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NASA NTRS1997

Vibrational force alters mRNA expression in osteoblasts

Serum-deprived mouse osteoblastic (MC3T3E1) cells were subjected to a vibrational force modeled by NASA to simulate a space shuttle launch (7.83 G rms). The mRNA levels for eight genes were investigated to determine the effect of vibrational force on mRNA expression. The mRNA levels of two growth-related protooncogenes, c-fos and c-myc, were up-regulated significantly within 30 min after vibration, whereas those of osteocalcin as well as transforming growth factor-beta1 were decreased significantly within 3 h after vibration. No changes were detected in the levels of beta-actin, histone H4, or cytoplasmic phospholipase A2 after vibration. No basal levels of cyclooxygenase-2 expression were detected. In addition, the extracellular concentrations of prostaglandin E2 (PGE2), a potent autocrine/paracrine growth factor in bone, were not significantly altered after vibration most likely due to the serum deprivation state of the osteoblasts. In comparison with the gravitational launch profile, vibrational-induced changes in gene expression were greater both in magnitude and number of genes activated. Taken together, these data suggest that the changes in mRNA expression are due to a direct mechanical effect of the vibrational force on the osteoblast cells and not to changes in the local PGE2 concentrations. The finding that launch forces induce gene expression is of utmost importance since many of the biological experiments do not dampen vibrational loads on experimental samples. This lack of dampening of vibrational forces may partially explain why 1-G onboard controls sometimes do not reflect 1-G ground controls. These data may also suggest that scientists use extra ground controls that are exposed to launch forces, have these forces dampened on launched samples, or use facilities such as Biorack that provide an onboard 1-G centrufuge in order to control for space shuttle launch forces.

NASA Discipline Cell Biology↗

NASA NTRS2003

Modeling beta-adrenergic control of cardiac myocyte contractility in silico

The beta-adrenergic signaling pathway regulates cardiac myocyte contractility through a combination of feedforward and feedback mechanisms. We used systems analysis to investigate how the components and topology of this signaling network permit neurohormonal control of excitation-contraction coupling in the rat ventricular myocyte. A kinetic model integrating beta-adrenergic signaling with excitation-contraction coupling was formulated, and each subsystem was validated with independent biochemical and physiological measurements. Model analysis was used to investigate quantitatively the effects of specific molecular perturbations. 3-Fold overexpression of adenylyl cyclase in the model allowed an 85% higher rate of cyclic AMP synthesis than an equivalent overexpression of beta 1-adrenergic receptor, and manipulating the affinity of Gs alpha for adenylyl cyclase was a more potent regulator of cyclic AMP production. The model predicted that less than 40% of adenylyl cyclase molecules may be stimulated under maximal receptor activation, and an experimental protocol is suggested for validating this prediction. The model also predicted that the endogenous heat-stable protein kinase inhibitor may enhance basal cyclic AMP buffering by 68% and increasing the apparent Hill coefficient of protein kinase A activation from 1.0 to 2.0. Finally, phosphorylation of the L-type calcium channel and phospholamban were found sufficient to predict the dominant changes in myocyte contractility, including a 2.6x increase in systolic calcium (inotropy) and a 28% decrease in calcium half-relaxation time (lusitropy). By performing systems analysis, the consequences of molecular perturbations in the beta-adrenergic signaling network may be understood within the context of integrative cellular physiology.

Non-NASA Center↗

NASA NTRS1990

Intraseasonal oscillations in the extratropics - Hopf bifurcation and topographic instabilities

A potential vorticity model in a beta-channel is used to analyze the resonant response of equivalent-barotropic flow to topography in the presence of a forced zonal jet with arbitrary meridional structure. The nonlinear dynamics near different resonances is studied considering both wave-wave and wave-zonal flow interactions. It is shown that Hopf bifurcations from stationary to periodic flows are possible due to the nonlinear instability of nonzonal, topographically forced flow. Low-frequency, finite-amplitude oscillations arise due to a combination of two factors: (1) nonlinear wave-wave interactions, which tend to reduce the Rossby wave frequency; and (2) wave-zonal flow interactions, which reflect the importance of wave momentum transport in shifting the westerly jet and of the topographic form drag. The physical mechanism of atmospherically realistic Hopf bifurcations depends crucially on the meridional profile of the mean zonal flow giving rise to a dipole-shaped resonance.

Jin, F.-F.↗

DOE OSTI2022

Electron Temperature Gradient Driven Transport Model for Tokamak Plasmas

A new model for electron temperature gradient (ETG) modes is developed as a component of the Multi-Mode anomalous transport module [T. Rafiq \textit{et al.,} Phys Plasmas \textbf{20}, 032506 (2013)] to predict a time dependent electron temperature profile in conventional and low aspect ratio tokamaks. This model is based on two-fluid equations that govern the dynamics of low-frequency short- and long-wavelength electromagnetic toroidal ETG driven drift modes. A low collisionality NSTX discharge is used to scan the plasma parameter dependence on the ETG real frequency, growth rate, and electron thermal diffusivity. Electron thermal transport is discovered in the deep core region where modes are more electromagnetic in nature. Several previously reported gyrokinetic trends are reproduced, including the dependencies of density gradients, magnetic shear, $\beta$ and gradient of $\beta$ $(\betap)$, collisionality, safety factor, and toroidicity, where $\beta$ is the ratio of plasma pressure to the magnetic pressure. The electron heat diffusivity associated with the ETG mode is discovered to be on a scale consistent with the experimental diffusivity determined by power balance analysis.

ETG↗

DOE OSTI2022

Testing Lepton Flavor Universality and CKM Unitarity with Rare Pion Decays in the PIONEER experiment

The physics motivation and the conceptual design of the PIONEER experiment, a next-generation rare pion decay experiment testing lepton flavor universality and CKM unitarity, are described. Phase I of the PIONEER experiment, which was proposed and approved at Paul Scherrer Institut, aims at measuring the charged-pion branching ratio to electrons vs. muons, $R_{e/\mu}$, 15 times more precisely than the current experimental result, reaching the precision of the Standard Model (SM) prediction at 1 part in $10^4$. Considering several inconsistencies between the SM predictions and data pointing towards the potential violation of lepton flavor universality, the PIONEER experiment will probe non-SM explanations of these anomalies through sensitivity to quantum effects of new particles up to the PeV mass scale. The later phases of the PIONEER experiment aim at improving the experimental precision of the branching ratio of pion beta decay (BRPB), $\pi^+\to \pi^0 e^+ \nu (\gamma)$, currently at $1.036(6)\times10^{-8}$, by a factor of three (Phase II) and an order of magnitude (Phase III). Such precise measurements of BRPB will allow for tests of CKM unitarity in light of the Cabibbo Angle Anomaly and the theoretically cleanest extraction of $|V_{ud}|$ at the 0.02% level, comparable to the deduction from superallowed beta decays.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗

NASA NTRS1997

A model for the kinetics of homotypic cellular aggregation under static conditions

We present the formulation and testing of a mathematical model for the kinetics of homotypic cellular aggregation. The model considers cellular aggregation under no-flow conditions as a two-step process. Individual cells and cell aggregates 1) move on the tissue culture surface and 2) collide with other cells (or aggregates). These collisions lead to the formation of intercellular bonds. The aggregation kinetics are described by a system of coupled, nonlinear ordinary differential equations, and the collision frequency kernel is derived by extending Smoluchowski's colloidal flocculation theory to cell migration and aggregation on a two-dimensional surface. Our results indicate that aggregation rates strongly depend upon the motility of cells and cell aggregates, the frequency of cell-cell collisions, and the strength of intercellular bonds. Model predictions agree well with data from homotypic lymphocyte aggregation experiments using Jurkat cells activated by 33B6, an antibody to the beta 1 integrin. Since cell migration speeds and all the other model parameters can be independently measured, the aggregation model provides a quantitative methodology by which we can accurately evaluate the adhesivity and aggregation behavior of cells.

Non-NASA Center↗

NASA NTRS2000

Regulation of Osteoblast Survival by the Extracellular Matrix and Gravity

Spaceflight adversely affects the skeleton, posing a substantial risk to astronaut's health during long duration missions. The reduced bone mass observed in growing animals following spaceflight is due at least in part to inadequate bone formation by osteoblasts. Thus, it is of central importance to identify basic cellular mechanisms underlying normal bone formation. The fundamental ideas underlying our research are that interactions between extracellular matrix proteins, integrin adhesion receptors, cytoplasmic signaling and cytoskeletal proteins are key ingredients for the proper functioning of osteoblasts, and that gravity impacts these interactions. As an in vitro model system we used primary fetal rat calvarial cells which faithfully recapitulate osteoblast differentiation characteristically observed in vivo. We showed that specific integrin receptors ((alpha)3(beta)1), ((alpha)5(beta)1), ((alpha)8(betal)1) and extracellular matrix proteins (fibronectin, laminin) were needed for the differentiation of immature osteoblasts. In the course of maturation, cultured osteoblasts switched from depending on fibronectin and laminin for differentiation to depending on these proteins for their very survival. Furthermore, we found that manipulating the gravity vector using ground-based models resulted in activation of key intracellular survival signals generated by integrin/extracellular matrix interactions. We are currently testing the in vivo relevance of some of these observations using targeted transgenic technology. In conclusion, mechanical factors including gravity may participate in regulating survival via cellular interactions with the extracellular matrix. This leads us to speculate that microgravity adversely affects the survival of osteoblasts and contributes to spaceflight-induced osteoporosis.

Globus. Ruth K.↗

NASA NTRS1986

The X-ray spectrm of the Coma Cluster of galaxies

The HEAO 1 A-2 and OSO 8 observations of the Coma Cluster of galaxies in the 2-60 keV energy band are presented. The spectrum is not well fitted by an isothermal bremsstrahlung model with an Fe line. To model the spectrum more accurately, we have performed fits of polytropic models and find that the gas is well fitted by an equation of state with polytropic index ranging between 1.38 and 1.6. This analysis reduces the total cluster mass by a factor of 3-5 below the optically derived virial mass. Using the best-fitting parameters, the gas is found to be a significant fraction (25 percent) of the total cluster mass. The Fe K-alpha line blend is strongly detected, from which we infer 0.18-0.36 solar abundance in the X-ray emitting gas. The Fe K-beta line blend is also weakly detected. The spectrum is not consistent with the existence of a hard X-ray tail at the flux level reported by Bazzano el al. (1984). In addition, the HEAO I scanning mode data place strong constraints on possible contaminating sources in the region surrounding Coma.

Henriksen, M. J.↗

NASA NTRS1990

Evolution of land mammal diversity in North America during the Cenozoic

The North American continental patterns of generic richness, extinction, and origination have been reexamined and analyzed in the context of alpha and beta species diversity. The major models of diversity are discussed as well as primary concepts and theories based on studies of living organisms. The adequacy of the fossil record is considered and patterns of genetic richness and species level diversity are outlined. Major shifts in mammalian community structures are reviewed and hypotheses are presented on diversity origin, regulation, and maintenance for the North American record. Results demonstrate a complex relationship between continental alpha and beta diversity characterized by marked changes through time and differences in patterns at each level. It is clear that both biotic and abiotic factors have strongly influenced the evolution of North American species diversity and that major restructuring occurred in Cenozoic mammalian communities.

Stucky, Richard K.↗

NASA NTRS1999

Thermal Emission Spectroscopy of 1 Ceres: Evidence for Olivine

Thermal emission spectra of the largest asteroid 1 Ceres obtained from the Kuiper Airborne Observatory display features that may provide information on its surface mineralogy. A plot of the Ceres spectrum (calibrated using alpha Boo as a standard) divided by a standard thermal model (STM) is shown. Also shown is the emissivity spectrum deduced from reflectivity measurements for olivine grains <5 microns in diameter. The general shape of the Ceres and the olivine curves agree in essential details, such as the maxima from 8 to 12 microns, the minimum between 12 and 14 microns, the broad peak near 17.5 micron, and the slope beyond 22 micron. (Use of the 10 to 15-micron grain reflectivities provides a better match to the 12- to 14-micron dip. We used a value of unity for beta, the beaming factor associated with small-scale surface roughness in our STM. Adjustment of beta to a lower value raises the long-wavelength side of the Ceres spectrum, providing an even better match to the olivine curve.) The emissivity behavior roughly matches the emission coefficients which were calculated for olivine particles with a particle radius of 3 microns. Their calculations show not only the negative slope from 23 to 25 pm, but a continued decrease past 30 micron. The Ceres emissivity is thus similar to that of small olivine grains from 8 to 30 micron, but olivine's emissivity is lower from 5 to 8 pm.

Witteborn, F. C.↗

NASA NTRS1983

Electrodynamic coupling in magnetically confined X-ray plasmas of astrophysical origin

Explicitly magnetic field-independent relationships that quantitatively connect the thermodynamic state of the confined beta-less-than-one X-ray plasma to the confining magnetic loop characteristics and the stressing velocity at beta greater than about one are presented. The derived relations fall into two categories: (1) diffuse heating resulting from efficient transport of energy throughout the magnetic loop volume, and (2) isolated heating within the electrodynamic dissipation shell. For each of these cases the Joule dissipation, shear viscous dissipation, and compressional dissipation are considered. Each of these models is characterized by three thermodynamic scalings that are parametrized by the magnetic loop properties and by the stressing velocity. Eliminating the magnetic field intermediary from these relations and normalizing the inverse aspect ratio and the magnetic expansion factor with respect to solar conditions results in a single, unique velocity scaling law for each model.

Ionson, J. A.↗

DOE OSTI2022

Solving Critical Problems of the Muon Collider Higgs Factory: Optics, Magnets and their Protection, Detector Backgrounds

A low-energy medium-luminosity Muon Collider (MC) is being studied as a possible Higgs Factory (HF). Electrons from muon decays will deposit more than 300 kW in superconducting magnets of the HF collider ring. This imposes significant challenges to superconducting (SC) magnets used in the MC storage ring (SR) and interaction regions (IR). Magnet designs are proposed which provide high operating gradient and magnetic field in a large aperture to accommodate the large size of muon beams (due to low beta*), as well as a cooling system to intercept the large heat deposition from the showers induced by decay electrons. The distribution of heat deposition in the MC SR lattice elements requires large-aperture magnets in order to accommodate thick high-Z absorbers to protect the SC coils. Based on the developed MARS15 model and intensive simulations, a sophisticated radiation protection system was designed for the collider SR and IR to bring the peak power density in the superconducting coils below the quench limit and reduce the dynamic heat deposition in the cold mass by a factor of 100. The system consists of tight tungsten masks in the magnet interconnect regions and elliptical tungsten liners in the magnet aperture optimized individually for each magnet. These also reduce the background particle fluxes in the collider detector.

43 PARTICLE ACCELERATORS↗

DOE OSTI2023

Simulating neutron stars with a flexible enthalpy-based equation of state parametrization in sp ECTRE

Numerical simulations of neutron star mergers represent an essential step toward interpreting the full complexity of multimessenger observations and constraining the properties of supranuclear matter. Currently, simulations are limited by an array of factors, including computational performance and input physics uncertainties, such as the neutron star equation of state. In this work, we expand the range of nuclear phenomenology efficiently available to simulations by introducing a new analytic parametrization of cold, beta-equilibrated matter that is based on the relativistic enthalpy. Here we show that the new enthalpy parametrization can capture a range of nuclear behavior, including strong phase transitions. We implement the enthalpy parametrization in the spectre code, simulate isolated neutron stars, and compare performance to the commonly used spectral and polytropic parametrizations. We find comparable computational performance for nuclear models that are well represented by either parametrization, such as simple hadronic equations of state. We show that the enthalpy parametrization further allows us to simulate more complicated hadronic models or models with phase transitions that are inaccessible to current parametrizations.

79 ASTRONOMY AND ASTROPHYSICS↗

DOE OSTI2024

Data-driven reevaluation of f t values in superallowed β decays

We present a comprehensive reevaluation of the ft values in superallowed nuclear β decays crucial for the precise determination of V ud and low-energy tests of the electroweak standard model. It consists of the first, fully data-driven analysis of the nuclear β decay form factor, that utilizes isospin relations to connect the nuclear charged weak distribution to the measurable charge distributions. This prescription supersedes previous shell-model estimations, and allows for a rigorous quantification of theory uncertainties in f which is absent in the existing literature. Furthermore, our new evaluation shows an overall downward shift of the central values of f at the level of 0.01%.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

NASA NTRS1996

Redox-mediated activation of latent transforming growth factor-beta 1

Transforming growth factor beta 1 (TGF beta) is a multifunctional cytokine that orchestrates response to injury via ubiquitous cell surface receptors. The biological activity of TGF beta is restrained by its secretion as a latent complex (LTGF beta) such that activation determines the extent of TGF beta activity during physiological and pathological events. TGF beta action has been implicated in a variety of reactive oxygen-mediated tissue processes, particularly inflammation, and in pathologies such as reperfusion injury, rheumatoid arthritis, and atherosclerosis. It was recently shown to be rapidly activated after in vivo radiation exposure, which also generates reactive oxygen species (ROS). In the present studies, the potential for redox-mediated LTGF beta activation was investigated using a cell-free system in which ROS were generated in solution by ionizing radiation or metal ion-catalyzed ascorbate reaction. Irradiation (100 Gray) of recombinant human LTGF beta in solution induced 26% activation compared with that elicited by standard thermal activation. Metal-catalyzed ascorbate oxidation elicited extremely efficient recombinant LTGF beta activation that matched or exceeded thermal activation. The efficiency of ascorbate activation depended on ascorbate concentrations and the presence of transition metal ions. We postulate that oxidation of specific amino acids in the latency-conferring peptide leads to a conformation change in the latent complex that allows release of TGF beta. Oxidative activation offers a novel route for the involvement of TGF beta in tissue processes in which ROS are implicated and endows LTGF beta with the ability to act as a sensor of oxidative stress and, by releasing TGF beta, to function as a signal for orchestrating the response of multiple cell types. LTGF beta redox sensitivity is presumably directed toward recovery of homeostasis; however, oxidation may also be a mechanism of LTGF beta activation that can be deleterious during disease mechanisms involving chronic ROS production.

Non-NASA Center↗

DOE OSTI2023

Measurement of the 2 ν β β Decay Rate and Spectral Shape of Mo 100 from the CUPID-Mo Experiment

Neutrinoless double beta decay (0νββ) is a yet unobserved nuclear process that would demonstrate Lepton number violation, a clear evidence of beyond standard model physics. The process two neutrino double beta decay (2νββ) is allowed by the standard model and has been measured in numerous experiments. In this Letter, we report a measurement of 2νββ decay half-life of 100 Mo to the ground state of 100 Ru of [7.07±0.02(stat)±0.11(syst)]×10 18 yr by the CUPID-Mo experiment. With a relative precision of ±1.6% this is the most precise measurement to date of a 2νββ decay rate in 100 Mo. In addition, we constrain higher-order corrections to the spectral shape, which provides complementary nuclear structure information. We report a novel measurement of the shape factor ξ 3,1 =0.45±0.03(stat)±0.05(syst) based on a constraint on the ratio of higher-order terms from theory, which can be reliably calculated. This is compared to theoretical predictions for different nuclear models. Finally, we also extract the first value for the effective axial vector coupling constant obtained from a spectral shape study of 2νββ decay.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

DOE OSTI2020

Sterile neutrinos and neutrinoless double beta decay in effective field theory

We investigate neutrinoless double beta decay (0νββ) in the presence of sterile neutrinos with Majorana mass terms. These gauge-singlet fields are allowed to interact with Standard-Model (SM) fields via renormalizable Yukawa couplings as well as higher-dimensional gauge-invariant operators up to dimension seven in the Standard Model Effective Field Theory extended with sterile neutrinos. At the GeV scale, we use Chiral effective field theory involving sterile neutrinos to connect the operators at the level of quarks and gluons to hadronic interactions involving pions and nucleons. This allows us to derive an expression for 0νββ rates for various isotopes in terms of phase-space factors, hadronic low-energy constants, nuclear matrix elements, the neutrino masses, and the Wilson coefficients of higher-dimensional operators. The required hadronic low-energy constants and nuclear matrix elements depend on the neutrino masses, for which we obtain interpolation formulae grounded in QCD and chiral perturbation theory that improve existing formulae that are only valid in a small regime of neutrino masses. The resulting framework can be used directly to assess the impact of 0νββ experiments on scenarios with light sterile neutrinos and should prove useful in global analyses of sterile-neutrino searches. We per- form several phenomenological studies of 0νββ in the presence of sterile neutrinos with and without higher-dimensional operators. We find that non-standard interactions involving sterile neutrinos have a dramatic impact on 0νββ phenomenology, and next-generation experiments can probe such interactions up to scales of $\mathcal O$ (100) TeV.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

NASA NTRS1974

ENDOR and ESR studies of a stable radical in irradiated cytidine

A model is proposed for a stable radical species formed by X-irradiation in a single crystal of cytidine and studied by electron nuclear double resonance (ENDOR) and electron spin resonance (ESR) techniques at room temperature. ENDOR and ESR spectra are analyzed to obtain the principal values of the spectroscopic splitting factor and the spectroscopic and hyperfine splitting tensors. The results show hyperfine coupling of an unpaired electron to one hydrogen nucleus and two slightly different geometric forms of the radical with small differences in hyperfine couplings. It is proposed that this radical is formed in the ribose sugar group with a hydrogen atom in a beta position coupling with respect to a carbon-centered unpaired electron and a spin density of approximately 0.2 on a carbon atom.

Allison, D. L.↗