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At least 91 records · Page 5

Three-dimensional organization of vestibular related eye movements to rotational motion in pigeons

During rotational motions, compensatory eye movement adjustments must continually occur in order to maintain objects of visual interest as stable images on the retina. In the present study, the three-dimensional organization of the vestibulo-ocular reflex in pigeons was quantitatively examined. Rotations about different head axes produced horizontal, vertical, and torsional eye movements, whose component magnitude was dependent upon the cosine of the stimulus axis relative to the animal's visual axis. Thus, the three-dimensional organization of the VOR in pigeons appears to be compensatory for any direction of head rotation. Frequency responses of the horizontal, vertical, and torsional slow phase components exhibited high pass filter properties with dominant time constants of approximately 3 s.

NASA Discipline Neuroscience↗

Tracking with the mind's eye

The two components of voluntary tracking eye-movements in primates, pursuit and saccades, are generally viewed as relatively independent oculomotor subsystems that move the eyes in different ways using independent visual information. Although saccades have long been known to be guided by visual processes related to perception and cognition, only recently have psychophysical and physiological studies provided compelling evidence that pursuit is also guided by such higher-order visual processes, rather than by the raw retinal stimulus. Pursuit and saccades also do not appear to be entirely independent anatomical systems, but involve overlapping neural mechanisms that might be important for coordinating these two types of eye movement during the tracking of a selected visual object. Given that the recovery of objects from real-world images is inherently ambiguous, guiding both pursuit and saccades with perception could represent an explicit strategy for ensuring that these two motor actions are driven by a single visual interpretation.

NASA Discipline Neuroscience↗

Stimulus information contaminates summation tests of independent neural representations of features

Many models of visual processing assume that visual information is analyzed into separable and independent neural codes, or features. A common psychophysical test of independent features is known as a summation study, which measures performance in a detection, discrimination, or visual search task as the number of proposed features increases. Improvement in human performance with increasing number of available features is typically attributed to the summation, or combination, of information across independent neural coding of the features. In many instances, however, increasing the number of available features also increases the stimulus information in the task, as assessed by an optimal observer that does not include the independent neural codes. In a visual search task with spatial frequency and orientation as the component features, a particular set of stimuli were chosen so that all searches had equivalent stimulus information, regardless of the number of features. In this case, human performance did not improve with increasing number of features, implying that the improvement observed with additional features may be due to stimulus information and not the combination across independent features.

NASA Discipline Space Human Factors↗

Plasticity of the human otolith-ocular reflex

The eye movement response to earth vertical axis rotation in the dark, a semicircular canal stimulus, can be altered by prior exposure to combined visual-vestibular stimuli. Such plasticity of the vestibulo-ocular reflex has not been described for earth horizontal axis rotation, a dynamic otolith stimulus. Twenty normal human subjects underwent one of two types of adaptation paradigms designed either to attenuate or enhance the gain of the semicircular canal-ocular reflex prior to undergoing otolith-ocular reflex testing with horizontal axis rotation. The adaptation paradigm paired a 0.2 Hz sinusoidal rotation about a vertical axis with a 0.2 Hz optokinetic stripe pattern that was deliberately mismatched in peak velocity. Pre- and post-adaptation horizontal axis rotations were at 60 degrees/s in the dark and produced a modulation in the slow component velocity of nystagmus having a frequency of 0.17 Hz due to putative stimulation of the otolith organs. Results showed that the magnitude of this modulation component response was altered in a manner similar to the alteration in semicircular canal-ocular responses. These results suggest that physiologic alteration of the vestibulo-ocular reflex using deliberately mismatched visual and semicircular canal stimuli induces changes in both canal-ocular and otolith-ocular responses. We postulate, therefore, that central nervous system pathways responsible for controlling the gains of canal-ocular and otolith-ocular reflexes are shared.

Non-NASA Center↗

Adaptive stretching of representations across brain regions and deep learning model layers

Prefrontal cortex (PFC) is known to modulate the visual system to favor goal-relevant information by accentuating task-relevant stimulus dimensions. Does the brain broadly re-configures itself to optimize performance by stretching visual representations along task-relevant dimensions? We considered a task that required monkeys to selectively attend on a trial-by-trial basis to one of two dimensions (color or motion direction) to make a decision. Although effects were most prominent in frontal areas, representations stretched along task-relevant dimensions in all sites considered: V4, MT, lateral PFC, frontal eye fields (FEF), lateral intraparietal cortex (LIP), and inferotemporal cortex (IT). Spike timing was crucial to this code. A deep learning model was trained on the same visual input and rewards as the monkeys. Despite lacking an explicit selective attention or other control mechanism, by minimizing error during learning, the model’s representations stretched along task-relevant dimensions, indicating that stretching is an adaptive strategy.

59 BASIC BIOLOGICAL SCIENCES↗

Color measurement and discrimination

The present investigation is concerned with new results which show that for test lights with slow temporal modulations, and thus little effect on the luminance system, the vector-difference hypothesis represents an adequate characterization of discrimination data. It is pointed out that for certain experimental conditions color measurements can be successfully extended to include a difference measure which predicts the discriminability of pairs of lights. When discrimination depends principally on opponent-channel responses, discrimination thresholds can be predicted from the detection contour alone. Attention is given to discriminations with a 6-Hz Gabor function, the categorization of stimulus regions, and the nature of the visual mechanisms.

Wandell, B. A.↗

Visual Vestibular Interaction in the Dynamic Visual Acuity Test during Voluntary Head Rotation

Although intact vestibular function is essential in maintaining spatial orientation, no good screening tests of vestibular function are available to the aviation community. High frequency voluntary head rotation was selected as a vestibular stimulus to isolate the vestibulo-ocular reflex (VOR) from visual influence. A dynamic visual acuity test that incorporates voluntary head rotation was evaluated as a potential vestibular function screening tool. Twenty-seven normal subjects performed voluntary sinusoidal head rotation at frequencies from 0.7-4.0 Hz under three different visual conditions: visually-enhanced VOR, normal VOR, and visually suppressed VOR. Standardized Baily-Lovie chart letters were presented on a computer monitor in front of the subject, who then was asked to read the letters while rotating his head horizontally. The electro-oculogram and dynamic visual acuity score were recorded and analyzed. There were no significant differences in gain or phase shift among three visual conditions in the frequency range of 2.8 to 4.0 Hz. The dynamic visual acuity score shifted less than 0.3 logMAR at frequencies under 2.0 Hz. The dynamic visual acuity test at frequencies a round 2.0 Hz can be recommended for evaluating vestibular function.

VISUAL ACUITY↗

Analytical comparison of transient and steady state visual evoked cortical potentials

To better describe the linear-dynamic properties of the human visual-cortical response system, transient and steady state Visual Evoked Response Potentials (VERP) were observed. The stimulus presentation device provided both the evoking stimulus (flickering or pulsing lights) and a video task display. The steady state stimulus was modulated by a complex, ten frequency, sum-of-sines, wave. The transient VERP was the time-locked average of the EEG to a series of narrow light pulses (pulse width of 10 msec). The Fourier transform of the averaged pulses had properties that approximate band limited white noise, i.e., a flat spectrum over the frequency region spanned by the 10 summed sines. The Fourier transform of both the steady state and the transient evoked potentials resulted in transfer that are equivalent and therefore comparable. To investigate the effects of task loading on evoked potentials, a grammatical reasoning task was provided. Results support the relevancy of continued application of a systems engineering approach for describing neurosensory functioning.

Junker, A. M.↗

Transcriptomic Analysis of Irradiated Mouse Retina Following Readaptation

Rodent models are used as analogs for studying the effects of spaceflight. NASA GeneLab provides access to relevant omics datasets generated from spaceflight and ground-based experiments allowing for additional retrospective analysis. In this study, we used GeneLab’s GLDS-203, a dataset generated by researchers at Loma Linda University to study the impact of prolonged unloading and/or low-dose radiation on mouse retina. We analyzed transcriptomics data from retina of mice irradiated with gamma-rays for 21 days followed by 7 days, 1 month, or 4 months of readaptation. We obtained raw gene counts from GeneLab and performed differential gene expression analysis after data normalization. For each of the three timepoints, we performed differential expression analysis to compare transcriptional profiles for retina from irradiated vs. non-irradiated (controls) mice, all exposed to gravity. We observed the highest number of differentially expressed genes at 7 days, followed by 1 month and 4 months. Enrichment analysis showed top pathways (adjusted p-value < 0.05) were related to transport along microtubule and photoreceptor cell development in the 7-day readaptation group. Fewer significantly enriched pathways were observed for the 1-month group and included mRNA metabolic processes and neuron differentiation. No significantly enriched pathways were found in the 4-month group. The Gene Ontology biological processes common between the 7 days and 1-month groups include visual perception, synapse organization, and perception of light stimulus. This analysis is part of a larger effort to characterize the molecular mechanisms involved in retinal readaptation following radiation exposure. Future analyses will include other related retina datasets in GeneLab repository to assess whether gene expression patterns are consistent across different study cohorts.

Prachi Kothiyal↗

Ernst Mach on the vestibular organ 100 years ago

The paper reviews the contributions of Ernst Mach to vestibular research. His experiments, mainly psychophysical in nature, included measurements of threshold and investigation of the vestibular-visual interaction. Among his conclusions are that the adequate stimulus for the semicircular canals must be pressure, and that the sustained endolymph flow theory of Breuer (1874) and Crum Brown (1874) is erroneous. Excerpts are given of Mach's publications on vestibular functions.-

Henn, V.↗

Changes in compensatory eye movements associated with simulated stimulus conditions of spaceflight

Compensatory vertical eye movement gain (CVEMG) was recorded during pitch oscillation in darkness before, during, and immediately after exposures to the stimulus rearrangement produced by the Preflight Adaptation Trainer (PAT) Tilt-Translation Device (TTD). The TTD is designed to elicit adaptive responses that are similar to those observed in microgravity-adapted astronauts. The data from Experiment 1 yielded a statistically significant CVEMG decrease following 15 min of exposure to a stimulus rearrangement condition where the phase angle between subject pitch tilt and visual scene translation was 270 deg; statistically significant gain decreases were not observed following exposures either to a condition where the phase angle between subject pitch and scene translation was 90 deg or to a no-stimulus-rearrangement condition. Experiment 2 replicated the 270-deg-phase condition from Experiment 1 and extended the exposure duration from 30 to 45 min. Statistically significant additional changes in CVEMG associated with the increased exposure duration were not observed. The adaptation time constant estimated fram the combined data from Experiments 1 and 2 was 29 min.

Harm, Deborah L.↗

Changes in Compensatory Eye Movements Associated with Simulated Stimulus Conditions of Spaceflight

Compensatory vertical eye movement gain (CVEMG) was recorded during pitch oscillation in darkness before, during and immediately after exposures to the stimulus rearrangement produced by the Preflight Adaptation Trainer (PAT) Tilt-Translation Device (TTD). The TTD is designed to elicit adaptive responses that are similar to those observed in microgravity-adapted astronauts. The data from Experiment 1 yielded a statistically significant CVEMG decrease following 15 minutes of exposure to a stimulus rearrangement condition where the phase angle between subject pitch tilt and visual scene translation was 270 degrees; statistically significant gain decreases were not observed following exposures either to a condition where the phase angle between subject pitch and scene translation was 90 degrees or to a no-stimulus-rearrangement condition. Experiment 2 replicated the 270 degree phase condition from Experiment 1 and extended the exposure duration from 30 to 45 minutes. Statistically significant additional changes in CVEMG associated with the increased exposure duration were not observed. The adaptation time constant estimated from the combined data from Experiments 1 and 2 was 29 minutes.

Harm, Deborah L.↗

Can Attention be Divided Between Perceptual Groups?

Previous work using Head-Up Displays (HUDs) suggests that the visual system parses the HUD and the outside world into distinct perceptual groups, with attention deployed sequentially to first one group and then the other. New experiments show that both groups can be processed in parallel in a divided attention search task, even though subjects have just processed a stimulus in one perceptual group or the other. Implications for models of visual attention will be discussed.

McCann, Robert S.↗

Perceptual adaptation in the use of night vision goggles

The image intensification (I sup 2) systems studied for this report were the biocular AN/PVS-7(NVG) and the binocular AN/AVS-6(ANVIS). Both are quite impressive for purposes of revealing the structure of the environment in a fairly straightforward way in extremely low-light conditions. But these systems represent an unusual viewing medium. The perceptual information available through I sup 2 systems is different in a variety of ways from the typical input of everyday vision, and extensive training and practice is required for optimal use. Using this sort of system involves a kind of perceptual skill learning, but is may also involve visual adaptations that are not simply an extension of normal vision. For example, the visual noise evident in the goggles in very low-light conditions results in unusual statistical properties in visual input. Because we had recently discovered a strong and enduring aftereffect of perceived texture density which seemed to be sensitive to precisely the sorts of statistical distortions introduced by I sup 2 systems, it occurred to use that visual noise of this sort might be a very adapting stimulus for texture density and produce an aftereffect that extended into normal vision once the goggles were removed. We have not found any experimental evidence that I sup 2 systems produce texture density aftereffects. The nature of the texture density aftereffect is briefly explained, followed by an accounting of our studies of I sup 2 systems and our most recent work on the texture density aftereffect. A test for spatial frequency adaptation after exposure to NVG's is also reported, as is a study of perceived depth from motion (motion parallax) while wearing the biocular goggles. We conclude with a summary of our findings.

Durgin, Frank H.↗

Testing Models for Perceptual Discrimination Using Repeatable Noise

Adding noise to stimuli to be discriminated allows estimation of observer classification functions based on the correlation between observer responses and relevant features of the noisy stimuli. Examples will be presented of stimulus features that are found in auditory tone detection and visual Vernier acuity. Using the standard signal detection model (Thurstone scaling), we derive formulas to estimate the proportion of the observer's decision variable variance that is controlled by the added noise. One is based on the probability of agreement of the observer with him/herself on trials with the same noise sample. Another is based on the relative performance of the observer and the model. When these do not agree, the model can be rejected. A second derivation gives the probability of agreement of observer and model when the observer follows the model except for internal noise. Agreement significantly less than this amount allows rejection of the model.

Ahumada, Albert J., Jr.↗

Masking by Gratings Predicted by an Image Sequence Discriminating Model: Testing Models for Perceptual Discrimination Using Repeatable Noise

Adding noise to stimuli to be discriminated allows estimation of observer classification functions based on the correlation between observer responses and relevant features of the noisy stimuli. Examples will be presented of stimulus features that are found in auditory tone detection and visual vernier acuity. using the standard signal detection model (Thurstone scaling), we derive formulas to estimate the proportion of the observers decision variable variance that is controlled by the added noise. one is based on the probability of agreement of the observer with him/herself on trials with the same noise sample. Another is based on the relative performance of the observer and the model. When these do not agree, the model can be rejected. A second derivation gives the probability of agreement of observer and model when the observer follows the model except for internal noise. Agreement significantly less than this amount allows rejection of the model.

Ahumada, Albert J., Jr.↗

A Preliminary Development of The Intelligent Change Detection System (ICDS): Using Machine Learning to Combat Change Blindness in Remote Operation Environments

The emergence of Advance Air Mobility (AAM) will increase the number and types of aerial vehicles operating in shared airspaces, which will subsequently affect the amount of actionable data that ground control station operators (GCSOs) will be expected to manage. In this environment, GCSOs are particularly susceptible to the visual perceptual phenomenon known as change blindness, in which a stimulus undergoes a change without the change being noticed by its observer. A machine agent designed to detect change blindness and mitigate the effects could improve human agent performance in a data-saturated remote operations environment. The objective of this paper is to describe a proof-of-concept system architecture that integrates real-time eye tracking and vehicle telemetry data to prevent human-agent errors resulting from change blindness while operating aircraft from a remote ground control station (GCS).

Real-Time Streaming Data Architecture↗

A Preliminary Development of The Intelligent Change Detection System (ICDS): Using Machine Learning to Combat Change Blindness in Remote Operation Environments

The emergence of Advance Air Mobility (AAM) will increase the number and types of aerial vehicles operating in shared airspaces, which will subsequently affect the amount of actionable data that ground control station operators (GCSOs) will be expected to manage. In this environment, GCSOs are particularly susceptible to the visual perceptual phenomenon known as change blindness, in which a stimulus undergoes a change without the change being noticed by its observer. A machine agent designed to detect change blindness and mitigate the effects could improve human agent performance in a data-saturated remote operations environment. The objective of this paper is to describe a proof-of-concept system architecture that integrates real-time eye tracking and vehicle telemetry data to prevent human-agent errors resulting from change blindness while operating aircraft from a remote ground control station (GCS).

Real-Time Streaming Data Architecture↗