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At least 91 records · Page 5

Model validation and error attribution for a drifting qubit

Qubit performance is often reported in terms of a variety of single-value metrics, each providing a facet of the underlying noise mechanism limiting performance. However, the value of these metrics may drift over long timescales, and reporting a single number for qubit performance fails to account for the low-frequency noise processes that give rise to this drift. Here, in this work, we demonstrate how we can use the distribution of these values to validate or invalidate candidate noise models. We focus on the case of randomized benchmarking (RB), where typically a single error rate is reported but this error rate can drift over time when multiple passes of RB are performed. We show that using a statistical test as simple as the Kolmogorov-Smirnov statistic on the distribution of RB error rates can be used to rule out noise models, assuming the experiment is performed over a long enough time interval to capture relevant low frequency noise. With confidence in a noise model, we show how care must be exercised when performing error attribution using the distribution of drifting RB error rate.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

TESTING MICROVARIABILITY IN QUASAR DIFFERENTIAL LIGHT CURVES USING SEVERAL FIELD STARS

Microvariability consists of small timescale variations of low amplitude in the photometric light curves of quasars and represents an important tool to investigate their inner core. Detection of quasar microvariations is challenging because of their non-periodicity, as well as the need for high monitoring frequency and a high signal-to-noise ratio. Statistical tests developed for the analysis of quasar differential light curves usually show either low power or low reliability, or both. In this paper we compare two statistical procedures to perform tests on several stars with enhanced power and high reliability. We perform light curve simulations of variable quasars and non-variable stars and analyze them with statistical procedures developed from the F-test and the analysis of variance. The results show a large improvement in the power of both statistical probes and a larger reliability when several stars are included in the analysis. The results from the simulations agree with those obtained from observations of real quasars. The high power and high reliability of the tests discussed in this paper improve the results that can be obtained from short and long timescale variability studies. These techniques are not limited to quasar variability; on the contrary, they can be easily implemented for other sources, such as variable stars. Their applications to future research and to the analysis of large-field photometric monitoring archives could reveal new variable sources.

79 ASTRONOMY AND ASTROPHYSICS↗

SU-E-T-317: Dosimetric Evaluation of Acuros XB Advanced Dose Calculation Algorithm in Head and Neck Patients

Purpose: The Acuros XB photon dose calculation algorithm is a newly implemented calculation technique within the Eclipse treatment planning system using deterministic solutions to the linear Boltzmann transport equations. The goal of this study is to assess the clinical impact of dose differences arising from a retrospective comparison of calculations performed using the Analytical Anisotropic Algorithm (AAA) and Acuros XB on patients. Methods: Ten head and neck patients receiving intensity modulated radiation therapy were selected as a pilot study. Initial evaluation was based on the percentage of the planning target volume (PTV) covered by the prescription dose, minimum dose within the PTV, and dose differences in critical structures. For patients receiving boost plans, dosimetric evaluations were performed on the plan sum of the primary and boost plans. Results: Among the ten patients there were a total of 21 PTVs corresponding to primary and boost volumes. Using the same normalization within Eclipse, the average percentage of the PTVs receiving the prescription dose were 95.6% for AAA and Acuros XB. The average minimum doses within the PTVs, expressed as a percentage of the prescription to the volume, were 82.3% and 83.6% for AAA and Acuros XB respectively. Neither comparison showed differences with statistical significance when subjected to a paired t-test. Statistical significance was found in the average difference of the maximum dose for the mandible (242.5cGy, p=0.0005) and cord with a 5mm radial expansion (105.0cGy, p=0.0005) and in the median dose for the left parotid (25.0cGy, p=0.0423) and oral cavity (36.3cGy, p=0.002). Conclusion: The Acuros XB dose calculation algorithm did not exhibit significant differences in PTV coverage when compared to the AAA algorithm. Significant differences in critical structures are likely attributed to the structures proximity to high atomic number materials or air cavities, regions of known difficulty for the AAA algorithm.

60 APPLIED LIFE SCIENCES↗

Symmetry of the CMB sky as a new test of its statistical isotropy. Non cosmological octupole?

In this article we propose a novel test for statistical anisotropy of the CMB ΔT( n-circumflex = (θ,φ)). The test is based on the fact, that the Galactic foregrounds have a remarkably strong symmetry with respect to their antipodal points with respect to the Galactic plane, while the cosmological signal should not be symmetric or asymmetric under these transitions. We have applied the test for the octupole component of the WMAP ILC 7 map, by looking at a{sub 3,1} and a{sub 3,3}, and their ratio to a{sub 3,2} both for real and imaginary values. We find abnormal symmetry of the octupole component at the level of 0.58%, compared to Monte Carlo simulations. By using the analysis of the phases of the octupole we found remarkably strong cross-correlations between the phases of the kinematic dipole and the ILC 7 octupole, in full agreement with previous results. We further test the multipole range 2 < l < 100, by investigating the ratio between the l+m = even and l+m = odd parts of power spectra. We compare the results to simulations of a Gaussian random sky, and find significant departure from the statistically isotropic and homogeneous case, for a very broad range of multipoles. We found that for the most prominent peaks of our estimator, the phases of the corresponding harmonics are coherent with phases of the octupole. We believe, our test would be very useful for detections of various types of residuals of the foreground and systematic effects at a very broad range of multipoles 2 ≤ l ≤ 1500−3000 for the forthcoming PLANCK CMB map, before any conclusions about primordial non-Gaussianity and statistical anisotropy of the CMB.

79 ASTRONOMY AND ASTROPHYSICS↗

Verification of Electromagnetic Physics Models for Parallel Computing Architectures in the GeantV Project

An intensive R&D and programming effort is required to accomplish new challenges posed by future experimental high-energy particle physics (HEP) programs. The GeantV project aims to narrow the gap between the performance of the existing HEP detector simulation software and the ideal performance achievable, exploiting latest advances in computing technology. The project has developed a particle detector simulation prototype capable of transporting in parallel particles in complex geometries exploiting instruction level microparallelism (SIMD and SIMT), task-level parallelism (multithreading) and high-level parallelism (MPI), leveraging both the multi-core and the many-core opportunities. We present preliminary verification results concerning the electromagnetic (EM) physics models developed for parallel computing architectures within the GeantV project. In order to exploit the potential of vectorization and accelerators and to make the physics model effectively parallelizable, advanced sampling techniques have been implemented and tested. In this paper we introduce a set of automated statistical tests in order to verify the vectorized models by checking their consistency with the corresponding Geant4 models and to validate them against experimental data.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Angular filter refractometry analysis using simulated annealing [An improved method for characterizing plasma density profiles using angular filter refractometry]

Here, a new method of analysis for angular filter refractometry images was developed to characterize laser-produced, long-scale-length plasmas using an annealing algorithm to iterative converge upon a solution. Angular filter refractometry (AFR) is a novel technique used to characterize the density pro files of laser-produced, long-scale-length plasmas. A synthetic AFR image is constructed by a user-defined density profile described by eight parameters, and the algorithm systematically alters the parameters until the comparison is optimized. The optimization and statistical uncertainty calculation is based on a minimization of the $\chi$2 test statistic. The algorithm was successfully applied to experimental data of plasma expanding from a flat, laser-irradiated target, resulting in average uncertainty in the density profile of 5-10% in the region of interest.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Defining window-boundaries for genomic analyses using smoothing spline techniques

High-density genomic data is often analyzed by combining information over windows of adjacent markers. Interpretation of data grouped in windows versus at individual locations may increase statistical power, simplify computation, reduce sampling noise, and reduce the total number of tests performed. However, use of adjacent marker information can result in over- or under-smoothing, undesirable window boundary specifications, or highly correlated test statistics. We introduce a method for defining windows based on statistically guided breakpoints in the data, as a foundation for the analysis of multiple adjacent data points. This method involves first fitting a cubic smoothing spline to the data and then identifying the inflection points of the fitted spline, which serve as the boundaries of adjacent windows. This technique does not require prior knowledge of linkage disequilibrium, and therefore can be applied to data collected from individual or pooled sequencing experiments. Moreover, in contrast to existing methods, an arbitrary choice of window size is not necessary, since these are determined empirically and allowed to vary along the genome.

59 BASIC BIOLOGICAL SCIENCES↗

A novel framework for increasing research transparency: Exploring the connection between diversity and innovation

A split sample/dual method research protocol is demonstrated to increase transparency while reducing the probability of false discovery. We apply the protocol to examine whether diversity in ownership teams increases or decreases the likelihood of a firm reporting a novel innovation using data from the 2018 United States Census Bureau’s Annual Business Survey. Transparency is increased in three ways: 1) all specification testing and identifying potentially productive models is done in an exploratory subsample that 2) preserves the validity of hypothesis test statistics fromde novoestimation in the holdout confirmatory sample with 3) all findings publicly documented in an earlier registered report and in this journal publication. Bayesian estimation procedures that leverage information from the exploratory stage included in the confirmatory stage estimation replace traditional frequentist null hypothesis significance testing. In addition to increasing statistical power by using information from the full sample, Bayesian methods directly estimate a probability distribution for the magnitude of an effect, allowing much richer inference. Estimated magnitudes of diversity along academic discipline, race, ethnicity, and foreign-born status dimensions are positively associated with innovation. A maximally diverse ownership team on these dimensions would be roughly six times more likely to report new-to-market innovation than a homophilic team.

Science & Technology - Other Topics↗

Detecting anomalies in CMB maps: a new method

Ever since WMAP announced its first results, different analyses have shown that there is weak evidence for several large-scale anomalies in the CMB data. While the evidence for each anomaly appears to be weak, the fact that there are multiple seemingly unrelated anomalies makes it difficult to account for them via a single statistical fluke. So, one is led to considering a combination of these anomalies. But, if we ''hand-pick'' the anomalies (test statistics) to consider, we are making an a posteriori choice. In this article, we propose two statistics that do not suffer from this problem. The statistics are linear and quadratic combinations of the a{sub ℓ m}'s with random co-efficients, and they test the null hypothesis that the a{sub ℓ m}'s are independent, normally-distributed, zero-mean random variables with an m-independent variance. The motivation for considering multiple modes is this: because most physical models that lead to large-scale anomalies result in coupling multiple ℓ and m modes, the ''coherence'' of this coupling should get enhanced if a combination of different modes is considered. In this sense, the statistics are thus much more generic than those that have been hitherto considered in literature. Using fiducial data, we demonstrate that the method works and discuss how it can be used with actual CMB data to make quite general statements about the incompatibility of the data with the null hypothesis.

79 ASTRONOMY AND ASTROPHYSICS↗

Performance analysis of Wald-statistic based network detection methods for radiation sources

There have been increasingly large deployments of radiation detection networks that require computationally fast algorithms to produce prompt results over ad-hoc sub-networks of mobile devices, such as smart-phones. These algorithms are in sharp contrast to complex network algorithms that necessitate all measurements to be sent to powerful central servers. In this work, at individual sensors, we employ Wald-statistic based detection algorithms which are computationally very fast, and are implemented as one of three Z-tests and four chi-square tests. At fusion center, we apply the K-out-of-N fusion to combine the sensors hard decisions. We characterize the performance of detection methods by deriving analytical expressions for the distributions of underlying test statistics, and by analyzing the fusion performances in terms of K, N, and the false-alarm rates of individual detectors. We experimentally validate our methods using measurements from indoor and outdoor characterization tests of the Intelligence Radiation Sensors Systems (IRSS) program. In particular, utilizing the outdoor measurements, we construct two important real-life scenarios, boundary surveillance and portal monitoring, and present the results of our algorithms.

Sen, Satyabrata↗

Image Distinguishability Analysis Testing Through Principal Components and Its Application to Hot Spot Scale Invariance

Hot spots are spatial regions of intense energy localization that govern initiation of secondary high explosives. Studies that characterize or compare simulated hot spots are frequently either qualitatively descriptive or resort to quantitative distribution functions that neglect stochastic variations and spatial correlations—effects that are also neglected in common comparison tests like the Kolmogorov–Smirnov test. To this end, we develop an image distinguishability analysis (IDA) test based on principal component (PC) analysis that makes pixel-by-pixel comparisons between small, for example, O(<10), image data sets. The IDA test makes comparisons through a generalized distance metric in the PC space and a test statistic that is derived to calculate mathematical equation-values. Here, we derive a statistical distribution and criticality criterion to determine whether images are distinguishable from established baselines. We apply the IDA test on images generated from molecular dynamics simulations of hot spots from pore collapse in TATB to assess scale invariance in the complex patterns of hot spots that form in a representative high explosive crystal. The IDA test shows that TATB hot spot spatial temperature fields and their derived temperature histograms exhibit scale-invariant features over specific intervals of shock orientation, strength, and initial pore diameter. However, the IDA test also shows that qualitatively different conclusions regarding invariance can be reached depending on whether the hot spot is treated as a spatially correlated field as opposed to a distribution function that lacks spatial information.

organic↗

Grid-based minimization at scale: Feldman-Cousins corrections for light sterile neutrino search

High Energy Physics (HEP) experiments generally employ sophisticated statistical methods to present results in searches of new physics. In the problem of searching for sterile neutrinos, likelihood ratio tests are applied to short-baseline neutrino oscillation experiments to construct confidence intervals for the parameters of interest. The test statistics of the form Δχ2 is often used to form the confidence intervals, however, this approach can lead to statistical inaccuracies due to the small signal rate in the region-of-interest. In this paper, we present a computational model for the computationally expensive Feldman-Cousins corrections to construct a statistically accurate confidence interval for neutrino oscillation analysis. The program performs a grid-based minimization over oscillation parameters and is written in C++. Our algorithms make use of vectorization through Eigen3, yielding a single-core speed-up of 350 compared to the original implementation, and achieve MPI data parallelism by employing DIY. We demonstrate the strong scaling of the application at High-Performance Computing (HPC) sites. We utilize HDF5 along with HighFive to write the results of the calculation to file.

Wospakrik, Marianette↗

First Searches for Axions and Axionlike Particles with the LUX Experiment

The first searches for axions and axionlike particles with the Large Underground Xenon experiment are presented. Under the assumption of an axioelectric interaction in xenon, the coupling constant between axions and electrons g Ae is tested using data collected in 2013 with an exposure totaling 95 live days ×118 kg. A double-sided, profile likelihood ratio statistic test excludes g Ae larger than 3.5 × 10 –12 (90% C.L.) for solar axions. Assuming the Dine-Fischler-Srednicki-Zhitnitsky theoretical description, the upper limit in coupling corresponds to an upper limit on axion mass of 0.12 eV/c 2 , while for the Kim-Shifman-Vainshtein-Zhakharov description masses above 36.6 eV/c 2 are excluded. For galactic axionlike particles, values of g Ae larger than 4.2 × 10 –13 are excluded for particle masses in the range 1–16 keV/c 2 . As a result, these are the most stringent constraints to date for these interactions.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

SU-F-I-80: Correction for Bias in a Channelized Hotelling Model Observer Caused by Temporally Variable Non-Stationary Noise

Purpose: Application of a channelized Hotelling model observer (CHO) over a wide range of x-ray angiography detector target dose (DTD) levels demonstrated substantial bias for conditions yielding low detectability indices (d’), including low DTD and small test objects. The purpose of this work was to develop theory and methods to correct this bias. Methods: A hypothesis was developed wherein the measured detectability index (d’b) for a known test object is positively biased by temporally variable non-stationary noise in the images. Hotelling’s T2 test statistic provided the foundation for a mathematical theory which accounts for independent contributions to the measured d’b value from both the test object (d’o) and non-stationary noise (d’ns). Experimental methods were developed to directly estimate d’o by determining d’ns and subtracting it from d’b, in accordance with the theory. Specifically, d’ns was determined from two sets of images from which the traditional test object was withheld. This method was applied to angiography images with DTD levels in the range 0 to 240 nGy and for disk-shaped iodine-based contrast targets with diameters 0.5 to 4.0 mm. Results: Bias in d’ was evidenced by d’b values which exceeded values expected from a quantum limited imaging system and decreasing object size and DTD. d’ns increased with decreasing DTD, reaching a maximum of 2.6 for DTD = 0. Bias-corrected d’o estimates demonstrated sub-quantum limited performance of the x-ray angiography for low DTD. Findings demonstrated that the source of non-stationary noise was detector electronic readout noise. Conclusion: Theory and methods to estimate and correct bias in CHO measurements from temporally variable non-stationary noise were presented. The temporal non-stationary noise was shown to be due to electronic readout noise. This method facilitates accurate estimates of d’ values over a large range of object size and detector target dose.

60 APPLIED LIFE SCIENCES↗

CORRELATING THE INTERSTELLAR MAGNETIC FIELD WITH PROTOSTELLAR JETS AND ITS SOURCES

This paper combines new CCD polarimetric data with previous information about protostellar objects in a search for correlations involving the interstellar magnetic field (ISMF). Specifically, we carried out an optical polarimetric study of a sample of 28 fields of 10' Multiplication-Sign 10' located in the neighborhood of protostellar jets and randomly spread over the Galaxy. The polarimetry of a large number of field stars is used to estimate both the average and dispersion of the ISMF direction in each region. The results of the applied statistical tests are as follows. Concerning the alignment between the jet direction and the ISMF, the whole sample does not show alignment. There is, however, a statistically significant alignment for objects of Classes 0 and I. Regarding the ISMF dispersion, our sample presents values slightly larger for regions containing T Tauri objects than for those harboring younger protostars. Moreover, the ISMF dispersion in regions containing high-mass objects tends to be larger than in those including only low-mass protostars. In our sample, the mean interstellar polarization as a function of the average interstellar extinction in a region reaches a maximum value around 3% for A(V) = 5, after which it decreases. Our data also show a clear correlation of the mean value of the interstellar polarization with the dispersion of the ISMF: the larger the dispersion, the smaller the polarization. Based on a comparison of our and previous results, we suggest that the dispersion in regions forming stars is larger than in quiescent regions.

79 ASTRONOMY AND ASTROPHYSICS↗

DefectTrack: a deep learning-based multi-object tracking algorithm for quantitative defect analysis of in-situ TEM videos in real-time

Abstract In-situ irradiation transmission electron microscopy (TEM) offers unique insights into the millisecond-timescale post-cascade process, such as the lifetime and thermal stability of defect clusters, vital to the mechanistic understanding of irradiation damage in nuclear materials. Converting in-situ irradiation TEM video data into meaningful information on defect cluster dynamic properties (e.g., lifetime) has become the major technical bottleneck. Here, we present a solution called the DefectTrack , the first dedicated deep learning-based one-shot multi-object tracking (MOT) model capable of tracking cascade-induced defect clusters in in-situ TEM videos in real-time. DefectTrack has achieved a Multi-Object Tracking Accuracy (MOTA) of 66.43% and a Mostly Tracked (MT) of 67.81% on the test set, which are comparable to state-of-the-art MOT algorithms. We discuss the MOT framework, model selection, training, and evaluation strategies for in-situ TEM applications. Further, we compare the DefectTrack with four human experts in quantifying defect cluster lifetime distributions using statistical tests and discuss the relationship between the material science domain metrics and MOT metrics. Our statistical evaluations on the defect lifetime distribution suggest that the DefectTrack outperforms human experts in accuracy and speed.

42 ENGINEERING↗

Emissions and Flame Structure Assessment of Aeroengine Micromixing Injectors for Lean Direct Injection of Hydrogen and Hydrogen/Natural Gas Blends

Abstract The present study focuses on whether adapting low emissions liquid fuel injection concepts can be applied to gaseous mixtures. The goal is to develop an injector with specific geometric characteristics that will achieve the lowest emissions. This is conducted by evaluating emissions and flame diagnostics on a set of test hardware that has been developed for combustion of pure hydrogen and hydrogen/methane mixtures. The current test hardware adapts lean direct injection concepts from aeroengine injectors to a ground-based engine based on target flows associated with a Solar Turbines Industrial Engine gas turbine. A statistical test plan was developed to assess these geometric characteristics using a three level Box Behnken design. The test plan investigates the effect of injector flow splits, air swirl, fuel swirl, pressure drop, preheat temperature, fuel composition, and the adiabatic flame temperature on the flame structure and emissions performance. A total of 16 injectors were considered for a total of 688 test points for emission and imaging data. Emissions data were reported on a mass basis in ng/J and chemical reactor network analysis were conducted to further interpret emissions behavior. Images were also captured to analyze the flame structure features of interest including reaction volume, flame length, flame spread, and flame width. With these results, a predictive model for emissions was made to conclude the most optimal injector configuration is to have the highest level of air split (more volume of air through the injector plate versus the injector) and air swirl angle for both methane and hydrogen gas mixtures. The predictive emissions level for all of these cases were below 10 ng/J.

08 HYDROGEN↗

Cervical Precancers and Cancers Attributed to HPV Types by Race and Ethnicity: Implications for Vaccination, Screening, and Management

Abstract Background Racial and ethnic variations in attribution of cervical precancer and cancer to human papillomavirus (HPV) types may result in different HPV vaccine protection, screening test coverage, and clinical management. Methods Pooling data from 7 US studies, we calculated the proportional attribution of precancers and cancers to HPV types using HPV DNA typing from diagnosis. All statistical tests were 2-sided. Results For all racial and ethnic groups, most cases of cervical intraepithelial neoplasia grade 3 (CIN3) (84.2%-90.8% of 5526) and squamous cell carcinoma (SCC) (90.4%-93.8% of 1138) were attributed to types targeted by the 9-valent vaccine. A higher proportion of CIN3s were attributed to nonvaccine HPV types among non-Hispanic Black women (15.8%) compared with non-Hispanic Asian or Pacific Islander (9.7%; P = .002), non-Hispanic White (9.2%; P < .001), and Hispanic (11.3%; P = .004) women. The proportion of SCCs attributed to 9-valent types was similar by race and ethnicity (P = .80). A higher proportion of CIN3s were attributed to nonvaccine HPV35 among non-Hispanic Black (9.0%) compared with non-Hispanic Asian or Pacific Islander (2.2%), non-Hispanic White (2.5%), and Hispanic (3.0%; all P < .001) women. Compared with CIN3, the proportion of SCCs attributed to HPV35 among non-Hispanic Black women (3.2%) was lower and closer to other groups (0.3%-2.1%; P = .70). Conclusion The 9-valent HPV vaccine will prevent nearly all cervical precancers and invasive cancers among major racial and ethnic groups in the United States. Adding HPV35 to vaccines could prevent a small percentage of CIN3s and SCCs, with greater potential impact for CIN3s among Black women. HPV screening tests target high-risk HPV types, including HPV35. Future genotyping triage strategies could consider the importance of HPV35- and other HPV16-related types.

Mix, Jacqueline (ORCID:0000000164187706)↗