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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 91 records · Page 5
All sourcesNASA NTRSDOE OSTI
NASA NTRS1975

Acute pulmonary pathology and sudden death in rats following the intravenous administration of the plasticizer, DI (2-ethylhexyl) phthalate, solubilized with Tween surfactants

Intravenous administration of 200-300 mg/kg of di(2-ethylhexyl)phthalate (DEHP) solubilized in aqueous solutions of several Tween surfactants caused respiratory distress in rats. There was a dose-dependent lethality with death generally occurring within 90 minutes after injection. The lungs from DEHP:Tween treated animals were enlarged, generally darkened, and in some cases showed hemorrhagic congestion. Neither the overt symptoms nor the morphologic alterations resulting from DEHP:Tween administration could be reproduced by intravenous administration of aqueous Tween solutions alone. The absence of pulmonary abnormalities following the intravenous administration of DEHP as an aqueous emulsion given either alone or even as soon as 2 minutes after pretreatment with Tween 80, suggests that the specific in vivo interaction between DEHP and Tween surfactants depends on the prior formation of water-soluble micelles of DEHP.

Schulz, C. O.↗
NASA NTRS1981

Pathogenesis of sudden death following water immersion (immersion syndrome)

Sympathetic activity under cold stress is investigated. Predominantly vagal cardio-depressive reflexes are discussed besides currently known mechanisms of sudden death after water immersion. Pronounced circulatory centralization in diving animals as well as following exposure in cold water indicates additional sympathetic activity. In cold water baths of 15 C, measurements indicate an increase in plasma catecholamine levels by more than 300 percent. This may lead to cardiac arrhythmias by the following mechanisms: cold water essentially induces sinus bradycardia; brady-and tachycardiarrhythmias may supervene as secondary complications; sinusbradycardia may be enhanced by sympathetic hypertonus. Furthermore, ectopic dysrhythmias are liable to be induced by the strictly sympathetic innervation of the ventricle. Myocardial ischemia following a rise in peripheral blood pressure constitutes another arrhythmogenic factor. Some of these reactions are enhanced by alcohol intoxication.

Buhring, M.↗
NASA NTRS1985

Assessment of Computer-based Geologic Mapping of Rock Units in the LANDSAT-4 Scene of Northern Death Valley, California

Geologists obtain low accuracy levels when maps derived from LANDSAT MSS data are compared with those made by conventional methods. Procedures developed for the IDIMS computer system and used to classify a subset of a TM image of the Death Valley, California - Nevada border are described. Despite the superior resolution, broader spectral coverage, and greater sensitivity inherent to the TM, the actual recorded measured accuracy was in the same narrow range (30 to 60%) recorded for MSS data from earlier LANDSATs. The supervised classification approach appears to be superior to the unsupervised approach when applied to vegetation-sparse surfaces composed of spectrally contrasting rock/soil units distributed in relatively flat to low relief terrain. As spatial resolution improves and optimal spectral bands for identifying rock materials are specified, use of classified multispectral remote sensing data from air and space when coupled with supporting field calibration and checks should become the dominant way in which geologic mapping is carried out in future decades.

Short, N. M.↗
NASA NTRS1984

Mapping alluvial fans in Death Valley, California, using multichannel thermal infrared images

Alluvial fans have been mapped in Death Valley, California using NASA's 8-12 micron six-channel airborne Thermal Infrared Multispectral Scanner (TIMS). Both composition and relative age differences were recognized. Age unit boundries are generally consistent with those obtained by conventional mapping. Composition was verified by field investigation and comparison with existing geologic maps. Bedrock and its young derived fan gravels have similar emissivities. The original composition of the fans is modified by differential erosion and weathering, permitting relative age mapping with TIMS.

Gillespie, A. R.↗
NASA NTRS1987

Kinematics at the intersection of the Garlock and Death Valley fault zones, California: Integration of TM data and field studies. LANDSAT TM investigation proposal TM-019

Processing and interpretation of Thematic Mapper (TM) data, extensive field work, and processing of SPOT data were continued. Results of these analyses led to the testing and rejecting of several of the geologic/tectonic hypotheses concerning the continuation of the Garlock Fault Zone (GFZ). It was determined that the Death Valley Fault Zone (DVFZ) is the major through-going feature, extending at least 60 km SW of the Avawatz Mountains. Two 5 km wide fault zones were identified and characterized in the Soda and Bristol Mountains, forming a continuous zone of NW trending faulting. Geophysical measurements indicate a buried connection between the Avawatz and the Soda Mountains Fault Zone. Future work will involve continued field work and mapping at key locations, further analyses of TM data, and conclusion of the project.

Abrams, Michael↗
NASA NTRS1987

Nonlinear dynamics, fractals, cardiac physiology and sudden death

The authors propose a diametrically opposite viewpoint to the generally accepted tendency of equating healthy function with order and disease with chaos. With regard to the question of sudden cardiac death and chaos, it is suggested that certain features of dynamical chaos related to fractal structure and fractal dynamics may be important organizing principles in normal physiology and that certain pathologies, including ventricular fibrillation, represent a class of 'pathological periodicities'. Some laboratory work bearing on the relation of nonlinear analysis to physiological and pathophysiological data is briefly reviewed, with tentative theories and models described in reference to the mechanism of ventricular fibrillation.

Goldberger, Ary L.↗
NASA NTRS1991

Geologic mapping in Death Valley, California/Nevada using NASA/JPL airborne systems (AVIRIS, TIMS, and AIRSAR)

A multi-sensor aircraft campaign called the Geologic Remote Sensing Field Experiment (GRSFE) conducted during 1989 resulted in acquisition of high quality multispectral images in the visible, near infrared, shortwave infrared, thermal infrared, and microwave regions of the electromagnetic spectrum. The airborne data sets include the Airborne Visible/Infrared Imaging Spectrometer (AVIRIS), the Thermal Infrared Multispectral Scanner (TIMS), and the Airborne Synthetic Aperture Radar (SAR). Ancillary data include Landsat Thematic Mapper, laboratory and field spectral measurements, and traditional geologic mapping. The GRSFE data for a site in the northern Death Valley, (California and Nevada) region were calibrated to physical units and geometrically registered to a map base. Various aspects of this experiment are briefly discussed.

Kruse, Fred A.↗
NASA NTRS1991

Quantitative investigations of geologic surfaces utilizing airborne visible/infrared imaging spectrometer (AVIRIS) and polarimetric radar (AIRSAR) data for Death Valley, California

Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) and polarimetric radar (AIRSAR) data were collected over Death Valley, California, USA, in September 1989. These two data sets were used to quantitatively characterize both the mineralogy and surface structure of the valley floor. Field mapping and characterization of the salt flats across the valley identified 16 separate units. The AVIRIS data were calibrated using the 'empirical line' method, and spectra extracted for the 16 units. A water vapor map was generated from the AVIRIS data and showed spatial variations in its distribution due to evaporation of surface water. Unmixing of the 16 spectral units produced maps of endmember abundance.

Kierein-Young, Kathryn S.↗
NASA NTRS1990

Melatonin concentrations in the sudden infant death syndrome

The melatonin levels in various body fluids of the sudden infant death syndrome (SIDS) infants are compared with those of infants of comparable age who died of other causes to examine a possible relationship between pineal function and SIDS. After adjusting for age differences, cerebrospinal fluid melatonin levels are found to be significantly lower in the SIDS infants. It is suggested that diminished melatonin production may be characteristic of SIDS and could represent an impairment in the maturation of physiologic circadian organization.

Sturner, W. Q.↗
NASA NTRS1993

Expert system-based mineral mapping in northern Death Valley, California/Nevada, using the Airborne Visible/Infrared Imaging Spectrometer (AVIRIS)

Integrated analysis of imaging spectrometer data and field spectral measurements were used in conjunction with conventional geologic field mapping to characterize bedrock and surficial geology at the northern end of Death Valley, California and Nevada. A knowledge-based expert system was used to automatically produce image maps showing the principal surface mineralogy from Airborne Visible/Infrared Imaging Spectrometer (AVIRIS) data. Linear spectral unmixing of the AVIRIS data allowed further determination of relative mineral, abundances and identification of mineral assemblages and mixtures. The imaging spectrometer data show the spatial distribution of spectrally distinct minerals occurring both as primary rockforming minerals and as alteration and weathering products. Field spectral measurements were used to verify the mineral maps and field mapping was used to extend the remote sensing results. Geographically referenced image maps produced from these data form new base maps from which to develop improved understanding of the processes of deposition and erosion affecting the present land surface.

Kruse, F. A.↗
NASA NTRS1992

Extraction of quantitative surface characteristics from AIRSAR data for Death Valley, California

Polarimetric Airborne Synthetic Aperture Radar (AIRSAR) data were collected for the Geologic Remote Sensing Field Experiment (GRSFE) over Death Valley, California, USA, in Sep. 1989. AIRSAR is a four-look, quad-polarization, three frequency instrument. It collects measurements at C-band (5.66 cm), L-band (23.98 cm), and P-band (68.13 cm), and has a GIFOV of 10 meters and a swath width of 12 kilometers. Because the radar measures at three wavelengths, different scales of surface roughness are measured. Also, dielectric constants can be calculated from the data. The AIRSAR data were calibrated using in-scene trihedral corner reflectors to remove cross-talk; and to calibrate the phase, amplitude, and co-channel gain imbalance. The calibration allows for the extraction of accurate values of rms surface roughness, dielectric constants, sigma(sub 0) backscatter, and polarization information. The radar data sets allow quantitative characterization of small scale surface structure of geologic units, providing information about the physical and chemical processes that control the surface morphology. Combining the quantitative information extracted from the radar data with other remotely sensed data sets allows discrimination, identification and mapping of geologic units that may be difficult to discern using conventional techniques.

Kierein-Young, K. S.↗
NASA NTRS2003

Preliminary Characterization of a Microbial Community of Rock Varnish from Death Valley, California

Rock varnish (also referred to as desert varnish in the literature because it is particularly noticeable in desert environments) is a dark, thin (typically 50-500 m thick), layered veneer composed of clay minerals cemented together by oxides and hydroxides of manganese and iron. Some scientists suggest that varnish may provide a historical record of environmental processes such as global warming and long-term climate change. However, despite more than 30 years of study using modern microanalytical and microbial culturing techniques, the nucleation and growth mechanisms of rock varnish remain a mystery. Rock varnish is of interest to the Mars science community because a varnish-like sheen has been reported on the rocks at the Viking Lander sites. It therefore important for us to understand the formation mechanisms of terrestrial varnish abiotic, biotic, or a combination of the two -- as this understanding may give us clues concerning the chemical and physical processes occurring on the surface of Mars. It is strongly believed by some in the biogeochemistry community that microbes have a role in forming rock varnish, and iron- and manganese-oxidation by microbes isolated from varnish has been extensively investigated. Only two of these studies have investigated the microbial genetics of varnish. These studies examined the morphological, physiological and molecular characteristics of microbes that had previously been cultured from various rock varnishes and identified the cultivars using 16S rDNA sequencing techniques. However, it is well known that most of organisms existing in nature are refractory to cultivation, so many important organisms would have been missed. The currently described work investigates the genetics of rock varnish microbial community from a site in the Whipple Mtns., south of Death Valley, CA, near Parker, Arizona. We employed both cultural and molecular techniques to characterize the microorganisms found within the varnish and surrounding soil with the objectives of (a) identifying microorganisms potentially involved in varnish formation, and (b) discovering microorganisms that simply use the varnish as an extreme habitat.

Kuhlman, K. R.↗
NASA NTRS2003

Stressed to death: implication of lymphocyte apoptosis for psychoneuroimmunology

Psychological and physical stressors best exemplify the intercommunication of the immune and the nervous systems. It has been shown that stress significantly impacts leukocyte cellularity and immune responses and alters susceptibility to various diseases. While acute stress has been shown to enhance immune responses, chronic stress often leads to immunosuppression. Among many criteria examined upon exposure to chronic stress, the reduction in lymphocyte mitogenic response and lymphocyte cellularity are commonly assessed. We have reported that chronic restraint stress could induce lymphocyte reduction, an effect dependent on endogenous opioids. Interestingly, the effect of endogenous opioids was found to be exerted through increasing the expression of a cell death receptor, Fas, and an increased sensitivity of lymphocytes to apoptosis. Stress-induced lymphocyte reduction was not affected by adrenalectomy. In this review, based on available literature and our recent data, we will discuss the role of the hypothalamic-pituitary-adrenal axis and endogenous opioids and examine the mechanisms by which chronic stress modulates lymphocyte apoptosis.

Review Literature↗
NASA NTRS2000

IR spectroscopic characteristics of cell cycle and cell death probed by synchrotron radiation based Fourier transform IR spectromicroscopy

Synchrotron radiation based Fourier transform IR (SR-FTIR) spectromicroscopy allows the study of individual living cells with a high signal to noise ratio. Here we report the use of the SR-FTIR technique to investigate changes in IR spectral features from individual human lung fibroblast (IMR-90) cells in vitro at different points in their cell cycle. Clear changes are observed in the spectral regions corresponding to proteins, DNA, and RNA as a cell changes from the G(1)-phase to the S-phase and finally into mitosis. These spectral changes include markers for the changing secondary structure of proteins in the cell, as well as variations in DNA/RNA content and packing as the cell cycle progresses. We also observe spectral features that indicate that occasional cells are undergoing various steps in the process of cell death. The dying or dead cell has a shift in the protein amide I and II bands corresponding to changing protein morphologies, and a significant increase in the intensity of an ester carbonyl C===O peak at 1743 cm(-1) is observed. Copyright John Wiley & Sons, Inc. Biopolymers (Biospectroscopy) 57: 329-335, 2000.

Non-NASA Center↗
NASA NTRS2000

An early ethylene up-regulated gene encoding a calmodulin-binding protein involved in plant senescence and death

35S-Labeled calmodulin (CaM) was used to screen a tobacco anther cDNA library. A positive clone (NtER1) with high homology to an early ethylene-up-regulated gene (ER66) in tomato, and an Arabidopsis homolog was isolated and characterized. Based on the helical wheel projection, a 25-mer peptide corresponding to the predicted CaM-binding region of NtER1 (amino acids 796-820) was synthesized. The gel-mobility shift assay showed that the peptide formed a stable complex with CaM only in the presence of Ca(2+). CaM binds to NtER1 with high affinity (K(d) approximately 12 nm) in a calcium-dependent manner. Tobacco flowers at different stages of development were treated with ethylene or with 1-methylcyclopropene for 2 h before treating with ethylene. Northern analysis showed that the NtER1 was rapidly induced after 15 min of exposure to ethylene. However, the 2-h 1-methylcyclopropene treatment totally blocked NtER1 expression in flowers at all stages of development, suggesting that NtER1 is an early ethylene-up-regulated gene. The senescing leaves and petals had significantly increased NtER1 induction as compared with young leaves and petals, implying that NtER1 is developmentally regulated and acts as a trigger for senescence and death. This is the first documented evidence for the involvement of Ca(2+)/CaM-mediated signaling in ethylene action.

Non-NASA Center↗
NASA NTRS1993

The Shape of Trail Canyon Alluvial Fan, Death Valley

A modified conic equation has been fit to high-resolution digital topographic data for Trail Canyon alluvial fan in Death Valley, California. Fits were accomplished for 3 individual fan units of different age.

Trail Canyon↗
NASA NTRS2009

From Research to Flight: Surviving the TRL Valley of Death for Robotic and Human Space Exploration

There must be a plan or opportunities for flight validation: a) To reduce the bottleneck of new technologies at the TRL Valley of Death; b) To allow frequent infusion of new technologies into flight missions. Risk must be tolerated for new technology flight experiments. Risk must also be accepted on early-adopting missions to enable new capabilities. Fundamental research is critical to taking the next giant leap in the scientific exploration of space. Technology push is often required to meet current mission requirements. Technology management requires more than issuing NRAs and overseeing contracts.

Johnson, Les↗