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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 955 records · Page 53
All sourcesNASA NTRSDOE OSTI
DOE OSTI2018

DN604: A platinum(II) drug candidate with classic SAR can induce apoptosis via suppressing CK2-mediated p-cdc25C subcellular localization in cancer cells

Highlights: • DN604 exhibited stronger comparable cytotoxicity to cisplatin. • DN604 showed more potent in vivo antitumor activity than carboplatin. • DN604 resulted in negligible toxic effects as the same effect as cisplatin in vivo. • DN604 could suppress CK2-induced p-cdc25C activation and subcellular localization. DN604, a carboplatin analogue with a functional dicarboxylato ligand, was deeply investigated to explore its ability to induce apoptosis as well as its antitumor mechanism of action. Both in vitro and in vivo assays indicated that DN604 could effectively inhibit cell viability of SGC-7901 gastric cancer cells and exhibited stronger antitumor activity than carboplatin and comparable activity to cisplatin. Significantly in contrast to cisplatin, DN604 resulted in negligible toxic effects in vivo with the same tumor growth inhibition effect as cisplatin. The mechanism study indicated that DN604 inhibited CK2-phosphorylated cdc25C activation to decrease p-cdc25C subcellular localization, leading to the inactivation of cdc2/Cyclin B and G2/M cell cycle arrest and apoptosis in SGC-7901 cancer cells. Our research revealed for the first time that the dicarboxylato ligand containing a suitable functional moiety as the leaving group in the platinum(II) complex can effectively induce cell cycle arrest and apoptosis via inhibiting key checkpoint proteins.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2024

Classical-quantum simulation of non-equilibrium Marshak waves

In the radiation hydrodynamic simulations used to design inertial confinement fusion (ICF) and pulsed power experiments, nonlinear radiation diffusion tends to dominate CPU time. This raises the interesting question of whether a quantum algorithm can be found for nonlinear radiation diffusion which provides a quantum speedup. Recently, such a quantum algorithm was introduced based on a quantum algorithm for solving systems of nonlinear partial differential equations (PDEs) which provides a quadratic quantum speedup. Here, we apply this quantum PDE (QPDE) algorithm to the problem of a non-equilibrium Marshak wave propagating through a cold, semi-infinite, optically thick target, where the radiation and matter fields are not assumed to be in local thermodynamic equilibrium. The dynamics is governed by a coupled pair of nonlinear PDEs which are solved using the QPDE algorithm, as well as two standard PDE solvers: (i) Python's py-pde solver; and (ii) the KULL ICF simulation code developed at Lawrence-Livermore National Laboratory. We compare the simulation results obtained using the QPDE algorithm and the standard PDE solvers and find excellent agreement.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗