Search NASA⌕ Search

SEARCH · Search NASA

Results for “Risk Factors”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 91 records · Page 5
All sourcesNASA NTRSDOE OSTI
NASA NTRS2022

Lake Champlain Water Resources: Using Earth Observations to Identify Spatial and Seasonal Trends of Harmful Algal Events in Lake Champlain

Lake Champlain provides clean drinking water for 35% of the surrounding watershed and offers recreational opportunities to millions of tourists. However, current levels of cyanobacteria and phosphorus created breeding grounds for harmful algal blooms (HABs). The excess of phosphorus runoff into Lake Champlain over the past decade encouraged toxic cyanobacterial formations, thereby increasing the severity of HABs towards local economy and ecology. In partnership with the Natural Resources Conservation Service (NRCS) Northeast Region, this project utilized Earth observations to identify risk factors associated with toxic algal blooms. The team detected historic algal bloom trends with Sentinel-2 Multispectral Instrument (MSI), Sentinel-3 Ocean and Land Color Instrument (OLCI), Landsat 8 Operational Land Imager (OLI) and Landsat 9 OLI-2. The team also used Sentinel-3 OLCI and the German Aerospace Center’s Earth Sensing Imagery Spectrometer (DESIS) to visualize algal bloom patterns and Landsat 8 OLI, Landsat 9 OLI-2, and Shuttle Radar Topography Mission (SRTM) to identify phosphorus sources within the watershed. The team’s analyses indicated an increase in cyanobacteria blooms during summer months from 2016-2022, with Missisquoi and St. Albans Bay exhibiting the greatest concentrations of toxic events. Furthermore, 16% of the watershed was identified as posing an immediate threat to the lake’s hydrology. The area of greatest concern was the Missisquoi Bay sub-watershed, with 229,044 acres of land prone to excessive phosphorus runoff. Providing this information to the NRCS Northeast Region enabled the organization to quantify risk factors associated with algal blooms and modify mitigation efforts to better target future bloom events.

Brianne Kendall↗
NASA NTRSDate not supplied

Identifying Outside Influences as Latent Factors to Risk in Human Performance

During the Acquisition Life Cycle for a program, there are several opportunities for the system in design to be adjusted in accordance with its changing landscape as it is being shaped by evolving policy and organizational culture. Human Systems Integration is integral to identifying these opportunities of change as there are a set number of activities that may account for altered operational states, human performance deviations, and overall component engagement if HSI is enacted early enough in the life cycle. Some changes that occur in the operational environment may not be accounted for since the organizational culture and practices are not currently a part of the HSI focus. Likewise, policy changes themselves from a top-to-bottom analysis may not have the appearance of effecting human performance until having gone through a trail-and-error period. Workarounds to adjust for unforeseen policy affects become the system's solution that usually includes changes in the training and education of the operators, maintainers, and support personnel. A system full of workarounds and off-normal practices, that cause operators to disregard the purpose of the design, coupled with the false notion that these activities are proven for successful system operation, is the very definition of “an accident waiting to happen”. Unforeseen changes in policies and practices that cause new and unusual activities to successfully and keep the system running, should be considered latent factors that may cause a potential mishap, and not part of the resilience that humans provide to the successful operation of the system. This presentation will explore how latent factors may find their way into system operations and how they can be identified and addressed.

Human Systems Integration↗
NASA NTRS2012

Effects of High Dietary HEME Iron and Radiation on Cardiovascular Function

The radiation related health risks to astronauts is of particular concern to NASA. Data support that exposure to radiation is associated with a number of disorders including a heightened risk for cardiovascular diseases. Independent of radiation, altered nutrient status (e.g. high dietary iron) also increases ones risk for cardiovascular disease. However, it is unknown whether exposure to radiation in combination with high dietary iron further increases ones cardiovascular risk. The intent of our proposal is to generate compulsory data examining the combined effect of radiation exposure and iron overload on sensitivity to radiation injury to address HRP risks: 1) Risk Factor of Inadequate Nutrition; 2) Risk of Cardiac Rhythm Problems; and 3) Risk of Degenerative Tissue or other Health Effects from Space Radiation. Towards our goal we propose two distinct pilot studies using the following specific aims: Vascular Aim 1: To determine the short-term consequences of the independent and combined effects of exposure to gamma radiation and elevated body iron stores on measures of endothelial function and cell viability and integrity. We hypothesize that animals that have high body iron stores and are exposed to gamma radiation will show a greater reduction in endothelial dependent nitric oxid production and larger pathological changes in endothelial integrity than animals that have only 1 of those treatments (either high iron stores or exposure to gamma radiation). Vascular Aim 2: Identify and compare the effects of gamma radiation and elevated body iron stores on the genetic and epigenetic regulation of proteins associated with endothelial cell function. We hypothesize that modifications of epigenetic control and posttranslational expression of proteins associated with endothelial cell function will be differentially altered in rats with high body iron stores and exposed to gamma radiation compared to rats with only 1 type of treatment. Cardiac Aim 1: To determine the short-term consequences of the independent and combined effects of gamma radiation and elevated body iron stores on measures of cardiac structure. We hypothesize that modifications to cardiac structure and function will be greater in rats with high body iron stores and exposed to gamma radiation than in rats that have only 1 of those treatments. Cardiac Aim 2: Identify and compare the effects of gamma radiation and elevated body iron stores on the genetic and epigenetic regulation of proteins associated with cardiac structure and function. We hypothesize that modifications of epigenetic control and posttranslational expression of proteins associated with cardiac contractile function will be differentially altered in rats with high body iron stores and exposed to gamma radiation compared to rats with only 1 type of treatment.

Westby, Christian M.↗
NASA NTRS1998

T wave alternans as a predictor of recurrent ventricular tachyarrhythmias in ICD recipients: prospective comparison with conventional risk markers

INTRODUCTION: The current standard for arrhythmic risk stratification is electrophysiologic (EP) testing, which, due to its invasive nature, is limited to patients already known to be at high risk. A number of noninvasive tests, such as determination of left ventricular ejection fraction (LVEF) or heart rate variability, have been evaluated as additional risk stratifiers. Microvolt T wave alternans (TWA) is a promising new risk marker. Prospective evaluation of noninvasive risk markers in low- or moderate-risk populations requires studies involving very large numbers of patients, and in such studies, documentation of the occurrence of ventricular tachyarrhythmias is difficult. In the present study, we identified a high-risk population, recipients of an implantable cardioverter defibrillator (ICD), and prospectively compared microvolt TWA with invasive EP testing and other risk markers with respect to their ability to predict recurrence of ventricular tachyarrhythmias as documented by ICD electrograms. METHODS AND RESULTS: Ninety-five patients with a history of ventricular tachyarrhythmias undergoing implantation of an ICD underwent EP testing, assessment of TWA, as well as determination of LVEF, baroreflex sensitivity, signal-averaged ECG, analysis of 24-hour Holter monitoring, and QT dispersion from the 12-lead surface ECG. The endpoint of the study was first appropriate ICD therapy for electrogram-documented ventricular fibrillation or tachycardia during follow-up. Kaplan-Meier survival analysis revealed that TWA (P < 0.006) and LVEF (P < 0.04) were the only significant univariate risk stratifiers. EP testing was not statistically significant (P < 0.2). Multivariate Cox regression analysis revealed that TWA was the only statistically significant independent risk factor. CONCLUSIONS: Measurement of microvolt TWA compared favorably with both invasive EP testing and other currently used noninvasive risk assessment methods in predicting recurrence of ventricular tachyarrhythmias in ICD recipients. This study suggests that TWA might also be a powerful tool for risk stratification in low- or moderate-risk patients, and needs to be prospectively evaluated in such populations.

Non-NASA Center↗
NASA NTRS2013

Evidence Report: Risk of Inadequate Human-Computer Interaction

Human-computer interaction (HCI) encompasses all the methods by which humans and computer-based systems communicate, share information, and accomplish tasks. When HCI is poorly designed, crews have difficulty entering, navigating, accessing, and understanding information. HCI has rarely been studied in an operational spaceflight context, and detailed performance data that would support evaluation of HCI have not been collected; thus, we draw much of our evidence from post-spaceflight crew comments, and from other safety-critical domains like ground-based power plants, and aviation. Additionally, there is a concern that any potential or real issues to date may have been masked by the fact that crews have near constant access to ground controllers, who monitor for errors, correct mistakes, and provide additional information needed to complete tasks. We do not know what types of HCI issues might arise without this "safety net". Exploration missions will test this concern, as crews may be operating autonomously due to communication delays and blackouts. Crew survival will be heavily dependent on available electronic information for just-in-time training, procedure execution, and vehicle or system maintenance; hence, the criticality of the Risk of Inadequate HCI. Future work must focus on identifying the most important contributing risk factors, evaluating their contribution to the overall risk, and developing appropriate mitigations. The Risk of Inadequate HCI includes eight core contributing factors based on the Human Factors Analysis and Classification System (HFACS): (1) Requirements, policies, and design processes, (2) Information resources and support, (3) Allocation of attention, (4) Cognitive overload, (5) Environmentally induced perceptual changes, (6) Misperception and misinterpretation of displayed information, (7) Spatial disorientation, and (8) Displays and controls.

Kritina Holden↗
NASA NTRS2015

Identification and Evaluation of Integration and Cross Cutting Issues Across HRP Risks

The HRP Integrated Research Plan contains the research plans for the 32 risks requiring research to characterize and mitigate. These risks to human health and performance in spaceflight are identified by evidence and each one focuses on a single aspect of human physiology or performance. They are further categorized by aspects of the spaceflight environment, such as altered gravity or space radiation, that that play a major role in their likelihood and consequence. From its inception the "integrate" in the Research Plan has denoted the integrated nature of risks to human health and performance, the connectedness of physiological systems within the human body regardless of the spaceflight environment, and the integrated response of the human body to the spaceflight environment. Common characteristics of the spaceflight environment include altered gravity, atmospheres and light/dark cycles, space radiation, isolation, noise, and periods of high or low workload. Long term exposure to this unique environment produces a suite of physiological effects such as stress; vision, neurocognitive and anthropometric changes; circadian misalignment; fluid shifts, deconditioning; immune dysregulation; and altered nutritional requirements. Matrix diagraming was used to systematically identify, analyze and rate the many-to-many relationships between environmental characteristics and the suite of physiological effects. It was also to identify patterns in the relationships of common physiological effects to each other. Analyses of patterns or relationships in these diagrams help to identify issues that cut across multiple risks. Cross cutting issues benefit from a multidisciplinary approach that synthesizes concepts or data from two or more disciplines to identify and characterize risk factors or develop countermeasures relevant to multiple risks. They also help to illuminate possible problem areas that may arise when a countermeasure impacts risks other than those which it was developed to mitigate, or identify groupings of physiological changes that are likely to occur that may impact the overall risk posture.

Steinberg, S. L.↗
NASA NTRS1994

Citrate and renal calculi: an update

Citrate is an inhibitor of the crystallization of stone-forming calcium salts. Hypocitraturia, frequently encountered in patients with nephrolithiasis, is therefore an important risk factor for stone formation. Potassium citrate provides physiological and physicochemical correction and inhibits new stone formation, not only in hypocitraturic calcium nephrolithiasis but also in uric acid nephrolithiasis. Inhibition of stone recurrence has now been validated by a randomized trial. Ongoing research has disclosed additional causes of hypocitraturia (sodium excess, low intestinal alkali absorption, but not primary citrate malabsorption). Moreover, new insights on potassium citrate action have been shown, notably that some of absorbed citrate escapes oxidation and contributes to the citraturic response, that ingestion with a meal does not sacrifice physiological or physicochemical action, that orange juice mimics but does not completely duplicate its actions, that potassium citrate may have a beneficial bone-sparing effect, that it may reduce stone fragments following ESWL, and that danger of aluminum toxicity is not great in subjects with functioning kidneys. Finally, the research on potassium citrate has led to two promising products, calcium citrate as an optimum calcium supplement and potassium-magnesium citrate which may be superior to potassium citrate in the management of stone disease.

NASA Discipline Regulatory Physiology↗
NASA NTRS2003

Patent foramen ovale and paradoxical systemic embolism: a bibliographic review

A patent foramen ovale (PFO) has been reported to be an important risk factor for cardioembolic cerebrovascular accidents through paradoxical systemic embolization, and it provides one potential mechanism for the paradoxical systemic embolization of venous gas bubbles produced after altitude or hyperbaric decompressions. Here, we present in a single document a summary of the original findings and views from authors in this field. It is a comprehensive review of 145 peer-reviewed journal articles related to PFO that is intended to encourage reflection on PFO detection methods and on the possible association between PFO and stroke. There is a heightened debate on whether aviators, astronauts, and scuba divers should go through screening for PFO. Because it is a source of an important controversy, we prefer to present the findings in the format of a neutral bibliographic review independent of our own opinions. Each cited peer-reviewed article includes a short summary in which we attempt to present potential parallels with the pathophysiology of decompression bubbles. Two types of articles are summarized, as follows. First, we report the original clinical and physiological findings which focus on PFO. The consistent reporting sequence begins by describing the method of detection of PFO and goal of the study, followed by bulleted results, and finally the discussion and conclusion. Second, we summarize from review papers the issues related only to PFO. At the end of each section, an abstract with concluding remarks based on the cited articles provides guidelines.

NASA Discipline Environmental Health↗
NASA NTRS2000

A Primary Care Approach to the Diagnosis and Management of Peripheral Arterial Disease

The objectives of this work are: (1) Be able to recognize characteristic symptoms of intermittent claudication (2) Diagnose PAD on the basis of history, physical exam, and simple limb blood pressure measurements (3) Recognize the significance of peripheral artery disease as a marker for coronary or cerebrovascular atherosclerosis (4) Provide appropriate medical management of atherosclerosis risk factors-- including use of antiplatelet therapy to reduce risk of myocardial infarction, stroke and death (5) Manage symptoms of intermittent claudication with program of smoking cessation, exercise, and medication The diagnosis of intermittent claudication secondary to peripheral artery disease (PAD) can often be made on the basis of history and physical examination. Additional evaluation of PAD is multi-modal and the techniques used will vary depending on the nature and severity of the patient's presenting problem. Most patients can be appropriately managed without referral for specialized diagnostic services or interventions.

Dawson, David L.↗
NASA NTRSDate not supplied

Knowledge Discovery for Early Failure Assessment of Complex Engineered Systems Using Natural Language Processing

Emerging complex engineered systems may have unexpected safety issues due to novel operational environments, increasing autonomy, human-machine interaction, and other factors. To prevent failures in operation or testing that necessitate costly redesign, it is desirable to predict likely failure modes early in the design process. Text-based information about past engineering failures presents one possible solution by facilitating the retrieval of information that can inform new designs. However, identifying documents containing relevant information and extracting required information can be prohibitively time-consuming when implemented at scale. In this research, an automated natural language processing-based framework is proposed to discover relevant knowledge from documents containing failure-related design information. Documents containing usable information are filtered using sentiment analysis based on a custom lexicon specialized for engineering design and by filtering out documents containing only irrelevant topics. Next, from the identified usable documents, information relating to engineering failures, contributing factors that can be controlled at design time (“risk factors”), and recommended preventative actions are extracted. Semantic similarity is then used to group similar pieces of extracted information for improved generalizability. The proposed framework is applied to NASA’s Lessons Learned Information System (LLIS). The framework can be used to identify documents containing usable failure-related design information from other databases, extract relevant information from these documents, and generalize the acquired knowledge such that it can be applied to novel systems.

Sequoia R. Andrade↗
NASA NTRS2014

2014 SRP Integration Transcript

HRP's mission is to reduce the risks to human health and performance during long-duration spaceflight. The HRP Integrated Research Plan (IRP) contains the research plans for the 32 risks that require research to characterize and mitigate. From its inception the "integrate" aspect of the IRP has denoted the integrated nature of risks to human health and performance. Even though each risk in the IRP has its own research plan and is tracked separately, the interrelated nature of health and performance requires that they be addressed in an integrative or holistic fashion so that the connectedness of physiological systems within the human body and the integrated response to spaceflight can be addressed. Common characteristics of the spaceflight environment include altered gravity, atmospheres, and light/dark cycles; space radiation; isolation; noise; and periods of high or low workload. Long-term exposure to this unique environment produces a suite of physiological effects such as stress; vision, neurocognitive, and anthropometric changes; circadian misalignment; fluid shifts; cardiovascular deconditioning; immune dysregulation; and altered nutritional requirements. Expanding cross-disciplinary integrative approaches that synthesize concepts or data from two or more disciplines would improve the identification and characterization risk factors, and enable the development of countermeasures relevant to multiple risks. Cross-disciplinary approaches might also help to illuminate problem areas that may arise when a countermeasure adversely impacts risks other than those which it was developed to mitigate, or to identify groupings of physiological changes that are likely to occur that may impact the overall risk posture. In 2014 HRP embarked on a pilot study that combined four SRPs (and 12 HRP risks) - Behavioral Health, Sensorimotor, Cardiovascular, and Bone/Muscle - specifically to discuss cross-disciplinary integration. The points outlined below were suggested to seed the discussion, within the bounding constraint that research plans must be feasible and relevant to the HRP mission. While these were suggested starting points, the overall guiding principle was to allow free discussion from panel members on any aspect of integrated research that they felt was important, Existing cross-disciplinary integration as documented in the IRP (HRR), Existing or needed integration already identified by HRP, but not yet well defined within the IRP, Areas of integration that are missing.

Steinberg, Susan↗
NASA NTRS2002

Ocular input for human melatonin regulation: relevance to breast cancer

The impact of breast cancer on women across the world has been extensive and severe. As prevalence of breast cancer is greatest in industrialized regions, exposure to light at night has been proposed as a potential risk factor. This theory is supported by the epidemiological observations of decreased breast cancer in blind women and increased breast cancer in women who do shift-work. In addition, human, animal and in vitro studies which have investigated the melatonin-cancer dynamic indicate an apparent relationship between light, melatonin and cancer, albeit complex. Recent developments in understanding melatonin regulation by light in humans are examined, with particular attention to factors that contribute to the sensitivity of the light-induced melatonin suppression response. Specifically, the role of spectral characteristics of light is addressed, and recent relevant action spectrum studies in humans and other mammalian species are discussed. Across five action spectra for circadian and other non-visual responses, a peak sensitivity between 446-484 nm was identified. Under highly controlled exposure circumstances, less than 1 lux of monochromatic light elicited a significant suppression of nocturnal melatonin. In view of the possible link between light exposure, melatonin suppression and cancer risk, it is important to continue to identify the basic related ocular physiology. Visual performance, rather than circadian function, has been the primary focus of architectural lighting systems. It is now necessary to reevaluate lighting strategies, with consideration of circadian influences, in an effort to maximize physiological homeostasis and health.

Review↗
NASA NTRS2003

Growth and Remodeling in Blood Vessels Studied In Vivo With Fractal Analysis

Every cell in the human body must reside in close proximity to a blood vessel (within approximately 200 mm) because blood vessels provide the oxygen, metabolite, and fluid exchanges required for cellular existence. The growth and remodeling of blood vessels are required to support the normal physiology of embryonic development, reproductive biology, wound healing and adaptive remodeling to exercise, as well as abnormal tissue change in diseases such as cancer, diabetes, and coronary heart disease. Cardiovascular and hemodynamic (blood flow dynamics) alterations experienced by astronauts during long-term spaceflight, including orthostatic intolerance, fluid shifts in the body, and reduced numbers of red (erythrocyte) and white (immune) blood cells, are identified as risk factors of very high priority in the NASA task force report on risk reduction for human spaceflight, the "Critical Path Roadmap."

Parsons-Wingerter, Patricia A.↗
NASA NTRS2014

Aviation Safety Risk Modeling: Lessons Learned From Multiple Knowledge Elicitation Sessions

Aviation safety risk modeling has elements of both art and science. In a complex domain, such as the National Airspace System (NAS), it is essential that knowledge elicitation (KE) sessions with domain experts be performed to facilitate the making of plausible inferences about the possible impacts of future technologies and procedures. This study discusses lessons learned throughout the multiple KE sessions held with domain experts to construct probabilistic safety risk models for a Loss of Control Accident Framework (LOCAF), FLightdeck Automation Problems (FLAP), and Runway Incursion (RI) mishap scenarios. The intent of these safety risk models is to support a portfolio analysis of NASA's Aviation Safety Program (AvSP). These models use the flexible, probabilistic approach of Bayesian Belief Networks (BBNs) and influence diagrams to model the complex interactions of aviation system risk factors. Each KE session had a different set of experts with diverse expertise, such as pilot, air traffic controller, certification, and/or human factors knowledge that was elicited to construct a composite, systems-level risk model. There were numerous "lessons learned" from these KE sessions that deal with behavioral aggregation, conditional probability modeling, object-oriented construction, interpretation of the safety risk results, and model verification/validation that are presented in this paper.

Luxhoj, J. T.↗
NASA NTRS2009

Evaluating Failures and Near Misses in Human Spaceflight History for Lessons for Future Human Spaceflight

There have been a number of studies done in the past drawn on lessons learned with regard to human loss-of-life events. Generally, the systemic causes and proximate causes for fatal events have both been examined in considerable detail. However, an examination of near-fatal accidents and failures that narrowly missed being fatal could be equally useful, not only in detecting causes, both proximate and systemic, but also for determining what factors averted disaster, what design decisions and/or operator actions prevented catastrophe. Additionally, review of risk factors for upcoming or future programs will often look at trending statistics, generally focusing on failure/success statistics. Unfortunately, doing so can give a skewed or misleading view of past reliability or a reliability that cannot be presumed to apply to a new program. One reason for this might be that failure/success criteria aren't the same across programs, but also that apparent success can hide systemic faults that, under other circumstances, can be fatal to a program with different parameters. A program with a number of near misses can look more reliable than a consistently healthy program with a single out-of-family failure and provide very misleading data if it is not examined in detail. This is particularly true for a manned space program where failure/success includes more than making a particular orbit. Augmenting reliability evaluations with this near miss data can provide insight and expand on the limitations of a strictly pass/fail evaluation. Even more importantly, a thorough understanding of these near miss events can identify conditions that prevented fatalities. Those conditions may be key to a programs reliability, but, without insight to the repercussions if such conditions were not in place, their importance may not be readily clear. As programs mature and political and fiscal responsibilities come to the fore, often there is considerable incentive to eliminate unnecessary conservatism, design margin, redundancy, operational support, testing, training, or safety oversight. An evaluation that demonstrates how these features and capabilities averted disaster can ensure processes that saved lives or missions are not discarded without appropriate review and understanding. Close examination of accidents that almost were can also highlight differences in design from one program to another, either justifying reliability comparisons or negating them. It can also provide considerable insight into how those saving factors were developed and implemented so that similar methods can be used to ensure appropriate life-saving and mission saving factors can be developed, even for a dissimilar space program. The lessons are appropriate for seasoned manned space programs and agencies, but crucial for untried agencies and organizations that are interested in sending man into space. The large body of publicly available near miss and accident data available provide invaluable insight into programmatic, technical, and even political issues that can be addressed before they impact safety. In this paper, we examine a number of these near misses and accidents and steps a program, agency, or potential spacefaring company might take to improve their chances of success and avoid mission or safety disasters using this data.

Barr, Stephanie↗
NASA NTRS1991

Mission safety evaluation report for STS-35: Postflight edition

Space Transportation System 35 (STS-35) safety risk factors that represent a change from previous flights that had an impact on this flight, and factors that were unique to this flight are discussed. While some changes to the safety risk baseline since the previous flight are included to highlight their significance in risk level change, the primary purpose is to insure that changes which were too late too include in formal changes through the Failure Modes and Effects Analysis/Critical Items List (FMEA/CIL) and Hazard Analysis process are documented along with the safety position, which includes the acceptance rationale.

Hill, William C.↗
NASA NTRSDate not supplied

Evaluation of the spaceflight cardiovascular risk using the clinical prediction model Astro-CHARM and the NASA Radiation Risk Model

- Exposure to space radiation may pose a risk for cardiovascular diseases (CVD) during and after spaceflight. - The CVD risk should be quantified to plan future long-duration space missions such as the manned flight to Mars. - Assessing CVD risk is complicated by its multifactorial nature, where an individual’s risk is strongly influenced by risk factors such as family history, blood pressure, and lipid profiles. - In the NASA Space Radiation Risk Model, the metrics of radiation exposure-induced cases (REIC) and radiation exposure-induced death (REID) are used to quantify the risk attributable to radiation over a lifetime after exposure.

Ianik Plante↗
NASA NTRS2007

An Additional Potential Factor for Kidney Stone Formation during Space Flights: Calcifying Nanoparticles (Nanobacteria): A Case Report

Spaceflight-induced microgravity appears to be a risk factor for the development of urinary calculi due to skeletal calcium liberation and other undefined factors, resulting in stone disease in crewmembers during and after spaceflight. Calcifying nanoparticles, or nanobacteria, reproduce at a more rapid rate in simulated microgravity conditions and create external shells of calcium phosphate in the form of apatite. The questions arises whether calcifying nanoparticles are niduses for calculi and contribute to the development of clinical stone disease in humans, who possess environmental factors predisposing to the development of urinary calculi and potentially impaired immunological defenses during spaceflight. A case of a urinary calculus passed from an astronaut post-flight with morphological characteristics of calcifying nanoparticles and staining positive for a calcifying nanoparticle unique antigen, is presented.

Jones, Jeffrey A.↗