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At least 91 records · Page 5

Compositional Effects on Nickel-Base Superalloy Single Crystal Microstructures

Fourteen nickel-base superalloy single crystals containing 0 to 5 wt% chromium (Cr), 0 to 11 wt% cobalt (Co), 6 to 12 wt% molybdenum (Mo), 0 to 4 wt% rhenium (Re), and fixed amounts of aluminum (Al) and tantalum (Ta) were examined to determine the effect of bulk composition on basic microstructural parameters, including gamma' solvus, gamma' volume fraction, volume fraction of topologically close-packed (TCP) phases, phase chemistries, and gamma - gamma'. lattice mismatch. Regression models were developed to describe the influence of bulk alloy composition on the microstructural parameters and were compared to predictions by a commercially available software tool that used computational thermodynamics. Co produced the largest change in gamma' solvus over the wide compositional range used in this study, and Mo produced the largest effect on the gamma lattice parameter and the gamma - gamma' lattice mismatch over its compositional range, although Re had a very potent influence on all microstructural parameters investigated. Changing the Cr, Co, Mo, and Re contents in the bulk alloy had a significant impact on their concentrations in the gamma matrix and, to a smaller extent, in the gamma' phase. The gamma phase chemistries exhibited strong temperature dependencies that were influenced by the gamma and gamma' volume fractions. A computational thermodynamic modeling tool significantly underpredicted gamma' solvus temperatures and grossly overpredicted the amount of TCP phase at 982 C. Furthermore, the predictions by the software tool for the gamma - gamma' lattice mismatch were typically of the wrong sign and magnitude, but predictions could be improved if TCP formation was suspended within the software program. However, the statistical regression models provided excellent estimations of the microstructural parameters based on bulk alloy composition, thereby demonstrating their usefulness.

MacKay, Rebecca A.↗

Changes in aerobic power of men, ages 25-70 yr

This study quantified and compared the cross-sectional and longitudinal influence of age, self-report physical activity (SR-PA), and body composition (%fat) on the decline of maximal aerobic power (VO2peak). The cross-sectional sample consisted of 1,499 healthy men ages 25-70 yr. The 156 men of the longitudinal sample were from the same population and examined twice, the mean time between tests was 4.1 (+/- 1.2) yr. Peak oxygen uptake was determined by indirect calorimetry during a maximal treadmill exercise test. The zero-order correlations between VO2peak and %fat (r = -0.62) and SR-PA (r = 0.58) were significantly (P < 0.05) higher that the age correlation (r = -0.45). Linear regression defined the cross-sectional age-related decline in VO2peak at 0.46 ml.kg-1.min-1.yr-1. Multiple regression analysis (R = 0.79) showed that nearly 50% of this cross-sectional decline was due to %fat and SR-PA, adding these lifestyle variables to the multiple regression model reduced the age regression weight to -0.26 ml.kg-1.min-1.yr-1. Statistically controlling for time differences between tests, general linear models analysis showed that longitudinal changes in aerobic power were due to independent changes in %fat and SR-PA, confirming the cross-sectional results.

Oxygen Consumption/physiology↗

Changes in aerobic power of women, ages 20-64 yr

This study quantified and compared the cross-sectional and longitudinal influence of age, self-report physical activity (SR-PA), and body composition (%fat) on the decline of maximal aerobic power (VO2peak) of women. The cross-sectional sample consisted of 409 healthy women, ages 20-64 yr. The 43 women of the longitudinal sample were from the same population and examined twice, the mean time between tests was 3.7 (+/-2.2) yr. Peak oxygen uptake was determined by indirect calorimetry during a maximal treadmill test. The zero-order correlation of -0.742 between VO2peak and %fat was significantly (P < 0.05) higher then the SR-PA (r = 0.626) and age correlations (r = -0.633). Linear regression defined the cross-sectional age-related decline in VO2peak at 0.537 ml.kg-1.min-1.yr-1. Multiple regression analysis (R = 0.851) showed that adding %fat and SR-PA and their interaction to the regression model reduced the age regression weight of -0.537, to -0.265 ml.kg-1.min-1.yr-1. Statistically controlling for time differences between tests, general linear models analysis showed that longitudinal changes in aerobic power were due to independent changes in %fat and SR-PA, confirming the cross-sectional results. These findings are consistent with men's data from the same lab showing that about 50% of the cross-sectional age-related decline in VO2peak was due to %fat and SR-PA.

Aging/physiology↗

A Universal Algorithm for the Detection of Bi-directional Gage Output Characteristics

A universal algorithm was developed that may be used to assess the bi-directional characteristics of the gage outputs of a wind tunnel strain-gage balance. The algorithm assumes that balance loads and gage outputs are described in the design format of the balance. It can also be applied to balance calibration data that is processed by using either the Iterative Method or the Non-Iterative Method. The algorithm uses an estimate of the bi-directional part of a gage output at load capacity as input. In addition, the statistical significance of the principle absolute value term in the regression model of either the gage output or the related primary load component is determined. A gage output is assumed to be bi-directional if two conditions are fulfilled: the bi-directional part of the output at load capacity exceeds 0.5 percent of the maximum output at load capacity; the p-value of the principle absolute value term of the regression model of the balance data is less than the threshold of 0.001. Data from the calibration of two six-component force balances and one five-component semi-span balance are used to illustrate the application of the universal detection algorithm.

wind tunnel test↗

Estimating Dust and Water Ice Content of the Martian Atmosphere From THEMIS Data

Researchers at JPL and Arizona State University conducted a comparative study of three candidate algorithms for estimating components of the Martian atmosphere, using raw (uncalibrated) data collected by the Thermal Emission Imaging System (THEMIS). THEMIS is an instrument onboard the Mars Odyssey spacecraft that acquires image data in five visible and nine infrared (IR) wavelength bands. The algorithms under study used data collected from eight of the nine IR bands to estimate the dust and water ice content of the atmosphere. Such an algorithm could be used in onboard data processing to trigger other algorithms that search for features of scientific interest and to reduce the volume of data transmitted to Earth. The algorithms studied were based on regression models. In the study, the optical depths estimated by these algorithms were compared with optical depths estimated in ground-based processing using fully calibrated data from both THEMIS and the Thermal Emission Spectrometer (TES). TES is an instrument onboard the Mars Global Surveyor spacecraft that also observes the planet at infrared wavelengths, but at a lower spatial resolution than THEMIS does. Of the algorithms studied, the one that performed best was based on a Gaussian Support Vector Machine regression model. The test results indicated that this algorithm, operating on the raw data, had error rates that were within the uncertainty associated with the estimates obtained by the groundbased analysis of the fully calibrated data. This level of fidelity demonstrates that these algorithms are sufficiently accurate for use in an onboard setting.

Bandfield, Joshua↗

Use of Minute-by-Minute Cardiovascular Measurements During Tilt Tests to Strengthen Inference on the Effect of Long-Duration Space Flight on Orthostatic Hypotension

Typical methodology for evaluating the effects of spaceflight on orthostatic hypotension (OH) has been survival analysis of tolerance times from 80 head-up tilt tests. However when scheduled test durations are short, there may not be enough failures to allow survival analysis to adequately estimate and compare the effects of flight phase (e.g. pre-flight, number of days post-flight), flight duration, and their interaction, as well as interactions with effects of interventions or countermeasures. The problem is exacerbated in the presence of a repeated measures design, in which subjects participate in tilt tests during various flight phases. Here we show how it is possible to dramatically improve the efficiency of statistical inference in this setting by making use of the additional information contained in minute-by-minute observations of cardiovascular parameters thought to be reflective of progression towards presyncope during tilt testing. Methods: We retrospectively examined operational tilt test (OTT; 10 -min 80 head-up tilt) data from 20 International Space Station (ISS) and 66 Shuttle astronauts 10 d before launch (L-10), on landing day (R+0) and during recovery (R+1, R+3, R+6-10) depending on the level of participation. Data from 5 ISS astronauts tested on R+0 or R+1 who used non-standard countermeasures were excluded. In addition to OTT survival time, 8 cardiovascular parameters (CP: heart rate, systolic, diastolic, and mean arterial blood pressure, pulse pressure, stroke volume, cardiac output, and total peripheral resistance) that might be predictive of progression towards presyncope were measured every minute of each OTT. Statistical analysis was predicated on a two ]stage model of causation. In the first stage, flight duration and time from landing affect the astronauts' degree of OH, which is manifested in the time trends and variation of the above CPs during OTTs. In the second stage, the behavior of these parameters directly affects OTT survival time. Actual analysis proceeded in the opposite direction. First we identified those CPs or linear combinations that best predicted OTT survival regardless of what spaceflight conditions led to OTT completion or presyncope. From these, we calculated a summary statistic (one per OTT) that best predicted survival. We then used mixed ]model regression analysis to relate changes in the summary statistic to flight phase and duration. Inference on the effects of phase, duration, and their interaction on OH follows directly from this second analysis. Results: A linear combination (W) of diastolic blood pressure (DBP) and stroke volume (SV) was found to be the best predictor of OTT survival using the complete data set of minute-by-minute observations of CPs for each OTT. Furthermore, the log-transformed standard deviation of W (Z = log SW) was found to be a strong predictor of survival in the reduced data set consisting of one observation per OTT. In other words, this measure of variability of W during an OTT was the best indicator of whether or not the subject could complete the 10-min test, with higher variability (i.e. higher values of Z) being associated with greater probability of failure. In the mixed-model regression analysis where Z was now treated as a outcome with flight phase and duration groups (ISS and STS) as predictors, we found that there was a significantly more variability in W (higher values of Z) for both groups at R+0, but with no evidence of an interaction until R+3, when the ISS group still had inflated variability, but not the STS group. Conclusions: Variability of the cardiovascular index W recovers more slowly after long-compared to short-duration spaceflight. Since high variability of W has also been shown to be predictive of OTT failure, a primary manifestation of OH, a logical conclusion is that recovery from OH also is slower after long-duration compared to short-duration spaceflights.

Feiveson, Alan H.↗

Application of artificial neural networks in hydrological modeling: A case study of runoff simulation of a Himalayan glacier basin

The simulation of runoff from a Himalayan Glacier basin using an Artificial Neural Network (ANN) is presented. The performance of the ANN model is found to be superior to the Energy Balance Model and the Multiple Regression model. The RMS Error is used as the figure of merit for judging the performance of the three models, and the RMS Error for the ANN model is the latest of the three models. The ANN is faster in learning and exhibits excellent system generalization characteristics.

Buch, A. M.↗

Regression Verification Using Impact Summaries

Regression verification techniques are used to prove equivalence of syntactically similar programs. Checking equivalence of large programs, however, can be computationally expensive. Existing regression verification techniques rely on abstraction and decomposition techniques to reduce the computational effort of checking equivalence of the entire program. These techniques are sound but not complete. In this work, we propose a novel approach to improve scalability of regression verification by classifying the program behaviors generated during symbolic execution as either impacted or unimpacted. Our technique uses a combination of static analysis and symbolic execution to generate summaries of impacted program behaviors. The impact summaries are then checked for equivalence using an o-the-shelf decision procedure. We prove that our approach is both sound and complete for sequential programs, with respect to the depth bound of symbolic execution. Our evaluation on a set of sequential C artifacts shows that reducing the size of the summaries can help reduce the cost of software equivalence checking. Various reduction, abstraction, and compositional techniques have been developed to help scale software verification techniques to industrial-sized systems. Although such techniques have greatly increased the size and complexity of systems that can be checked, analysis of large software systems remains costly. Regression analysis techniques, e.g., regression testing [16], regression model checking [22], and regression verification [19], restrict the scope of the analysis by leveraging the differences between program versions. These techniques are based on the idea that if code is checked early in development, then subsequent versions can be checked against a prior (checked) version, leveraging the results of the previous analysis to reduce analysis cost of the current version. Regression verification addresses the problem of proving equivalence of closely related program versions [19]. These techniques compare two programs with a large degree of syntactic similarity to prove that portions of one program version are equivalent to the other. Regression verification can be used for guaranteeing backward compatibility, and for showing behavioral equivalence in programs with syntactic differences, e.g., when a program is refactored to improve its performance, maintainability, or readability. Existing regression verification techniques leverage similarities between program versions by using abstraction and decomposition techniques to improve scalability of the analysis [10, 12, 19]. The abstractions and decomposition in the these techniques, e.g., summaries of unchanged code [12] or semantically equivalent methods [19], compute an over-approximation of the program behaviors. The equivalence checking results of these techniques are sound but not complete-they may characterize programs as not functionally equivalent when, in fact, they are equivalent. In this work we describe a novel approach that leverages the impact of the differences between two programs for scaling regression verification. We partition program behaviors of each version into (a) behaviors impacted by the changes and (b) behaviors not impacted (unimpacted) by the changes. Only the impacted program behaviors are used during equivalence checking. We then prove that checking equivalence of the impacted program behaviors is equivalent to checking equivalence of all program behaviors for a given depth bound. In this work we use symbolic execution to generate the program behaviors and leverage control- and data-dependence information to facilitate the partitioning of program behaviors. The impacted program behaviors are termed as impact summaries. The dependence analyses that facilitate the generation of the impact summaries, we believe, could be used in conjunction with other abstraction and decomposition based approaches, [10, 12], as a complementary reduction technique. An evaluation of our regression verification technique shows that our approach is capable of leveraging similarities between program versions to reduce the size of the queries and the time required to check for logical equivalence. The main contributions of this work are: - A regression verification technique to generate impact summaries that can be checked for functional equivalence using an off-the-shelf decision procedure. - A proof that our approach is sound and complete with respect to the depth bound of symbolic execution. - An implementation of our technique using the LLVMcompiler infrastructure, the klee Symbolic Virtual Machine [4], and a variety of Satisfiability Modulo Theory (SMT) solvers, e.g., STP [7] and Z3 [6]. - An empirical evaluation on a set of C artifacts which shows that the use of impact summaries can reduce the cost of regression verification.

Backes, John↗

Applying NASA-STD-7009 Standard for Models and Simulations to Surrogate and Other Statistical Models

NASA-STD-7009A, Standard for Models and Simulations, contains a worthy and insightfully-crafted credibility assessment. That set of metrics is intended to accumulate and communicate information that can be critical for users and their customers in evaluating findings due to a model or simulation. Was the model designed for the present use? Is it validated in the domain it’s being applied to? And so on. The standard was originally focused on physics-based models, but it can be applied more generally. It can – and should – be applied to high-impact statistical models, including surrogate models based on larger models and sims and regression models based directly on data. A key issue with many of such models is their relative simplicity compared to most M&S despite their use in high-risk engineering decisions. This report will make a case for using this Standard for a wider class of models, and how it might actually add value in excess of its cost for not only stakeholders, but modelers themselves. A rough example showing compliance for a statistical model is included.

K L Johnson↗

Modeling of topographic effects on Antarctic sea ice using multivariate adaptive regression splines

The role of seafloor topography in the spatial variations of the southern ocean sea ice cover as observed (every other day) by the Nimbus 7 scanning multichannel microwave radiometer satellite in the years 1980, 1983, and 1984 is studied. Bottom bathymetry can affect sea ice surface characteristics because of the basically barotropic circulation of the ocean south of the Antarctic Circumpolar current. The main statistical tool used to quantify this effect is a local nonparametric regression model of sea ice concentration as a function of the depth and its first two derivatives in both meridional and zonal directions. First, we model the relationship of bathymetry to sea ice concentration in two sudy areas, one over the Maud Rise and the other over the Ross Sea shelf region. The multiple correlation coefficient is found to average 44% in the Maud Rise study area and 62% in the Ross Sea study area over the years 1980, 1983, and 1984. Second, a strategy of dividing the entire Antarctic region into an overlapping mosaic of small areas, or windows is considered. Keeping the windows small reduces the correlation of bathymetry with other factors such as wind, sea temperature, and distance to the continent. We find that although the form of the model varies from window to window due to the changing role of other relevant environmental variables, we are left with a spatially consistent ordering of the relative importance of the topographic predictors. For a set of three representative days in the Austral winter of 1980, the analysis shows that an average of 54% of the spatial variation in sea ice concentration over the entire ice cover can be attributed to topographic variables. The results thus support the hypothesis that there is a sea ice to bottom bathymetry link. However this should not undermine the considerable influence of wind, current, and temperature which affect the ice distribution directly and are partly responsible for the observed bathymetric effects.

De Veaux, Richard D.↗

Use of Machine Learning to Reduce Uncertainties in Particle Number Concentration and Aerosol Indirect Radiative Forcing Predicted by Climate Models

The radiative forcing of anthropogenic aerosols associated with aerosol–cloud interactions (RF(sub aci)) remains the largest source of uncertainty in climate prediction. The calculation of particle number concentration (PNC), one of the critical parameters affecting RF(sub aci), is generally simplified in climate models. Here we employ outputs from long-term (30-years) simulations of a global size-resolved (sectional) aerosol microphysics model and a machine-learning tool to develop a Random Forest Regression Model (RFRM) for PNC. We have implemented the PNC RFRM in GISS-ModelE2.1 with a mass-based One-Moment Aerosol module, which is one of CMIP6 models. Compared to the default setting, the GISS-ModelE2.1 simulation based on RFRM reduces the changes of cloud droplet number concentration associated with anthropogenic emissions, and decreases the RF(sub aci) from −1.46 W⋅m(exp −2) to −1.11 W⋅m(exp −2). This work highlights a promising approach based on machine learning to reduce uncertainties of climate models in predicting PNC and RF(sub aci) without compromising their computing efficiency.

Radiative forcing↗

NASA Experimental Program to Stimulate Competitive Research: South Carolina

The use of an appropriate relationship model is critical for reliable prediction of future urban growth. Identification of proper variables and mathematic functions and determination of the weights or coefficients are the key tasks for building such a model. Although the conventional logistic regression model is appropriate for handing land use problems, it appears insufficient to address the issue of interdependency of the predictor variables. This study used an alternative approach to simulation and modeling urban growth using artificial neural networks. It developed an operational neural network model trained using a robust backpropagation method. The model was applied in the Myrtle Beach region of South Carolina, and tested with both global datasets and areal datasets to examine the strength of both regional models and areal models. The results indicate that the neural network model not only has many theoretic advantages over other conventional mathematic models in representing the complex urban systems, but also is practically superior to the logistic model in its capability to predict urban growth with better - accuracy and less variation. The neural network model is particularly effective in terms of successfully identifying urban patterns in the rural areas where the logistic model often falls short. It was also found from the area-based tests that there are significant intra-regional differentiations in urban growth with different rules and rates. This suggests that the global modeling approach, or one model for the entire region, may not be adequate for simulation of a urban growth at the regional scale. Future research should develop methods for identification and subdivision of these areas and use a set of area-based models to address the issues of multi-centered, intra- regionally differentiated urban growth.

Sutton, Michael A.↗

Salience Assignment for Multiple-Instance Regression

We present a Multiple-Instance Learning (MIL) algorithm for determining the salience of each item in each bag with respect to the bag's real-valued label. We use an alternating-projections constrained optimization approach to simultaneously learn a regression model and estimate all salience values. We evaluate this algorithm on a significant real-world problem, crop yield modeling, and demonstrate that it provides more extensive, intuitive, and stable salience models than Primary-Instance Regression, which selects a single relevant item from each bag.

regression↗

Comparison of Electrical Output Format Options for the Analysis of Strain-Gage Balance Calibration Data

Fundamental characteristics of three gage output formats are discussed that may be used to both interpret and analyze wind tunnel strain-gage balance data. The first output format uses raw outputs, i.e., absolute voltage measurements, for the analysis. This choice requires an intercept term in the regression model of the outputs if the Iterative Method is chosen for the load prediction. Raw outputs can be used for the analysis of all known output characteristics as long as the Iterative Method is applied. However, raw outputs cannot be used to analyze data of a balance with bi-directional outputs if the Non-Iterative Method is chosen for the analysis. The second output format, i.e., difference type 1, uses the difference between raw outputs and the natural zeros of the balance gages for the analysis. In this case, the use of the intercept term becomes optional. Analysis results for difference type 1 will exactly match analysis results obtained by using raw outputs as long as identical math models are used for the regression analysis. In addition, difference type 1 may be used to analyze data of a balance with bi directional outputs if an analyst prefers to process data using the Non-Iterative Method. The third output format, i.e., difference type 2, uses the difference between raw outputs and the outputs of the zero load point of a load series for the data analysis. The application of this format is only recommended if the maximum magnitude of all tare loads of a given balance calibration data set is less than two percent of capacity. Data from the calibration of a force balance is used to illustrate the application of the three gage output formats.

Wind Tunnel Strain-Gage Balance↗

On neural networks in identification and control of dynamic systems

This paper presents a discussion of the applicability of neural networks in the identification and control of dynamic systems. Emphasis is placed on the understanding of how the neural networks handle linear systems and how the new approach is related to conventional system identification and control methods. Extensions of the approach to nonlinear systems are then made. The paper explains the fundamental concepts of neural networks in their simplest terms. Among the topics discussed are feed forward and recurrent networks in relation to the standard state-space and observer models, linear and nonlinear auto-regressive models, linear, predictors, one-step ahead control, and model reference adaptive control for linear and nonlinear systems. Numerical examples are presented to illustrate the application of these important concepts.

Phan, Minh↗

Dynamic Ensemble Prediction of Cognitive Performance in Space

Astronauts are exposed to a unique set of stressors in spaceflight. Microgravity, isolation, confinement, and environmental and operational hazards: all of these can impact sleep, vigilant attention, and alertness, which are critical to mission success. In this paper, we seek to understand the most important predictors of alertness over the course of a space mission, using self-reported, cognitive, and environmental data collected from 24 astronauts on 6-month missions to the International Space Station (ISS). Alertness was repeatedly and objectively assessed on the ISS with a brief 3-minute Psychomotor Vigilance Test (PVT) that is highly sensitive to sleep deprivation. To relate PVT performance to time-varying and sparsely-measured environmental, operational, and psychological covariates, we propose a n ensemble prediction model comprising of linear mixed effects regression, random forest, and functional concurrent regression models. An extensive cross-validation procedure reveals that this ensemble outperforms any one of its components alone. We also discover that a participant’s past performance, reported fatigue and stress, and temperature and radiation exposure were among the most important variables associated with alertness. This method is broadly applicable to environmental studies where the main goal is accurate, individualized prediction involving a mixture of person-level traits and irregularly measured time series.

Danni Tu↗

Watching Without Seeing a Tool to Surveil Astronaut Health Outcomes While Maintaining Astronaut Medical Privacy

BACKGROUND The Privacy Act of 1974 regulates the use a nd disclosure of personally identifiable information by US Federal agencies. The Act applies to biographical, financial, a nd other identity-linked information, a s well a s personal health information (PHI). As such, the use of astronaut PHI is limited to authorized personnel for preapproved uses, with data reporting often limited to aggregated information about groups. These limitations on the use a nd reporting of astronaut PHI complicates surveillance efforts, wherein epidemiologists a t the National Aeronautics and Space Administration (NASA)monitor the incidence of targeted health conditions in the astronaut population, or to discover emerging trends of aging and disease. Stratification on one or more covariates –particularly time-period, sex, a nd mission participation –can lead to extremely small datasets such that the reporting of results is potentially attributable to individuals. An additional challenge is the small size of the astronaut population, both in terms of numbers of individuals a s well a s in terms of density of exposure time. Such small datasets yield volatile rate estimates that are difficult to interpret. To a id the epidemiological surveillance efforts, a surveillance tool is required that can (a) satisfy the need for rapid computation of condition-specific incidence and mortality rates; (b) improve the statistical estimates of these estimated rates; and (c) maintain astronaut privacy. Here we describe a nd demonstrate such a tool. METHODS We devised a system that models incidence a nd mortality rates rather than calculating them directly. This ha s the advantage of using all the available data to derive the estimates, lea ding to rates that a re not attributable to any one individual, a nd a re a s numerically stable a s they can be given the extremely limited data. The system models disease endpoints using a Poisson regression model with exposure density (measured in person-years) a s a n offset term. By doing so the model is estimating event counts per person-year, equivalent to modeling the rates directly. It uses a standard (pre-specified)set of covariates; the system does not engage in “model-building” as model parsimony is not the goa l. Instead, it is explicitly recognized that if a covariate is not statistically significant a nd not a confounder then it will likely have very little effect on the estimate of the incidence a nd mortality rates. Users are able to specify the disease endpoint of interest and the covariates over which they would like to stratify. The system then uses the resulting model to compute the estimated rates for the user-chosen configuration of variables as visualizes those either over an age range within a specified time-period, or over time for astronauts with a specified age range. RESULTS The first iteration of the tool computes incidence a nd mortality rates for cardiovascular conditions and cancers. Code ha s been developed to retrieve the appropriate data from the IMPALA analysis platform, compute the models for incidence a nd mortality, a nd then use those models to generate the corresponding rate curves. A companion graphical user interface allows the user to specify the curves and visualize the results. CONCLUSIONS It is important to note that the rapid surveillance tool described here is neither meant to be a definitive assessment of the incidence or mortality of any particular disease or condition in the astronaut population, nor is it meant to be used for research purposes. Rather, it is meant as an early indicator that in-depth investigation may be warranted. By automating a repetitive process and leveraging carefully curated astronaut health outcomes, the tool makes possible a rapid “first look” into known areas of concern, and, if used judiciously, may surface new areas of concern for long-term astronaut health. This work is supported in part by the Translational Research Institute for Space Health (TRISH) through NASA Cooperative Agreement NNX16AO69A.

R J Reynolds↗