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At least 91 records · Page 5

Altered susceptibility to motion sickness as a function of subgravity level.

Large interindividual differences among 74 normal subjects in the change in susceptibility to motion sickness with effective lifting of the normal g-load by parabolic flight maneuvers were recorded with high test-retest reliability. Most subjects, who were required to make standardized head movements while seated in a chair rotating at a constant speed, demonstrated either a substantial increase or a decrease in susceptibility, in confirmation of a previous study, while a few appeared to be more or less unaffected by the 1 g to 0 g gravitational change. A similar test procedure conducted with eighteen of the subjects at lunar- and Martian-gravity levels revealed further interindividual differences in susceptibility as a function of g-level.

Miller, E. F., II↗

Stress corrosion cracking susceptibility of 18 Ni maraging steel

The stress corrosion cracking (SCC) resistance of 18Ni maraging steel (grades 200, 250, 300, and 350) was determined in 3.5 percent salt (NaCl) solution, synthetic sea water, high humidity, and outside MSFC atmosphere. All grades of the maraging steel were found to be susceptible to SCC in varying degrees according to their strengths, with the lowest strength steel (grade 200) being the least susceptible and the highest strength steel (grade 350), the most susceptible to SCC. The SCC resistance of 250 grade maraging steel was also evaluated in salt and salt-chromate solutions using fracture mechanics techniques. The threshold value, K sub SCC, was found to be approximately 44 MN/sq m square root m, (40 ksi square root in.) or 40 percent of the K sub Q value.

Humphries, T. S.↗

Comparison of five levels of motion sickness severity as the basis for grading susceptibility

The motion sickness susceptibility of 275 healthy male subjects was measured quantitatively by a standardized laboratory procedure using a Stille rotational chair. The results, in terms of velocity of the chair and the number of active head movements, were combined into a single numerical score that represented the total stressor stimulus sustained in reaching, in turn, each of five specific criteria for diagnosing the severity of motion sickness. The stressor value (E factor) of a single head movement at each test rpm was adjusted to yield an equivalent susceptibility score (Coriolis Sickness Susceptibility Index, or CSSI) independent of the endpoint selected. Close agreement among the CSSI scores obtained at each endpoint was found in intercorrelations, test-retest reliability coefficients, and frequency distributions, which reflected the orderliness and stability in the appearance, ramification, and intensification of the acute symptomatology evoked in progressing from mild malaise to frank sickness.

Miller, E. F., II↗

Individual differences in susceptibility to motion sickness among six Skylab astronauts

Motion sickness was studied in Skylab crewmen. By mission-day 8 (MD 8), astronauts were virtually free of motion sickness symptoms after rotation and linear acceleration tests. None of the Skylab-II astronauts (crewmen 1-3) was motion sick aloft, but astronaut 6 of the Skylab-III crew experienced motion sickness within an hour after transition into orbit. All three astronauts (4-6) of Skylab-III experienced motion sickness in the workshop, where astronaut 6 was most susceptible and astronaut 4 least susceptible. The higher susceptibility of SL-III crewmen in the workshop, as compared with SL-II crewmen, may be attributable to the fact that they were based in the command module (CM) less than one-third as long as were SL-II astronauts. I.e., the unnatural movements permitted in the open spaces of the workshop entrained more complex interactions of unusual vestibular and visual stimuli than did those in the CM. The observed reduced liability to kinetosis relative to earth may be due to absence of the gravity stimulus to the otolith organs.

Graybiel, A.↗

Magnetization and magnetic susceptibilities of GdH3, HoH3, ErH3 and YbH3

The magnetic susceptibility of powdered samples of HoH3, ErH3, GdH3 and YbH3 have been measured in the temperature range from 4.2 to 1.2 K. Two broad, local maxima are observed in the variation of chi versus T for GdH3, with maxima in (delta chi delta T) versus T at 1.8 K and 3.3 K. The inverse susceptibilities for HoH3 and ErH3 both obey a Curies-Weiss law over a limited range (4.2 to 2.6K and 4.2 to 2 K respectively) with values for the Weiss constant of -4.25 K and -1.11 K, and effective moments of 8.6 and 7.7 Bohr magnetons respectively. The susceptibility of YbH3 is independent of temperature over the range investigated. High-field magnetization measurements yield extrapolated saturation moments of 7.0 + or - 0.25 Bohr magnetons/ion for GdH3, 6.1 + or - 0.2 Bohr magnetons/ion for HoH3 and 3.74 + or - 0.11 Bohr magnetons/ion for ErH3. In addition, ErH3 exhibits a van Vleck paramagnetism in the high field region.

Flood, D. J.↗

Observed differences in learning ability of heart rate self-regulation as a function of hypnotic susceptibility

Three groups of eight male and female subjects (aged 20-27 yr) categorized by low and high hypnotic susceptibility were taught to control their heart rates by means of an appropriate autogenic therapy/biofeedback technique. The experimental groups were trained by autogenic therapy and biofeedback, while the control group received only biofeedback. Significant differences are observed in all psychological test scores between subjects of high and low hypnotic susceptibility. The results confirm that (1) there are qualitative and quantitative differences between the performance of individuals with high and low hypnotic susceptibility; (2) interindividual-variability tests yield data relevant to individual performance in visceral learning tasks; (3) the combined autogenic therapy/biofeedback/verbal feedback technique is suitable for conditioning large stable autonomic responses in humans; and (4) this kind of conditioning is effective in eliminating or alleviating physiological reactions to some environmental stressors.

Cowings, P. S.↗

Susceptibility measurements on the superconducting properties of Nb-Ge alloys

A susceptibility apparatus to measure superconducting properties of samples made in the MSFC Drop Tube was used to measure the transition temperature (Tc) and susceptibilities of Nb and Nb Ge Alloys prepared in bulk spherical (2-4 mm diameter) form using a 32 m drop tube in which containerless low gravity solidification could take place. Results indicate that a drop tube processing environment was beneficial for increasing the Tc of the superconducting phase of the material over that of arc melted material. The increase in Tc is found to be related to the amount of solidification of the total sample that took place before reaching the bottom of the drop tube. In phase and quadrature phase measurements of the specimen's susceptibility indicated that some improvement in homogeneity takes place in drop tube processing. These phase measurements also indicated little or no shielding of a lower Tc phase by a higher Tc filamentary structure.

Rathz, T. J.↗

ac susceptibility of thermally annealed and neutron irradiated Cu-Ni alloys

Thermal annealing and high-flux neutron irradiation are used to vary the degree of short-range atomic order in Cu-Ni alloys of composition 40, 50, and 60 at. pct Ni. The magnetic state is measured by ac magnetic susceptibility measurements. It is shown that annealing at 350 C causes significant changes in the susceptibility of all the samples. In the 50 and 60 at. pct Ni samples, the transition is broadened and extended to higher temperatures, while the 40 at. pct Ni sample changes from a paramagnetic system to a weakly ferromagnetic system. The neutron irradiation, in contrast to the thermal treatment, causes the development of smaller size cluster formations. The irradiated 60 at. pct Ni sample exhibits no change in the shape of its susceptibility curve from that of the quenched sample, whereas, the 40 pct alloy is changed, by irradiation, from a paramagnetic system to a spin-glass system.

Catchings, R. M., III↗

Theoretical study relating the two-photon absorption cross section to the susceptibility controlling four-wave mixing

A theory that it is necessary to extract a two-photon absorption cross section from a mixing signal is developed. The dependence of the cross section on the third-order susceptibility is shown and both the mixing signal and reference signal dependences on the susceptibility are given. Techniques to process the measured value of the susceptibility and relate it to the cross section are developed and limits of validity are established. Finally, a comparison is made between the expression for the cross section presently reported and values given elsewhere.

Burris, J.↗

Endocrine correlates of susceptibility to motion sickness

Motion sickness releases ACTH, epinerphrine, and norepinephrine. The endocrine responses to motion sickness, adaptive responses leading to the resolution of the syndrome, and the way in which antimotion-sickness drugs influence the endocrine responses were studied. Susceptible or insusceptible subjects were administered antimotion-sickness drugs prior to stressful stimulation. Insusceptible subjects displayed more pronounced elevations of ACTH, epinephrine, and norepinephrine after stressful motion. Predrug levels of ACTH were higher in insusceptible subjects (p less than 0.01). Acute blockade of hormone responses to stressful motion or alteration of levels of ACTH by drugs were not correlated with individual susceptibility. No correlation was apparent between epinephrine and ACTH release. These endocrine differences may represent neurochemical markers for susceptibility to motion, stress, or general adaptability, and it may be that the chronic modulation of their levels might be more effective in preventing motion sickness than the acute blockage or stimulation of specific receptors.

Kohl, R. L.↗

Oculomotor function during space flight and susceptibility to space motion sickness

Horizontal vestibulo-ocular reflex (VOR) and saccadic eye movements (SEM) were studied in 18 subjects before and during five Space Shuttle missions to evaluate the effects of weightlessness and correlations between results and susceptibility to and actual presence of space motion sickness (SMS). Active sinusoidal head oscillation was the stimulus for VOR tests with vision (VVOR), with eyes shaded (VOR-ES), and VOR suppression (VOR-S). Eye movements were recorded by electrooculography and head position by a potentiometer. No pathological nystagmus or other abnormal eye movements were seen. No significant in-flight changes were seen in the gain, phase shift or waveform of VVOR, VOR-ES or VOR-S. Statistically significant increases in saccadic latency and decreases in saccadic velocity were seen, with no change in saccadic accuracy. Preflight differences between SMS susceptible and nonsusceptible subjects were noted only in VOR-S, with less complete suppression in susceptible subjects, a finding also seen in flight. During flight, VVOR gain was significantly increased in three nonaffected subjects. Saccades of SMS-affected subjects showed increased latency and velocity and decreased accuracy compared to saccades of unaffected subjects.

Thornton, William E.↗

Development of an Antimicrobial Susceptibility Testing Method Suitable for Performing During Space Flight

Very little is known regarding the affects of the microgravity environment of space flight upon the action of antimicrobial agents on bacterial pathogens. This study was undertaken to develop a simple method for conducting antibacterial susceptibility tests during a Space Shuttle mission. Specially prepared susceptibility test research cards (bioMerieux Vitek, Hazelwood, MO) were designed to include 6-11 serial two-fold dilutions of 14 antimicrobial agents, including penicillins, cephalosporins, a Beta-lactamase inhibitor, vancomycin, erythromycin, tetracycline, gentamicin, ciprofloxacin, and trimethoprim/sulfamethoxazole. Minimal inhibitory concentrations (MICS) of the drugs were determined by visual reading of color endpoints in the Vitek research cards made possible by incorporation of a colorimetric growth indicator (alamarBlue(Trademark), Accumed International, Westlake, OH). This study has demonstrated reproducible susceptibility results when testing isolates of Staphylococcus aurezis, Group A Streptococcus, Enterococcusfaecalis, Escherichia coli (beta-lactamase positive and negative strains), Klebsiella pneumoniae, Enterobacter cloacae, and Pseudomoiias aeruginosa. In some instances, the MICs were comparable to those determined using a standard broth microdilution method, while in some cases the unique test media and format yielded slightly different values, that were themselves reproducible. The proposed in-flight experiment will include inoculation of the Vitek cards on the ground prior to launch of the Space Shuttle, storage of inoculated cards at refrigeration temperature aboard the Space Shuttle until experiment initiation, then incubation of the cards for 18-48 h prior to visual interpretation of MICs by the mission's astronauts. Ground-based studies have shown reproducible MICs following storage of inoculated cards for 7 days at 4-8 C to accommodate the mission's time schedule and the astronauts' activities. For comparison, ground-based control (normal gravity) MIC values will be generated by simultaneous inoculation and incubation of a second set of test cards in a laboratory at the launch site. This procedure can provide a safe and compact experiment that should yield new information on the affects of microgravity on the biological activities of various classes of antibiotics.

Jorgensen, James H.↗

Transmission Measurement of the Third-Order Susceptibility of Gold

Gold nanoparticle composites are known to display large optical nonlinearities. In order to assess the validity of generalized effective medium theories (EMT's) for describing the linear and nonlinear optical properties of metal nanoparticle composites, knowledge of the linear and nonlinear susceptibilities of the constituent materials is a prerequisite. In this study the inherent nonlinearity of the metal is measured directly (rather than deduced from a suitable EMT) using a very thin gold film. Specifically, we have used the z-scan technique at a wavelength near the transmission window of bulk gold to measure the third-order susceptibility of a continuous thin gold film deposited on a quartz substrate surface-modified with a self-assembled monolayer to promote adhesion and uniformity without affecting the optical properties. We compare our results with predictions which ascribe the nonlinear response to a Fermi-smearing mechanism. Further, we note that the sign of the nonlinear susceptibility is reversed from that of gold nanoparticle composites.

Smith, David D.↗

Non-Invasive Assessment of Susceptibility to Ventricular Arrhythmias During Simulated Microgravity

The Cardiovascular Alterations Team is currently conducting studies to determine what alterations in hemodynamic regulation result from sixteen days of simulated microgravity exposure in normal human subjects. In this project we make additional measurements on these same study subjects in order to determine whether there is an increase in susceptibility to ventricular arrhythmias resulting from simulated microgravity exposure. Numerous anecdotal and documented reports from the past 30 years suggest that the incidence of ventricular arrhythmias among astronauts is increased during space flight. For example, documented runs of ventricular tachycardia have been recorded from crew members of Skylab and Mir, there was much attention given by the lay press to Mir Commander Vasily Tslbliyev's complaints of heart rhythm irregularities in July of 1997, and cardiovascular mechanisms may have been causal in the recent death of an experimental primate shortly after return from space. In 1986, a Mir cosmonaut, Alexander Laveikin, was brought home and replaced with an alternate cosmonaut as a result of cardiac dysrhythmias that began during extravehicular activity. Furthermore, at a joint NASA/NSBRI workshop held in January 1998, cardiac arrhythmias were identified as the highest priority cardiovascular risk to a human Mars mission. Despite the evidence for the risk of a potentially lethal arrhythmia resulting from microgravity exposure, the effects of space flight and the associated physiologic stresses on cardiac conduction processes are not known, and an increase in cardiac susceptibility to arrhythmias has never been quantified. In this project, we are determining whether simulated space flight increases the risk of developing life-threatening heart rhythm disturbances such as sustained ventricular tachycardia (defined as ventricular tachycardia lasting at least 30 seconds or resulting in hemodynamic collapse) and ventricular fibrillation. We are obtaining measures of cardiac susceptibility to ventricular arrhythmias in subjects exposed to simulated space flight in the Human Studies Core protocol being conducted by the Cardiovascular Alterations Team, which involves sixteen days .of bed rest. In particular, we are applying a powerful new non-invasive technology, developed in Professor Cohen's laboratory at MIT for the quantitative assessment of the risk of life-threatening ventricular arrhythmias. This technology involves the measurement of microvolt levels of T wave alternans (TWA) during exercise stress, and was recently granted approval by the Food and Drug Administration to be used for the clinical evaluation of patients suspected to be at risk of ventricular arrhythmias. In addition, we are obtaining 24 hour Holter monitoring (to detect non-sustained ventricular tachycardia and to assess heart rate variability). We are also conducting protocols to obtain these same measures on a monthly basis for up to four months in subjects in the Bone Demineralization/calcium Metaboloism Team's long term bed rest study.

Cohen, Richard J.↗

Persistence of Gamma-H2AX Foci in Irradiated Bronchial Cells Correlates with Susceptibility to Radiation Associated Lung Cancer in Mice

The risk of developing radiation-induced lung cancer differs between different strains of mice, but the underlying cause of the strain differences is unknown. Strains of mice also differ in their ability to efficiently repair DNA double strand breaks resulting from radiation exposure. We phenotyped mouse strains from the CcS/Dem recombinant congenic strain set for their efficacy in repairing DNA double strand breaks during protracted radiation exposures. We monitored persistent gamma-H2AX radiation induced foci (RIF) 24 hours after exposure to chronic gamma-rays as a surrogate marker for repair deficiency in bronchial epithelial cells for 17 of the CcS/Dem strains and the BALB/cHeN founder strain. We observed a very strong correlation R2 = 79.18%, P < 0.001) between the level of persistent RIF and radiogenic lung cancer percent incidence measured in the same strains. Interestingly, spontaneous levels of foci in non-irradiated strains also showed good correlation with lung cancer incidence (R2=32.74%, P =0.013). These results suggest that genetic differences in DNA repair capacity largely account for differing susceptibilities to radiation-induced lung cancer among CcS/Dem mouse strains and that high levels of spontaneous DNA damage is also a relatively good marker of cancer predisposition. In a smaller pilot study, we found that the repair capacity measured in peripheral blood leucocytes also correlated well with radiogenic lung cancer susceptibility, raising the possibility that such phenotyping assay could be used to detect radiogenic lung cancer susceptibility in humans.

Ochola, Donasian O.↗

Observational Constraint on Cloud Susceptibility Weakened by Aerosol Retrieval Limitations

Aerosol-cloud interactions remain a major uncertainty in climate research. Studies have indicated that model estimates of cloud susceptibility to aerosols frequently exceed satellite estimates, motivating model reformulations to increase agreement. Here we show that conventional ways of using satellite information to estimate susceptibility can serve as only a weak constraint on models because the estimation is sensitive to errors in the retrieval procedures. Using instrument simulators to investigate differences between model and satellite estimates of susceptibilities, we find that low aerosol loading conditions are not well characterized by satellites, but model clouds are sensitive to aerosol perturbations in these conditions. We quantify the observational requirements needed to constrain models, and find that the nighttime lidar measurements of aerosols provide a better characterization of ten- uous aerosols. We conclude that observational uncertainties and limitations need to be accounted for when assessing the role of aerosols in the climate system.

Ma, Po-Lun↗

Conducted Susceptibility Data Adaptation Tool

The purpose of this research project is to help NASA scientists increase effectivity in testing by reducing the amount of time required for data conversion from initial measurements to the analysis stage. This project resulted in a data conversion tool developed in python using the openpyxl library. When lab personnel perform the Conducted Susceptibility 101 (CS101) and Conducted Susceptibility 02 (CS02) tests in the Semi-anechoic Electromagnetic Compatibility Test Facility at NASA Langley Research Center, the driving code produces a text file under the .DAT extension.The data must be manually converted the .DAT file into an Excel file line by line for data analysis.The Conducted Susceptibility Data Adaptation Tool (CSDAT) uses python code to convert the .DAT files to spreadsheets automatically which saves lab personnel time which they could use for faster analysis as well as prevents possible human error such as leaving out a line of data in the manual conversion process.

Gabriel Johnson↗

Fairfax Water Resources: Estimating Urban Flood Susceptibility, Historical Flooding Extent, and Land Cover Change in Fairfax County, Virginia to Aid in Flood Mitigation Planning

Between 2000 and 2020, Fairfax County, Virginia experienced extreme weather events that caused severe flooding and degradation of roads, businesses, and other public property. A single flood event on July 8th, 2019 resulted in $14.8 million in damages. These flood events routinely impact the community, often resulting in power outages, school closures, and downed trees. The Fairfax County Department of Public Works and Environmental Services partnered with DEVELOP to explore how remotely sensed data could be integrated to support its current flood mitigation efforts. This project used environmental factors such as elevation, slope, and topographic wetness index from Earth observation derived data to map flood susceptibility. We utilized Landsat 5 Thematic Mapper (TM), Landsat 7 Enhanced Thematic Mapper Plus (ETM+), Landsat 8 Operational Land Imager (OLI), Sentinel-1 C-Band Synthetic Aperture Radar (C-SAR), and Sentinel-2 Multispectral Instrument (MSI) to map historic flooding events in Fairfax County. These maps will support flood management practices for the Fairfax County Department of Public Works and Environmental Services through the integration of remotely sensed data. Our results show that developed areas in the county are more susceptible to flooding, coinciding with analysis of flood factors, which indicated that imperviousness and tree canopy were the most influential drivers in flood susceptibility. Other results show that using Earth observations to map historical flooding is limited in urban areas due to false positives from SAR imagery between water and shadows. Further research is necessary to evolve the historical flood mapping technique if Earth observations are to be incorporated in future historical flood analysis.

Kaitlynn Hietpas↗