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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 973 records · Page 54
All sourcesNASA NTRSDOE OSTI
DOE OSTI2017

Diazotroph Community Characterization via a High-Throughput nifH Amplicon Sequencing and Analysis Pipeline

The dinitrogenase reductase gene ( nifH ) is the most widely established molecular marker for the study of nitrogen-fixing prokaryotes in nature. A large number of PCR primer sets have been developed for nifH amplification, and the effective deployment of these approaches should be guided by a rapid, easy-to-use analysis protocol. Bioinformatic analysis of marker gene sequences also requires considerable expertise. In this study, we advance the state of the art for nifH analysis by evaluating nifH primer set performance, developing an improved amplicon sequencing workflow, and implementing a user-friendly bioinformatics pipeline. Furthermore, the developed amplicon sequencing workflow is a three-stage PCR-based approach that uses established technologies for incorporating sample-specific barcode sequences and sequencing adapters. Based on our primer evaluation, we recommend the Ando primer set be used with a modified annealing temperature of 58°C, as this approach captured the largest diversity of nifH templates, including paralog cluster IV/V sequences. To improve nifH sequence analysis, we developed a computational pipeline which infers taxonomy and optionally filters out paralog sequences. In addition, we employed an empirical model to derive optimal operational taxonomic unit (OTU) cutoffs for the nifH gene at the species, genus, and family levels. A comprehensive workflow script named TaxADivA (TAXonomy Assignment and DIVersity Assessment) is provided to ease processing and analysis of nifH amplicons. Our approach is then validated through characterization of diazotroph communities across environmental gradients in beach sands impacted by the Deepwater Horizon oil spill in the Gulf of Mexico, in a peat moss-dominated wetland, and in various plant compartments of a sugarcane field. IMPORTANCE: Nitrogen availability often limits ecosystem productivity, and nitrogen fixation, exclusive to prokaryotes, comprises a major source of nitrogen input that sustains food webs. The nifH gene, which codes for the iron protein of the nitrogenase enzyme, is the most widely established molecular marker for the study of nitrogen-fixing microorganisms (diazotrophs) in nature. In this study, a flexible sequencing/analysis pipeline, named TaxADivA, was developed for nifH amplicons produced by Illumina paired-end sequencing, and it enables an inference of taxonomy, performs clustering, and produces output in formats that may be used by programs that facilitate data exploration and analysis. Diazotroph diversity and community composition are linked to ecosystem functioning, and our results advance the phylogenetic characterization of diazotroph communities by providing empirically derived nifH similarity cutoffs for species, genus, and family levels. Thus, the utility of our pipeline is validated for diazotroph communities in a variety of ecosystems, including contaminated beach sands, peatland ecosystems, living plant tissues, and rhizosphere soil.

59 BASIC BIOLOGICAL SCIENCES↗
DOE OSTI2011

ORNL ADCP Post-Processing Guide and MATLAB Algorithms for MHK Site Flow and Turbulence Analysis

Standard methods, along with guidance for post-processing the ADCP stationary measurements using MATLAB algorithms that were evaluated and tested by Oak Ridge National Laboratory (ORNL), are presented following an overview of the ADCP operating principles, deployment methods, error sources and recommended protocols for removing and replacing spurious data.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2013

Demand Response Performance of GE Hybrid Heat Pump Water Heater

This report describes a project to evaluate and document the DR performance of HPWH as compared to ERWH for two primary types of DR events: peak curtailments and balancing reserves. The experiments were conducted with GE second-generation “Brillion”-enabled GeoSpring hybrid water heaters in the PNNL Lab Homes, with one GE GeoSpring water heater operating in “Standard” electric resistance mode to represent the baseline and one GE GeoSpring water heater operating in “Heat Pump” mode to provide the comparison to heat pump-only demand response. It is expected that “Hybrid” DR performance, which would engage both the heat pump and electric elements, could be interpolated from these two experimental extremes. Signals were sent simultaneously to the two water heaters in the side-by-side PNNL Lab Homes under highly controlled, simulated occupancy conditions. This report presents the results of the evaluation, which documents the demand-response capability of the GE GeoSpring HPWH for peak load reduction and regulation services. The sections describe the experimental protocol and test apparatus used to collect data, present the baselining procedure, discuss the results of the simulated DR events for the HPWH and ERWH, and synthesize key conclusions based on the collected data.

Demand Response↗
DOE OSTI2016

Low-Cost Proton Conducting Membranes for PEM Fuel Cells

Proton exchange membrane (PEM) is the key component in PEM fuel cells that critically determines the system performance and its economic viability. Presently, the state-of-the-art PEMs, such as Nafion membranes, are based on perfluorosulfonic acid (PFSA) ionomers. But these ionomer materials are expensive, particularly at the low volumes that will be needed for initial commercialization. Besides, they are not suitable for fuel cells operated beyond 100°C, because of the limitations connected to the humidification requirement of such membrane materials, limiting the maximum operating temperature to about 90°C. Fuel cells for transportation applications are required to operate in a wide temperature range from –20°C to 120°C. Low-cost PEMs with capabilities in a range of temperature and humidity conditions are urgently needed to meet the DOE fuel cell targets for transportation applications. Amsen Technologies LLC chooses to address the DOE call with a novel reinforced PEM approach based on new, non-PFSA proton conducting ionomers developed from our previous DOE SBIR projects. Along with this approach is the use of very cheap, ultra thin and highly porous microporous polymer meshes as the support for the membrane. The new PEM is expected to have significant cost advantages over traditional PEMs. The microporous polyolefin support costs $2-3/m 2 ; and the new ionomers that Amsen has developed are estimated at ~$\$$250/kg at the higher end including material costs and labor costs (which may go down in the future as the processing is optimized and production scaled up). These have led to an estimate of total material cost for the membrane at $\$$11 to $\$$12/m 2 , offering high potential of meeting the DOE cost targets (≤$\$$20/m 2 ) after adding processing cost and profit margin. The Phase I results have successfully demonstrated that it is very promising to develop the intended low-cost, high-performance PEM membrane. Suitable material system has been identified, and suitable process for forming the new PEM has been developed. Uniform membranes have been reproducibly fabricated. These membranes have been extensively characterized and evaluated in terms of microstructural features, and relevant physical and chemical properties including proton conductivity and area specific proton resistance in a range of temperature and humidity conditions, resistance to electronic conduction, water uptake/swelling, dimensional stability, chemical stability, and mechanical durability. Membrane electrode assemblies (MEA) with the new membrane have been successfully prepared and tested for fuel cell operation. The new PEM showed higher proton conductivity than Nafion membranes for all measurement conditions used in Phase I. With high proton conductivity and ultra-thin thickness (~20 /m), the new membrane showed high promise to met DOE targets for the low ASR. The ASR targets have been met for relatively high RH but not yet for RH ≤ 70%. Further optimization in ionomer chemistry and membrane processing is needed in order to meet the ASR targets for a wide range of temperature and humidity conditions. The new membrane showed fairly high electronic resistance at 1373 ohm cm 2 , meeting the DOE target for electronic resistance (> 1000 ohm cm 2 ). The new membrane also has demonstrated promisingly high chemical stability, high mechanical durability, and high dimensional stability. Fuel cell operation using MEAs with the new membrane have shown the same level of fuel cell performance as MEAs with Nafion membranes. Overall, the new membrane has been demonstrated to have high potential of meeting all DOE performance targets for fuel cell applications as well as the cost targets. The manufacturers of PEM fuel cells, PEM electrolyzers, redox flow batteries, and MEA are the end-users and customers of PEMs. For commercialization purpose and potential partnering relations, we have been talking with many such manufacturers. They have responded with extremely high interest in the new PEM being developed in the present technology. Accomplishments so far have laid down a strong base for Amsen to further the development efforts on this new PEM and to pursue commercialization. The near-term future work will be mainly focused on further development and systematical optimization of the material system, processing, and performance of the new membrane; systematical evaluation of the new membrane in terms of all relevant properties including long-term mechanical, chemical, and combined chemical/mechanical durabilities using DOE specified testing protocols; development of production scale-up scheme; and preparation for commercialization.

08 HYDROGEN↗
DOE OSTI2022

Securing Inverter Communication: Proactive Intrusion Detection and Mitigation System to Tap, Analyze, and Act

The electric grid has undergone rapid, revolutionary changes in recent years; from the addition of advanced smart technologies to the growing penetration of distributed energy resources (DERs) to increased interconnectivity and communications. However, these added communications, access interfaces, and third-party software to enable autonomous control schemes and interconnectivity also expand the attack surface of the grid. To address the gap of DER cybersecurity and secure the grid-edge to motivate a holistic, defense-in-depth approach, a proactive intrusion detection and mitigation system (PIDMS) device was developed to secure PV smart inverter communications. The PIDMS was developed as a distributed, flexible bump-in-the-wire (BITW) solution for protecting PV smart inverter communications. Both cyber (network traffic) and physical (power system measurements) are processed using network intrusion monitoring tools and custom machinelearning algorithms for deep packet analysis and cyber-physical event correlation. The PIDMS not only detects abnormal events but also deploys mitigations to limit or eliminate system impact; the PIDMS communicates with peer PIDMSs at different locations using the MQTT protocol for increased situational awareness and alerting. The details of the PIDMS methodology and prototype development are detailed in this report as well as the evaluation results within a cyber-physical emulation environment and subsequent industry feedback.

14 SOLAR ENERGY↗
DOE OSTI2023

A Bifunctional Pt/CeO 2 -Cu 1 /CeO 2 Catalyst System for Isooctane Oxidation under Fully Simulated Engine-Exhaust Condition: Eliminating the Inhibition by CO

Pt-based catalysts, because of their outstanding activity for hydrocarbon oxidation, are widely used in the engine-exhaust aftertreatment system to remove hydrocarbon emissions. However, the CO and NO x present in real engine exhausts compete with hydrocarbons for active Pt sites, and thus inhibit hydrocarbon oxidation. In this work, we evaluated the inhibition effects of CO and NO on isooctane oxidation over a Pt/CeO 2 catalyst under the simulated condition of the US DRIVE test protocol (S-GDI, stoichiometric gasoline direct injection). We also leveraged a low-cost single-atom Cu 1 /CeO 2 catalyst, which is highly active for low-temperature CO oxidation, to eliminate the inhibition effect of CO. Specifically, by physically mixing Cu 1 /CeO 2 and Pt/CeO 2 , all the CO is completely converted below 200 °C under simulated exhaust condition, which helps lower the isooctane oxidation temperature. However, the unconverted NO still strongly suppresses HC oxidation. Possible strategies to address the NO inhibitor were proposed.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗
NASA NTRS1989

The DAB model of drawing processes

The problem of automatic drawing was investigated in two ways. First, a DAB model of drawing processes was introduced. DAB stands for three types of knowledge hypothesized to support drawing abilities, namely, Drawing Knowledge, Assimilated Knowledge, and Base Knowledge. Speculation concerning the content and character of each of these subsystems of the drawing process is introduced and the overall adequacy of the model is evaluated. Second, eight experts were each asked to understand six engineering drawings and to think aloud while doing so. It is anticipated that a concurrent protocol analysis of these interviews can be carried out in the future. Meanwhile, a general description of the videotape database is provided. In conclusion, the DAB model was praised as a worthwhile first step toward solution of a difficult problem, but was considered by and large inadequate to the challenge of automatic drawing. Suggestions for improvements on the model were made.

Hochhaus, Larry W.↗
NASA NTRS2015

Bone Loss During Spaceflight: Available Models and Counter-Measures

There is ongoing concern for human health during spaceflights. Of particular interest is the uncoupling of bone remodeling and its resultant effect on calcium metabolism and bone loss. The calculated average loss of bone mineral density (BMD) is approximately 1-1.5% per month of spaceflight. The effect of decreased BMD on associated fractures in astronauts is not known. Currently on the International Space Station (ISS), bone loss is managed through dietary supplements and modifications and resistance exercise regimen. As the duration of space flights increases, a review of the current methods available for the prevention of bone loss is warranted. The goal of this project is to review and summarize recent studies that have focused on maintaining BMD during exposure to microgravity. Interventions were divided into physical (Table 1), nutritional (Table 2), or pharmacologic (Table 3) categories. Physical modalities included resistance exercise, low level vibration, and low intensity pulsed ultrasound. Nutritional interventions included altering protein, salt, and fat intake; and vitamin D supplementation. Pharmacologic interventions included the use of bisphosphonates and beta blockers. Studies reported outcomes based on bone density determined by DXA bone scan, micro-architecture of histology and microCT, and serum and urine markers of bone turnover. The ground analog models utilized to approximate osseous physiology in microgravity included human patients previously paralyzed or subjects confined to bedrest. Ground analog animal models include paralysis, immobilization and ovariectomies. As a result of the extensive research performed there is a multi-modality approach available for the management of BMD during spaceflight that includes resistance training, nutrition and dietary supplements. However, there is a paucity of literature describing a formalized tiered protocol to guide investigators through the progression from animal models to human patient ground analogs to experiments on the ISS. With regards to testing, further evaluation to determine the association between non-invasive tests and fracture during and after spaceflight needs to be performed.

Morris, Jonathan↗
NASA NTRS2015

Nearly a Decade of CALIPSO Observations of Asian and Saharan Dust Properties Near Source and Transport Regions

The lidar on the Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO) mission, makes robust measurements of dust and has generated a length of record that is significant both seasonally and inter-annually. We exploit this record to determine a multi-year climatology of the properties of Asian and Saharan dust, in particular seasonal optical depths, layer frequencies, and layer heights of dust gridded in accordance with the Level 3 data products protocol, between 2006-2015. The data are screened using standard CALIPSO quality assurance flags, cloud aerosol discrimination (CAD) scores, overlying features and layer properties. To evaluate the effects of transport on the morphology, vertical extent and size of the dust layers, we compare probability distribution functions of the layer integrated volume depolarization ratios, geometric depths and integrated attenuated color ratios near the source to the same distributions in the far field or transport region. CALIPSO is collaboration between NASA and Centre National D'études Spatiales (CNES), was launched in April 2006 to provide vertically resolved measurements of cloud and aerosol distributions. The primary instrument on the CALIPSO satellite is the Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP), a near-nadir viewing two-wavelength polarization-sensitive instrument. The unique nature of CALIOP measurements make it quite challenging to validate backscatter profiles, aerosol type, and cloud phase, all of which are used to retrieve extinction and optical depth. To evaluate the uncertainty in the lidar ratios, we compare the values computed from dust layers overlying opaque water clouds, considered nominal, with the constant lidar ratio value used in the CALIOP algorithms for dust. We also explore the effects of noise on the CALIOP retrievals at daytime by comparing the distributions of the properties at daytime to the nighttime distributions.

Omar, Ali H.↗
DOE OSTI2013

Thinking Tools for Successful Collaborative Initiatives - 13351

Successful collaboration requires effective communication and collective problem solving. Regardless of the subject area --- environmental remediation, waste management, program planning and budgeting --- those involved must focus their efforts in an orderly and cooperative manner. A thinking tool is a technique used to get individuals to focus on specific components of the task at the same time and to eliminate the 'noise' that accompanies communications among individuals with different objectives and different styles of communicating. For example, one of these thinking tools is a technique which enables a working group to delineate its roles, responsibilities and communication protocols so that it can deliver the right information to the right people at the right time. Another enables a group to objectively and collectively evaluate and improve a policy, plan, or program. A third technique enables a group to clarify its purpose and direction while generating interest and buy-in. A fourth technique makes it possible for a group with polarized opinions to acknowledge their differences as well as what they have in common. A fifth technique enables a group to consider a subject of importance from all perspectives so as to produce a more comprehensive and sustainable solution. These thinking tools make effective communication and collective problem solving possible in radioactive waste management and remediation. They can be used by a wide spectrum of professionals including policy specialists, program administrators, program and project managers, and technical specialists. (author)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
NASA NTRS2024

Xplo-SA9T: Optimization of Sorbent Technology With Existing and New Amine Variants for Carbon Dioxide Removal and Humidity Control

Scrubbing of the spacesuit air stream to control humidity and regulate carbon dioxide (CO 2 ) relies on amine-loaded resins, colloquially known as sorbents. The efficacy of Rapid Cycle Amine technology relies on the propensity of nitrogens toward adsorption of CO 2 while simultaneously offering regenerative properties under vacuum or positive pressure. The commonly utilized sorbent, SA9T, was recreated and evaluated further to increase stability and serve as a benchmark comparison for newly synthesized amine sorbent technologies. Ongoing storage studies with eight different environments will allow the development of applicable storage protocols and provide insight into possible ammonia generation pathways. Attempts to alleviate the known issues with SA9T included the alteration of the primary amine (tetraethylenepentamine), the choice of resin, and the particle size distribution. In-house CO 2 breakthrough experiments were conducted using a specialized apparatus that can simulate spacesuit conditions, offering high-quality triplicate capacity analysis affording direct comparison to known adsorbents in the literature. Thermo-Desorption Gas Chromatography Mass Spectrometry studies on the synthesized materials revealed any reagent or solvent offgassing while Nuclear Magnetic Resonance spectroscopy tracked the stability of the bound amine. Scanning Electron Microscope images of sieved materials provided a more accurate size interpretation facilitating synthetic design and pressure drop elimination. All efficient sorbents were synthesized to a commercial batch scale subsequent to evaluation including Xplo-SA9T.

John R Tidwell↗
DOE OSTI2024

Integrated Transmission and Distribution Co-Simulation Platform for Demonstration of Bulk Grid Services Using Distributed Energy Resources

In September 2020, the Federal Energy Regulatory Commission (FERC) released Order 2222, which opens wholesale markets to small-capacity distributed energy resources (DERs), recognizing their potential in improving operational efficiency by providing bulk grid services. Therefore, a co-simulation capability that can connect transmission and distribution (T&D) simulations and evaluate the impacts of DER provision of bulk grid services is needed. In this paper, we present a new integrated T&D co-simulation platform that incorporates T&D system simulators, DER aggregator/group strategies, and a co-simulation coordinator. Industry-standard communication protocols are employed to mimic real-world conditions. Secondary frequency regulation is selected as the representative bulk grid service, and we simulate the responses of DERs to the frequency regulation signals. The simulation results for a solar-rich distribution feeder in Colorado, USA, demonstrate how the T&D co-simulation setup is used to evaluate the contributions of DERs to minimize the bulk grid frequency deviation.

24 POWER TRANSMISSION AND DISTRIBUTION↗
DOE OSTI2017

Chapter 12: Survey Design and Implementation for Estimating Gross Savings Cross-Cutting Protocol. The Uniform Methods Project: Methods for Determining Energy Efficiency Savings for Specific Measures

This chapter presents an overview of best practices for designing and executing survey research to estimate gross energy savings in energy efficiency evaluations. A detailed description of the specific techniques and strategies for designing questions, implementing a survey, and analyzing and reporting the survey procedures and results is beyond the scope of this chapter. So for each topic covered below, readers are encouraged to consult articles and books cited in References, as well as other sources that cover the specific topics in greater depth. This chapter focuses on the use of survey methods to collect data for estimating gross savings from energy efficiency programs.

29 ENERGY PLANNING, POLICY, AND ECONOMY↗
DOE OSTI2015

A whole wilderness of warning: Assessing economic consequences of nuclear releases - 15494

The consequences of the Fukushima Dai-ichi disaster may provide a useful analogue for assessing the consequences of an accident involving the transport of spent nuclear fuel in the United States. An unexamined, to date, aspect of the Fukushima Dai-ichi disaster is the wide disagreement about the economic consequences of the release. There exist a variety of different estimates and different models and methods for performing these estimates, but not a systematic way to address the range of issues such a disaster generated. This paper examines the sources, methods, data, and assumptions used to prepare economic consequence estimates of the disaster. This paper compares and contrasts these estimates and evaluates them for their reliability. The wide dispersion of consequence assessments as defined by various media and agency impact reports in the post-Fukushima era are evidence that such variability does not serve the industry, regulators, government or researchers well. While a protocol exists to gauge the intensity of an incident (INES Scale) no pre-existing methodology exists to measure the various socioeconomic impacts associated with a radiological disaster, be it induced by a natural disaster incident or human initiated. This paper argues that an improved method will be necessary and suggests some parameters for such a method. Nevada has started the dialogue on such a comprehensive methodology (Ballard 2012, Ballard 2014). Despite this effort by a stakeholder, the regulatory agencies involved in nuclear waste shipments in the United States appear reluctant to begin a dialogue about how to address the full range and scope of issues. Resolution of this problem will be a necessary prerequisite to any large scale shipping program. It will be necessary to adopt a standardized methodology to assess consequences of a radiological emergency and incorporate this into the environmental impact statement process for the shipping program. This analytical deficiency should be addressed by these agencies/regulators and in preparation for the potential movement of nuclear waste in the quantities necessary to service the nuclear power industry and to address the existing spent nuclear fuel (SNF) stockpiles across the United States. It will be necessary to demonstrate to stakeholders that the benefits of shipping radioactive substances this dangerous outweigh the costs of a possible accident or terrorist incident. The nuclear energy industry should support funding for these assessment studies in order to provide a basis for discussions about the costs and benefits of the shipments. The studies would provide stakeholders with clarity about the possible consequences of the program. The studies will also assist Japan in its efforts to understand what their disaster means for that country. This paper will begin the dialogue on how such analytical protocols could be constructed to pre-stage the research necessary to assess such consequences. (authors)

12 MANAGEMENT OF RADIOACTIVE AND NON-RADIOACTIVE W↗
NASA NTRS1999

Non-Invasive Assessment of Susceptibility to Ventricular Arrhythmias During Simulated Microgravity

The Cardiovascular Alterations Team is currently conducting studies to determine what alterations in hemodynamic regulation result from sixteen days of simulated microgravity exposure in normal human subjects. In this project we make additional measurements on these same study subjects in order to determine whether there is an increase in susceptibility to ventricular arrhythmias resulting from simulated microgravity exposure. Numerous anecdotal and documented reports from the past 30 years suggest that the incidence of ventricular arrhythmias among astronauts is increased during space flight. For example, documented runs of ventricular tachycardia have been recorded from crew members of Skylab and Mir, there was much attention given by the lay press to Mir Commander Vasily Tslbliyev's complaints of heart rhythm irregularities in July of 1997, and cardiovascular mechanisms may have been causal in the recent death of an experimental primate shortly after return from space. In 1986, a Mir cosmonaut, Alexander Laveikin, was brought home and replaced with an alternate cosmonaut as a result of cardiac dysrhythmias that began during extravehicular activity. Furthermore, at a joint NASA/NSBRI workshop held in January 1998, cardiac arrhythmias were identified as the highest priority cardiovascular risk to a human Mars mission. Despite the evidence for the risk of a potentially lethal arrhythmia resulting from microgravity exposure, the effects of space flight and the associated physiologic stresses on cardiac conduction processes are not known, and an increase in cardiac susceptibility to arrhythmias has never been quantified. In this project, we are determining whether simulated space flight increases the risk of developing life-threatening heart rhythm disturbances such as sustained ventricular tachycardia (defined as ventricular tachycardia lasting at least 30 seconds or resulting in hemodynamic collapse) and ventricular fibrillation. We are obtaining measures of cardiac susceptibility to ventricular arrhythmias in subjects exposed to simulated space flight in the Human Studies Core protocol being conducted by the Cardiovascular Alterations Team, which involves sixteen days .of bed rest. In particular, we are applying a powerful new non-invasive technology, developed in Professor Cohen's laboratory at MIT for the quantitative assessment of the risk of life-threatening ventricular arrhythmias. This technology involves the measurement of microvolt levels of T wave alternans (TWA) during exercise stress, and was recently granted approval by the Food and Drug Administration to be used for the clinical evaluation of patients suspected to be at risk of ventricular arrhythmias. In addition, we are obtaining 24 hour Holter monitoring (to detect non-sustained ventricular tachycardia and to assess heart rate variability). We are also conducting protocols to obtain these same measures on a monthly basis for up to four months in subjects in the Bone Demineralization/calcium Metaboloism Team's long term bed rest study.

Cohen, Richard J.↗
DOE OSTI2015

Super-resolution reconstruction in frequency, image, and wavelet domains to reduce through-plane partial voluming in MRI

Purpose: To compare and evaluate the use of super-resolution reconstruction (SRR), in frequency, image, and wavelet domains, to reduce through-plane partial voluming effects in magnetic resonance imaging. Methods: The reconstruction of an isotropic high-resolution image from multiple thick-slice scans has been investigated through techniques in frequency, image, and wavelet domains. Experiments were carried out with thick-slice T2-weighted fast spin echo sequence on the Academic College of Radiology MRI phantom, where the reconstructed images were compared to a reference high-resolution scan using peak signal-to-noise ratio (PSNR), structural similarity image metric (SSIM), mutual information (MI), and the mean absolute error (MAE) of image intensity profiles. The application of super-resolution reconstruction was then examined in retrospective processing of clinical neuroimages of ten pediatric patients with tuberous sclerosis complex (TSC) to reduce through-plane partial voluming for improved 3D delineation and visualization of thin radial bands of white matter abnormalities. Results: Quantitative evaluation results show improvements in all evaluation metrics through super-resolution reconstruction in the frequency, image, and wavelet domains, with the highest values obtained from SRR in the image domain. The metric values for image-domain SRR versus the original axial, coronal, and sagittal images were PSNR = 32.26 vs 32.22, 32.16, 30.65; SSIM = 0.931 vs 0.922, 0.924, 0.918; MI = 0.871 vs 0.842, 0.844, 0.831; and MAE = 5.38 vs 7.34, 7.06, 6.19. All similarity metrics showed high correlations with expert ranking of image resolution with MI showing the highest correlation at 0.943. Qualitative assessment of the neuroimages of ten TSC patients through in-plane and out-of-plane visualization of structures showed the extent of partial voluming effect in a real clinical scenario and its reduction using SRR. Blinded expert evaluation of image resolution in resampled out-of-plane views consistently showed the superiority of SRR compared to original axial and coronal image acquisitions. Conclusions: Thick-slice 2D T2-weighted MRI scans are part of many routine clinical protocols due to their high signal-to-noise ratio, but are often severely affected by through-plane partial voluming effects. This study shows that while radiologic assessment is performed in 2D on thick-slice scans, super-resolution MRI reconstruction techniques can be used to fuse those scans to generate a high-resolution image with reduced partial voluming for improved postacquisition processing. Qualitative and quantitative evaluation showed the efficacy of all SRR techniques with the best results obtained from SRR in the image domain. The limitations of SRR techniques are uncertainties in modeling the slice profile, density compensation, quantization in resampling, and uncompensated motion between scans.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2015

SU-E-E-12: Validation of the Implementation of Different CT Scanners in Proton Treatment Planning

Purpose: To quantify the impact of the relationship of CT number and Relative Stopping Power (RSP) among different CT-scanners in the evaluation of dose distribution, for different tumor sites and proton therapy modalities like Pencil Beam and Uniform Scanning. Methods: The same tissue characterization phantom was used to analyze the difference in the X-rays energy spectra of 2 CT scanners of the same vendor. One CT is for planning and the other for treatment verification. The Hounsfield unit (HU) variations and associated dosimetric uncertainty were investigated in uniform scanning and pencil beam treatment plans of different sites. At the same time comparisons of the CT calibration curve were done using the same acquisition protocols. The phantom was imaged on a 16 multi-row CT scanner, with energies of 120 and 140 kVp,currents of 263 and 245 mA and slice thickness of 2 and 3mm respectively. The dosimetric uncertainty of the plans was evaluated in a homogeneus phantom comparing DVHs, gamma index criteria 3% 3mm, and range between them. Results: The variation of HU was within the standard deviation of the average for each tissue substitute. The curves fitted with a bilinear interpolation show a maximum deviation in high density materials like cortical bone and solid water, where the HU values deviated more than 0,6% for the 120kVp protocol. For the others curves the deviation was more than 2% for low densities materials. The gamma index uncertainty criteria passed in all the cases. Conclusion: The HU variations for the different scanners were ≤3%. Lower than the 3,5% uncertainties considered in our treatment planning system. The dosimetric analysis shows that the X-ray spectrum has a small effect on the HU-RSP curve, allowing the use of a single tissue characterization curve in our proton treatment planning system for plans verifications.

60 APPLIED LIFE SCIENCES↗