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At least 937 records · Page 52

Development of cell-based assay for predictively evaluating the FcγR-mediated human immune cell activation by therapeutic monoclonal antibodies

Therapeutic monoclonal antibodies (mAbs) have important roles in treatments for various cancers and inflammatory diseases. Their highly target specificities provide controlled safety profiles. However, therapeutic mAbs commonly pose a risk of the induction of the release of cytokines, which may result in adverse events including infusion reaction and cytokine release syndrome. Several mechanisms are involved in the cytokine releases induced by therapeutic mAbs, and the activation of immune effector cells via Fcγ receptors (FcγRs) is one of the putative mechanisms for most IgG-subclass mAbs. The relationship between cytokine releases and mAbs' Fc functions is not fully understood. Here we developed a simple reporter cell-based assay for estimating the FcγR-mediated activation of human immune effector cells by mAbs. Our use of the cell-based assay to compare Fc-engineered mAbs with different FcγR-activation profiles revealed that the releases of inflammatory cytokines and chemokines from human peripheral blood mononuclear cells (hPBMCs) induced by the mAbs were elevated by treatment with Fc-engineered mAbs with higher FcγR-activation properties. Our results also suggested the involvement of monocytic effector cells in the activation of hPBMCs as sources of released cytokines and chemokines, which may lead to the immune cell-mediated adverse events. Our new reporter cell assay is a promising tool for evaluating and predicting the activation of human immune cells by novel Fc-engineered mAbs. - Highlights: • A simple reporter assay for estimating the FcγR activation by mAbs is developed. • mAbs with higher FcγR-activation properties strongly activate hPBMC. • Monocytic effector cells are involved in the activation of hPBMCs by mAbs. • The reporter assay is useful for predicting the FcγR-mediated responses of hPBMCs.

60 APPLIED LIFE SCIENCES↗

Effects of coronal disturbances on the ionization state of the solar wind

A theoretical investigation of the relationship between physical conditions in coronal disturbances and the ionization states of the resulting perturbed solar wind was conducted. Available measurements of active solar wind associated with solar flares often show an enhanced degree of ionization (e.g., Fe(+17)), implying that the measured solar wind material is flare-heated at its coronal source. In contrast, other active solar wind flows sometimes show anomalously low degrees of ionization (e.g., He(+)), implying that some solar material is expelled from the corona without ever reaching coronal temperatures. The effects of impulsive heat and/or momentum addition in the corona on the hydrodynamics and ionization state of the corona and solar wind were studied. One of the primary objectives of the current grant was the development of a software package suitable for: (1) generating models for the effects of impulsive heat and/or momentum deposition on plasma temperatures, densities and flow velocities; and (2) calculating the ionization state of the solar wind as a function of the location, duration and magnitude of heat and/or momentum deposition.

Withbroe, G. L.↗

SU-C-9A-04: Alternative Analytic Solution to the Paralyzable Detector Model to Calculate Deadtime and Deadtime Loss

Purpose: Some common methods to solve for deadtime are (1) dual-source method, which assumes two equal activities; (2) model fitting, which requires multiple acquisitions as source decays; and (3) lossless model, which assumes no deadtime loss at low count rates. We propose a new analytic alternative solution to calculate deadtime for paralyzable gamma camera. Methods: Deadtime T can be calculated analytically from two distinct observed count rates M1 and M2 when the ratio of the true count rates alpha=N2/N1 is known. Alpha can be measured as a ratio of two measured activities using dose calibrators or via radioactive decay. Knowledge of alpha creates a system with 2 equations and 2 unknowns, i.e., T and N1. To verify the validity of the proposed method, projections of a non-uniform phantom (4GBq 99mTc) were acquired in using Siemens SymbiaS multiple times over 48 hours. Each projection has >100kcts. The deadtime for each projection was calculated by fitting the data to a paralyzable model and also by using the proposed 2-acquisition method. The two estimates of deadtime were compared using the Bland-Altmann method. In addition, the dependency of uncertainty in T on uncertainty in alpha was investigated for several imaging conditions. Results: The results strongly suggest that the 2-acquisition method is equivalent to the fitting method. The Bland-Altman analysis yielded mean difference in deadtime estimate of ∼0.076us (95%CI: -0.049us, 0.103us) between the 2-acquisition and model fitting methods. The 95% limits of agreement were calculated to be -0.104 to 0.256us. The uncertainty in deadtime calculated using the proposed method is highly dependent on the uncertainty in the ratio alpha. Conclusion: The 2-acquisition method was found to be equivalent to the parameter fitting method. The proposed method offers a simpler and more practical way to analytically solve for a paralyzable detector deadtime, especially during physics testing.

07 ISOTOPE AND RADIATION SOURCES↗

Segmented Gamma Scanner for Small Containers of Uranium Processing Waste- 12295

The Segmented Gamma Scanner (SGS) is commonly utilized in the assay of 55-gallon drums containing radioactive waste. Successfully deployed calibration methods include measurement of vertical line source standards in representative matrices and mathematical efficiency calibrations. The SGS technique can also be utilized to assay smaller containers, such as those used for criticality safety in uranium processing facilities. For such an application, a Can SGS System is aptly suited for the identification and quantification of radionuclides present in fuel processing wastes. Additionally, since the significant presence of uranium lumping can confound even a simple 'pass/fail' measurement regimen, the high-resolution gamma spectroscopy allows for the use of lump-detection techniques. In this application a lump correction is not required, but the application of a differential peak approach is used to simply identify the presence of U-235 lumps. The Can SGS is similar to current drum SGSs, but differs in the methodology for vertical segmentation. In the current drum SGS, the drum is placed on a rotator at a fixed vertical position while the detector, collimator, and transmission source are moved vertically to effect vertical segmentation. For the Can SGS, segmentation is more efficiently done by raising and lowering the rotator platform upon which the small container is positioned. This also reduces the complexity of the system mechanism. The application of the Can SGS introduces new challenges to traditional calibration and verification approaches. In this paper, we revisit SGS calibration methodology in the context of smaller waste containers, and as applied to fuel processing wastes. Specifically, we discuss solutions to the challenges introduced by requiring source standards to fit within the confines of the small containers and the unavailability of high-enriched uranium source standards. We also discuss the implementation of a previously used technique for identifying the presence of uranium lumping. The SGS technique is a well-accepted NDA technique applicable to containers of almost any size. It assumes a homogenous matrix and activity distribution throughout the entire container; an assumption that is at odds with the detection of lumps within the assay item typical of uranium-processing waste. This fact, in addition to the difficultly in constructing small reference standards of uranium-bearing materials, required the methodology used for performing an efficiency curve calibration to be altered. The solution discussed in this paper is demonstrated to provide good results for both the segment activity and full container activity when measuring heterogeneous source distributions. The application of this approach will need to be based on process knowledge of the assay items, as biases can be introduced if used with homogenous, or nearly homogenous, activity distributions. The bias will need to be quantified for each combination of container geometry and SGS scanning settings. One recommended approach for using the heterogeneous calibration discussed here is to assay each item using a homogenous calibration initially. Review of the segment activities compared to the full container activity will signal the presence of a non-uniform activity distribution as the segment activity will be grossly disproportionate to the full container activity. Upon seeing this result, the assay should either be reanalyzed or repeated using the heterogeneous calibration. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗

The multiple depleted mantle components in the Hawaiian-Emperor chain

Oceanic island basalts are targeted for geochemical study because they provide a direct window into mantle composition and a wealth of information on the dynamics and timescales associated with Earth mixing. Previous studies mainly focused on the shield volcanic stage of oceanic islands and the more fusible, enriched mantle components that are easily distinguished in those basalts. Mantle depleted compositions are typically more difficult to resolve unless large amounts of this material participated in mantle melting (e.g., mid-ocean ridges), or unique processes allow for their compositions to be erupted undiluted, such as very small degrees of melting of a source with minimal fusible enriched components (e.g., rejuvenated basalts) or as xenoliths (e.g., abyssal peridotites). Mantle depleted components, defined here as material with low time-integrated Rb/Sr (low 87 Sr/ 86 Sr) and high time-integrated Sm/Nd and Lu/Hf ratios (high 143 Nd/ 144 Nd and 176 Hf/ 177 Hf) relative to primitive mantle, derive from a potentially very large volume reservoir (up to 80% of the mantle), and therefore need adequate characterization in order estimate the composition of the Earth and mantle-derived melts. Here, this review focuses on mantle depleted compositions in oceanic island basalts using the Hawaiian-Emperor chain as a case study. The Hawaiian-Emperor chain is the ~6000 km long geological record of the deeply sourced Hawaiian mantle plume, active for >81 Myr. Hawaiian volcanism evolves through four volcanic stages as a volcano traverses the Hawaiian plume: alkalic preshield, tholeiitic shield (80–90% volcano volume), alkalic postshield (~1%), and silica undersaturated rejuvenated (<0.1%). We report Pb-Sr-Nd-Hf isotope compositions and trace element concentrations of three rejuvenated Northwest Hawaiian Ridge basalts and compare them to an exhaustive compiled dataset of basalts from the Hawaiian Islands to the Emperor Seamounts. The Northwest Hawaiian Ridge (NWHR) includes 51 volcanoes spanning ~42 m.y. between the bend in the Hawaiian-Emperor chain and the Hawaiian Islands where there is no high-precision isotopic data published on the rejuvenated-stage over ~47% of the chain. NWHR and Hawaiian Island rejuvenated basalts are geochemically similar, indicating a consistent source for rejuvenated volcanism over ~12.5 million years. In contrast, shield-stage basalts from the oldest Emperor Seamounts are more depleted in isotopic composition (i.e., higher 176 Hf/ 177 Hf, and 143 Nd/ 144 Nd with lower 87 Sr/ 86 Sr and 208 Pb*/ 206 Pb*) and trace element concentrations (i.e., much lower concentrations of highly incompatible elements) than all other depleted Hawaiian basalts younger than the bend, including NWHR rejuvenated basalts. The strongly depleted source for the oldest Emperor Seamounts (>70 Ma) was likely related to interaction with the Kula-Pacific-Izanagi mid-ocean ridge spreading system active near the Hawaiian plume in the Late Cretaceous. In contrast, the incompatible trace element ratios of NWHR rejuvenated basalts require a distinct source in the Hawaiian mantle plume that was imprinted by ancient (>1 Ga) partial melting, likely ancient recycled oceanic lithosphere. This review of the geochemistry of Hawaiian depleted components documents the need for the sampling of multiple distinctive depleted compositions, each preferentially melted during specific periods of Hawaiian plume activity. This suggests that the composition of depleted components can evolve during the lifetime of the mantle plume, as observed for enriched components in the Hawaiian mantle plume. Changes in the composition of depleted components are dominantly controlled by the upper mantle tectonic configurations at the time of eruption (i.e., proximity to a mid-ocean ridge), as this effect overwhelms the signal imparted by potentially sampling different lower mantle components through time.

07 ISOTOPE AND RADIATION SOURCES↗

REVEALING THE HEAVILY OBSCURED ACTIVE GALACTIC NUCLEUS POPULATION OF HIGH-REDSHIFT 3CRR SOURCES WITH CHANDRA X-RAY OBSERVATIONS

Chandra observations of a complete, flux-limited sample of 38 high-redshift (1 < z < 2), low-frequency-selected (and so unbiased in orientation) 3CRR radio sources are reported. The sample includes 21 quasars (=broad-line radio galaxies) and 17 narrow-line radio galaxies (NLRGs) with matched 178 MHz radio luminosity (log L{sub R}(5 GHz) {approx}44-45). The quasars have high radio core fraction, high X-ray luminosities (log L{sub X} {approx}45-46), and soft X-ray hardness ratios (HR {approx}-0.5) indicating low obscuration. The NLRGs have lower core fraction, lower apparent X-ray luminosities (log L{sub X} {approx}43-45), and mostly hard X-ray hardness ratios (HR >0) indicating obscuration (N{sub H} {approx}10{sup 22}-10{sup 24} cm{sup -2}). These properties and the correlation between obscuration and radio core fraction are consistent with orientation-dependent obscuration as in unification models. About half the NLRGs have soft X-ray hardness ratios and/or a high [O III] emission line to X-ray luminosity ratio suggesting obscuration by Compton thick (CT) material so that scattered nuclear or extended X-ray emission dominates (as in NGC 1068). The ratios of unobscured to Compton-thin (10{sup 22} cm{sup -2} < N{sub H}(int) <1.5 Multiplication-Sign 10{sup 24} cm{sup -2}) to CT (N{sub H}(int) >1.5 Multiplication-Sign 10{sup 24} cm{sup -2}) is 2.5:1.4:1 in this high-luminosity, radio-selected sample. The obscured fraction is 0.5, higher than is typically reported for active galactic nuclei at comparable luminosities from multi-wavelength surveys (0.1-0.3). Assuming random nuclear orientation, the unobscured half-opening angle of the disk/wind/torus structure is {approx}60 Degree-Sign and the obscuring material covers 30 Degree-Sign , {approx}12 Degree-Sign of which is CT. The multi-wavelength properties reveal that many NLRGs have intrinsic absorption 10-1000 Multiplication-Sign higher than indicated by their X-ray hardness ratios, and their true L{sub X} values are {approx}10-100 Multiplication-Sign larger than the hardness-ratio absorption corrections would indicate.

79 ASTRONOMY AND ASTROPHYSICS↗

Hard X-ray observations of ultraluminous infrared galaxies

X-ray flux upper limits of 2-10 keV for ultraluminous infrared galaxies were drawn from the HEAO A-1 data base. The hard X-ray luminosities of these sources are much weaker relative to their total luminosities than would be expected for Seyfert 1 galaxies or quasi-stellar objects. Because of the low level of interstellar extinction for hard X-rays, this result suggests that the ultraluminous galaxies are not powered by embedded QSOs that are otherwise similar to other QSOs. Three other possibilities are: (1) the infrared galaxies may contain a form of X-ray-quiet active nucleus; (2) the X-ray sources in active nuclei may not turn on until after the circumnuclear gas has cleared; or (3) the bulk of the infrared luminosity in these galaxies may be generated by intense circumnuclear star formation.

Rieke, G. H.↗

Adaptive structures for precision controlled large space systems

The development of adaptive structural systems is reviewed and the potential of these systems in meeting some of the requirements for NASA future space missions is demonstrated. Particular attention is given to the characteristics of a viscous damper in the micron displacement regime; the optimal placement of active and passive members into a truss structure; a system identification test using the active members as excitation sources; a concept for deforming a lightweight composite honeycomb optical panel to correct for on-orbit distortions by using piezoelectric actuators attached to the back facesheet; and the results of an active member vibration control experiment in a reduced gravity environment.

Garba, John A.↗

XMM-NEWTON OBSERVATIONS OF LUMINOUS SOURCES IN NEARBY GALAXIES NGC 4395, NGC 4736, AND NGC 4258

We present the results of a study of non-nuclear discrete sources in a sample of three nearby spiral galaxies (NGC 4395, NGC 4736, and NGC 4258) based on XMM-Newton archival data supplemented with Chandra data for spectral and timing analyses. A total of 75 X-ray sources have been detected within the D{sub 25} regions of the target galaxies. The large collecting area of XMM-Newton makes the statistics sufficient to obtain spectral fitting for 16 (about 20%) of these sources. Compiling the extensive archival exposures available, we were able to obtain the detailed spectral shapes of diverse classes of point sources. We have also studied temporal properties of these luminous sources. Eleven of them are found to show short-term (less than 80 ks) variation while eight of them show long-term variation within factors of {approx}2-5 during a time interval of {approx}2-12 years. Timing analysis provides strong evidence that most of these sources are accreting X-ray binary systems. One source that has properties different from others was suspected to be a supernova remnant, and our follow-up optical observation confirmed this. Our results indicate that sources within the three nearby galaxies are showing a variety of source populations, including several ultraluminous X-ray sources, X-ray binaries, transients together with a super soft source, and a background active galactic nucleus candidate.

79 ASTRONOMY AND ASTROPHYSICS↗

Distribution and Sources of Tropospheric Aerosols Over the Western North Atlantic During ACTIVATE (February-March 2020)

The Aerosol Cloud meTeorology Interactions oVer the western ATlantic Experiment (ACTIVATE) is a five-year (2019-2023) NASA Earth-Venture Suborbital-3 (EVS-3) mission to robustly characterize aerosol-cloud-meteorology interactions during February-June, with a focus on marine boundary layer clouds. This characterization requires understanding of aerosol composition, distribution, transport pathways, and sources. Here we use the GEOS-Chem chemical transport model driven by the MERRA-2 reanalysis to simulate tropospheric carbon monoxide (CO) and aerosols over the western North Atlantic Ocean (WNAO) during the first field deployment of ACTIVATE (February-March 2020). CO is used as a tracer to diagnose transport pathways for continental pollution outflow to the WNAO. The aerosol simulation represents all major aerosols including sulfate-nitrate-ammonium (SNA), mineral dust, sea salt, black and organic carbon aerosols. Model-simulated mixing ratios of SNA and organic carbon are compared with aircraft observations. We show that intensive aerosol mass measurements in the lower troposphere over the North American outflow region during ACTIVATE provide strong constraints on model aerosol wet scavenging. Comparisons of model aerosol extinctions with the airborne High Spectral Resolution Lidar-2 (HSRL-2) measurements indicate that the model generally captures continental outflow of aerosols and enhanced extinctions associated with sea salt. Simulated aerosol optical depths (AODs) and extinction vertical profiles are also compared with satellite retrievals from MODIS/Aqua and CALIOP/CALIPSO, respectively. CALIOP sometimes observes enhanced aerosol extinction at altitudes between ~1.5km and ~2.0km south of 32°N. The model reproduces this enhancement and attributes it to coarse-mode sea salt associated with high relative humidity. The relative contributions of continental and oceanic sources to the aerosol loading, AOD, and their distributions over the study domain will also be discussed.

aerosols↗

Experimental approaches for the development of gamma spectroscopy well logging system

This article discusses experimental approaches for the development of gamma spectroscopy well logging system. Considering the size of borehole sonde, we customize 2 x 2 inches inorganic scintillators and the system including high voltage, preamplifier, amplifier and multichannel analyzer (MCA). The calibration chart is made by test using standard radioactive sources so that the measured count rates are expressed by energy spectrum. Optimum high-voltage supplies and the measurement parameters of each detector are set up by experimental investigation. Also, the responses of scintillation detectors have been examined by analysis according to the distance between source and detector. Because gamma spectroscopy well logging needs broad spectrum, high sensitivity and resolution, the energy resolution and sensitivity as a function of gamma ray energy are investigated by analyzing the gamma ray activities of the radioactive sources.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

On a solar origin for the cosmogenic nuclide event of 775 A.D

We explore requirements for a solar particle event (SPE) and flare capable of producing the cosmogenic nuclide event of 775 A.D., and review solar circumstances at that time. A solar source for 775 would require a >1 GV spectrum ∼45 times stronger than that of the intense high-energy SPE of 1956 February 23. This implies a >30 MeV proton fluence (F {sub 30}) of ∼8 × 10{sup 10} proton cm{sup –2}, ∼10 times larger than that of the strongest 3 month interval of SPE activity in the modern era. This inferred F {sub 30} value for the 775 SPE is inconsistent with the occurrence probability distribution for >30 MeV solar proton events. The best guess value for the soft X-ray classification (total energy) of an associated flare is ∼X230 (∼9 × 10{sup 33} erg). For comparison, the flares on 2003 November 4 and 1859 September 1 had observed/inferred values of ∼X35 (∼10{sup 33} erg) and ∼X45 (∼2 × 10{sup 33} erg), respectively. The estimated size of the source active region for a ∼10{sup 34} erg flare is ∼2.5 times that of the largest region yet recorded. The 775 event occurred during a period of relatively low solar activity, with a peak smoothed amplitude about half that of the second half of the 20th century. The ∼1945-1995 interval, the most active of the last ∼2000 yr, failed to witness a SPE comparable to that required for the proposed solar event in 775. These considerations challenge a recent suggestion that the 775 event is likely of solar origin.

79 ASTRONOMY AND ASTROPHYSICS↗

X-ray Optics for BES Light Source Facilities

Each new generation of synchrotron radiation sources has delivered an increase in average brightness 2 to 3 orders of magnitude over the previous generation. The next evolution toward diffraction-limited storage rings will deliver another 3 orders of magnitude increase. For ultrafast experiments, free electron lasers (FELs) deliver 10 orders of magnitude higher peak brightness than storage rings. Our ability to utilize these ultrabright sources, however, is limited by our ability to focus, monochromate, and manipulate these beams with X-ray optics. X-ray optics technology unfortunately lags behind source technology and limits our ability to maximally utilize even today’s X-ray sources. With ever more powerful X-ray sources on the horizon, a new generation of X-ray optics must be developed that will allow us to fully utilize these beams of unprecedented brightness. The increasing brightness of X-ray sources will enable a new generation of measurements that could have revolutionary impact across a broad area of science, if optical systems necessary for transporting and analyzing X-rays can be perfected. The high coherent flux will facilitate new science utilizing techniques in imaging, dynamics, and ultrahigh-resolution spectroscopy. For example, zone-plate-based hard X-ray microscopes are presently used to look deeply into materials, but today’s resolution and contrast are restricted by limitations of the current lithography used to manufacture nanodiffractive optics. The large penetration length, combined in principle with very high spatial resolution, is an ideal probe of hierarchically ordered mesoscale materials, if zone-plate focusing systems can be improved. Resonant inelastic X-ray scattering (RIXS) probes a wide range of excitations in materials, from charge-transfer processes to the very soft excitations that cause the collective phenomena in correlated electronic systems. However, although RIXS can probe high-energy excitations, the most exciting and potentially revolutionary science involves soft excitations such as magnons and phonons; in general, these are well below the resolution that can be probed by today’s optical systems. The study of these low-energy excitations will only move forward if advances are made in high-resolution gratings for the soft X-ray energy region, and higher-resolution crystal analyzers for the hard X-ray region. In almost all the forefront areas of X-ray science today, the main limitation is our ability to focus, monochromate, and manipulate X-rays at the level required for these advanced measurements. To address these issues, the U.S. Department of Energy (DOE) Office of Basic Energy Sciences (BES) sponsored a workshop, X-ray Optics for BES Light Source Facilities, which was held March 27–29, 2013, near Washington, D.C. The workshop addressed a wide range of technical and organizational issues. Eleven working groups were formed in advance of the meeting and sought over several months to define the most pressing problems and emerging opportunities and to propose the best routes forward for a focused R&D program to solve these problems. The workshop participants identified eight principal research directions (PRDs), as follows: Development of advanced grating lithography and manufacturing for high-energy resolution techniques such as soft X-ray inelastic scattering. Development of higher-precision mirrors for brightness preservation through the use of advanced metrology in manufacturing, improvements in manufacturing techniques, and in mechanical mounting and cooling. Development of higher-accuracy optical metrology that can be used in manufacturing, verification, and testing of optomechanical systems, as well as at wavelength metrology that can be used for quantification of individual optics and alignment and testing of beamlines. Development of an integrated optical modeling and design framework that is designed and maintained specifically for X-ray optics. Development of nanolithographic techniques for improved spatial resolution and efficiency of zone plates. Development of large, perfect single crystals of materials other than silicon for use as beam splitters, seeding monochromators, and high-resolution analyzers. Development of improved thin-film deposition methods for fabrication of multilayer Laue lenses and high-spectral-resolution multilayer gratings. Development of supports, actuator technologies, algorithms, and controls to provide fully integrated and robust adaptive X-ray optic systems. Development of fabrication processes for refractive lenses in materials other than silicon. The workshop participants also addressed two important nontechnical areas: our relationship with industry and organization of optics within the light source facilities. Optimization of activities within these two areas could have an important effect on the effectiveness and efficiency of our overall endeavor. These are crosscutting managerial issues that we identified as areas that needed further in-depth study, but they need to be coordinated above the individual facilities. Finally, an issue that cuts across many of the optics improvements listed above is routine access to beamlines that ideally are fully dedicated to optics research and/or development. The success of the BES X-ray user facilities in serving a rapidly increasing user community has led to a squeezing of beam time for vital instrumentation activities. Dedicated development beamlines could be shared with other R&D activities, such as detector programs and novel instrument development. In summary, to meet the challenges of providing the highest-quality X-ray beams for users and to fully utilize the high-brightness sources of today and those that are on the horizon, it will be critical to make strategic investments in X-ray optics R&D. This report can provide guidance and direction for effective use of investments in the field of X-ray optics and potential approaches to develop a better-coordinated program of X-ray optics development within the suite of BES synchrotron radiation facilities. Due to the importance and complexity of the field, the need for tight coordination between BES light source facilities and with industry, as well as the rapid evolution of light source capabilities, the workshop participants recommend holding similar workshops at least biannually.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

Ion-implanted high microwave power indium phosphide transistors

Encapsulated rapid thermal annealing (RTA) has been used in the fabrication of InP power MISFETs with ion-implanted source, drain, and active-channel regions. The MISFETs had a gate length of 1.4 microns. Six to ten gate fingers per device, with individual gate finger widths of 100 or 125 microns, were used to make MISFETs with total gate widths of 0.75, 0.8, or 1 mm. The source and drain contact regions and the channel region of the MISFETs were fabricated using Si implants in InP at energies from 60 to 360 keV with doses of (1-560) x 10 to the 12th/sq cm. The implants were activated using RTA at 700 C for 30 sec in N2 or H2 ambients using an Si3N4 encapsulant. The high-power high-efficiency MISFETs were characterized at 9.7 GHz, and the output microwave power density for the RTA conditions used was as high as 2.4 W/mm. For a 1-W input at 9.7 GHz gains up to 3.7 dB were observed, with an associated power-added efficiency of 29 percent and output power density 70 percent greater than that of GaAs MESFETs.

Biedenbender, Michael D.↗

Magnetic Separatrix as the Source Region of the Plasma Supply for an Active-region Filament

Solar filaments can be formed via chromospheric evaporation followed by condensation in the corona or by the direct injection of cool plasma from the chromosphere to the corona. We here confirm with high-resolution H α data observed by the 1.6 m New Solar Telescope of the Big Bear Solar Observatory on 2015 August 21 that an active-region filament is maintained by the continuous injection of cold chromospheric plasma. We find that the filament is rooted along a bright ridge in H α , which corresponds to the intersection of a magnetic quasi-separatrix layer with the solar surface. This bright ridge consists of many small patches whose sizes are comparable to the width of the filament threads. It is found that upflows originate from the brighter patches of the ridge, whereas the downflows move toward the weaker patches of the ridge. The whole filament is composed of two opposite-direction streams, implying that longitudinal oscillations are not the only cause of the counterstreamings, and unidirectional siphon flows with alternative directions are another possibility.

79 ASTRONOMY AND ASTROPHYSICS↗

Steam gasification of waste tyre: Influence of process temperature on yield and product composition

Highlights: ► Steam gasification of waste tyre as matter and energy recovery treatment. ► Process temperature affects products yield and gas composition. ► High temperature promotes hydrogen production. ► Char exploitation as activated carbon or carbon source. - Abstract: An experimental survey of waste tyre gasification with steam as oxidizing agent has been conducted in a continuous bench scale reactor, with the aim of studying the influence of the process temperature on the yield and the composition of the products; the tests have been performed at three different temperatures, in the range of 850–1000 °C, holding all the other operational parameters (pressure, carrier gas flow, solid residence time). The experimental results show that the process seems promising in view of obtaining a good quality syngas, indicating that a higher temperature results in a higher syngas production (86 wt%) and a lower char yield, due to an enhancement of the solid–gas phase reactions with the temperature. Higher temperatures clearly result in higher hydrogen concentrations: the hydrogen content rapidly increases, attaining values higher than 65% v/v, while methane and ethylene gradually decrease over the range of the temperatures; carbon monoxide and dioxide instead, after an initial increase, show a nearly constant concentration at 1000 °C. Furthermore, in regards to the elemental composition of the synthesis gas, as the temperature increases, the carbon content continuously decreases, while the oxygen content increases; the hydrogen, being the main component of the gas fraction and having a small atomic weight, is responsible for the progressive reduction of the gas density at higher temperature.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

EXTREME STAR FORMATION IN THE HOST GALAXIES OF THE FASTEST GROWING SUPERMASSIVE BLACK HOLES AT z = 4.8

We report new Herschel observations of 25 z {approx_equal} 4.8 extremely luminous optically selected active galactic nuclei (AGNs). Five of the sources have extremely large star-forming (SF) luminosities, L{sub SF}, corresponding to SF rates (SFRs) of 2800-5600 M{sub Sun} yr{sup -1} assuming a Salpeter initial mass function. The remaining sources have only upper limits on their SFRs, but stacking their Herschel images results in a mean SFR of 700 {+-} 150 M{sub Sun} yr{sup -1}. The higher SFRs in our sample are comparable to the highest observed values so far at any redshift. Our sample does not contain obscured AGNs, which enables us to investigate several evolutionary scenarios connecting supermassive black holes and SF activity in the early universe. The most probable scenario is that we are witnessing the peak of SF activity in some sources and the beginning of the post-starburst decline in others. We suggest that all 25 sources, which are at their peak AGN activity, are in large mergers. AGN feedback may be responsible for diminishing the SF activity in 20 of them, but is not operating efficiently in 5 others.

79 ASTRONOMY AND ASTROPHYSICS↗

High Efficiency Waste Heat Harvesting Using Novel Thermal Oscillators

The aim of this project was to enable practical energy generation from waste heat using pyroelectric (PE) materials with unprecedented efficiency. This aim was accomplished by engineering novel heat switches that overcome the current roadblock to pyroelectric energy harvesting. The heat switches produce a sustain temporal temperature differences from a constant flux heat source. Pyroelectric materials produce transient voltages in response to this generated temperature oscillation. The project solved the inability to generate sustained temperature cycles by utilizing LCEs to achieve passive thermal switching, or EDH of thermal fluid to actively bridging/de-bridging between heat source and pyroelectric layer.

30 DIRECT ENERGY CONVERSION↗