Search NASA⌕ Search

SEARCH · Search NASA

Results for “genetic material”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 91 records · Page 5

Observational and Data Reduction Techniques to Optimize Mineralogical Characterizations of Asteroid Surface Materials

Mineralogy is the key to determining the compositional history of the asteroids and to determining the genetic relationships between the asteroids and meteorites. The most sophisticated remote mineralogical characterizations involve the quantitative extraction of specific diagnostic parameters from reflectance spectra and the use of quantitative interpretive calibrations to determine the presence, abundance and/or composition of mineral phases in a surface material. Although this approach is potentially subject to systematic errors, it provides the only consistent set of asteroid surface material characterizations.

Gaffey, M. J.↗

Thermal Conductivity Estimation from Transient Test Data with Embedded Thermocouples using Genetic Algorithm Optimization

Inverse heat transfer methodology previously developed to estimate thermal properties of high temperature fibrous insulation from embedded thermocouples was applied to the thermoplastic polymer, polyether-ether-ketone (PEEK). A small experimental setup was utilized to test the PEEK sample between temperatures of 300 K and 525 K at atmospheric pressure. Cylindrical plugs of PEEK with three thermocouples embedded at various depths were incorporated in the test sample. The experimental PEEK thermocouple data were used as the boundary and initial conditions of a one-dimensional numerical thermal model to predict the internal temperatures of the material. The thermal conductivity of PEEK was estimated with the Continuous Genetic Algorithm optimization technique by searching for the coefficients of a functional form of thermal conductivity that minimized the difference between the experimentally measured and model predicted internal temperature values. The thermal testing, one-dimensional numerical thermal model, optimization algorithm, analysis, and results are presented.

Thermal Properties↗

High Resolution Imaging and Analysis of Terrestrial Impact Glass: Amorphous Materials, Phyllosilicates and Everything in Between

Introduction: Impact cratering is one of the most ubiquitous geologic processes shaping the surface of all solid bodies in our solar system. Impacts are also a major source of clay minerals, poorly crystalline clay-like phases and amorphous (i.e., lacking long-range atomic order) materials on Earth and Mars. Phyllosilicates and amorphous materials have consistently formed a major component (~20-70 wt%) of every single drilled rock and soil sample in Gale Crater on Mars, as determined by the CheMin instrument on Curiosity. The origin of the amorphous component is speculative, but could be primary impact or volcanic-produced glass(es) deposited via aeolian or fluvial processes, secondary aqueous alteration products or chemical precipitates; it is likely to be a combination of all three possibilities. Efforts to determine the composition of these materials across the rover’s traverse through Gale Crater are ongoing. Naturally occurring amorphous phases are found in a variety of environments on Earth, and terrestrial analogue studies may help shed light on how they may have formed on Mars. Primary and altered impact glass are likely widespread on Mars and may have contributed to the amorphous component found throughout Gale Crater. In its pristine, unaltered state, impact glass (i.e., melt glass) is considered amorphous. However, truly unaltered glass is rarely preserved in crater fill impactites as it quickly alters in the post-impact environ-ment, commonly forming a mixture of hydrated aluminosilicate phases whose structures are not always discernable at the microscale (i.e., they may be amorphous or contain short-range order). These phases are part of an incredibly complex group of materials; differences in their composition and crystalline structure (or lack thereof) and genetic relationship to the more well-crystalline clay minerals are often only discernable at the nanoscale, beyond the resolution of traditional X-ray diffractometers (XRD) and scanning electron microscopes/microprobes (SEM/EPMA) alone. In this contribution, we summarize recent results from ongoing characterization of clay minerals, poorly crystalline clay-like phases, and amorphous materials preserved in altered terrestrial impact glass from the Chicxulub (~66 Ma) and Ries (~15 Ma) impact structures. This work has been performed using a combination of high-resolution transmission electron microscopy (HR-TEM), SEM, microprobe/EPMA, Raman spectroscopy and XRD.

Impact crater↗

Chemical fractionations in meteorites. V - Volatile and siderophile elements in achondrites and ocean ridge basalts.

Eighteen achondrites and 4 terrestrial basalts (3 ocean ridge, 1 continental) were analyzed by radiochemical neutron activation analysis for Ag, Au, Bi, Br, Cd, Co, Cs, Cu, Ga, In, Ir, Rb, Se, Tl and Zn. Samples included 7 eucrites, 5 howardites, 2 nakhlites, 2 shergottites, an angrite, and an aubrite. Light and dark portions of the gas-rich meteorites Kapoeta and Pesyanoe were analyzed separately. Nakhlites and shergottites have volatile element abundances similar to those in ocean ridge basalts; eucrites, howardites, and angrites show greater depletions by an order of magnitude and less similar abundance patterns. In terms of a two-component model of planetary accretion, the parent planets contained the following percentages of low-temperature material: eucrites 0.8, nakhlites 38, shergottites 28. Shergottites may be genetically related to L-chondrites. The siderophile element pattern of achondrites resembles that of the moon, but with less extreme depletions.

Laul, J. C.↗

Whole-cell biocomputing

The ability to manipulate systems on the molecular scale naturally leads to speculation about the rational design of molecular-scale machines. Cells might be the ultimate molecular-scale machines and our ability to engineer them is relatively advanced when compared with our ability to control the synthesis and direct the assembly of man-made materials. Indeed, engineered whole cells deployed in biosensors can be considered one of the practical successes of molecular-scale devices. However, these devices explore only a small portion of cellular functionality. Individual cells or self-organized groups of cells perform extremely complex functions that include sensing, communication, navigation, cooperation and even fabrication of synthetic nanoscopic materials. In natural systems, these capabilities are controlled by complex genetic regulatory circuits, which are only partially understood and not readily accessible for use in engineered systems. Here, we focus on efforts to mimic the functionality of man-made information-processing systems within whole cells.

Non-NASA Center↗

"Genetically Engineered" Nanoelectronics

The quantum mechanical functionality of nanoelectronic devices such as resonant tunneling diodes (RTDs), quantum well infrared-photodetectors (QWIPs), quantum well lasers, and heterostructure field effect transistors (HFETs) is enabled by material variations on an atomic scale. The design and optimization of such devices requires a fundamental understanding of electron transport in such dimensions. The Nanoelectronic Modeling Tool (NEMO) is a general-purpose quantum device design and analysis tool based on a fundamental non-equilibrium electron transport theory. NEW was combined with a parallelized genetic algorithm package (PGAPACK) to evolve structural and material parameters to match a desired set of experimental data. A numerical experiment that evolves structural variations such as layer widths and doping concentrations is performed to analyze an experimental current voltage characteristic. The genetic algorithm is found to drive the NEMO simulation parameters close to the experimentally prescribed layer thicknesses and doping profiles. With such a quantitative agreement between theory and experiment design synthesis can be performed.

Klimeck, Gerhard↗

A model for the origin of Martian polygonal terrain

Extensive areas of the Martian northern plains in Utopia and Acidalia Planitiae are characterized by 'polygonal terrain.' Polygonal terrain consists of material cut by complex troughs defining a pattern resembling mudcracks, columnar joints, or frost-wedge polygons on the Earth. However, the Martian polygons are orders of magnitude larger than these potential Earth analogs, leading to severe mechanical difficulties for genetic models based on simple analogy arguments. Stratigraphic studies show that the polygonally fractured material in Utopia Planitia was deposited on a land surface with significant topography, including scattered knobs and mesas, fragments of ancient crater rims, and fresh younger craters. Sediments or volcanics deposited over topographically irregular surfaces can experience differential compaction producing drape folds. Bending stresses due to these drape folds would be superposed on the pervasive tensile stresses due to desiccation or cooling, such that the probability of fracturing is enhanced above buried topographic highs and suppressed above buried topographic lows. Thus it was proposed that the scale of the Martian polygons is controlled by the spacing of topographic highs on the buried surface rather than by the physics of the shrinkage process.

Mcgill, G. E.↗

Effects of Buckling Knockdown Factor, Internal Pressure and Material on the Design of Stiffened Cylinders

A design study was conducted to investigate the effect shell buckling knockdown factor (SBKF), internal pressure and aluminum alloy material selection on the structural weight of stiffened cylindrical shells. Two structural optimization codes were used for the design study to determine the optimum minimum-weight design for a series of design cases, and included an in-house developed genetic algorithm (GA) code and PANDA2. Each design case specified a unique set of geometry, material, knockdown factor combinations and loads. The resulting designs were examined and compared to determine the effects of SBKF, internal pressure and material selection on the acreage design weight and controlling failure mode. This design study shows that use of less conservative SBKF values, including internal pressure, and proper selection of material alloy can result in significant weight savings for stiffened cylinders. In particular, buckling-critical cylinders with integrally machined stiffener construction can benefit from the use of thicker plate material that enables taller stiffeners, even when the stiffness, strength and density properties of these materials appear to be inferior.

Lovejoy, Andrew E.↗

3D Construction of Biologically Derived Materials

System for the 3D Construction of Biologically Derived Materials, Structures, and Parts NASA has developed a novel approach for macroscale biomaterial production by combining synthetic biology with 3D printing. Cells are biologically engineered to deposit desired materials, such as proteins or metals, derived from locally available resources. The bioengineered cells build different materials in a specified 3D pattern to produce novel microstructures with precise molecular composition, thickness, print pattern, and shape. Scaffolds and reagents can be used for further control over material product. This innovation provides modern design and fabrication techniques for custom-designed organic or organic-inorganic composite biomaterials produced from limited resources. Benefits Conserves resources. Few raw or bulk starting materials needed Enables custom design of diverse materials Fast, portable, macroscale, on-demand manufacturing High-fidelity microstructures Uses commercially available parts Applications Biomaterials, biotechnology Organic-inorganic composite materials On-demand manufacturing In situ resource utilization Space stations Military Infrastructure materials The Technology Once genes for a desired material type, delivery mode, control method and affinity have been chosen, assembling the genetic components and creating the cell lines can be done with well-established synthetic biology techniques. A 3D microdeposition system is used to make a 3D array of these cells in a precise, microstructure pattern and shape. The engineered cells are suspended in a printable 'ink'. The 3D microdeposition system deposits minute droplets of the cells onto a substrates surface in a designed print pattern. Additional printer passes thicken the material. The cell array is fed nutrients and reagents to activate the engineered genes within the cells to create and deposit the desired molecules. These molecules form the designed new material. If desired, the cells may be removed by flushing. The end product is thus a 3D composite microstructure comprising the novel material. This innovation provides a fast, controlled production of natural, synthetic, and novel biomaterials with minimum resource overhead and reduced pre- and post-processing requirements.

3D↗

High Efficiency Thermoelectric Radioisotope Power Systems

The work performed and whose results presented in this report is a joint effort between the University of New Mexico s Institute for Space and Nuclear Power Studies (ISNPS) and the Jet Propulsion Laboratory (JPL), California Institute of Technology. In addition to the development, design, and fabrication of skutterudites and skutterudites-based segmented unicouples this effort included conducting performance tests of these unicouples for hundreds of hours to verify theoretical predictions of the conversion efficiency. The performance predictions of these unicouples are obtained using 1-D and 3-D models developed for that purpose and for estimating the actual performance and side heat losses in the tests conducted at ISNPS. In addition to the performance tests, the development of the 1-D and 3-D models and the development of Advanced Radioisotope Power systems for Beginning-Of-Life (BOM) power of 108 We are carried out at ISNPS. The materials synthesis and fabrication of the unicouples are carried out at JPL. The research conducted at ISNPS is documented in chapters 2-5 and that conducted at JP, in documented in chapter 5. An important consideration in the design and optimization of segmented thermoelectric unicouples (STUs) is determining the relative lengths, cross-section areas, and the interfacial temperatures of the segments of the different materials in the n- and p-legs. These variables are determined using a genetic algorithm (GA) in conjunction with one-dimensional analytical model of STUs that is developed in chapter 2. Results indicated that when optimized for maximum conversion efficiency, the interfacial temperatures between various segments in a STU are close to those at the intersections of the Figure-Of-Merit (FOM), ZT, curves of the thermoelectric materials of the adjacent segments. When optimizing the STUs for maximum electrical power density, however, the interfacial temperatures are different from those at the intersections of the ZT curves, but close to those at the intersections the characteristic power, CP, curves of the thermoelectric materials of the adjacent segments (CP = T(sup 2)Zk and has a unit of W/m). Results also showed that the number of the segments in the n- and p-legs of the STUs optimized for maximum power density are generally fewer than when the same unicouples are optimized for maximum efficiency. These results are obtained using the 1-D optimization model of STUs that is detailed in chapter 2. A three-dimensional model of STUs is developed and incorporated into the ANSYS commercial software (chapter 3). The governing equations are solved, subject to the prescribed

El-Genk, Mohamed↗

Pristine Igneous Rocks and the Early Differentiation of Planetary Materials

Our studies are highly interdisciplinary, but are focused on the processes and products of early planetary and asteroidal differentiation, especially the genesis of the ancient lunar crust. Most of the accessible lunar crust consists of materials hybridized by impact-mixing. Rare pristine (unmixed) samples reflect the original genetic diversity of the early crust. We studied the relative importance of internally generated melt (including the putative magma ocean) versus large impact melts in early lunar magmatism, through both sample analysis and physical modeling. Other topics under investigation included: lunar and SNC (martian?) meteorites; igneous meteorites in general; impact breccias, especially metal-rich Apollo samples and polymict eucrites; effects of regolith/megaregolith insulation on thermal evolution and geochronology; and planetary bulk compositions and origins. We investigated the theoretical petrology of impact melts, especially those formed in large masses, such as the unejected parts of the melts of the largest lunar and terrestrial impact basins. We developed constraints on several key effects that variations in melting/displacement ratio (a strong function of both crater size and planetary g) have on impact melt petrology. Modeling results indicate that the impact melt-derived rock in the sampled, megaregolith part of the Moon is probably material that was ejected from deeper average levels than the non-impact-melted material (fragmental breccias and unbrecciated pristine rocks). In the largest lunar impacts, most of the impact melt is of mantle origin and avoids ejection from the crater, while most of the crust, and virtually all of the impact-melted crust, in the area of the crater is ejected. We investigated numerous extraordinary meteorites and Apollo rocks, emphasizing pristine rocks, siderophile and volatile trace elements, and the identification of primary partial melts, as opposed to partial cumulates. Apollo 15 sample 15434,28 is an extraodinarily large glass spherule, nearly if not entirely free of meteoritic contamination, and provides insight into the diversity of mare basalts in the Hadley-Apennine region. Apollo 14 sample 14434 is in many respects a new rock type, intermediate between nonmare gabbronorites and mare basalts. We helped to both plan and implement a consortium to study the Yamato-793605 SNC/martian meteorite.

Warren, Paul H.↗

Lunar Habitat Optimization Using Genetic Algorithms

Long-duration surface missions to the Moon and Mars will require bases to accommodate habitats for the astronauts. Transporting the materials and equipment required to build the necessary habitats is costly and difficult. The materials chosen for the habitat walls play a direct role in protection against each of the mentioned hazards. Choosing the best materials, their configuration, and the amount required is extremely difficult due to the immense size of the design region. Clearly, an optimization method is warranted for habitat wall design. Standard optimization techniques are not suitable for problems with such large search spaces; therefore, a habitat wall design tool utilizing genetic algorithms (GAs) has been developed. GAs use a "survival of the fittest" philosophy where the most fit individuals are more likely to survive and reproduce. This habitat design optimization tool is a multiobjective formulation of up-mass, heat loss, structural analysis, meteoroid impact protection, and radiation protection. This Technical Publication presents the research and development of this tool as well as a technique for finding the optimal GA search parameters.

SanScoucie, M. P.↗

Genetically Engineered Microelectronic Infrared Filters

A genetic algorithm is used for design of infrared filters and in the understanding of the material structure of a resonant tunneling diode. These two components are examples of microdevices and nanodevices that can be numerically simulated using fundamental mathematical and physical models. Because the number of parameters that can be used in the design of one of these devices is large, and because experimental exploration of the design space is unfeasible, reliable software models integrated with global optimization methods are examined The genetic algorithm and engineering design codes have been implemented on massively parallel computers to exploit their high performance. Design results are presented for the infrared filter showing new and optimized device design. Results for nanodevices are presented in a companion paper at this workshop.

Cwik, Tom↗

Multidisciplinary design optimization using genetic algorithms

Multidisciplinary design optimization (MDO) is an important step in the conceptual design and evaluation of launch vehicles since it can have a significant impact on performance and life cycle cost. The objective is to search the system design space to determine values of design variables that optimize the performance characteristic subject to system constraints. Gradient-based optimization routines have been used extensively for aerospace design optimization. However, one limitation of gradient based optimizers is their need for gradient information. Therefore, design problems which include discrete variables can not be studied. Such problems are common in launch vehicle design. For example, the number of engines and material choices must be integer values or assume only a few discrete values. In this study, genetic algorithms are investigated as an approach to MDO problems involving discrete variables and discontinuous domains. Optimization by genetic algorithms (GA) uses a search procedure which is fundamentally different from those gradient based methods. Genetic algorithms seek to find good solutions in an efficient and timely manner rather than finding the best solution. GA are designed to mimic evolutionary selection. A population of candidate designs is evaluated at each iteration, and each individual's probability of reproduction (existence in the next generation) depends on its fitness value (related to the value of the objective function). Progress toward the optimum is achieved by the crossover and mutation operations. GA is attractive since it uses only objective function values in the search process, so gradient calculations are avoided. Hence, GA are able to deal with discrete variables. Studies report success in the use of GA for aircraft design optimization studies, trajectory analysis, space structure design and control systems design. In these studies reliable convergence was achieved, but the number of function evaluations was large compared with efficient gradient methods. Applicaiton of GA is underway for a cost optimization study for a launch-vehicle fuel-tank and structural design of a wing. The strengths and limitations of GA for launch vehicle design optimization is studied.

Unal, Resit↗

Oxygen isotope studies of ordinary chondrites

Several stages in the evolution of ordinary chondritic meteorites are recorded in the oxygen isotopic composition of the meteorites and their separable components (chondrules, fragments, clasts, and matrix). The whole-rock isotopic compositions reflect the iron-group of the meteorite (H, L, or LL). Isotopic uniformity of H3 to H6 and L3 to L6 are consistent with closed-system metamorphism within each parent body. LL3 chondrites differ slightly from LL4 to LL6, implying a small degree of open-system aqueous alteration and carbon reduction. On the scale of individual chondrules, the meteorites are isotopically heterogeneous, allowing recognition of the solar-nebular processes of chondrule formation. Chondrules for all classes of ordinary chondrites are derived from a common population, which was separate from the population of chondrules in carbonaceous or enstatite chondrites. Chondrules define an isotopic mixing line dominated by exchange between (O - 16)-rich and (O - 16)-poor reservoirs. The oxygen isotopic compositions of chondrites serve as 'fingerprints' for identification of genetic association with other meteorite types (achondrites and iron) and for recognition of source materials in meteoritic breccias.

Clayton, Robert N.↗

The role of clinical pharmacology in molecular genetics

PROBLEM: Discovering the causes of unusual phenotypes in human subjects is an important aspect of patient-oriented research. MATERIAL: The tools of clinical pharmacology are uniquely useful in addressing these problems. PATIENTS, SUBJECTS, OR CASE HISTORIES: We evaluated a 42-year-old patient with lifelong orthostatic hypotension and ptosis of the eyelids. He underwent a series of biochemical, physiological, and pharmacological tests outlined in this article. RESULTS: These studies indicated that sympathetic innervation was intact but that the sympathetic neurotransmitter was dopamine rather than norepinephrine. These results demonstrated that dopamine-beta-hydroxylase deficiency underlies the clinical abnormalities of this patient. CONCLUSION: In selected individuals with unusual phenotypes, the techniques of clinical chemistry and clinical pharmacology can define the nature of the defect at almost the resolution of the human genome.

NASA Discipline Regulatory Physiology↗

Young Pb-Isotopic Ages of Chondrules in CB Carbonaceous Chondrites

CB (Bencubbin-type) carbonaceous chondrites differ in many ways from more familiar CV and CO carbonaceous chondrites and from ordinary chondrites. CB chondrites are very rich in Fe-Ni metal (50-70 vol%) and contain magnesian silicates mainly as angular to sub-rounded clasts (or chondrules) with barred olivine (BO) or cryptocrystalline (CC) textures. Both metal and silicates appear to have formed by condensation. The sizes of silicate clasts vary greatly between the two subgroups of CB chondrites: large (up to one cm) in CB(sub a) chondrites, and typically to much much less than 1 mm in CB(sub b) chondrites. The compositional and mineralogical differences between these subgroups and between the CB(sub s) and other types of chondrites suggest different environment and possibly different timing of chondrule formation. In order to constrain the timing of chondrule forming processes in CB(sub s) and understand genetic relationship between their subgroups, we have determined Pb-isotopic ages of silicate material from the CB(sub a) chondrite Gujba and CB(sub b) chondrite Hammadah al Hamra 237 (HH237 hereafter).

Amelin, Yuri↗