deployment of multiple satellites including the Hubble Space Telescope, Gamma Ray Observatory, Magellan and Galileo. More recent efforts include the construction of the Ares transportation system and a return to human exploration beyond low-Earth orbit. The author also urges for continued space exploration via the National Space Policy through the authorization of Congress.

Horack, John M.↗
NASA NTRS2009

The Rocket Balloon (Rocketball): Applications to Science, Technology, and Education

Originally envisioned to study upper atmospheric phenomena, the Rocket Balloon system (or Rocketball for short) has utility in a range of applications, including sprite detection and in-situ measurements, near-space measurements and calibration correlation with orbital assets, hurricane observation and characterization, technology testing and validation, ground observation, and education. A salient feature includes the need to reach space and near-space within a critical time-frame and in adverse local meteorological conditions. It can also provide for the execution of technology validation and operational demonstrations at a fraction of the cost of a space flight. In particular, planetary entry probe proof-of-concepts can be examined. A typical Rocketball operational scenario consists of a sounding rocket launch and subsequent deployment of a balloon above a desired location. An obvious advantage of this combination is the additional mission 'hang-time' rendered by the balloon once the sounding rocket flight is completed. The system leverages current and emergent technologies at the NASA Goddard Space Flight Center and other organizations.

Esper, Jaime↗
NASA NTRS1987

Data catalog series for space science and applications flight missions. Volume 1B: Descriptions of data sets from planetary and heliocentric spacecraft and investigations

The main purpose of the data catalog series is to provide descriptive references to data generated by space science flight missions. The data sets described include all of the actual holdings of the Space Science Data Center (NSSDC), all data sets for which direct contact information is available, and some data collections held and serviced by foreign investigators, NASA and other U.S. government agencies. This volume contains narrative descriptions of planetary and heliocentric spacecraft and associated experiments. The following spacecraft series are included: Mariner, Pioneer, Pioneer Venus, Venera, Viking, Voyager, and Helios. Separate indexes to the planetary and interplanetary missions are also provided.

Horowitz, Richard↗
NASA NTRS1972

Operating executive for the DSIF tracking subsystem software

The advanced engineering model of the DSIF tracking subsystem (DTS) is being developed by the Deep Space Instrumentation Facility. The DTS will provide effective and reliable tracking and data acquisition support for the complex planetary and interplanetary space flight missions planned for the 1970's. The nucleus of the subsystem is a Honeywell H832 digital computer. The design and capabilities of the real-time operating executive software are described.

Poulson, P. L.↗
NASA NTRS1975

Planetary quarantine: Principles, methods, and problems

Requirements for planetary quarantine programs focus on microbial life forms as the primary contamination threat carried by spacecraft to a planet, or back to earth from another planet or outer space. Constraints on planetary flight missions and forthcoming Martian landings are depicted.

Hall, L. B.↗
NASA NTRS1982

NASA Deep Space Network operating control

The primary function of the Deep Space Network (DSN) is to provide effective and reliable tracking and data acquisition for planetary and interplanetary space flight missions. This involves providing data to flight project mission operations, accepting commands from mission operations and transmitting the commands to stations and spacecraft, and providing a record of telemetry and command data to mission operations. Also included are network performance monitoring, the generation of predictions for antenna pointing and signal acquisition, network scheduling, and network validation tests. Descriptions are given of the three facilities and six systems of the DSN. Also described are interfaces, automation and standardized procedures, and discrepancy reporting. It is pointed out that the greatest challenge facing the DSN is the implementation of NASA's Network Consolidation Program, which is scheduled to be completed in 1986. The objectives of this program are enumerated.

Weisman, W. D.↗
NASA NTRS2023

Molecular Identification of Microbial Contaminants

Microorganisms can have significant impacts on the success of NASA’s missions, including the integrity of materials, the reliability of scientific results, and maintenance of crew health. Robust cleaning and sterilization protocols are currently in place in NASA facilities, but agency experts agree that microbial contamination is unavoidable and its impact on NASA’s missions and science must be minimized. Therefore, it is critical to understand: 1) what specific microorganisms are present, 2) how they may impact scientific objectives, and 3) how to select appropriate mitigation strategies. The Marshall Space Flight Center (MSFC) Planetary Protection (PP) microbiology lab historically relied solely upon enumeration of culturable microbial contamination associated with spacecraft materials or cleanrooms. However, this process is time consuming, many microbes cannot be cultured, and very few can be identified with any fidelity using NASA standard microbiological methods. The work described in this white paper includes the establishment of molecular identification capabilities at MSFC, including DNA isolation, amplification, purification, and Sanger sequencing. This capability will not only improve planetary protection efforts at MSFC (i.e. by identifying contaminating microorganisms in cleanrooms or on spacecraft) but also offers a service center-wide for the identification of contaminants that arise in other projects, processing locations, or during set up and roll out of spacecraft. This work also lays the foundation for higher throughput efforts to identify large populations of microbes across the lifetime of a project and serves as the starting point for future work into whole genome sequencing, non-culture based methods, or additional characterization studies. Ultimately, accurate identification informs appropriate mitigation strategies, increasing the chances of success for NASA’s missions and objectives.

C. D. Cassilly↗
NASA NTRS2020

Orbiting and In-Situ Lidars for Earth and Planetary Applications

At NASA Goddard Space Flight Center (GSFC), we have been developing spaceborne lidar instruments for Earth and planetary sciences. We have successfully flown a several missions in the past based on mature diode pumped solid-state laser transmitters. In recent years we have been developing advanced laser technologies for applications such as laser spectroscopy, laser communications, and interferometry. In this paper, we will discuss recent experimental progress on these systems and instrument prototypes for ongoing development efforts.

Space instruments↗
NASA NTRS2007

Myotonometry as a Surrogate Measure of Muscle Strength

Space flight-induced muscle atrophy/neuromuscular degradation and the consequent decrements in crew-member performance are of increasing concern as mission duration lengthens, and planetary exploration after extended space flight is planned. Pre- to post-flight strength measures have demonstrated that specific countermeasures, such as resistive exercise, are effective at countering microgravity-induced muscle atrophy and preventing decrements in muscle strength. However, in-flight assessment/monitoring of exercise countermeasure effectiveness will be essential during exploration class missions due to their duration. The ability to modify an exercise countermeasure prescription based on such real-time information will allow each individual crew member to perform the optimal amount and type of exercise countermeasure to maintain performance. In addition, such measures can be used to determine if a crew member is physically capable of performing a particular mission-related task during exploration class missions. The challenges faced in acquiring such data are those common to all space operations, namely the requirement for light-weight, low power, mechanically reliable technologies that make valid measurements in microgravity, in this case of muscle strength/neuromuscular function. Here we describe a simple, light-weight, low power, non-invasive device, known as the Myotonometer, that measures tissue stiffness as an indirect measure of muscle contractile state and muscle force production. Repeat myotonometer measurements made at the same location on the surface of the rectis femoris muscle (as determined using a 3D locator device, SEM plus or minus 0.34 mm) were shown to be reproducible over time at both maximal voluntary contraction (MVC) and at rest in a total of 17 sedentary subjects assessed three times over a period of seven days. In addition, graded voluntary isometric force production (i.e. 20%, 40%, 60%, 80% & 100% of MVC) during knee extension was shown to be significantly (p less than 0.01) correlated with contemporaneous myotonometer measurements made on the rectis femoris muscle in a total of 16 healthy subjects (8 males, 8 females). Further-more, this device has been operationally tested during parabolic flight demonstrating its suitability for use in a microgravity environment. Our data indicates that the Myotonometer is a viable surrogate measure of muscle contractile state/tone and of muscle strength/force production. Additional studies are required to assess the suitability of this technique for assessing these measures in de-conditioned subjects such as crew-members.

Ang, B. S.↗
NASA NTRS1975

Shuttle launched flight tests - Supporting technology for planetary entry missions

The feasibility of conducting Space Shuttle-launched earth entry flight tests to enhance the technology base for second generation planetary entry missions is examined. Outer planet entry environments are reviewed, translated into earth entry requirements and used to establish entry test system design and cost characteristics. Entry speeds up to those needed to simulate radiative heating levels of more than 30 kW/sq cm are shown to be possible. A standardized recoverable test bed concept is described that is capable of accommodating a wide range of entry technology experiments. The economic advantage of shared Shuttle launches are shown to be achievable through a test system configured to the volume constraints of a single Spacelab pallet using existing propulsion components.

Vetter, H. C.↗
NASA NTRS1972

Advanced propulsion systems for space flight.

For flights over lunar and planetary distances, propulsion systems producing more total impulse per unit mass of propellant and unit mass of vehicle than provided by chemical rocket engines are desirable. Among many different nonchemical space propulsion systems considered only two have reached a level of significant development. These systems are the nuclear fission rocket, and the electric rocket. A third system, the nuclear fusion rocket, may come into being after the problem of controlling the fusion reaction has been solved.

Stuhlinger, E.↗
NASA NTRS1972

The deep space network, volume 10

Progress on the Deep Space Network (DSN) supporting research and technology is reported. The objectives, functions and facilities of the DSN are described along with the mission support for the following: interplanetary flight projects, planetary flight projects, and manned space flight projects. Work in advanced engineering and communications systems is reported along with changes in hardware and software configurations in the DSN/MSFN tracking stations.

Source record↗