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Creating Benchmark Data for Artificial Intelligence and Machine Learning Space Biology Research

To identify an appropriate AI/ML approach for a specific problem, the best practice is to measure algorithm performance through the benchmarking process. A scientific benchmark consists of an AI-ready dataset and a reference implementation on a specific scientific question. The NASA Science Mission Directorate (SMD) has started the “Benchmark Initiative for AI/ML to create scientific benchmark datasets in three applications: 1) scientific benchmarking, which finds the best algorithm for a specific problem; 2) application benchmarking, which measures algorithm performance against a set of parameters; and 3) system benchmarking, which evaluates performance of hardware and software architecture. Currently, there are no standardized datasets available to benchmark AI/ML algorithms in the domain of space biology. In this work, we constructed two AI/ML-ready biological datasets from experiments in space-flown mice: cellular imaging and RNA-seq. First, radiation-exposed immune cells harbor DNA damage foci that can be fluorescently marked to visualize the amount of damage following exposure to ionizing radiation. However, such large datasets are difficult to analyze visually, due to imaging inconsistencies and human bias, and classical image processing approaches can fail on imaging artifacts. AI/ML are therefore exciting alternative, providing the speed of machines and the accuracy of humans. We have made this dataset available at https://registry.opendata.aws/bps_microscopy/. Second, high-throughput nucleic acid sequencing (DNA-seq, RNA-seq) has become widespread in biomedical research due to the growing availability and affordability of these assays. However, most sequencing datasets suffer from high dimensionality and low sample count. In this work, we used a generative adversarial network to synthesize a standardized, AI-ready, publicly available benchmark dataset for space biology RNA-seq data with sufficient space-flown and ground control mouse liver samples from NASA GeneLab. This dataset is available at https://registry.opendata.aws/bps_rnaseq/. These datasets are now fully open the Space Biology community to test their favorite AI/ML approaches.

James Casaletto↗

The Importance of Meteorite Collections to Sample Return Missions: Past, Present, and Future Considerations

While much of the scientific community s current attention is drawn to sample return missions, it is the existing meteorite and cosmic dust collections that both provide the paradigms to be tested by these missions and the context for interpreting the results. Recent sample returns from the Stardust and Hayabusa missions provided us with new materials and insights about our Solar System history and processes. As an example, Stardust sampled CAIs among the population of cometary grains, requiring extensive and unexpected radial mixing in the early solar nebula. This finding would not have been possible, however, without extensive studies of meteoritic CAIs that established their high-temperature, inner Solar System formation. Samples returned by Stardust also revealed the first evidence of a cometary amino acid, a discovery that would not have been possible with current in situ flight instrument technology. The Hayabusa mission provided the final evidence linking ordinary chondrites and S asteroids, a hypothesis that developed from centuries of collection and laboratory and ground-based telescopic studies. In addition to these scientific findings, studies of existing meteorite collections have defined and refined the analytical techniques essential to studying returned samples. As an example, the fortuitous fall of the Allende CV3 and Murchison CM2 chondrites within months before the return of Apollo samples allowed testing of new state-of-the-art analytical facilities. The results of those studies not only prepared us to better study lunar materials, but unanticipated discoveries changed many of our concepts about the earliest history and processes of the solar nebula. This synergy between existing collections and future space exploration is certainly not limited to sample return missions. Laboratory studies confirmed the existence of meteorites from Mars and raised the provocative possibility of preservation of ancient microbial life. The laboratory studies in turn led to a new wave of Mars exploration that ultimately could lead to sample return focused on evidence for past or present life. This partnership between collections and missions will be increasingly important in the coming decades as we discover new questions to be addressed and identify targets for for both robotic and human exploration . Nowhere is this more true than in the ultimate search for the abiotic and biotic processes that produced life. Existing collections also provide the essential materials for developing and testing new analytical schemes to detect the rare markers of life and distinguish them from abiotic processes. Large collections of meteorites and the new types being identified within these collections, which come to us at a fraction of the cost of a sample return mission, will continue to shape the objectives of future missions and provide new ways of interpreting returned samples.

Welzenbach, L. C.↗

Overview of the Galileo Probe Mission to Jupiter

The Galileo Probe entered the atmosphere of Jupiter on December 7, 1995, for the first time directly sampling the atmosphere of one of the outer planets. The entry was the most difficult ever attempted in terms of heat and deceleration loads. The probe and all scientific instruments functioned successfully, and returned data on composition, clouds, thermal structure, winds, energy balance, lightning, and inner radiation belts. A probe mission overview is presented, highlighting the key mission events and major science objectives. The purpose of the overview is to set the stage for the following papers which describe findings from the probe scientific investigations and discuss implications of the probe results.

Young, Richard E.↗

Allan Hills 76005 Polymict Eucrite Pairing Group: Curatorial and Scientific Update on a Jointly Curated Meteorite

Allan Hills 76005 (or 765) was collected by the joint US-Japan field search for meteorites in 1976-77. It was described in detail as "pale gray in color and consists of finely divided macrocrystalline pyroxene-rich matrix that contains abundant clastic fragments: (1) Clasts of white, plagioclase-rich rocks. (2) Medium-gray, partly devitrified, cryptocrystalline. (3) Monomineralic fragments and grains of pyroxene, plagioclases, oxide minerals, sulfides, and metal. In overall appearance it is very similar to some lunar breccias." Subsequent studies found a great diversity of basaltic clast textures and compositions, and therefore it is best classified as a polymict eucrite. Samples from the 1976-77, 77-78, and 78-79 field seasons (76, 77, and 78 prefixes) were split between US and Japan (NIPR). The US specimens are currently at NASA-JSC, Smithsonian Institution, or the Field Museum in Chicago. After this initial finding of ALH 76005, the next year s team recovered one additional mass ALH 77302, and then four additional masses were found during the third season ALH 78040 and ALH 78132, 78158 and 78165. The joint US-Japan collection effort ended after three years and the US began collecting in the Trans-Antarctic Mountains with the 1979-80 and subsequent field seasons. ALH 79017 and ALH 80102 were recovered in these first two years, and then in 1981-82 field season, 6 additional masses were recovered from the Allan Hills. Of course it took some time to establish pairing of all of these specimens, but altogether the samples comprise 4292.4 g of material. Here will be summarized the scientific findings as well as some curatorial details of how specimens have been subdivided and allocated for study. A detailed summary is also presented on the NASA-JSC curation webpage for the HED meteorite compendium.

Righter, K.↗

The Shuttle Environment Workshop, executive summary and workshop procedures

One of the main experimental monitors used to determine the environment in the payload bay was the Induced Environment Contamination Monitor. This package of instruments has made environmental measurements during STS flights with a high degree of success. This has shown that the shuttle environment is relatively free of contaminants, except for special instances of increased abundance of methane, water vapor and particulates. Results of these measurements are rapidly becoming more available. In establishing the Shuttle Environment Workshop, the findings were shared with scientific experimenters, users and other individuals who need to know what the Shuttle is like and what experimenters may expect in the payload bay. The Workshop was centered around results obtained from the environmental measurements made on the Shuttle. The program agenda for the workshop is given. The procedures and flow of communications for the workshop are indicated.

Lehmann, J.↗

Feasibility of reduced gravity experiments involving quiescent, uniform particle cloud combustion

The study of combustible particle clouds is of fundamental scientific interest as well as a practical concern. The principal scientific interests are the characteristic combustion properties, especially flame structure, propagation rates, stability limits, and the effects of stoichiometry, particle type, transport phenomena, and nonadiabatic processes on these properties. The feasibility tests for the particle cloud combustion experiment (PCCE) were performed in reduced gravity in the following stages: (1) fuel particles were mixed into cloud form inside a flammability tube; (2) when the concentration of particles in the cloud was sufficiently uniform, the particle motion was allowed to decay toward quiescence; (3) an igniter was energized which both opened one end of the tube and ignited the suspended particle cloud; and (4) the flame proceeded down the tube length, with its position and characteristic features being photographed by high-speed cameras. Gravitational settling and buoyancy effects were minimized because of the reduced gravity enviroment in the NASA Lewis drop towers and aircraft. Feasibility was shown as quasi-steady flame propagation which was observed for fuel-rich mixtures. Of greatest scientific interest is the finding that for near-stoichiometric mixtures, a new mode of flame propagation was observed, now called a chattering flame. These flames did not propagate steadily through the tube. Chattering modes of flame propagation are not expected to display extinction limits that are the same as those for acoustically undisturbed, uniform, quiescent clouds. A low concentration of fuel particles, uniformly distributed in a volume, may not be flammable but may be made flammable, as was observed, through induced segregation processes. A theory was developed which showed that chattering flame propagation was controlled by radiation from combustion products which heated the successive discrete laminae sufficiently to cause autoignition.

Ross, Howard D.↗

Solving large sparse eigenvalue problems on supercomputers

An important problem in scientific computing consists in finding a few eigenvalues and corresponding eigenvectors of a very large and sparse matrix. The most popular methods to solve these problems are based on projection techniques on appropriate subspaces. The main attraction of these methods is that they only require the use of the matrix in the form of matrix by vector multiplications. The implementations on supercomputers of two such methods for symmetric matrices, namely Lanczos' method and Davidson's method are compared. Since one of the most important operations in these two methods is the multiplication of vectors by the sparse matrix, methods of performing this operation efficiently are discussed. The advantages and the disadvantages of each method are compared and implementation aspects are discussed. Numerical experiments on a one processor CRAY 2 and CRAY X-MP are reported. Possible parallel implementations are also discussed.

Philippe, Bernard↗

Report on the international Cambodian crater expedition, 1992

It has been proposed that Tonle Sap, a lake in Cambodia, 100 km long and 30 km wide, marks the location of an elongate basin formed by the oblique impact of a comet or asteroid. The impact is considered to have produced melted ejecta found now as tektites over much of southeast Asia and Australia. The location of the lake, its approximate age, its size, and the orientation of its long axis (toward Australia) are consistent with this hypothesis. Our scientific objectives were to find impact or shock metamorphosed rocks unambiguously related to the Tonle Sap basin, to collect samples of rocks that may represent those melted to produce Australasian tektites, and to learn as much as possible about Cambodian geology. Using 1:200,000-scale geologic maps with fairly detailed descriptions of the rock units, we selected a number of acceptable 'phnoms' (hills that rise abruptly out of the surrounding plain) that may contain rocks affected by the postulated Tonle Sap impact. A map of central Cambodia is shown, and the locations of sites where samples were collected are indicated. A list of those sites, together with a description of the rocks reported to be present at each site, is given. No obviously shock-metamorphosed or suevite-like rocks were observed. Recent alluvium surrounding Tonle Sap is judged to be lake sediment deposited when the lake surface was at a higher elevation.

Hartung, J.↗

NASA/DOD Aerospace Knowledge Diffusion Research Project. Paper 40: Technical communications in aerospace education: A study of AIAA student members

This paper describes the preliminary analysis of a survey of the American Institute of Aeronautics and Astronautics (AIAA) student members. In the paper we examine (1) the demographic characteristics of the students, (2) factors that affected their career decisions, (3) their career goals and aspirations, and (4) their training in technical communication and techniques for finding and using aerospace scientific and technical information (STI). We determine that aerospace engineering students receive training in technical communication skills and the use of STI. While those in the aerospace industry think that more training is needed, we believe the students receive the appropriate amount of training. We think that the differences between the amount of training students receive and the perception of training needs is related partially to the characteristics of the students and partially to the structure of the aerospace STI dissemination system. Overall, we conclude that the students' technical communication training and knowledge of STI, while limited by external forces, makes it difficult for students to achieve their career goals.

Kennedy, John M.↗

NASA/DOD Aerospace Knowledge Diffusion Research Project. Paper 46: Technical communications in aerospace: A comparison across four countries

In this paper we describe the preliminary analysis of four groups of aerospace engineering and science students -- student members of the American Institute of Aeronautics and Astronautics (AIAA) and students from universities in Japan, Russia, and Great Britain. We compare: (1) the demographic characteristics of the students; (2) factors that affected their career decision; (3) their career goals and aspirations; (4) their training in technical communication; and (5) their training in techniques for finding and using aerospace scientific and technical information (STI). Many employers in the US aerospace industry think there is a need for increased training of engineering students in technical communication. Engineers in the US and other countries believe that technical communication skills are critical for engineers' professional success. All students in our study agree about the importance of technical communication training for professional success, yet relatively few are happy with the instruction they receive. Overall, we conclude that additional instruction in technical communication and accessing STI would make it easier for students to achieve their career goals.

Kennedy, John M.↗

Carbon nanotube scanning probe for imaging in aqueous environment

Carbon nanotubes (CNTs) used as a probe for scanning probe microscopy has become one of the many potential usages of CNTs that is finding real applications in scientific research and industrial communities. It has been proposed that the unique mechanical buckling properties of the CNT would lessen the imaging force exerted on the sample and, thus, make CNT scanning probes ideal for imaging soft materials, including biological samples in liquid environments. The hydrophobic nature of the CNT graphitic sidewall is clearly chemically incompatible with the aqueous solution requirements in some biological imaging applications. In this paper, we present electron micrograph results demonstrating the instability of CNT scanning probes when submerged in aqueous solution. Moreover, we also introduce a novel approach to resolve this chemical incompatibility problem. By coating the CNT probe with ethylenediamine, thus rendering the CNT probe less hydrophobic, we demonstrate the liquid imaging capability of treated CNT probes. Experimental data for imaging in aqueous solutions are presented, which include an ultrathin Ir film and DNA molecules on a mica surface.

Microscopy, Atomic Force/methods↗

Computational Simulations and the Scientific Method

As scientific simulation software becomes more complicated, the scientific-software implementor's need for component tests from new model developers becomes more crucial. The community's ability to follow the basic premise of the Scientific Method requires independently repeatable experiments, and model innovators are in the best position to create these test fixtures. Scientific software developers also need to quickly judge the value of the new model, i.e., its cost-to-benefit ratio in terms of gains provided by the new model and implementation risks such as cost, time, and quality. This paper asks two questions. The first is whether other scientific software developers would find published component tests useful, and the second is whether model innovators think publishing test fixtures is a feasible approach.

Kleb, Bil↗

Imaging Spectrometry-Concepts and System Tradeoffs

The concept of imaging spectrometry is finding broad application in scientific instrumentation for earth-based, airborne, and space applications. An imaging spectrometer is characterized by the combination of imaging with complete sampling in the spectral domain. In so doing, material identification can be accomplished and displayed in conjunction with the conventional recognizable image. An image spectrometer incorporates a wide variety of techniques, including focal plane arrays, imaging and spectrometer optics, and spectral dispersing devices. The design of a successful system involves a complex set of tradeoffs incorporating the properties and limitations of the various technologies. For applications in the infrared, additional technologies such as focal plane cooling are required, and the other technologies present more limitations and constraints.

Herring, M.↗

Planetary Exploration of Lava Tubes with Lidar at Craters of the Moon, Idaho

We completed a lidar survey of lava tubes in Idaho as an analog to the exploration of pits on the Moon and Mars. Pits are exploration targets for future missions because they provide both lucrative science and possible shelter. Exploration at these sites will require innovative engineering to access the interiors. We present findings that demonstrate the scientific and operational potential of lidar within such challenging environments, and discuss our results for Indian Tunnel, the largest tube we surveyed (Fig. 1).

LAVA Tubes↗

2015 Occupant Protection Standing Review Panel

The 2015 Occupant Protection (OP) Risk Standing Review Panel (from here on referred to as the SRP) participated in a WebEx/teleconference with members of the Space Human Factors and Habitability (SHFH) Element, representatives from the Human Research Program (HRP), NASA Headquarters, and NASA Research and Education Support Services on November 3, 2015 (list of participants is in Section VII of this report). The SRP reviewed the updated research plans for the Risk of Injury from Dynamic Loads (OP Risk). The SRP agrees that the Gaps are relevant and appropriate to mitigate the injury risk. All the appropriate and relevant Tasks have been identified to fill the Gaps. Depending upon the findings, additional tasks may need to be identified or modified. Excellent progress has been made since the 2014 SRP meeting. Publications in peer-reviewed journals validate the scientific merit of the research findings. As detailed in this report, the SRP has specific comments, guidance, and information in the following areas: human finite element modeling, human vs. surrogate dynamic responses, chest injury risk curves, matched pair testing of Test device for Human Occupant Restraint (THOR) and Hybrid III, and disc herniation risk analysis.

Steinberg, Susan↗

Lunar Sample Compendium

The purpose of the Lunar Sample Compendium will be to inform scientists, astronauts and the public about the various lunar samples that have been returned from the Moon. This Compendium will be organized rock by rock in the manor of a catalog, but will not be as comprehensive, nor as complete, as the various lunar sample catalogs that are available. Likewise, this Compendium will not duplicate the various excellent books and reviews on the subject of lunar samples (Cadogen 1981, Heiken et al. 1991, Papike et al. 1998, Warren 2003, Eugster 2003). However, it is thought that an online Compendium, such as this, will prove useful to scientists proposing to study individual lunar samples and should help provide backup information for lunar sample displays. This Compendium will allow easy access to the scientific literature by briefly summarizing the significant findings of each rock along with the documentation of where the detailed scientific data are to be found. In general, discussion and interpretation of the results is left to the formal reviews found in the scientific literature. An advantage of this Compendium will be that it can be updated, expanded and corrected as need be.

Meyer, Charles↗

Planet X probe: A fresh new look at an old familiar place

Planet X Probe utilizes a Get Away Special (GAS) payload to provide a large student population with a remote Earth sensing experimental package. To provide a cooperative as well as a competitive environment, the effort is targeted at all grade levels and at schools in different geographical regions. LANDSAT capability allows students to investigate the Earth, its physical makeup, its resources, and the impact of man. This project also serves as an educational device to get students to stand back and take a fresh look at their home planet. The key element is to treat the familiar Earth as an unknown planet with knowledge based only on what is observable and provable from the images obtained. Through participation, a whole range of experiences will include: (1) mission planning; (2) research and pilot projects to train teams; (3) identification and recruitment of scientific mentors and dialogue; (4) selection of a student advisory team to be available during the mission; (5) analysis of data and compilation of findings; (6) report preparation, constucted along sound scientific principles; and (7) presentation and defense of findings before a meeting of competitive student groups and scientist in the field.

Nicholson, James↗