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The NASA Artemis program will return humans to the moon. This time, with the help of commercial and international partners, the program’s objective is a permanent moon base. The moon base infrastructure, including an orbiting moon station and moon surface assets, will be developed for astronauts to stay for the long haul to learn to live and work on another planet in preparation for an eventual Humans-to-Mars mission. As the roundtrip communication delays increase in deep space exploration, more onboard systems autonomy and functionality will be needed to maintain and control the vehicle or habitat. These mission constraints will change the current Earth-based spacecraft ground control support approach that will demand more safe, efficient, and effective Computer-Human Interface (CHI) control. For Artemis, CHI is defined as the elements that the crew interfaces with-audio, video, lighting, and crew controls. Understanding how CHI will need to evolve to support deep space missions will be critical for the Artemis program-especially crew controls which is the focus of this paper. How does NASA ensure crew controls are reliable to control complex systems and prevent a catastrophic event due to human error-especially when the astronauts could be physiologically and/or psychologically impaired? NASA’s approach to mitigating catastrophic hazards in human spaceflight system development such as crew controls is through a holistic system engineering and Human System Integration methodology that embraces NASA’s Human-Rating Requirements-ensuring human performance characteristics to control/safely recover the crew from hazardous situations within the human interface design are considered. This paper discusses, at a high level, CHI for the Artemis program. Next, a discussion of what it means to human-rate a space system crew controls and how trust in the human-computer interface begins with the NASA human rating requirements. Finally, a discussion on how systems engineering, and the human system integration process ensures that crew control implementation incorporates the NASA human-rating requirements.