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Preclinical Evaluation of Promitil, a Radiation-Responsive Liposomal Formulation of Mitomycin C Prodrug, in Chemoradiotherapy

Purpose: To examine the effect of radiation on in vitro drug activation and release of Promitil, a pegylated liposomal formulation of a mitomycin C (MMC) lipid-based prodrug; and examine the efficacy and toxicity of Promitil with concurrent radiation in colorectal cancer models. Methods and Materials: Promitil was obtained from Lipomedix Pharmaceuticals (Jerusalem, Israel). We tested the effects of radiation on release of active MMC from Promitil in vitro. We next examined the radiosensitization effect of Promitil in vitro. We further evaluated the toxicity of a single injection of free MMC or Promitil when combined with radiation by assessing the effects on blood counts and in-field skin and hair toxicity. Finally, we compared the efficacy of MMC and Promitil in chemoradiotherapy using mouse xenograft models. Results: Mitomycin C was activated and released from Promitil in a controlled-release profile, and the rate of release was significantly increased in medium from previously irradiated cells. Both Promitil and MMC potently radiosensitized HT-29 cells in vitro. Toxicity of MMC (8.4 mg/kg) was substantially greater than with equivalent doses of Promitil (30 mg/kg). Mice treated with human-equivalent doses of MMC (3.3 mg/kg) experienced comparable levels of toxicity as Promitil-treated mice at 30 mg/kg. Promitil improved the antitumor efficacy of 5-fluorouracil–based chemoradiotherapy in mouse xenograft models of colorectal cancer, while equitoxic doses of MMC did not. Conclusions: We demonstrated that Promitil is an attractive agent for chemoradiotherapy because it demonstrates a radiation-triggered release of active drug. We further demonstrated that Promitil is a well-tolerated and potent radiosensitizer at doses not achievable with free MMC. These results support clinical investigations using Promitil in chemoradiotherapy.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

ON THE NATURE OF THE mHz X-RAY QUASI-PERIODIC OSCILLATIONS FROM ULTRALUMINOUS X-RAY SOURCE M82 X-1: SEARCH FOR TIMING-SPECTRAL CORRELATIONS

Using all the archival XMM-Newton X-ray (3-10 keV) observations of the ultraluminous X-ray source (ULX) M82 X-1, we searched for a correlation between its variable mHz quasi-periodic oscillation (QPO) frequency and its hardness ratio (5-10 keV/3-5 keV), an indicator of the energy spectral power-law index. When stellar-mass black holes (StMBHs) exhibit type-C low-frequency QPOs ({approx}0.2-15 Hz), the centroid frequency of the QPO is known to correlate with the energy spectral index. The detection of such a correlation would strengthen the identification of M82 X-1's mHz QPOs as type-C and enable a more reliable mass estimate by scaling its QPO frequencies to those of type-C QPOs in StMBHs of known mass. We resolved the count rates and the hardness ratios of M82 X-1 and a nearby bright ULX (source 5/X42.3+59) through surface brightness modeling. We detected QPOs in the frequency range of 36-210 mHz during which M82 X-1's hardness ratio varied from 0.42 to 0.47. Our primary results are (1) that we do not detect any correlation between the mHz QPO frequency and the hardness ratio (a substitute for the energy spectral power-law index) and (2) similar to some accreting X-ray binaries, we find that M82 X-1's mHz QPO frequency increases with its X-ray count rate (Pearson's correlation coefficient = +0.97). The apparent lack of a correlation between the QPO centroid frequency and the hardness ratio poses a challenge to the earlier claims that the mHz QPOs of M82 X-1 are the analogs of the type-C low-frequency QPOs of StMBHs. On the other hand, it is possible that the observed relation between the hardness ratio and the QPO frequency represents the saturated portion of the correlation seen in type-C QPOs of StMBHs-in which case M82 X-1's mHz QPOs can still be analogous to type-C QPOs.

79 ASTRONOMY AND ASTROPHYSICS↗

Influence of Coronal Abundance Variations

The PI of this project was Jeff Scargle of NASA/Ames. Co-I's were Alma Connors of Eureka Scientific/Wellesley, and myself. Part of the work was subcontracted to Eureka Scientific via SAO, with Vinay Kashyap as PI. This project was originally assigned grant number NCC2-1206, and was later changed to NCC2-1350 for administrative reasons. The goal of the project was to obtain, derive, and develop statistical and data analysis tools that would be of use in the analyses of high-resolution, high-sensitivity data that are becoming available with new instruments. This is envisioned as a cross-disciplinary effort with a number of "collaborators" including some at SA0 (Aneta Siemiginowska, Peter Freeman) and at the Harvard Statistics department (David van Dyk, Rostislav Protassov, Xiao-li Meng, Epaminondas Sourlas, et al). We have developed a new tool to reliably measure the metallicities of thermal plasma. It is unfeasible to obtain high-resolution grating spectra for most stars, and one must make the best possible determination based on lower-resolution, CCD-type spectra. It has been noticed that most analyses of such spectra have resulted in measured metallicities that were significantly lower than when compared with analyses of high- resolution grating data where available (see, e.g., Brickhouse et al., 2000, ApJ 530,387). Such results have led to the proposal of the existence of so-called Metal Abundance Deficient, or "MAD" stars (e.g., Drake, J.J., 1996, Cool Stars 9, ASP Conf.Ser. 109, 203). We however find that much of these analyses may be systematically underestimating the metallicities, and using a newly developed method to correctly treat the low-counts regime at the high-energy tail of the stellar spectra (van Dyk et al. 2001, ApJ 548,224), have found that the metallicities of these stars are generally comparable to their photospheric values. The results were reported at the AAS (Sourlas, Yu, van Dyk, Kashyap, and Drake, 2000, BAAS 196, v32, #54.02), and at the conference on Statistical Challenges in Modem Astronomy (Sourlas, van Dyk, Kashyap, Drake, and Pease, 2003, SCMA 111, Eds. E.D.Feigelson, G.J.Babu, New York:Springer, p489-490). We also described the limitations of one of the most egregiously misused and misapplied statistical tests in astrophysical literature, the F-test for verifying model components (Protassov, van Dyk, Connors, Kashyap, and Siemiginowska, 2002, ApJ, 571,545). Indeed, a search through the ApJ archives turned up 170 papers in the 5 previous years that used the F-test explicitly in some form or the other, and with the vast majority of them not using it correctly! Indeed, looking at just 4 issues of the ApJ in 2001, we found 13 instances of its use, of which nine were demonstrably incorrect. Clearly, it is difficult to understate the importance of this issue. We also worked on speeding up Bayes Blocks and Sparse Bayes Blocks algorithms to make them more tractable for large searches. We also supported staistics students and postdocs in both explicit physics- model-based (spectra with tens of thousands of atomic lines) and "model-free" -- i.e. non-parametric or semi-parametric -- algorithms. Work on using more of the latter is just beginning; while using multi-scale methods for Poisson imaging has come to hition. In fact, "An Image Restoration Technique with Error Estimates", by D. Esch, A. Connors, M. Karovska, and D. van Dyk, was published by ApJ (Esch et a1.2004, ApJ, 610, 1213). The code has been delivered to M. Karovska for CXC; and is available for beta-testing upon request. The other large project we worked on was on the self-consistent modeling of logN-logs curves in the Poisson limit. logN-logs curves are a fundamental tool in the study of source populations, luminosity functions, and cosmological parameters. However, their determination is hampered by statistical effects such as the Eddington bias, incompleteness due to detection efficiency, faint source flux fluctuations, etc. We have develed a new and powerful method using the full Poisson machinery that allows us to model the logN-logs distribution of X-ray sources in a self-consistent manner. Because we properly account for all the above statistical effects, our modeling is valid over the full range of the data, and not just for strong sources, as is normally done. Using a Bayesian approach and modeling the fluxes with known functional forms such as simple or broken power-laws, and conditioning the expected photon counts on the fluxes, the background contamination, effective area, detector vignetting, and detection probability, we can delve deeply into the low counts regime and extend the usefulness of medium sensitivity surveys such as ChAMP by orders of magnitude. The built-in flexibility of the algorithm also allows a simultaneous analysis of multiple datasets. We have applied this analysis to a set a Chandra observations (Sourlas, Kashyap, Zezas, van Dyk, 2004, HEAD #8, #16.32)

Scargle, Jeffrey D.↗

Matrix models and stochastic growth in Donaldson-Thomas theory

We show that the partition functions which enumerate Donaldson-Thomas invariants of local toric Calabi-Yau threefolds without compact divisors can be expressed in terms of specializations of the Schur measure. We also discuss the relevance of the Hall-Littlewood and Jack measures in the context of BPS state counting and study the partition functions at arbitrary points of the Kaehler moduli space. This rewriting in terms of symmetric functions leads to a unitary one-matrix model representation for Donaldson-Thomas theory. We describe explicitly how this result is related to the unitary matrix model description of Chern-Simons gauge theory. This representation is used to show that the generating functions for Donaldson-Thomas invariants are related to tau-functions of the integrable Toda and Toeplitz lattice hierarchies. The matrix model also leads to an interpretation of Donaldson-Thomas theory in terms of non-intersecting paths in the lock-step model of vicious walkers. We further show that these generating functions can be interpreted as normalization constants of a corner growth/last-passage stochastic model.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Salmonella Inactivation During Extrusion of an Oat Flour Model Food

Abstract Little research exists on Salmonella inactivation during extrusion processing, yet many outbreaks associated with low water activity foods since 2006 were linked to extruded foods. The aim of this research was to study Salmonella inactivation during extrusion of a model cereal product. Oat flour was inoculated with Salmonella enterica serovar Agona, an outbreak strain isolated from puffed cereals, and processed using a single‐screw extruder at a feed rate of 75 kg/h and a screw speed of 500 rpm. Extrudate samples were collected from the barrel outlet in sterile bags and immediately cooled in an ice–water bath. Populations were determined using standard plate count methods or a modified most probable number when populations were low. Reductions in population were determined and analyzed using a general linear model. The regression model obtained for the response surface tested was Log ( N R / N O ) = 20.50 + 0.82 T − 141.16a w – 0.0039 T 2 + 87.91 a w 2 ( R 2 = 0.69). The model showed significant ( p < 0.05) linear and quadratic effects of a w and temperature and enabled an assessment of critical control parameters. Reductions of 0.67 ± 0.14 to 7.34 ± 0.02 log CFU/g were observed over ranges of a w (0.72 to 0.96) and temperature (65 to 100 °C) tested. Processing conditions above 82 °C and 0.89 a w achieved on average greater than a 5‐log reduction of Salmonella . Results indicate that extrusion is an effective means for reducing Salmonella as most processes commonly employed to produce cereals and other low water activity foods exceed these parameters. Thus, contamination of an extruded food product would most likely occur postprocessing as a result of environmental contamination or through the addition of coatings and flavorings.

Anderson, Nathan M.↗

Radiological risk of building materials using homemade airtight radon chamber

Soil based building materials known to contain various amounts of natural radionuclide mainly {sup 238}U and {sup 232}Th series and {sup 40}K. In general most individuals spend 80% of their time indoors and the natural radioactivity in building materials is a main source of indoor radiation exposure. The internal exposure due to building materials in dwellings and workplaces is mainly caused by the activity concentrations of short lived {sup 222}Radon and its progenies which arise from the decay of {sup 226}Ra. In this study, the indoor radon concentration emanating from cement brick, red-clay brick, gravel aggregate and Portland cement samples were measured in a homemade airtight radon chamber using continuous radon monitor 1029 model of Sun Nuclear. Radon monitor were left in the chamber for 96 hours with an hour counting time interval. From the result, the indoor radon concentrations for cement brick, red-clay brick, gravel aggregate and Portland cement samples determined were 396 Bq m{sup −3}, 192 Bq m{sup −3}, 176 Bq m{sup −3} and 28 Bq m{sup −3}, respectively. The result indicates that the radon concentration in the studied building materials have more than 100 Bq m{sup −3} i.e. higher than the WHO action level except for Portland cement sample. The calculated annual effective dose for cement brick, red-clay brick, gravel aggregate and Portland cement samples were determined to be 10 mSv y{sup −1}, 4.85 mSv y{sup −1}, 4.44 mSv y{sup −1} and 0.72 mSv y{sup −1}, respectively. This study showed that all the calculated effective doses generated from indoor radon to dwellers or workers were in the range of limit recommended ICRP action levels i.e. 3 - 10 mSv y{sup −1}. As consequences, the radiological risk for the dwellers in terms of fatal lifetime cancer risk per million for cement brick, red-clay brick, gravel aggregate and Portland cement were calculated to be 550, 267, 244 and 40 persons respectively.

54 ENVIRONMENTAL SCIENCES↗

THE UNIMODAL DISTRIBUTION OF BLUE STRAGGLER STARS IN M75 (NGC 6864)

We have used a combination of multiband high-resolution and wide-field ground-based observations to image the Galactic globular cluster M75 (NGC 6864). The extensive photometric sample covers the entire cluster extension, from the very central regions out to the tidal radius, allowing us to determine the center of gravity and to construct the most extended star density profile ever published for this cluster. We also present the first detailed star counts in the very inner regions. The star density profile is well reproduced by a standard King model with core radius r{sub c} {approx} 5.''4 and intermediate-high concentration c {approx} 1.75. The present paper presents a detailed study of the blue straggler star (BSS) population and its radial distribution. A total of 62 bright BSSs (with m{sub F255W} {approx}< 21, corresponding to m{sub F555W} {approx}< 20) have been identified, and they have been found to be highly segregated in the cluster core. No significant upturn in the BSS frequency has been observed in the outskirts of M75, in contrast to several other clusters studied with the same technique. This observational fact is quite similar to what has been found in M79 (NGC 1904) by Lanzoni et al. Indeed, the BSS radial distributions in the two clusters are qualitatively very similar, even if in M75 the relative BSS frequency seems to decrease significantly faster than in M79: it decreases by a factor of five (from 3.4 to 0.7) within 1r{sub c} . Such evidence indicates that the vast majority of the cluster heavy stars (binaries) have already sunk to the core.

79 ASTRONOMY AND ASTROPHYSICS↗

NuSTAR AND SWIFT OBSERVATIONS OF THE BLACK HOLE CANDIDATE XTE J1908+094 DURING ITS 2013 OUTBURST

The black hole (BH) candidate XTE J1908+094 went into outburst for the first time since 2003 in 2013 October. We report on an observation with the Nuclear Spectroscopic Telescope Array (NuSTAR) and monitoring observations with Swift during the outburst. NuSTAR caught the source in the soft state: the spectra show a broad relativistic iron line, and the light curves reveal a ∼40 ks flare, with the count rate peaking about 40% above the non-flare level and with significant spectral variation. A model combining a multi-temperature thermal component, a power law, and a reflection component with an iron line provides a good description of the NuSTAR spectrum. Although relativistic broadening of the iron line is observed, it is not possible to constrain the BH spin with these data. The variability of the power-law component, which can also be modeled as a Comptonization component, is responsible for the flux and spectral change during the flare, suggesting that changes in the corona (or possibly continued jet activity) are the likely cause of the flare.

79 ASTRONOMY AND ASTROPHYSICS↗

THE CHANDRA X-RAY POINT-SOURCE CATALOG IN THE DEEP2 GALAXY REDSHIFT SURVEY FIELDS

We present the X-ray point-source catalog produced from the Chandra Advanced CCD Imaging Spectrometer (ACIS-I) observations of the combined {approx}3.2 deg{sup 2} DEEP2 (XDEEP2) survey fields, which consist of four {approx}0.7-1.1 deg{sup 2} fields. The combined total exposures across all four XDEEP2 fields range from {approx}10 ks to 1.1 Ms. We detect X-ray point sources in both the individual ACIS-I observations and the overlapping regions in the merged (stacked) images. We find a total of 2976 unique X-ray sources within the survey area with an expected false-source contamination of Almost-Equal-To 30 sources ({approx}< 1%). We present the combined log N-log S distribution of sources detected across the XDEEP2 survey fields and find good agreement with the Extended Chandra Deep Field and Chandra-COSMOS fields to f{sub X,0.5-2keV} {approx} 2x10{sup -16} erg cm{sup -2}s{sup -1}. Given the large survey area of XDEEP2, we additionally place relatively strong constraints on the log N-log S distribution at high fluxes (f{sub X,0.5-2keV} {approx} 3x10{sup -14} erg cm -{sup 2}s{sup -1}), and find a small systematic offset (a factor {approx}1.5) toward lower source numbers in this regime, when compared to smaller area surveys. The number counts observed in XDEEP2 are in close agreement with those predicted by X-ray background synthesis models. Additionally, we present a Bayesian-style method for associating the X-ray sources with optical photometric counterparts in the DEEP2 catalog (complete to R{sub AB} < 25.2) and find that 2126 ( Almost-Equal-To 71.4% {+-} 2.8%) of the 2976 X-ray sources presented here have a secure optical counterpart with a {approx}< 6% contamination fraction. We provide the DEEP2 optical source properties (e.g., magnitude, redshift) as part of the X-ray-optical counterpart catalog.

79 ASTRONOMY AND ASTROPHYSICS↗

The isotropic radio background revisited

We present an extensive analysis on the determination of the isotropic radio background. We consider six different radio maps, ranging from 22 MHz to 2.3 GHz and covering a large fraction of the sky. The large scale emission is modeled as a linear combination of an isotropic component plus the Galactic synchrotron radiation and thermal bremsstrahlung. Point-like and extended sources are either masked or accounted for by means of a template. We find a robust estimate of the isotropic radio background, with limited scatter among different Galactic models. The level of the isotropic background lies significantly above the contribution obtained by integrating the number counts of observed extragalactic sources. Since the isotropic component dominates at high latitudes, thus making the profile of the total emission flat, a Galactic origin for such excess appears unlikely. We conclude that, unless a systematic offset is present in the maps, and provided that our current understanding of the Galactic synchrotron emission is reasonable, extragalactic sources well below the current experimental threshold seem to account for the majority of the brightness of the extragalactic radio sky.

79 ASTRONOMY AND ASTROPHYSICS↗

Preliminary clustering properties of the DESI BGS bright targets using DR9 Legacy Imaging Surveys

ABSTRACT We characterize the selection cuts and clustering properties of a magnitude-limited sample of bright galaxies that is part of the Bright Galaxy Survey (BGS) of the Dark Energy Spectroscopic Instrument (DESI) using the ninth data release of the Legacy Imaging Surveys (DR9). We describe changes in the DR9 selection compared to the DR8 one and we also compare the DR9 selection in three distinct regions: BASS/MzLS in the north Galactic Cap (NGC), DECaLS in the NGC, and DECaLS in the south Galactic Cap (SGC). We investigate the systematics associated with the selection and assess its completeness by matching the BGS targets with the Galaxy and Mass Assembly (GAMA) survey. We measure the angular clustering for the overall bright sample (rmag ≤ 19.5) and as function of apparent magnitude and colour. This enables to determine the clustering strength r0 and slope γ by fitting a power-law model that can be used to generate accurate mock catalogues for this tracer. We use a counts-in-cells technique to explore higher order statistics and cross-correlations with external spectroscopic data sets in order to check the evolution of the clustering with redshift and the redshift distribution of the BGS targets using clustering redshifts. While this work validates the properties of the BGS bright targets, the final target selection pipeline and clustering properties of the entire DESI BGS will be fully characterized and validated with the spectroscopic data of Survey Validation.

79 ASTRONOMY AND ASTROPHYSICS↗

Cosmology constraints from shear peak statistics in Dark Energy Survey Science Verification data

Shear peak statistics has gained a lot of attention recently as a practical alternative to the two point statistics for constraining cosmological parameters. We perform a shear peak statistics analysis of the Dark Energy Survey (DES) Science Verification (SV) data, using weak gravitational lensing measurements from a 139 deg$^2$ field. We measure the abundance of peaks identified in aperture mass maps, as a function of their signal-to-noise ratio, in the signal-to-noise range $0<\mathcal S / \mathcal N<4$. To predict the peak counts as a function of cosmological parameters we use a suite of $N$-body simulations spanning 158 models with varying $\Omega_{\rm m}$ and $\sigma_8$, fixing $w = -1$, $\Omega_{\rm b} = 0.04$, $h = 0.7$ and $n_s=1$, to which we have applied the DES SV mask and redshift distribution. In our fiducial analysis we measure $\sigma_{8}(\Omega_{\rm m}/0.3)^{0.6}=0.77 \pm 0.07$, after marginalising over the shear multiplicative bias and the error on the mean redshift of the galaxy sample. We introduce models of intrinsic alignments, blending, and source contamination by cluster members. These models indicate that peaks with $\mathcal S / \mathcal N>4$ would require significant corrections, which is why we do not include them in our analysis. We compare our results to the cosmological constraints from the two point analysis on the SV field and find them to be in good agreement in both the central value and its uncertainty. As a result, we discuss prospects for future peak statistics analysis with upcoming DES data.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Supersymmetric Sachdev-Ye-Kitaev models

We discuss a supersymmetric generalization of the Sachdev-Ye-Kitaev (SYK) model. These are quantum mechanical models involving N Majorana fermions. The supercharge is given by a polynomial expression in terms of the Majorana fermions with random coefficients. The Hamiltonian is the square of the supercharge. The N = 1 model with a single supercharge has unbroken supersymmetry at large N , but nonperturbatively spontaneously broken supersymmetry in the exact theory. We analyze the model by looking at the large N equation, and also by performing numerical computations for small values of N . We also compute the large N spectrum of “singlet” operators, where we find a structure qualitatively similar to the ordinary SYK model. We also discuss an N = 2 version. In this case, the model preserves supersymmetry in the exact theory and we can compute a suitably weighted Witten index to count the number of ground states, which agrees with the large N computation of the entropy. In both cases, we discuss the supersymmetric generalizations of the Schwarzian action which give the dominant effects at low energies.

79 ASTRONOMY AND ASTROPHYSICS↗

Improving I/O-aware Workflow Scheduling via Data Flow Characterization and trade-off Analysis

The scientific computing paradigm has transitioned from compute-intensive to I/O-intensive and memory-intensive in the past decade, especially when data-driven science has become common practice. Numerous empirical I/O-aware scheduling optimizations have been developed by incorporating I/O capacity and bandwidth as constraints into scheduling. Unfortunately, there is a lack of data flow (I/O) characterization tool and an understanding of trade-offs between concurrency, locality, and I/O bandwidth. To bridge the gap, this work 1) presents a set of descriptors to characterize, organize, and visualize I/O profiles, including flow size, I/O bandwidth, and operation count, which group data flows by I/O types, tasks, and files; 2) proposes an I/O Roofline model-based trade-off analysis to find the optimal trade-off between flow operational intensity, concurrency, and flow performance. The I/O descriptors generate useful insights into complicated I/O behaviors, suggesting distinct concurrency, storage, and scheduling to be used by types, tasks, and files. The proposed trade-off analysis guides scheduling decisions that generate resource assignment with the best flow parallelism. We evaluate our I/O-aware scheduling methodology on a highly I/O-intensive workflow–1000 Genomes. The experimental results demonstrate speedups of up to 2.4× compared to the state-of-the- art methods.

Guo, Luanzheng [BATTELLE (PACIFIC NW LAB)]↗

Non-destructive Assay Measurements Using the RPI Lead Slowing Down Spectrometer

The use of a Lead Slowing-Down Spectrometer (LSDS) is consid- ered as a possible option for non-destructive assay of fissile material of used nuclear fuel. The primary objective is to quantify the 239Pu and 235U fissile content via a direct measurement, distinguishing them through their characteristic fission spectra in the LSDS. In this pa- per, we present several assay measurements performed at the Rensse- laer Polytechnic Institute (RPI) to demonstrate the feasibility of such a method and to provide benchmark experiments for Monte Carlo cal- culations of the assay system. A fresh UOX fuel rod from the RPI Criticality Research Facility, a 239PuBe source and several highly en- riched 235U discs were assayed in the LSDS. The characteristic fission spectra were measured with 238U and 232Th threshold fission cham- bers, which are only sensitive to fission neutron with energy above the threshold. Despite the constant neutron and gamma background from the PuBe source and the intense interrogation neutron flux, the LSDS system was able to measure the characteristic 235U and 239Pu responses. All measurements were compared to Monte Carlo simula- tions. It was shown that the available simulation tools and models are well suited to simulate the assay, and that it is possible to calculate the absolute count rate in all investigated cases.

Lead Slowing Down Spectrometer↗

Multiplicity Counting

This set of slides begins by giving background and a review of neutron counting; three attributes of a verification item are discussed: 240 Pu eff mass; α, the ratio of (α,n) neutrons to spontaneous fission neutrons; and leakage multiplication. It then takes up neutron detector systems – theory & concepts (coincidence counting, moderation, die-away time); detector systems – some important details (deadtime, corrections); introduction to multiplicity counting; multiplicity electronics and example distributions; singles, doubles, and triples from measured multiplicity distributions; and the point model: multiplicity mathematics.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Summing Corrections For La-140 On Counter 137 [Slides]

The counting of filters for gamma activity is often done with the sample situated very close or wrapped around the detector. This improves the counting statistics but can increase the probability of summing and affect the calculation of yield. An MCNP model of counter 137 (a 65% HPGe detector) was used to compute the total and peak efficiencies for two sample types, 40 and 20. The type 40 is a long filter strip wrapped in a Marinelli beaker which sits around the detector in an annular fashion. The type 20 is a 8.4 in radius filter, quarter-folded and placed flat on the detector face. A comparison of the peak efficiency computed in MCNP was compared to the measured efficiency to ensure consistency. Using the measured peak efficiency and MCNP-computed total efficiency, the TrueCoinc program was run to estimate the summing values for La-140 peaks. The results showed the summing out of two peaks (487 and 1596 keV) was around 6-8% in for both sample types.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗