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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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NASA NTRS1994

Determining F-factor using ground-based Doppler radar: Validation and results

Using a two-dimensional linear least-squares method applied to Doppler radar data, we test the viability of determining F-factor remotely. The ultimate application of such an algorithm will be supplying real-time F-factor maps, derived from ground-based Doppler radars to air traffic control personnel and pilots. Data from NASA deployments to the MIT/Lincoln Lab TDWR testbed radar in Orlando in 1991 and 1992 along with NASA deployments to the NCAR TDWR testbed radar in Denver are examined. Preliminary analyses show that the two-dimensional method correlates reasonably well with in situ measurements. Several effects, independent of the method used, act to reduce the correlation to less than one. These include time differences between radar and aircraft data, vertical misalignment between the aircraft and the radar beam, different spatial resolution scales between aircraft and radar data, inhomogeneous radar beam filling, noise in radar data that eludes filtering, and phase lag between time and space due to low pass filtering of the aircraft data. In the final assessment, it appears that a shear-based F-factor algorithm is preferable to the currently implemented TDWR algorithms which lack any local shear estimates.

Elmore, K. L.↗

NASA NTRS1993

Develop advanced nonlinear signal analysis topographical mapping system

The SSME has been undergoing extensive flight certification and developmental testing, which involves some 250 health monitoring measurements. Under the severe temperature pressure, and dynamic environments sustained during operation, numerous major component failures have occurred, resulting in extensive engine hardware damage and scheduling losses. To enhance SSME safety and reliability, detailed analysis and evaluation of the measurements signal are mandatory to assess its dynamic characteristics and operational condition. Efficient and reliable signal detection techniques will reduce catastrophic system failure risks and expedite the evaluation of both flight and ground test data, and thereby reduce launch turn-around time. The basic objective of this contract are threefold: (1) Develop and validate a hierarchy of innovative signal analysis techniques for nonlinear and nonstationary time-frequency analysis. Performance evaluation will be carried out through detailed analysis of extensive SSME static firing and flight data. These techniques will be incorporated into a fully automated system. (2) Develop an advanced nonlinear signal analysis topographical mapping system (ATMS) to generate a Compressed SSME TOPO Data Base (CSTDB). This ATMS system will convert tremendous amounts of complex vibration signals from the entire SSME test history into a bank of succinct image-like patterns while retaining all respective phase information. A high compression ratio can be achieved to allow the minimal storage requirement, while providing fast signature retrieval, pattern comparison, and identification capabilities. (3) Integrate the nonlinear correlation techniques into the CSTDB data base with compatible TOPO input data format. Such integrated ATMS system will provide the large test archives necessary for a quick signature comparison. This study will provide timely assessment of SSME component operational status, identify probable causes of malfunction, and indicate feasible engineering solutions. The final result of this program will yield an ATMS system of nonlinear and nonstationary spectral analysis software package integrated with the Compressed SSME TOPO Data Base (CSTDB) on the same platform. This system will allow NASA engineers to retrieve any unique defect signatures and trends associated with different failure modes and anomalous phenomena over the entire SSME test history across turbo pump families.

Jong, Jen-Yi↗

DOE OSTI2021

New Orthophoto Generation Strategies from UAV and Ground Remote Sensing Platforms for High-Throughput Phenotyping

Remote sensing platforms have become an effective data acquisition tool for digital agriculture. Imaging sensors onboard unmanned aerial vehicles (UAVs) and tractors are providing unprecedented high-geometric-resolution data for several crop phenotyping activities (e.g., canopy cover estimation, plant localization, and flowering date identification). Among potential products, orthophotos play an important role in agricultural management. Traditional orthophoto generation strategies suffer from several artifacts (e.g., double mapping, excessive pixilation, and seamline distortions). The above problems are more pronounced when dealing with mid- to late-season imagery, which is often used for establishing flowering date (e.g., tassel and panicle detection for maize and sorghum crops, respectively). In response to these challenges, this paper introduces new strategies for generating orthophotos that are conducive to the straightforward detection of tassels and panicles. The orthophoto generation strategies are valid for both frame and push-broom imaging systems. The target function of these strategies is striking a balance between the improved visual appearance of tassels/panicles and their geolocation accuracy. The new strategies are based on generating a smooth digital surface model (DSM) that maintains the geolocation quality along the plant rows while reducing double mapping and pixilation artifacts. Moreover, seamline control strategies are applied to avoid having seamline distortions at locations where the tassels and panicles are expected. The quality of generated orthophotos is evaluated through visual inspection as well as quantitative assessment of the degree of similarity between the generated orthophotos and original images. Several experimental results from both UAV and ground platforms show that the proposed strategies do improve the visual quality of derived orthophotos while maintaining the geolocation accuracy at tassel/panicle locations.

54 ENVIRONMENTAL SCIENCES↗

DOE OSTI2020

Predicting 3D Motions from Single-Camera Optical Test Data

In a typical optical test, a stereo camera pair is required to measure the three-dimensional motion of a test article; one camera typically only measures motions in the image plane of the camera, and measurements in the out-of-plane direction are missing. Finite element expansion techniques provide a path to estimate responses from a test at unmeasured degrees of freedom. Treating the case of a single camera as a measurement with unmeasured degrees of freedom, a finite element model is used to expand to the missing third dimension of the image data, allowing a full-field, three-dimensional measurement to be obtained from a set of images from a single camera. The key to this technique relies on the mapping of finite element deformations to image deformations, creating a set of mode shape images that are used to filter the response in the image into modal responses. These modal responses are then applied to the finite element model to estimate physical responses at all finite element model degrees of freedom. The mapping from finite element model to image is achieved using synthetic images produced by a rendering software. Finally, the technique is applied first to a synthetic deformation image, and then is validated using an experimental set of images.

47 OTHER INSTRUMENTATION↗

DOE OSTI2026

Correlation of Surface Acoustic Wave (SAW) force myography sensor output with elbow joint torque

Accurate assessment of skeletal muscle forces and net joint torque is essential for preventing fatigue-related injuries, optimizing physical training, and monitoring disease progression in neuromuscular conditions. However, existing joint torque evaluation techniques are hindered by limited portability and high operational costs, confining their use to controlled laboratory or clinical settings. Despite substantial advances in wearable joint torque estimation systems, ongoing challenges such as power constraints, bulky wired setups, and susceptibility to environmental or motion artifacts underscore the urgent need for truly batteryless, wireless solutions deployable in real-world settings. This paper proposes a novel surface acoustic wave (SAW)-based force myography (FMG) system for noninvasive measurement of joint torque, validated against a gold-standard electromechanical dynamometer. The approach uses a single SAW sensor embedded in an armband to detect volumetric biceps brachii changes, with a second-order polynomial mapping sensor output and elbow angle to torque. Seven participants were tested in both isometric (15°–90°) and isokinetic (10°/s and 20°/s) supinated elbow flexion tasks. Under isometric conditions, subject-specific calibration achieved a normalized root-mean-square error (NRMSE) of 13.6% ± 6.0% and R 2 = 0.834 ± 0.180, while a group-level model yielded 14.4% ± 6.8% and 0.808 ± 0.208, respectively. For isokinetic trials, the group model produced an NRMSE of 24.1% ± 6.6% at 10°/s and 24.9% ± 08.9% at 20°/s, highlighting the feasibility of using a single-sensor SAW-FMG setup across different speeds. Because SAW devices support wireless, battery-free operation, the proposed system offers a pathway to portable, real-time monitoring for sports medicine, rehabilitation, and clinical diagnostics.

36 MATERIALS SCIENCE↗

DOE OSTI2011

Poisson-Boltzmann-Nernst-Planck model

The Poisson-Nernst-Planck (PNP) model is based on a mean-field approximation of ion interactions and continuum descriptions of concentration and electrostatic potential. It provides qualitative explanation and increasingly quantitative predictions of experimental measurements for the ion transport problems in many areas such as semiconductor devices, nanofluidic systems, and biological systems, despite many limitations. While the PNP model gives a good prediction of the ion transport phenomenon for chemical, physical, and biological systems, the number of equations to be solved and the number of diffusion coefficient profiles to be determined for the calculation directly depend on the number of ion species in the system, since each ion species corresponds to one Nernst-Planck equation and one position-dependent diffusion coefficient profile. In a complex system with multiple ion species, the PNP can be computationally expensive and parameter demanding, as experimental measurements of diffusion coefficient profiles are generally quite limited for most confined regions such as ion channels, nanostructures and nanopores. We propose an alternative model to reduce number of Nernst-Planck equations to be solved in complex chemical and biological systems with multiple ion species by substituting Nernst-Planck equations with Boltzmann distributions of ion concentrations. As such, we solve the coupled Poisson-Boltzmann and Nernst-Planck (PBNP) equations, instead of the PNP equations. The proposed PBNP equations are derived from a total energy functional by using the variational principle. We design a number of computational techniques, including the Dirichlet to Neumann mapping, the matched interface and boundary, and relaxation based iterative procedure, to ensure efficient solution of the proposed PBNP equations. Two protein molecules, cytochrome c551 and Gramicidin A, are employed to validate the proposed model under a wide range of bulk ion concentrations and external voltages. Extensive numerical experiments show that there is an excellent consistency between the results predicted from the present PBNP model and those obtained from the PNP model in terms of the electrostatic potentials, ion concentration profiles, and current-voltage (I-V) curves. The present PBNP model is further validated by a comparison with experimental measurements of I-V curves under various ion bulk concentrations. Numerical experiments indicate that the proposed PBNP model is more efficient than the original PNP model in terms of simulation time.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

DOE OSTI2017

Scidac-Data: Enabling Data Driven Modeling of Exascale Computing

Here, the SciDAC-Data project is a DOE-funded initiative to analyze and exploit two decades of information and analytics that have been collected by the Fermilab data center on the organization, movement, and consumption of high energy physics (HEP) data. The project analyzes the analysis patterns and data organization that have been used by NOvA, MicroBooNE, MINERvA, CDF, D0, and other experiments to develop realistic models of HEP analysis workflows and data processing. The SciDAC-Data project aims to provide both realistic input vectors and corresponding output data that can be used to optimize and validate simulations of HEP analysis. These simulations are designed to address questions of data handling, cache optimization, and workflow structures that are the prerequisites for modern HEP analysis chains to be mapped and optimized to run on the next generation of leadership-class exascale computing facilities. We present the use of a subset of the SciDAC-Data distributions, acquired from analysis of approximately 71,000 HEP workflows run on the Fermilab data center and corresponding to over 9 million individual analysis jobs, as the input to detailed queuing simulations that model the expected data consumption and caching behaviors of the work running in high performance computing (HPC) and high throughput computing (HTC) environments. In particular we describe how the Sequential Access via Metadata (SAM) data-handling system in combination with the dCache/Enstore-based data archive facilities has been used to develop radically different models for analyzing the HEP data. We also show how the simulations may be used to assess the impact of design choices in archive facilities.

97 MATHEMATICS AND COMPUTING↗

DOE OSTI2021

Accelerated Creep Testing of Inconel 718 Using the Stepped Isostress Method (SSM)

This paper demonstrates the stepped isostress method (SSM); an accelerated creep test (ACT) for the rapid assessment of metallic materials. The SSM test is based on the time-temperature-stress superposition principle (TTSSP) where temperature and/or stress are step increased to accelerate the time-to-rupture. The SSM test has proven successful for the ACT of polymers and polymeric composites but has yet to be proven for metallic materials. In this study, new test matrix design rules for the SSM of metals are established based on deformation mechanism, time-temperature transformation, and time-temperature precipitation maps. A test matrix of SSM and conventional creep tests (CCTs) are executed for alloy Inconel 718 at 750°C (1382°F) with stress levels ranging from 100 to 350 MPa. Validation CCT data is gathered from the Japan National Institute of Material Science (NIMS). Material constants for the Sine-hyperbolic (Sinh) constitutive model are calibrated using the SSM data and employed to predict the conventional creep response. Here, when blindly compared to the CCT data, the SSM calibrated Sinh model can accurately predict the conventional creep response across logarithmic decades and thus accelerate the capture of conventional creep data. Fractography indicates ductile fracture by transgranular microvoid coalescence (TMVC) with the same fracture mode observed in both SSM and CCT specimens. Creep cavitation is indicated by the population, smoothness, and size of microvoids.

36 MATERIALS SCIENCE↗

NASA NTRS1990

A3I visibility modeling project

The Army-NASA Aircrew Aircraft Integration program is supporting a joint project to build a visibility computer-aided design (CAD) tool. CAD has become an essential tool in modern engineering applications. CAD tools are used to create engineering drawings and to evaluate potential designs before they are physically realized. The visibility CAD tool will provide the design engineer with a tool to aid in the location and specification of windows, displays, and control in crewstations. In an aircraft cockpit the location of instruments and the emissive and reflective characteristics of the surfaces must be determined to assure adequate aircrew performance. The visibility CAD tool will allow the designer to ask and answer many of these questions in the context of a three-dimensional graphical representation of the cockpit. The graphic representation of the cockpit is a geometrically valid model of the cockpit design. A graphic model of a pilot, called the pilot manikin, can be placed naturalistically in the cockpit model. The visibility tool has the capability of mapping the cockpit surfaces and other objects modeled in this graphic design space onto the simulated pilot's retinas for a given visual fixation.

Larimer, James↗

NASA NTRS1992

Correction techniques for depth errors with stereo three-dimensional graphic displays

Three-dimensional (3-D), 'real-world' pictorial displays that incorporate 'true' depth cues via stereopsis techniques have proved effective for displaying complex information in a natural way to enhance situational awareness and to improve pilot/vehicle performance. In such displays, the display designer must map the depths in the real world to the depths available with the stereo display system. However, empirical data have shown that the human subject does not perceive the information at exactly the depth at which it is mathematically placed. Head movements can also seriously distort the depth information that is embedded in stereo 3-D displays because the transformations used in mapping the visual scene to the depth-viewing volume (DVV) depend intrinsically on the viewer location. The goal of this research was to provide two correction techniques; the first technique corrects the original visual scene to the DVV mapping based on human perception errors, and the second (which is based on head-positioning sensor input data) corrects for errors induced by head movements. Empirical data are presented to validate both correction techniques. A combination of the two correction techniques effectively eliminates the distortions of depth information embedded in stereo 3-D displays.

Parrish, Russell V.↗

NASA NTRS1994

Evolution of Southern Hemisphere spring air masses observed by HALOE

The evolution of Southern Hemisphere air masses observed by the Halogen Occultation Experiment (HALOE) during September 21 through October 15, 1992, is investigated using isentropic trajectories computed from United Kingdom Meteorological Office (UKMO) assimilated winds and temperatures. Maps of constituent concentrations are obtained by accumulation of air masses from previous HALOE occultations. Lagged correlations between initial and subsequent HALOE observations of the same air mass are used to validate the air mass trajectories. High correlations are found for lag times as large as 10 days. Frequency distributions of the air mass constituent concentrations are used to examine constituent distributions in and around the Southern Hemisphere polar vortex.

Pierce, R. Bradley↗

NASA NTRS1987

Logistic Risk Model for the Unique Effects of Inherent Aerobic Capacity on (+)G(sub z) Tolerance Before and After Simulated Weightlessness

Small sample size (n less than 1O) and inappropriate analysis of multivariate data have hindered previous attempts to describe which physiologic and demographic variables are most important in determining how long humans can tolerate acceleration. Data from previous centrifuge studies conducted at NASA/Ames Research Center, utilizing a 7-14 d bed rest protocol to simulate weightlessness, were included in the current investigation. After review, data on 25 women and 22 men were available for analysis. Study variables included gender, age, weight, height, percent body fat, resting heart rate, mean arterial pressure, Vo(sub 2)max and plasma volume. Since the dependent variable was time to greyout (failure), two contemporary biostatistical modeling procedures (proportional hazard and logistic discriminant function) were used to estimate risk, given a particular subject's profile. After adjusting for pro-bed-rest tolerance time, none of the profile variables remained in the risk equation for post-bed-rest tolerance greyout. However, prior to bed rest, risk of greyout could be predicted with 91% accuracy. All of the profile variables except weight, MAP, and those related to inherent aerobic capacity (Vo(sub 2)max, percent body fat, resting heart rate) entered the risk equation for pro-bed-rest greyout. A cross-validation using 24 new subjects indicated a very stable model for risk prediction, accurate within 5% of the original equation. The result for the inherent fitness variables is significant in that a consensus as to whether an increased aerobic capacity is beneficial or detrimental has not been satisfactorily established. We conclude that tolerance to +Gz acceleration before and after simulated weightlessness is independent of inherent aerobic fitness.

Ludwig, David A.↗

NASA NTRS2006

An Assessment of NASA Glenn's Aeroacoustic Experimental and Predictive Capabilities for Installed Cooling Fans: Aerodynamic Performance - Part 1

Driven by the need for low production costs, electronics cooling fans have evolved differently than the bladed components of gas turbine engines which incorporate multiple technologies to enhance performance and durability while reducing noise emissions. Drawing upon NASA Glenn's experience in the measurement and prediction of gas turbine engine aeroacoustic performance, tests have been conducted to determine if these tools and techniques can be extended for application to the aerodynamics and acoustics of electronics cooling fans. An automated fan plenum installed in NASA Glenn's Acoustical Testing Laboratory was used to map the overall aerodynamic and acoustic performance of a spaceflight qualified 80 mm diameter axial cooling fan. In order to more accurately identify noise sources, diagnose performance limiting aerodynamic deficiencies, and validate noise prediction codes, additional aerodynamic measurements were recorded for two operating points: free delivery and a mild stall condition. Non-uniformities in the fan s inlet and exhaust regions captured by Particle Image Velocimetry measurements, and rotor blade wakes characterized by hot wire anemometry measurements provide some assessment of the fan aerodynamic performance. The data can be used to identify fan installation/design changes which could enlarge the stable operating region for the fan and improve its aerodynamic performance and reduce noise emissions.

VanZante, Dale E.↗

DOE OSTI2016

SciDAC-Data, A Project to Enabling Data Driven Modeling of Exascale Computing

The SciDAC-Data project is a DOE funded initiative to analyze and exploit two decades of information and analytics that have been collected by the Fermilab Data Center on the organization, movement, and consumption of High Energy Physics data. The project will analyze the analysis patterns and data organization that have been used by the NOvA, MicroBooNE, MINERvA and other experiments, to develop realistic models of HEP analysis workflows and data processing. The SciDAC-Data project aims to provide both realistic input vectors and corresponding output data that can be used to optimize and validate simulations of HEP analysis. These simulations are designed to address questions of data handling, cache optimization and workflow structures that are the prerequisites for modern HEP analysis chains to be mapped and optimized to run on the next generation of leadership class exascale computing facilities. We will address the use of the SciDAC-Data distributions acquired from Fermilab Data Center’s analysis workflows and corresponding to around 71,000 HEP jobs, as the input to detailed queuing simulations that model the expected data consumption and caching behaviors of the work running in HPC environments. In particular we describe in detail how the Sequential Access via Metadata (SAM) data handling system in combination with the dCache/Enstore based data archive facilities have been analyzed to develop the radically different models of the analysis of HEP data. We present how the simulation may be used to analyze the impact of design choices in archive facilities.

Mubarak, M.↗

DOE OSTI2019

Magnetic Field Mapper

The scientific program at the Integrable Optics Test Accelerator (IOTA) ring depends on a wide variety of specialized magnets, and validation of their field quality is important for ensuring proper performance. A number of these magnetic elements have both high field quality and a small physical aperture, and adequate field-mapping solutions have not been readily available in house or with external vendors. To solve this problem, a new magnetic-field mapping device needs to be developed. This new system features a high-precision tesla-meter, with a low-profile three-axis Hall probe, and stepper motors to allow for high-speed, accurate positioning of the probe. This new Magnetic Field Mapper (MFM), shown in Figure 1, will be capable of quickly mapping a wide variety of magnets to high precision, thus eliminating the need to send magnets off-site for expensive and time-consuming mapping.

43 PARTICLE ACCELERATORS↗

NASA NTRS2000

LIS Validation at The KSC-ER

Each year, thousands of lightning electric field disturbances are recorded and archived by the ground-based field mill (FM) network at the NASA Kennedy Space Center (KSC) and USAF Eastern Range (ER). The FM network has a range of several tens of kilometers, and a digital accuracy of 4 V/m. It has provided years of continuous lightning warning surveillance to KSC-ER space vehicle launch operations, and has undergone one major hardware upgrade since its inception in the early 1970s. Additional KSC lightning warning data is derived from a multistation radio time-of-arrival system called Lightning Detection and Ranging (LDAR). This system provides the location and space-time mapping of individual lightning channels (for both cloud and ground flashes). Additional lightning information for the KSC region is available from the National Lightning Detection Network (NLDN) and a 5-station local magnetic direction finder network. In this study, all of the above mentioned data are used to ground-validate data derived from the Lightning Imaging Sensor (LIS) onboard the Tropical Rainfall Measuring Mission (TRMM). The FM network can be used to retrieve the charges deposited in a lightning flash, provided the flash is within a few kilometers of the FM Network. Although it is rare to obtain a TRMM overpass of thunderstorms hat occur this close to the FM network, seven such storms have been found and examined in this study. We compare the times and locations of LIS optical pulses with the spatial-temporal character of the FM, LDAR, and magnetic direction finder data. We also inter-compare LIS optical pulse amplitude data with FM-derived charge magnitudes, number of LDAR radio sources, and peak current values from magnetic direction finder data. Generally speaking, LIS lightning locations and times agree favorably with the KSC ground-based systems for most cases, but little correlation appears to exist between optical pulse amplitude and any of charge, # LDAR sources, peak current), owing possibly to the effects of source complexity and/or cloud multiple scattering.

Koshak, William J.↗

NASA NTRS1994

Develop advanced nonlinear signal analysis topographical mapping system

The Space Shuttle Main Engine (SSME) has been undergoing extensive flight certification and developmental testing, which involves some 250 health monitoring measurements. Under the severe temperature, pressure, and dynamic environments sustained during operation, numerous major component failures have occurred, resulting in extensive engine hardware damage and scheduling losses. To enhance SSME safety and reliability, detailed analysis and evaluation of the measurements signal are mandatory to assess its dynamic characteristics and operational condition. Efficient and reliable signal detection techniques will reduce catastrophic system failure risks and expedite the evaluation of both flight and ground test data, and thereby reduce launch turn-around time. The basic objective of this contract are threefold: (1) develop and validate a hierarchy of innovative signal analysis techniques for nonlinear and nonstationary time-frequency analysis. Performance evaluation will be carried out through detailed analysis of extensive SSME static firing and flight data. These techniques will be incorporated into a fully automated system; (2) develop an advanced nonlinear signal analysis topographical mapping system (ATMS) to generate a Compressed SSME TOPO Data Base (CSTDB). This ATMS system will convert tremendous amount of complex vibration signals from the entire SSME test history into a bank of succinct image-like patterns while retaining all respective phase information. High compression ratio can be achieved to allow minimal storage requirement, while providing fast signature retrieval, pattern comparison, and identification capabilities; and (3) integrate the nonlinear correlation techniques into the CSTDB data base with compatible TOPO input data format. Such integrated ATMS system will provide the large test archives necessary for quick signature comparison. This study will provide timely assessment of SSME component operational status, identify probable causes of malfunction, and indicate feasible engineering solutions. The final result of this program will yield an ATMS system of nonlinear and nonstationary spectral analysis software package integrated with the Compressed SSME TOPO Data Base (CSTDB) on the same platform. This system will allow NASA engineers to retrieve any unique defect signatures and trends associated with different failure modes and anomalous phenomena over the entire SSME test history across turbo pump families.

Source record↗

DOE OSTI2014

SU-E-T-20: A Novel Hybrid CBCT, Bioluminescence and Fluorescence Tomography System for Preclinical Radiation Research

Purpose: A novel standalone bioluminescence and fluorescence tomography (BLT and FT) system equipped with high resolution CBCT has been built in our group. In this work, we present the system calibration method and validate our system in both phantom and in vivo environment. Methods: The CBCT is acquired by rotating the animal stage while keeping the x-ray source and detector panel static. The optical signal is reflected by the 3-mirror system to a multispectral filter set and then delivered to the CCD camera with f/1.4 lens mounted. Nine fibers passing through the stage and in contact with the mouse skin serve as the light sources for diffuse optical tomography (DOT) and FT. The anatomical information and optical properties acquired from the CBCT and DOT, respectively, are used as the priori information to improve the BLT/FT reconstruction accuracy. Flat field correction for the optical system was acquired at multiple wavelengths. A home-built phantom is used to register the optical and CBCT coordinates. An absolute calibration relating the CCD photon counts rate to the light fluence rate emitted at animal surface was developed to quantify the bioluminescence power or fluorophore concentration. Results: An optical inhomogeneous phantom with 2 light sources (3mm separation) imbedded is used to test the system. The optical signal is mapped onto the mesh generated from CBCT for optical reconstruction. Our preliminary results show that the center of mass can be reconstructed within 2.8mm accuracy. A live mouse with the light source imbedded is also used to validate our system. Liver or lung metastatic luminescence tumor model will be used for further testing. Conclusion: This hybrid system transforms preclinical research to a level that even sub-palpable volume of cells can be imaged rapidly and non-invasively, which largely extends the scope of radiobiological research. The research is supported by the NCI grant R01CA158100-01.

60 APPLIED LIFE SCIENCES↗