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Maximum Oxygen Uptake During and After Long-Duration Space Flight

Decreased maximum oxygen consumption (VO2max) during and after space flight may impair a crewmember s ability to perform mission-critical work that is high intensity and/or long duration in nature (Human Research Program Integrated Research Plan Risk 2.1.2: Risk of Reduced Physical Performance Capabilities Due to Reduced Aerobic Capacity). When VO2max was measured in Space Shuttle experiments, investigators reported that it did not change during short-duration space flight but decreased immediately after flight. Similar conclusions, based on the heart rate (HR) response of Skylab crewmembers, were made previously concerning long-duration space flight. Specifically, no change in the in-flight exercise HR response in 8 of 9 Skylab crewmembers indicated that VO2max was maintained during flight, but the elevated exercise HR after flight indicated that VO2max was decreased after landing. More recently, a different pattern of in-flight exercise HR response, and assumed changes in VO2max, emerged from routine testing of International Space Station (ISS) crewmembers. Most ISS crewmembers experience an elevated in-flight exercise HR response early in their mission, with a gradual return toward preflight levels as the mission progresses. Similar to previous reports, exercise HR is elevated after ISS missions and returns to preflight levels by 30 days after landing. VO2max has not been measured either during or after long-duration space flight. The purposes of the ISS VO2max experiment are (1) to measure VO2max during and after long-duration spaceflight, and (2) to determine if submaximal exercise test results can be used to accurately estimate VO 2max.

Moore, Alan D., Jr.↗

Building a Shared Definitional Model of Long Duration Human Spaceflight

In 1956, on the eve of human space travel Strughold first proposed a simple classification of the present and future stages of manned flight that identified key factors, risks and developmental stages for the evolutionary journey ahead. As we look to optimize the potential of the ISS as a gateway to new destinations, we need a current shared working definitional model of long duration human space flight to help guide our path. Initial search of formal and grey literature augmented by liaison with subject matter experts. Search strategy focused on both the use of term long duration mission and long duration spaceflight, and also broader related current and historical definitions and classification models of spaceflight. The related sea and air travel literature was also subsequently explored with a view to identifying analogous models or classification systems. There are multiple different definitions and classification systems for spaceflight including phase and type of mission, craft and payload and related risk management models. However the frequently used concepts of long duration mission and long duration spaceflight are infrequently operationally defined by authors, and no commonly referenced classical or gold standard definition or model of these terms emerged from the search. The categorization (Cat) system for sailing was found to be of potential analogous utility, with its focus on understanding the need for crew and craft autonomy at various levels of potential adversity and inability to gain outside support or return to a safe location, due to factors of time, distance and location.

Orr, M.↗

The Effects of Long-Duration Spaceflight on Training Retention and Transfer

Training our crew members for long duration, exploration-class missions will have to maximize long-term retention and transfer of the trained skills. The expected duration of the missions, our inability to predict all the possible tasks the crew will be called upon to perform, and the low training-to-mission time ratio require that the training be maximally effective such that the skills acquired during training will be retained and will be transferrable across a wide range of specific tasks that are different from the particular tasks used during training. However, to be able to design training that can achieve these ambitious goals, we must first understand the ways in which long-duration spaceflight affects training retention and transfer. Current theories of training retention and transfer are largely based on experimental studies conducted at university laboratories using undergraduate students as participants. Furthermore, all such studies have been conducted on Earth. We do not know how well the results of these studies predict the performance of crew members. More specifically, we do not know how well the results of these studies predict the performance of crew members in space and especially during long-duration missions. To address this gap in our knowledge, the current on-going study seeks to test the null hypothesis that performance of university undergraduate students on Earth on training retention and transfer tests do in fact predict accurately the performance of crew members during long-duration spaceflights. To test this hypothesis, the study employs a single 16-month long experimental protocol with 3 different participant groups: undergraduate university students, crew members on the ground, and crew members in space. Results from this study will be presented upon its completion. This poster presents results of study trials of the two tasks used in this study: a data entry task and a mapping task. By researching established training principles, by examining future needs, and by using current practices in spaceflight training as test beds, this research project is mitigating program risks and generating templates and requirements to meet future training needs.

ISS↗

The Effects of Long-Duration Spaceflight on Training Retention and Transfer

Training our crew members for long duration, exploration-class missions will have to maximize long-term retention and transfer of the trained skills. The expected duration of the missions, our inability to predict all the possible tasks the crew will be called upon to perform, and the low training-to-mission time ratio require that the training be maximally effective such that the skills acquired during training will be retained and will be transferrable across a wide range of specific tasks that are different from the particular tasks used during training. However, to be able to design training that can achieve these ambitious goals, we must first understand the ways in which long-duration spaceflight affects training retention and transfer. Current theories of training retention and transfer are largely based on experimental studies conducted at university laboratories using undergraduate students as participants. Furthermore, all such studies have been conducted on Earth. We do not know how well the results of these studies predict the performance of crew members. More specifically, we do not know how well the results of these studies predict the performance of crew members in space and especially during long-duration missions. To address this gap in our knowledge, the current on-going study seeks to test the null hypothesis that performance of university undergraduate students on Earth on training retention and transfer tests do in fact predict accurately the performance of crew members during long-duration spaceflights. To test this hypothesis, the study employs a single 16-month long experimental protocol with 3 different participant groups: undergraduate university students, crew members on the ground, and crew members in space. Results from this study will be presented upon its completion. This poster presents results of study trials of the two tasks used in this study: a data entry task and a mapping task. By researching established training principles, by examining future needs, and by using current practices in spaceflight training as test beds, this research project is mitigating program risks and generating templates and requirements to meet future training needs.

training↗

Bone and Cartilage Degeneration in Mice Following Long-Duration Spaceflight: The Role of Bone Marrow Stem Cells

The detrimental effects of mechanical unloading in microgravity, including the musculo-skeletal system, are well documented. However, the effects of mechanical unloading on joint health and the interaction between bone and cartilage specifically, are less well known. Our ongoing studies with the mouse bone model have identified the failure of normal stem cell-based tissue regeneration, in addition to tissue degeneration, as a significant concern for long-duration spaceflight, especially in the mesenchymal and hematopoietic tissue lineages. Furthermore, we have identified the cell cycle arrest molecule, CDKN1ap21, as specifically up-regulated during spaceflight exposure and localized to osteoprecursors on the bone surface and chondroprogenitors in articular cartilage that are both required for normal tissue regeneration. The 30-day BionM1 and 37-day Rodent Research 1 (RR1) missions enabled the possibility of studying these effects in long-duration microgravity experiments. We hypothesized that the inhibition of stem cell-based tissue regeneration in short-duration spaceflight would continue during long-duration spaceflight resulting in significant tissue alterations and we specifically studied the hip joint (pelvis and proximal femur) to elucidate these effects. To test this hypothesis we analyzed bone and bone marrow stem cells using techniques including high-resolution Microcomputed Tomography (MicroCT), in-vivo differentiation and migration assays, and whole transcriptome expression profiling. We found that exposure to spaceflight for 30 days results in a significant decrease in bone volume fraction (-31), trabecular thickness (-14) and trabecular number (-20). Similar decrements in bone volume fraction (-27), trabecular number (-13) and trabecular thickness (-17) were found in female mice exposed to 37 days spaceflight. Furthermore, high-resolution MicroCT and immunohistochemical analysis of spaceflight tissues revealed a severe disruption of the epiphyseal boundary, resulting in endochondral ossification of the femoral head and perforation of articular cartilage by bone. This suggests that spaceflight in microgravity may cause rapid induction of an aging-like phenotype with signs of osteoarthritic disease in the hip joint. Microarray analysis also revealed that the top pathways altered during spaceflight include activation of matrix metalloproteinases, oxidative stress signaling and inflammation in both whole bone tissue and isolated bone marrow stem cells. In conclusion, the observed inhibition of stem cell-based tissue regeneration persists during long-duration spaceflight. Furthermore, spaceflight mice exhibit disruption of the epiphyseal boundary and endochondral ossification of the femoral head, and an inhibition of stem cell based tissue regeneration, which, taken together, may indicate onset of an accelerated aging phenotype with signs of osteoarthritic disease.

Cartilage↗

The Influence of Frequency and Duration Of Seismic Ground Motion On The Size Of Triggered Landslides—A Regional View

Observation, theory, and intuition all suggest that larger earthquakes should trigger larger landslides. Many factors could contribute to this, including depth-dependent shear strength or non-linearity of ground motion in soils and rock, but we hypothesize that the key characteristics of large earthquakes causing this phenomenon are (in addition to magnitude) the frequency and duration of the strong ground motion. Because of the paucity of site-specific data for detailed analysis, we take a regional approach to this question by analyzing strong-motion records and earthquake-induced landslide (EQIL) inventories from six well-documented earthquakes. Ground motion is characterized using earthquake magnitude and the median durations and frequencies (mean periods) of subsets of strong-motion records relevant to landslide triggering. EQIL inventories are characterized using the median landslide area of the entire inventory as well as the median areas of the largest 1% of the landslides and the largest 10 landslides. We then compare ground-motion characteristics with landslide size statistics to determine possible correlations. Comparisons of all earthquake- and landslide-size statistics show strong positive correlations between landslide size and (1) magnitude, (2) ground-motion duration, and (3) mean period. Although all the ground-motion measures yield highly correlated regressions, mean period appears to be the best overall predictor of landslide size. Landslide modeling using Newmark's sliding-block method also shows that longer mean periods and durations and larger magnitudes correlate strongly with increases in modeled displacements. These results support our hypothesis that increasing period and duration of seismic ground motion are the physical factors driving increased landslide sizes for larger earthquakes. Additional studies including data from a much larger set of earthquakes is needed to confirm the results of this initial study.

Hakan Tanyas↗

Recommended Crew Systems Capabilities for a Mars Ascent Vehicle as a Function of Flight Duration

In many human Mars exploration architectures, a Mars Ascent Vehicle (MAV) is used at the end of a surface stay to transport crew from the Martian surface to a waiting in-space transportation vehicle. It is possible for this transportation vehicle to be placed in any of several different Mars orbits, the selection of which drives the flight duration of the MAV from launch to docking and the amount of propellant required on the transportation vehicle to reach the same orbit. This paper identifies existing NASA standards and supplies habitability subject matter expert recommendations for the human habitation capabilities of the MAV as a function of flight duration. Living and working functions that may potentially be carried aboard a MAV are assessed. Flight durations considered include up to 8 hours, 8-24 hours, 1-2 days, 2-3 days, 3-4 days, and 4-7 days, which book end flight durations necessary to reach the transportation vehicle at different possible Mars orbits. This analysis will determine if there are key durations that serve as significant break points in required MAV capability.

MAV↗

Incidence and Progression of Chorioretinal Folds During Long-Duration Spaceflight

Importance: The primary contributing factor for development of chorioretinal folds during spaceflight is unknown. Characterizing fold types that develop and tracking their progression may provide insight into the pathophysiology of spaceflight-associated neuro-ocular syndrome and elucidate the risk of fold progression for future exploration-class missions exceeding 12 months in duration. Objective: To determine the incidence and presentation of chorioretinal folds in long-duration International Space Station crew members and objectively quantify the progression of choroidal folds during spaceflight. Design, Setting, and Participants: In this retrospective cohort study, optical coherence tomography scans of the optic nerve head and macula of crew members completing long-duration spaceflight missions were obtained on Earth prior to spaceflight and during flight. A panel of experts examined the scans for the qualitative presence of chorioretinal folds. Peripapillary total retinal thickness was calculated to identify eyes with optic disc edema, and choroidal folds were quantified based on surface roughness within macular and peripapillary regions of interest. Interventions or Exposures: Spaceflight missions ranging 6 to 12 months. Main Outcomes and Measures: Incidence of peripapillary wrinkles, retinal folds, and choroidal folds; peripapillary total retinal thickness; and Bruch membrane surface roughness. Results: A total of 36 crew members were analyzed (mean [SD] age, 46 [6] years; 7 [19%] female). Chorioretinal folds were observed in 12 of 72 eyes (17%; 6 crew members). In eyes with early signs of disc edema, 10 of 42 (24%) had choroidal folds, 4 of 42 (10%) had inner retinal folds, and 2 of 42 (5%) had peripapillary wrinkles. Choroidal folds were observed in all eyes with retinal folds and peripapillary wrinkles. Macular choroidal folds developed in 7 of 12 eyes (4 of 6 crew members) with folds and progressed with mission duration; these folds extended into the fovea in 6 eyes. Circumpapillary choroidal folds developed predominantly superior, nasal, and inferior to the optic nerve head and increased in prevalence and severity with mission duration. Conclusions and Relevance: Choroidal folds were the most common fold type to develop during spaceflight; this differs from reports in idiopathic intracranial hypertension, suggesting differences in the mechanisms underlying fold formation. Quantitative measures demonstrate the development and progression of choroidal folds during weightlessness, and these metrics may help to assess the efficacy of spaceflight-associated neuro-ocular syndrome countermeasures.

Connor R. Ferguson↗

Astronaut Sleep Duration Varies by Timing of Scheduled Sleep

INTRODUCTION: Studies find that humans average approximately six hours of sleep per night in space, which is less than they sleep on Earth. Such short sleep duration has been associated with reduced alertness and performance in space. It is unclear whether this sleep loss is related to modifiable factors, such as irregular scheduling, poor sleep environment, and excessive workload or due to features of spaceflight that alter physiology (e.g., microgravity). Recent missions have afforded crew better, more stable sleep and work schedules, and an improved sleep environment. Despite these improvements, schedules do still vary enough to cause decrements in sleep duration. METHODS: Crewmembers (n = 19) who volunteered for the NASA Standard Measures protocol between January 2019 and March 2022 were provided with actiwatches (Phillips, Respironics, Bend OR) that they wore for two bouts of data collection lasting two weeks each before flight (at approximately L-270 and L-180), either continuously (n = 9) or for two weeks every two months while in space (n = 10), and for seven days postflight, immediately upon return to Earth (R+0). A regularly scheduled (or “nominal”) sleep episode would take place between the hours of 9:30pm and 6:00am. We looked at sleep outcomes (sleep duration, wake after sleep onset [WASO], sleep efficiency) depending on the distance from nominal sleep offset to see whether scheduled sleep period affected sleep durations and other metrics of sleep quality. RESULTS: Crewmembers provided data from 402 nights preflight, 2,137 nights inflight, and 275 nights postflight. They averaged 7.33 hours of sleep per night (± 1.16, SD) in space. Though this was significantly less sleep than they achieved preflight (7.87 ± 1.10) or postflight (7.75 ± 1.43, p < .01), this duration of sleep meets the recommended amount for optimal human health and well-being. For every hour after the nominal sleep period a crewmember woke up, their total sleep increased by 25 minutes (up to 5 hours). CONCLUSIONS: We conclude that humans are capable of achieving sufficient sleep in space, especially when their schedules afford adequate sleep (namely, schedules that phase delay rather than advance). Future studies are needed to determine whether microgravity impacts sleep architecture and sleep quality. Going forward, it is imperative that crewmembers are provided with stable schedules, with moderate workload, and environments that are conducive to sleep.

fatigue↗

Activity start time and duration: incorporating regret theory into joint discrete–continuous models

Activity start time and duration decisions are two key elements of activity-travel behaviour. As an effort towards a more realistic representation of individuals’ decision behaviour, this paper presents a new copula-based joint model of activity start time and duration. In this work, we incorporate the regret theory into the joint modelling framework, which assumes that individuals tend to avoid the situation where non-chosen alternatives outperform the chosen one in one or more attributes. The proposed joint model comprises a hybrid utility-regret model as the discrete component to estimate activity start time and a hazard duration model as the continuous component to estimate activity duration. The comparative analysis of estimation results reveals that the proposed structure is statistically superior to the utility-based joint model and independent models. We also found that applying the regret-based decision rule for variables of travel time and travel time variability significantly improves the model.

42 ENGINEERING↗

Analysis of the Duration of Rising Tone Chorus Elements

Abstract The duration of chorus elements is an important parameter to understand chorus excitation and to quantify the effects of nonlinear wave‐particle interactions on energetic electron dynamics. In this work, we analyze the duration of rising tone chorus elements statistically using Van Allen Probes data. We present the distribution of chorus element duration ( τ ) as a function of magnetic local time (MLT) and the geomagnetic activity level characterized by auroral electrojet ( A E ) index. We show that the typical value of τ for nightside and dawnside is about 0.12 s, smaller than that for dayside and duskside by about a factor of 2 to 4. Using a previously developed hybrid code, DAWN, we suggest that the background magnetic field inhomogeneity might be an important factor in controlling the chorus element duration. We also report that τ is larger during quiet times and shorter during moderate and active periods; this result is consistent with the MLT dependence of τ and the occurrence pattern of chorus waves at different levels of geomagnetic activity. We then investigate the correlation between τ and the frequency chirping rate (Γ). We show that, from observation, τ scales with Γ as , suggesting that statistically the frequency range of chorus elements ( τ Γ) should be roughly the same for different elements. These findings should be useful to the further development of a theoretical model of chorus excitation and to the quantification of nonlinear wave‐particle interactions on energetic electron dynamics.

Teng, S.↗

Shortened Duration of Global Warming Slowdowns with Elevated Greenhouse Gas Emissions

Continuous emissions of anthropogenic greenhouse gases (GHGs) and aerosols in the last 160 years have resulted in an increasing trend of global mean surface temperatures (GMSTs). Due to interactions with natural variability, rates of the combined anthropogenically and naturally induced warming trends are characterized by significant slowdowns and speedups on decadal timescales. In this work, by analyzing observed and model-simulated data, we investigate how the duration of these episodes will change with different strengths of GHG and aerosol forcing. We found that the duration of warming slowdowns can be more than 30 yr with a slower rate of anthropogenic emissions but would shorten to about 5 yr with a higher one. This duration reduction depends on both the magnitude of the climate response to anthropogenic forcing and the strength of the internal variability. Moreover, the warming slowdowns can still occur even towards the end of this century under high emissions scenarios but with significantly shortened duration.

54 ENVIRONMENTAL SCIENCES↗

Nanocrystalline non-stoichiometric SBT: Effect of milling duration on structural and electrical characteristics

In the present work, nanocrystalline specimens of non-stoichiometric Strontium Bismuth Tantalate (SBT) ferroelectric ceramics were synthesized by mechanical activation process using a high energy planetary ball mill. The powders were milled for different milling durations (5, 10, 20 h) keeping the milling speed fixed at 300 rpm. Microstructural characterizations have been performed using X-ray diffraction, scanning electron microscopy, electron diffraction and transmission electron microscopy. Nanocrystallites with average grain size in the range of 30-50 nm are observed to be formed. Grain size is observed to decrease with increasing milling duration. Detailed dielectric study as a function of temperature has been carried out. It is observed that dielectric constant increases and dielectric loss decreases with increasing milling duration. The observed characteristics have been explained in terms of increased number of grain boundaries due to the reduction of granular size. - Highlights: Black-Right-Pointing-Pointer In the present work nano crystalline non-stoichiometric SBT has been synthesized. Black-Right-Pointing-Pointer The technique involved is mechanical activation (high energy ball milling). Black-Right-Pointing-Pointer The milling duration has been optimized. Black-Right-Pointing-Pointer Sr0.8Bi2.2Ta2O9 milled for 20 hours exhibit enhanced electrical characteristics.

36 MATERIALS SCIENCE↗

Development of high-voltage pulse-slicer unit with variable pulse duration for pulse radiolysis system

A high-voltage pulse-slicer unit with variable pulse duration has been developed and integrated with a 7 MeV linear electron accelerator (LINAC) for pulse radiolysis investigation. The pulse-slicer unit provides switching voltage from 1 kV to 10 kV with rise time better than 5 ns. Two MOSFET based 10 kV switches were configured in differential mode to get variable duration pulses. The high-voltage pulse has been applied to the deflecting plates of the LINAC for slicing of electron beam of 2 {mu}s duration. The duration of the electron beam has been varied from 30 ns to 2 {mu}s with the optimized pulse amplitude of 7 kV to get corresponding radiation doses from 6 Gy to 167 Gy.

43 PARTICLE ACCELERATORS↗

New approach of determinations of earthquake moment magnitude using near earthquake source duration and maximum displacement amplitude of high frequency energy radiation

The new approach method to determine the magnitude by using amplitude displacement relationship (A), epicenter distance ({Delta}) and duration of high frequency radiation (t) has been investigated for Tasikmalaya earthquake, on September 2, 2009, and their aftershock. Moment magnitude scale commonly used seismic surface waves with the teleseismic range of the period is greater than 200 seconds or a moment magnitude of the P wave using teleseismic seismogram data and the range of 10-60 seconds. In this research techniques have been developed a new approach to determine the displacement amplitude and duration of high frequency radiation using near earthquake. Determination of the duration of high frequency using half of period of P waves on the seismograms displacement. This is due tothe very complex rupture process in the near earthquake. Seismic data of the P wave mixing with other wave (S wave) before the duration runs out, so it is difficult to separate or determined the final of P-wave. Application of the 68 earthquakes recorded by station of CISI, Garut West Java, the following relationship is obtained: Mw = 0.78 log (A) + 0.83 log {Delta}+ 0.69 log (t) + 6.46 with: A (m), d (km) and t (second). Moment magnitude of this new approach is quite reliable, time processing faster so useful for early warning.

58 GEOSCIENCES↗

Convoluted effect of laser fluence and pulse duration on the property of a nanosecond laser-induced plasma into an argon ambient gas at the atmospheric pressure

We studied the behavior of the plasma induced by a nanosecond infrared (1064 nm) laser pulse on a metallic target (Al) during its propagation into argon ambient gas at the atmospheric pressure and especially over the delay interval ranging from several hundred nanoseconds to several microseconds. In such interval, the plasma is particularly interesting as a spectroscopic emission source for laser-induced plasma spectroscopy (LIBS). We show a convoluted effect between laser fluence and pulse duration on the structure and the emission property of the plasma. With a relatively high fluence of about 160 J/cm{sup 2} where a strong plasma shielding effect is observed, a short pulse of about 4 ns duration is shown to be significantly more efficient to excite the optical emission from the ablation vapor than a long pulse of about 25 ns duration. While with a lower fluence of about 65 J/cm{sup 2}, a significantly more efficient excitation is observed with the long pulse. We interpret our observations by considering the post-ablation interaction between the generated plume and the tailing part of the laser pulse. We demonstrate that the ionization of the layer of ambient gas surrounding the ablation vapor plays an important role in plasma shielding. Such ionization is the consequence of laser-supported absorption wave and directly dependent on the laser fluence and the pulse duration. Further observations of the structure of the generated plume in its early stage of expansion support our explanations.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

The effects of pulse duration on ablation pressure driven by laser radiation

The effects of laser pulse duration on the ablation pressure induced by laser radiation are investigated using Al target. Numerical simulation results using one dimensional radiation hydro code for laser intensities from 5×10{sup 12}W/cm{sup 2} to 5×10{sup 13}W/cm{sup 2} and pulse durations from 0.5 ns to 20 ns are presented. These results suggest that the laser intensity scaling law of ablation pressure differs for different pulse durations. And the theoretical analysis shows that the effects of laser pulse duration on ablation pressure are mainly caused by two regimes: the unsteady-state flow and the radiative energy loss to vacuum.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Generation of gamma radiation by a subterawatt ultrashort laser pulse: optimisation of preplasma and pulse duration

We report an experimental and numerical study of the acceleration of electrons in a plasma interacting with a subterawatt laser pulse (intensity of ∼3 × 10{sup 18} W cm{sup −2} at a pulse duration of 50 fs). A preplasma layer on the surface of a molybdenum target is formed by an additional laser pulse with a duration of 8 ns and an intensity of ∼2 × 10{sup 12} W cm{sup −2}. It is shown that an increase in the laser pulse duration to 1700 fs at a constant energy (and a proportional decrease in intensity) leads to an increase in the yield of bremsstrahlung γ-radiation by more than an order of magnitude when the nanosecond pulse is ahead of the femtosecond one by 15 − 25 ns. Interferometry data and results of diagnostics of optical and γ-radiation of a plasma demonstrate that the collisional ionisation of atoms by electrons oscillating in the field of such a laser pulse plays an essential role in the formation of electron density profile. The sensitivity of the described effect to the level of amplified spontaneous emission is determined, despite the nanosecond pulse impact. Numerical simulations show that at a large pulse duration, the acceleration of electrons is stipulated by the beaking of plasma waves excited during stimulated Raman scattering of laser radiation. (paper)

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗