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At least 91 records · Page 5

Virtual Guidance Ultrasound: A Tool to Obtain Diagnostic Ultrasound for Remote Environments

Astronauts currently acquire ultrasound images on the International Space Station with the assistance of real-time remote guidance from an ultrasound expert in Mission Control. Remote guidance will not be feasible when significant communication delays exist during exploration missions beyond low-Earth orbit. For example, there may be as much as a 20- minute delay in communications between the Earth and Mars. Virtual-guidance, a pre-recorded audio-visual tutorial viewed in real-time, is a viable modality for minimally trained scanners to obtain diagnostically-adequate images of clinically relevant anatomical structures in an autonomous manner. METHODS: Inexperienced ultrasound operators were recruited to perform carotid artery (n = 10) and ophthalmic (n = 9) ultrasound examinations using virtual guidance as their only instructional tool. In the carotid group, each each untrained operator acquired two-dimensional, pulsed, and color Doppler of the carotid artery. In the ophthalmic group, operators acquired representative images of the anterior chamber of the eye, retina, optic nerve, and nerve sheath. Ultrasound image quality was evaluated by independent imaging experts. RESULTS: Eight of the 10 carotid studies were judged to be diagnostically adequate. With one exception the quality of all the ophthalmic images were adequate to excellent. CONCLUSION: Diagnostically-adequate carotid and ophthalmic ultrasound examinations can be obtained by untrained operators with instruction only from an audio/video tutorial viewed in real time while scanning. This form of quick-response-guidance, can be developed for other ultrasound examinations, represents an opportunity to acquire important medical and scientific information for NASA flight surgeons and researchers when trained medical personnel are not present. Further, virtual guidance will allow untrained personnel to autonomously obtain important medical information in remote locations on Earth where communication is difficult or absent.

Caine,Timothy L.↗

Beyond Fair: Engagement, Data Usability, and Open Community Productivity through the NASA Open Science Data Repository

The FAIR principle (findable, accessible, interoperable, and reusable) governs the storage and sharing of NASA space biology and health data[1]. These guiding principles maximize reuse of data and the reproducibility of scientific findings. The NASA Open Science Data Repository (OSDR; an expansion of NASA GeneLab) was built on the FAIR principles and houses over 500 studies and close to 1000 datasets from decades of space life sciences experiments. OSDR embodies the FAIR principles through data governance that includes mediated, embargoed, and fully open access data. The FAIR data governance principles were recently proposed to be expanded to encompass a FAIREST framework for assessing research data repositories (FAIR + Engagement, Social connections, and Trust)[2]. FAIREST emphasizes the importance of data repositories engaging with the scientific community and gaining the trust of researchers regarding data quality. Trust also refers to the TRUST principles developed for assessment of digital repositories: Transparency, Responsibility, User Focus, Sustainability, Technology[3]. We present the “Open Science for Life in Space” Analysis Working Groups (AWGs) as evidence regarding the power of engagement, social connections, and trust which has enhanced OSDR’s capabilities and productivity. AWG members engage in two main activities. One, members provide feedback on OSDR scientific standards for data ingestion, curation, and reuse (study, subject and assay metadata; processing pipelines; dataset formats and uniformed structures for machine-readability). Two, AWG members collaborate to mine-reuse OSDR data to conduct scientific analysis. With nearly 800 active members, the AWGs have resulted in 32 publications re-using OSDR data and contributed many papers in two major special issues in Cell (2020) and Nature (2024). AWGs also serve as networking groups, facilitate social connections between researchers at all levels of experience, and also have a social online ‘Forum’ used to keep members informed on projects and opportunities. This community-centric, productive, and trustworthy data culture has resulted in a broader effect with international space agencies, academics, and the commercial space sector wanting to submit their data to OSDR. Ten studies of Inspiration 4 data were recently publicly released by OSDR, as were some JAXA human data. Coming up soon in OSDR are data submissions from the European Space Agency, Virgin Galactic PIs, and SpaceX Polaris Dawn. A major benefit of OSDR is the array of standardized and uniformly formatted data (which was developed through AWG member consensus), from which visualization tools, analysis tools, and machine learning models can be built or trained. This talk will cover the Multi-Study Visualization Tool, the Environmental Data Application, RadLab, and a UCSF-NSF funded knowledge graph biomedical health discovery tool ‘SPOKE’ currently being integrated with OSDR. OSDR also provides training programs in bioinformatics and machine learning to improve the scientific community’s awareness of data availability and to boost their ability to perform data analysis. The increasing engagement of the scientific community and the public with technologies powered by artificial intelligence (AI) heightens the need for data analysis to be transparent. The AI for Life in Space initiative leverages the data products provided in OSDR to train AI models, with an emphasis on explainable and trustworthy AI, which would not be possible without FAIR data and metadata. Overall, here we will demonstrate the importance for NASA life sciences data repositories to adhere to the FAIREST framework, by providing examples and success stories from different aspects of OSDR.

data↗

Apollo 11 - Crew observations

Apollo 11 mission crew observation of operational and scientific phenomena associated with lunar landings, discussing preflight geologic training and briefings

Aldrin, E. E.↗

Translating Research Into Airline Practice: Case Studies In Collaboration

Airline training departments are avid customers for research that will help them enhance the effectiveness of training and the safety of flight operations. However, various factors often make it difficult for training department managers to draw upon the large body of human factors research, e.g.: research may not address the specific questions facing the training departments, the research literature may not be in a form that training managers can readily interpret, researchers' recommendations may be too expensive or impractical to implement, etc. This panel will discuss ways in which researchers can work with training departments to design research and translate findings into products that airlines can use readily. This collaboration is most effective when it is an integral part of the study from its inception. To illustrate the process of collaboration we will use as a case study the recently completed LOFT (Line Oriented Flight Training) Debriefing research project. We will summarize the findings from that study and discuss how we translated those findings into two training tools: a manual on how to facilitate LOFT debriefings and a video that illustrates facilitation techniques in a realistically enacted debriefing. In some cases, instead of starting a new research project, training department needs can be addressed by reviewing the existing research literature and using expert opinion to develop products that specifically address those needs. To illustrate this approach we will discuss a recent informal working group of scientists and airline personnel that met to develop training material to enhance situation awareness. This group reviewed scientific literature and ASRS (Aviation Safety Reporting System) reports, analyzed contributing factors, and produced a model for managing situation awareness.

Dismukes, R. Key↗

STS-107 Crew Training Clip

The STS-107 is a Multidiscipline Microgravity and Earth Science Research Mission to conduct international scientific investigations in orbit. The crew consists of Payload Specialist Ilan Ramon, Commander Rick Husband, Pilot William McCool, and Mission Specialists David Brown, Laurel Clark, Michael Anderson, and Kalpana Chawla. The crewmembers are shown getting suited in the Pre-Launch Ingress and Egress training area. The other areas of training include Payload Experiment in Fixed Base/Spacehab, Mist Experiment Combustion Module 2, Phab 4 Experiment in CCT Mid-deck and Payload Experiment Demo-Protein Crystal Growth.

Source record↗

LSKnowledge: Nexus for Transformative Scientific Discoveries and Enhanced Information Retrieval in NASA Life Sciences Portal

We stand at the brink of an extraordinary transformation in the field of AI, driven by the convergence of generative AI and semantic technologies (e.g., knowledge graphs). This fusion holds immense potential and could redefine the future of scientific exploration, particularly in the realm of life sciences research. In this context, we shed light on the pivotal roles that Large Language Models (LLMs) and semantic technologies will play in advancing research, unearthing and comprehending life sciences information through innovative approaches, and empowering researchers to extract insights from NASA's extensive Life Sciences Data Archive. Within the NASA Life Sciences Portal (NLSP), the integration of LLMs and semantic technologies unlocks several advanced capabilities. First and foremost, it equips scientists with sophisticated tools to manage the ever-expanding wealth of scientific literature and data. Furthermore, it facilitates the creation of knowledge graphs that visually represent intricate relationships among biological entities, enabling comprehensive systems-level analysis. Additionally, the fusion of generative AI (including LLMs) and semantic technology can significantly benefit NASA's life sciences research by enhancing information retrieval and hypothesis generation. These tools enhance natural language understanding, facilitating knowledge discovery within NLSP. The overarching vision is to establish a cohesive knowledge ecosystem within NLSP, harnessing the power of LLMs and semantic technologies to synthesize and cross-reference data from diverse missions, disciplines, and research domains. This holistic approach ultimately deepens our understanding of how space environments impact life sciences data. To advance this initiative, we have launched LSKnowledge, aimed at enhancing the information retrieval capabilities of NLSP. In the short term, our primary goal is to develop a robust semantic search system. This system will empower HRP (Human Research Program) researchers to navigate NLSP data repositories more efficiently and precisely, catalyzing the process of hypothesis formation and scientific breakthroughs. To achieve this, we have employed pre-trained LLMs as part of a semantic search tool that can rank and highlight the most relevant records for user queries. To assess the tool's performance, we have curated a set of approximately 200 queries from subject matter experts (SMEs) and manually ranked the top records retrieved by both the current search system and the new semantic search, using SME judgments as the gold standard for relevancy. Herein, we present the results of our comparative analysis and illustrate how these findings have informed the fine-tuning of the system for enhanced performance. In the long term, our objectives include 1) retrieving publicly available information and integrating it with NLSP data to provide more precise answers to user queries, and 2) incorporating non-textual information from the NLSP database into our approach. In conclusion, the fusion of LLMs and semantic technologies within NLSP represents a pioneering stride towards reshaping the landscape of scientific discovery. This synergy not only equips researchers with powerful tools to navigate the burgeoning sea of information but also facilitates a deeper understanding of complex biological relationships, all while accelerating hypothesis generation and knowledge discovery. Through our initiative, LSKnowledge, we are committed to continually refining and expanding these capabilities, with the aim of not only enhancing information retrieval but also integrating diverse data sources to provide more precise insights. In the grand vision, NLSP strives to become the cornerstone of a comprehensive knowledge ecosystem, unraveling the enigmatic intricacies of life sciences phenomena in the context of space environments.

Life Sciences↗

Airborne simulation of Shuttle/Spacelab management and operation

The ASSESS (Airborne Science/Spacelab Experiments System Simulation) program is discussed. A simulated Spacelab operation was carried out aboard the CV-990 airborne laboratory at Ames Research Center. A scientific payload was selected to conduct studies in upper atmospheric physics and infrared astronomy with principal investigators from France, the Netherlands, England and the U.S. Two experiment operators (EOs) from the U.S. and two from Europe were trained to function as proxies for the principal investigators in operating, maintaining, and repairing the scientific instruments. The simulated mission, in which the EOs and a Mission Manager were confined to the aircraft and living quarters for a 1-week period while making scientific observations during nightly flights, provided experience in the overall management of a complex international payload, experiment preparation, testing, and integration, the training and selection of proxy operators, and data handling.

Mulholland, D. R.↗

Volcanic Field Sites for Artemis Testing and Training

The Artemis Program will reestablish human presence on the Moon and lead to a new era of scientific discovery and exploration. Led by the National Aeronautics and Space Administration (NASA), the Artemis Program is a collaboration of space agencies and companies around the world. An integrated effort between various disciplines of science, engineering, and mission operations is currently developing methods, facilities, and analog field locations to train astronauts and test hardware and concepts of operations. These efforts aim to best prepare for the next steps of human exploration on the lunar surface and beyond. Numerous terrestrial volcanic field sites were evaluated and selected for their unique roles in helping to prepare for the lunar surface mission phases. This effort heavily leveraged the comprehensive academic research conducted at these field sites, as well as the tremendous Apollo heritage. The currently selected volcanic field sites include the San Francisco Volcanic Field in Northern Arizona, the Potrillo Volcanic Field in southern New Mexico, the highlands of Iceland, and the Southwestern Nevada Volcanic Field. Within each of these volcanic field sites numerous specific testing and training locations are being further developed utilizing the analogous terrain and unique features in these regions. Recent Artemis testing and training events have been conducted at a number of these volcanic field sites by both a dedicated Artemis Geology Training Team and a Joint Extra Vehicular Activity (EVA) Testing Team. This presentation will highlight the selected sites as well as the objectives and accomplishments of some of the recent field-testing events and training courses. Additionally, we continually strive to pursue additional sites, locations, data sets, collaborations, and partnerships in this endeavor and welcome knowledge transfer and community input.

Trevor Graff↗

The Chemistry of Early Self-Replicating Systems

The NASA Specialized Center of Research and Training (NSCORT) in Exobiology is a consortium of scientists at the University of California at San Diego (UCSD), The Salk Institute for Biological Studies (Salk) and The Scripps Research Institute (TSRI). All three institutions are located in close geographical proximity in La Jolla, California. The NSCORT/Exobiology is administered through the Scripps Institution of Oceanography. Since its inception in January 1992, the NSCORT in Exobiology has made major contributions with respect to the question of how life began on Earth. The Principal Investigators (PIs) and their associated Fellows have published numerous articles in peer reviewed journals on topics relevant to Exobiology. They have presented papers and sponsored symposia at several meetings of national and international scientific societies. A total of 30 undergraduate, 12 graduate and 15 postdoctoral Fellows have been supported by the NSCORT. The Fellows have met on their own at least once a month to discuss Exobiology topics and research progress. The NSCORT has arranged seminars and evening discussion meetings, and offered an undergraduate class on "Biochemical Evolution" as well as graduate courses dealing with topics in Exobiology. A visiting scientist program has allowed 11 scientists from the U.S. and 4 foreign countries to conduct cooperative research with the various PIs. An active outreach program has been initiated, which includes an Exobiology high school level teaching module and curriculum guide, and an elementary school level booklet about basic atomic structure and formation of the universe, Sun and Earth. A World Wide Web Homepage (http://www-chem.ucsd.edu/-nscort/ NSCORT.html) has been developed, which describes the NSCORT activities, research programs and Fellowship opportunities. The various activities of the NSCORT in Exobiology have received wide-spread coverage in both the scientific and public media. The major function of the NSCORT is the training of young scientists in the field of Exo- biology. Thus, the bulk of the $1,000,000 annual budget is used to support the research and training of undergraduate, graduate and post-doctoral Fellows who are selected on a competitive basis. About five Fellows at each level are supported each year. Our goal is to train scientists whose major research interest is Exobiology, but whose mastery in the classical fields of chemistry, biology and earth science is so strong that they outstanding candidates for either graduate school or academic tenure-track positions in departments at leading national and international Universities. Applicants for these Fellowships are solicited by advertisements in journals such as Science and Nature and in organizational newsletters such as the one published by the International Society for the Study of the Origin of Life (ISSOL), by contacting academic and NASA colleagues working in Exobiology or related fields and by recruiting students who have already been admitted into the various academic programs with which the PIs are affiliated.

Bada, Jeffrey L.↗

Sterilization training manual

Spacecraft sterilization training manual provides a basic understanding of microbiological techniques and presents scientific information in language intelligible to shop personnel.

Quinn, E. A.↗

Training of cosmonauts and astronauts

The biomedical and preflight training of spacecraft crews is discussed based on a survey of scientific and technical literature in the U.S. and U.S.S.R. Experience gained from high velocity and high altitude aircraft flights, predictions of human reactions and theoretical models of human adaptation to the new environment of space, and actual spaceflight experience provided scientists and specialists with data from which the state of human health in space could be predicted and life support measures developed.

Gurovskiy, N. N.↗

Clean assembly and integration techniques for the Hubble Space Telescope High Fidelity Mechanical Simulator

A mechanical simulator of the Hubble Space Telescope (HST) Aft Shroud was built to perform verification testing of the Servicing Mission Scientific Instruments (SI's) and to provide a facility for astronaut training. All assembly, integration, and test activities occurred under the guidance of a contamination control plan, and all work was reviewed by a contamination engineer prior to implementation. An integrated approach was followed in which materials selection, manufacturing, assembly, subsystem integration, and end product use were considered and controlled to ensure that the use of the High Fidelity Mechanical Simulator (HFMS) as a verification tool would not contaminate mission critical hardware. Surfaces were cleaned throughout manufacturing, assembly, and integration, and reverification was performed following major activities. Direct surface sampling was the preferred method of verification, but access and material constraints led to the use of indirect methods as well. Although surface geometries and coatings often made contamination verification difficult, final contamination sampling and monitoring demonstrated the ability to maintain a class M5.5 environment with surface levels less than 400B inside the HFMS.

Hughes, David W.↗

New Directions for NASA's Advanced Life Support Program

Advanced Life Support (ALS), an element of Human Systems Research and Technology s (HSRT) Life Support and Habitation Program (LSH), has been NASA s primary sponsor of life support research and technology development for the agency. Over its history, ALS sponsored tasks across a diverse set of institutions, including field centers, colleges and universities, industry, and governmental laboratories, resulting in numerous publications and scientific articles, patents and new technologies, as well as education and training for primary, secondary and graduate students, including minority serving institutions. Prior to the Vision for Space Exploration (VSE) announced on January 14th, 2004 by the President, ALS had been focused on research and technology development for long duration exploration missions, emphasizing closed-loop regenerative systems, including both biological and physicochemical. Taking a robust and flexible approach, ALS focused on capabilities to enable visits to multiple potential destinations beyond low Earth orbit. ALS developed requirements, reference missions, and assumptions upon which to structure and focus its development program. The VSE gave NASA a plan for steady human and robotic space exploration based on specific, achievable goals. Recently, the Exploration Systems Architecture Study (ESAS) was chartered by NASA s Administrator to determine the best exploration architecture and strategy to implement the Vision. The study identified key technologies required to enable and significantly enhance the reference exploration missions and to prioritize near-term and far-term technology investments. This technology assessment resulted in a revised Exploration Systems Mission Directorate (ESMD) technology investment plan. A set of new technology development projects were initiated as part of the plan s implementation, replacing tasks previously initiated under HSRT and its sister program, Exploration Systems Research and Technology (ESRT). The Exploration Life Support (ELS) Project, under the Exploration Technology Development Program, has recently been initiated to perform directed life support technology development in support of Constellation and the Crew Exploration Vehicle (CEV). ELS) has replaced ALS, with several major differences. Thermal Control Systems have been separated into a new stand alone project (Thermal Systems for Exploration Missions). Tasks in Advanced Food Technology have been relocated to the Human Research Program. Tasks in a new discipline area, Habitation Engineering, have been added. Research and technology development for capabilities required for longer duration stays on the Moon and Mars, including bioregenerative system, have been deferred.

Barta, Daniel J.↗

NASA SSERVI: Bridging Science and Human Exploration

The NASA Solar System Exploration Research Virtual Institute (SSERVI) is a virtual institute focused on research at the intersection of science and human exploration, training the next generation of exploration scientists, and developing the broad scientific and technical community. Part of SSERVI’s mission is to act as a hub for opportunities that engage the larger scientific and exploration communities in order to form new interdisciplinary, research-focused collaborations. This talk will describe the research efforts of the SSERVI domestic teams that constitute the U.S. complement of the Institute and how the Institute engages the community through workshops, conferences, online seminars and classes, student exchange programs and internships. In addition, this talk will discuss SSERVI’s current international partnerships, a key part of its global mission.

SSERVI↗

CloudSat - From the A-Train to the C-Train

The CloudSat satellite was launched from Vandenberg Air Force Base, in California, on April 28, 2006. It was launched with the CALIPSO satellite, a joint mission between the National Aeronautics and Space Administration (NASA) and the Centre National D'Etudes Spatiales (CNES). CloudSat and CALIPSO were designed to fly in formation with each other, to combine their complimentary scientific measurements. The two missions were maneuvered into the Earth Science Afternoon Constellation (A-Train) shortly after launch and have flown in formation together since then. Originally designed to fly for 22 months, the CloudSat satellite has far exceeded expectations. Inflight anomalies on CloudSat necessitated changes to both the daily concept of operations and formation flying operations with CALIPSO. In 2011, a severe battery anomaly restricted CloudSat science data collection and maneuverability to the sunlit portions of the orbit. In 2017, CloudSat suffered a reaction wheel failure, triggering the criteria established to exit the A-Train. CloudSat successfully exited the A-Train in early 2018, suspending formation flying and joint science observations with CALIPSO. The joint CloudSat/CALIPSO science team continued collaboration with discussions focused on resuming joint observations. As both satellites were aging and CALIPSO was nearing the exhaustion of satellite propellant, the decision was made to lower CloudSat to the CALIPSO graveyard orbit, to be joined by CALIPSO as soon as feasible. With NASA’s approval, CloudSat was maneuvered to the lower orbit over the course of several months in mid-2018. Once CloudSat was in place, and with approval from CNES, CALIPSO began the delicate dance of lowering their orbit and re-aligning the satellite ground tracks. CloudSat and CALIPSO resumed formation flying in the newly dubbed C-Train (CloudSat and CALIPSO) orbit in the Fall of 2018. The ingenuity of the CloudSat and CALIPSO teams made the concept of the C-Train a reality. This paper will discuss the decision processes and the operational challenges the CloudSat flight team faced while designing and implementing the C-Train.

Witkowski, M.M.↗

High School Citizen Scientists Use AI/ML to Predict Intra-Ocular Pressure From Gene Expression Data for Spaceflown Mice

Artificial Intelligence (AI) and Machine Learning (ML) have increasingly become pivotal in biological and biomedical research, largely due to the culture of open data sharing and its associated benefits. The methodologies inherent in AI/ML are particularly adept at identifying and forecasting biological phenotypes from the vast amounts of data generated by next-generation sequencing technologies. These techniques offer substantial promise for advancing research in space biosciences and for the development of automated systems for monitoring space health. Nevertheless, there are crucial aspects to consider when training, validating, and testing machine learning models in both biological research and clinical contexts. It is essential that Open Science principles, including data sharing and the availability of open-source code, are complemented by high-quality, publicly accessible training resources. These resources should focus on best practices and include modules based on real-world scientific cases and data to ensure that future AI/ML practitioners gain practical experience with genuine problems. Addressing this knowledge gap, we have designed, developed, and delivered both interactive and self-paced training programs for citizen scientists worldwide, enabling them to utilize AI/ML for space biology research. This initiative was made possible through generous funding from a Transformation to Open Science Training grant. The interactive training sessions, conducted this summer, utilized AI/ML techniques to analyze data from the Open Science Data Repository, specifically targeting the effects of spaceflight on ocular structure and function. The dataset OSD-583, from the Rodent Research 9 mission, provides experimental data detailing the ocular responses of mice subjected to a 35-day spaceflight, compared with ground control counterparts. Using OSD-583 as observational data, our summer training participants applied AI/ML methods to predict intraocular pressure from RNA-seq data and identify the genes most predictive of the observed responses. Further analysis through pathway enrichment and gene set enrichment revealed that these genes are involved in molecular and cellular processes contributing to retinal degeneration.

James Casaletto↗

Lunar International Science Coordination/Calibration Targets

A new era of international lunar exploration has begun and will expand over the next four years with data acquired from at least four sophisticated remote sensing missions: KAGUYA (SELENE) [Japan], Chang'E [China], Chandrayaan-l [India], and LRO [United States]. It is recognized that this combined activity at the Moon with modern sophisticated sensors wi II provide unprecedented new information about the Moon and will dramatically improve our understanding of Earth's nearest neighbor. It is anticipated that the blooming of scientific exploration of the Moon by nations involved in space activities will seed and foster peaceful international coordination and cooperation that will benefit all. Summarized here are eight Lunar International Science Coordination/Calibration Targets (L-ISCT) that are intended to a) allow cross-calibration of diverse multi-national instruments and b) provide a focus for training young scientists about a range of lunar science issues. The targets, discussed at several scientific forums, were selected for coordinated science and instrument calibration of orbital data. All instrument teams are encouraged to participate in a coordinated activity of early-release data that will improve calibration and validation of data across independent and diverse instruments.

Head, J. W.↗

Automating CapCom: Pragmatic Operations and Technology Research for Human Exploration of Mars

During the Apollo program, NASA and the scientific community used terrestrial analog sites for understanding planetary features and for training astronauts to be scientists. More recently, computer scientists and human factors specialists have followed geologists and biologists into the field, learning how science is actually done on expeditions in extreme environments. Research stations have been constructed by the Mars Society in the Arctic and American southwest, providing facilities for hundreds of researchers to investigate how small crews might live and work on Mars. Combining these interests-science, operations, and technology-in Mars analog field expeditions provides tremendous synergy and authenticity to speculations about Mars missions. By relating historical analyses of Apollo and field science, engineers are creating experimental prototypes that provide significant new capabilities, such as a computer system that automates some of the functions of Apollo s CapCom. Thus, analog studies have created a community of practice-a new collaboration between scientists and engineers-so that technology begins with real human needs and works incrementally towards the challenges of the human exploration of Mars.

Clancey, William J.↗