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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 109 records · Page 6
All sourcesNASA NTRSDOE OSTI
DOE OSTI2016

WE-FG-BRA-10: Radiodosimetry of a Novel Alpha Particle Therapy Targeted to Uveal Melanoma: Absorbed Dose to Organs in Mice

Purpose: The melanocortin-1 receptor (MC1R) is expressed in 94% of uveal melanomas and is described as an ideal target for this untreatable disease. MC1RL is a high affinity MC1R specific peptidomimetic ligand that can serve as a scaffold for therapeutic conjugates such as alpha particle emitting isotopes. The purpose of this study was to assess normal tissue distribution and risk as a result of using the DOTA chelator conjugated to MC1RL to deliver {sup 225}Ac: MC1RL-DOTA-{sup 225}Ac. Methods: 17 non-tumor bearing BALB/c mice were intravenously injected with the novel MC1RL-DOTA-{sup 225}Ac radiopharmaceutical with an average initial administered activity of 2.5 µCi. After the injection, three groups of animals (6, 6, and 5 per group) were euthanized at 24, 48, and 96 hour time points. A total of 11 organs of interest were harvested at each time point including kidneys and liver. Since the emitted alpha particles from {sup 225}Ac and its daughter products are not easy to detect directly, the isomeric gamma spectra were measured instead in the tissue samples using a modified Atomlab™ Gamma Counter (Biodex Medical Systems, Inc) and converted using factors for gamma ray abundance per alpha decay. Dosimetry was performed using measured radioactivity distribution in organs and the generalized internal dosimetry schema of MIRD pamphlet #21. Results: Our calculations have shown that the maximum absorbed dose was delivered to the liver with a total of 47 cGy per 96 hour period. The average dose per kidney was calculated to be 21 cGy. Heart, brain, lung, spleen, skin doses ranged from 0.01 to 1 cGy over the same time period. All animals gained weight over the 110 day decay period and no organ damage was observed by pathology. Conclusion: Based on our results, the risk of using the MC1RL-DOTA-{sup 225}Ac compound is relatively small in terms of deterministic radiation effects. Funding Support: NIH/NCI P50CA168536-03 Skin SPORE; NIH/NCI Phase I SBIR Contract #HHSN261201500067C; Imaging and Technology Center of Excellence at Moffitt. Disclosures and Conflict of Interest: Collaboration with Modulation Therapeutics, Inc.(MTI) and has been partially funded by sub-contracts from MTI via collaboration on a NIH/NCI phase I SBIR contract.

60 APPLIED LIFE SCIENCES↗
NASA NTRS2001

Gene amplification and microsatellite instability induced in tumorigenic human bronchial epithelial cells by alpha particles and heavy ions

Gene amplification and microsatellite alteration are useful markers of genomic instability in tumor and transformed cell lines. It has been suggested that genomic instability contributes to the progression of tumorigenesis by accumulating genetic changes. In this study, amplification of the carbamyl-P-synthetase, aspartate transcarbamylase, dihydro-orotase (CAD) gene in transformed and tumorigenic human bronchial epithelial (BEP2D) cells induced by either alpha particles or (56)Fe ions was assessed by measuring resistance to N-(phosphonacetyl)-l-aspartate (PALA). In addition, alterations of microsatellite loci located on chromosomes 3p and 18q were analyzed in a series of primary and secondary tumor cell lines generated in nude mice. The frequency of PALA-resistant colonies was 1-3 x 10(-3) in tumor cell lines, 5-8 x 10(-5) in transformed cells prior to inoculation into nude mice, and less than 10(-7) in control BEP2D cells. Microsatellite alterations were detected in all 11 tumor cell lines examined at the following loci: D18S34, D18S363, D18S877, D3S1038 and D3S1607. No significant difference in either PALA resistance or microsatellite instability was found in tumor cell lines that were induced by alpha particles compared to those induced by (56)Fe ions.

Non-NASA Center↗
DOE OSTI2021

Collective Analysis of Alpha Particle Losses Due to Self-Absorption by Mass Loading on Radioactive Particulate Glass Fiber Filters

In this study, we derived a relationship between filter mass loading and the percent loss during analysis using the mass loading data collected from six previous studies of self-absorption. Components of mass loading include particulate dust, radioactive particulates, and filter material. In a research report published in 1984, Higby calculated a minimum burial depth for an alpha particle to be lost due to absorption (100% loss) of about 3.7 mg/cm 2 based on calculations for the range of 239-Pu alpha particles in glass fiber filters. From there, Higby concluded that a correction factor of 0.85 assumes approximately 15% losses in the count rate of both alpha and beta particles. In 2000, Luetzelschwab et al. recommended assuming a 40% loss at a loading of 3.3 mg/cm 2 and a 28% loss for a loading of 2.3 mg/cm 2 which included the frontal face mass of the filter. More recently, the 100% losses due to absorption were reported to be in the 10 mg/cm 2 range. Presented here is a trinomial relationship method of relating percent loss due to self-absorption to filter mass loading, based on data reported by Higby, Luetzelschwab et al., Huang et al., Barnett et al., Smith et al., and Hogue et al. Under normal operating conditions at the stacks monitored by Effluent Management, the mass loading of sample filters averages 0.09 ± 0.12 (2s) mg/cm 2 (excluding negative values and outliers) and ranges from 0 mg/cm 2 to 0.24 mg/cm 2 . Based on current mass loading results for Effluent Management stack sample filters, the forced-zero trinomial relationship method estimated self-absorption losses of less than 5%. Because American National Standards Institute/Health Physics Society N13.1-2011 guidelines indicate a correction factor should be used when the penetration of radioactive material into the collection media or self-absorption of radiation by the material collected would reduce the count rate by more than 5%, it is possible continued application of a correction factor to the Effluent Management stack samples is no longer necessary. Nevertheless, continuing to assign a correction factor at the 5% threshold (i.e., 0.95) would be a conservative approach.

36 MATERIALS SCIENCE↗
NASA NTRS1962

Effect of Alpha-Particle Irradiation on Brain Glycogen in the Rat

The studies of Klatzo, Miquel, Tobias and Haymaker (1961) have shown that one of the earliest and most sensitive indications of the effects of alpha-particle irradiation on rat bran is the appearance of glycogen granules mainly in the neuroglia of the exposed area of the brain. Periodic acid-Schiff (PAS) positive, alpha-amylase soluble granules were demonstrated within 12 hr after irradiation, preceding by approximately 36 hr the first microscopically detectable vascular permeability disturbances, as shown by the fluorescein labeled serum protein technique. These studies suggested that the injurious effects of alpha-particle energy were on cellular elements primarily, according to the physical properties and distribution of the radiation in the tissue, and that the vascular permeability disturbances played a secondary role in pathogenesis. The purpose of this study was to correlate the histochemical observations on glycogen with a quantitative assessment of the glycogen in the irradiated brain tissue. It is felt that such a study may contribute to the understanding of radiation injury at the molecular level. A practical aspect of this problem is that the information on biological radiation effects due to accelerated particles from the cyclotron source, is employed in this study, is applicable to radiation from cosmic particles both in free space and entrapped in the Van Allen belts.

Wolfe, L. S.↗
DOE OSTI2015

DISSIPATION OF PARALLEL AND OBLIQUE ALFVÉN-CYCLOTRON WAVES—IMPLICATIONS FOR HEATING OF ALPHA PARTICLES IN THE SOLAR WIND

We perform 2.5D hybrid simulations with massless fluid electrons and kinetic particle-in-cell ions to study the temporal evolution of ion temperatures, temperature anisotropies, and velocity distribution functions in relation to the dissipation and turbulent evolution of a broadband spectrum of parallel and obliquely propagating Alfvén-cyclotron waves. The purpose of this paper is to study the relative role of parallel versus oblique Alfvén-cyclotron waves in the observed heating and acceleration of alpha particles in the fast solar wind. We consider collisionless homogeneous multi-species plasma, consisting of isothermal electrons, isotropic protons, and a minor component of drifting α particles in a finite-β fast stream near the Earth. The kinetic ions are modeled by initially isotropic Maxwellian velocity distribution functions, which develop nonthermal features and temperature anisotropies when a broadband spectrum of low-frequency nonresonant, ω ≤ 0.34 Ω{sub p}, Alfvén-cyclotron waves is imposed at the beginning of the simulations. The initial plasma parameter values, such as ion density, temperatures, and relative drift speeds, are supplied by fast solar wind observations made by the Wind spacecraft at 1 AU. The imposed broadband wave spectra are left-hand polarized and resemble Wind measurements of Alfvénic turbulence in the solar wind. The imposed magnetic field fluctuations for all cases are within the inertial range of the solar wind turbulence and have a Kraichnan-type spectral slope α = −3/2. We vary the propagation angle from θ = 0° to θ = 30° and θ = 60°, and find that the heating of alpha particles is most efficient for the highly oblique waves propagating at 60°, whereas the protons exhibit perpendicular cooling at all propagation angles.

79 ASTRONOMY AND ASTROPHYSICS↗
NASA NTRS1988

Downstream energetic proton and alpha particles during quasi-parallel interplanetary shock events

This paper considers the energetic particle populations in the downstream region of three quasi-parallel interplanetary shock events, which was explored using the ISEE 3 Ultra Low Energy Charge Analyzer sensor, which unambiguously identifies protons and alpha particles using the electrostatic deflection versus residual energy technique. The downstream particles were found to exhibit anisotropies due largely to convection in the solar wind. The spectral indices of the proton and the alpha-particle distribution functions were found to be remarkably constant during the downstream period, being generally insensitive to changes in particle flux levels, magnetic field direction, and solar wind densities. In two of the three events, the proton and the alpha spectra were the same throughout the entire downstream period, supporting the prediction of diffusive shock acceleration theory.

Tan, L. C.↗
NASA NTRS1992

Hit rates and radiation doses to nuclei of bone lining cells from alpha-particle-emitting radionuclides

Factors relating the local concentration of a bone-seeking alpha-particle emitter to the mean hit rate have been determined for nuclei of bone lining cells using a Monte Carlo procedure. Cell nuclei were approximated by oblate spheroids with dimensions and location taken from a previous histomorphometric study. The Monte Carlo simulation is applicable for planar and diffuse labels at plane or cylindrical bone surfaces. Additionally, the mean nuclear dose per hit, the dose mean per hit, the mean track segment length and its second moment, the percentage of stoppers, and the frequency distribution of the dose have been determined. Some basic features of the hit statistics for bone lining cells have been outlined, and the consequences of existing standards of radiation protection with regard to the hit frequency to cell nuclei are discussed.

NASA Discipline Musculoskeletal↗
NASA NTRS1996

AlfvWaves, Alpha Particles, and Pickup Ions in the Solar Wind

The alpha particles at high latitudes are traveling significantly faster than the effective wave speed, unlike the in-ecliptic situation and the discrepancy between effective wave speed and the Alfvspeed calculated with all known corrections is also larger than in the ecliptic.

amplitude of velocity fluctuations amplitude of fi↗
NASA NTRS1972

Alpha-particle spectrometer experiment

Mapping the radon emanation of the moon was studied to find potential areas of high activity by detection of radon isotopes and their daughter products. It was felt that based on observation of regions overflown by Apollo spacecraft and within the field of view of the alpha-particle spectrometer, a radon map could be constructed, identifying and locating lunar areas of outgassing. The basic theory of radon migration from natural concentrations of uranium and thorium is discussed in terms of radon decay and the production of alpha particles. The preliminary analysis of the results indicates no significant alpha emission.

Gorenstein, P.↗
NASA NTRS1995

Non-gyrotropic proton and alpha-particle velocity distributions in the solar wind: TAUS observations and stability analysis

Ion velocity distribution functions have been measured with high time resolution by the TAUS plasma instrument on the PHOBOS mission to Mars in 1989. The unambiguous separation of protons and alpha-particles by TAUS enabled us to study the nonthermal features of their distributions separately and to analyze the stability of the distributions against excitation of waves in the cyclotron-frequency domain. Typical nonthermal features include temperature anisotropies, with T(sub perpendicular) larger than T(sub parallel), and ion beam populations drifting along the local magnetic field direction. Also, distinctly non-gyrotropic alpha-particle velocity distributions were sometimes found. Non-gyrotropy strongly changes the wave dispersion and gives rise to new growing modes, related to the coupling of the standard wave modes existing in gyrotropic plasma. It is found that for the measured non-gyrotropic ion distributions the right-hand polarized wave can also be excited by a temperature anistropy instead of the usual beam drift.

Astudillo, H. F.↗
DOE OSTI2013

Search for {alpha}-states in {sup 13}C via elastic resonant scattering of {alpha} particles on {sup 9}Be

We will discuss new experimental data concerning the elastic resonant scattering of {alpha}-particles on {sup 9}Be nuclei at bombarding energies from 3.5 MeV up to 9.9 MeV. Several excitation functions have been obtained at different polar angles, mainly in the backward hemisphere in the centre of mass frame. Excitation functions show various anomalies that can be linked to the presence of various excited states in the {sup 13}C compound nucleus. In the literature, some of these states have been proposed to belong to rotational bands built on deformed a-cluster excited state. Unfortunately, up to date the spin-parity assignment of many of these states is doubtful. The set of excitation functions we obtained from the present experiment can contribute to improve spectroscopy of highling excited states of {sup 13}C.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗