Search NASA⌕ Search

SEARCH · Search NASA

Results for “Inhibitors”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 109 records · Page 6
All sourcesNASA NTRSDOE OSTI
NASA NTRS1978

Corrosion inhibitors for solar heating and cooling systems

Candidate materials were tested for their ability to limit corrosion under conditions that approximate those found in typical solar-energy system. In addition to presentation of data, report also includes discussion of different forms of corrosion and recommendations for future work.

Tabony, J. H.↗
NASA NTRS1997

Effect of Metal Alloys, Degradation Inhibitors, Temperatures, and Exposure Duration on the Stability of Poly(hexafluoropropene oxide) Fluid

Results of the action of 440C steel, Ti(4Al,4Mn), and Ti(6Al,4V) alloys on poly(hexafluoropropene oxide) fluid and the degradation inhibition by phosphate esters, phosphine, and monophospha-s-triazine are reported. The effects of temperature, exposure duration, and metal surface area are discussed. The studies show clearly the autocatalytic nature of the metal-promoted degradation, which explains the effectiveness of the degradation-arresting additives, even in the case of the highly detrimental titanium alloys.

Paciorek, Kazimiera J. L.↗
NASA NTRS1995

Inhibition of the ATPase from Halobacterium Saccharovorum by Thiol Inhibitors: Evidence for the Presence of More Than One Essential Cysteinyl Residue

The vacuolar-like ATPase from Halobacterium saccha vorum is inhibited by N-ethylmaleimide and p-chloromercudphenylsulfonate. The failure of adenine nucleotides to protect against p-chloromercuriphenyisulfonate inhibition, of p-chloromercuriphenylsulfonate to protect against N-ethylmaleimide inhibition, and the difference in the temperature dependence of inactivation infers that the enzyme contains at least two thiols that are essential for enzyme activity. CNBr cleavage of C-14-N-ethylmaleimide labeled subunit results in two radioactive peptides that locates the N-ethylmaleimide-reactive cysteinyl residue as cysteine-262 in the H. salinarium sequence.

Hochstein, Lawrence I.↗
NASA NTRS1988

Self Injury Inhibitor

There are approximately 50,000 autistic and retarded people in the United States alone, and many of them engage in self-injurious behavior, principally compulsive headbanging. Hope is offered by an automated unit, manufactured at Johns Hopkins University, called the Self-Injurious Behavior Inhibiting System (SIBIS). Components of SIBIS are stimulus module which is worn on upper arm or leg, and headgear which includes an impact detector and a transmitter on back of head. When there is a blow to the head it is sensed by impact detector which generates a coded signal that is automatically transferred to stimulus module which delivers a mild electrical stimulus to the skin for less than 1/10 of a second. Stimulus is sufficient to halt headbanging. Microprocessor computes impacts allowing measurement of patient progress.

Source record↗
NASA NTRS1985

Polyamine levels as related to growth, differentiation and senescence in protoplast-derived cultures of Vigna aconitifolia and Avena sativa

We have previously reported that aseptically cultured mesophyll protoplasts of Vigna divide rapidly and regenerate into complete plants, while mesophyll protoplasts of Avena divide only sporadically and senesce rapidly after isolation. We measured polyamine titers in such cultures of Vigna and Avena, to study possible correlations between polyamines and cellular behavior. We also deliberately altered polyamine titer by the use of selective inhibitors of polyamine biosynthesis, noting the effects on internal polyamine titer, cell division activity and regenerative events. In Vigna cultures, levels of free and bound putrescine and spermidine increased dramatically as cell division and differentiation progressed. The increase in bound polyamines was largest in embryoid-forming callus tissue while free polyamine titer was highest in root-forming callus. In Avena cultures, the levels of total polyamines decreased as the protoplast senesced. The presence of the inhibitors alpha-difluoromethyl-arginine (specific inhibitor of arginine decarboxylase), alpha-difluoromethylornithine (specific inhibitor of ornithine decarboxylase) and dicyclohexylamine (inhibitor of spermidine synthase) reduced cell division and organogenesis in Vigna cultures. Addition of low concentration of polyamines to such cultures containing inhibitors or removal of inhibitors from the culture medium restored the progress of growth and differentiation with concomitant increase in polyamine levels.

NASA Program Space Biology↗
NASA NTRS2016

Corrosion-Activated Micro-Containers for Environmentally Friendly Corrosion Protective Coatings

This work concerns the development of environmentally friendly encapsulation technology, specifically designed to incorporate corrosion indicators, inhibitors, and self-healing agents into a coating, in such a way that the delivery of the indicators and inhibitors is triggered by the corrosion process, and the delivery of self-healing agents is triggered by mechanical damage to the coating. Encapsulation of the active corrosion control ingredients allows the incorporation of desired autonomous corrosion control functions such as: early corrosion detection, hidden corrosion detection, corrosion inhibition, and self-healing of mechanical damage into a coating. The technology offers the versatility needed to include one or several corrosion control functions into the same coating.The development of the encapsulation technology has progressed from the initial proof-of-concept work, in which a corrosion indicator was encapsulated into an oil-core (hydrophobic) microcapsule and shown to be delivered autonomously, under simulated corrosion conditions, to a sophisticated portfolio of micro carriers (organic, inorganic, and hybrid) that can be used to deliver a wide range of active corrosion ingredients at a rate that can be adjusted to offer immediate as well as long-term corrosion control. The micro carriers have been incorporated into different coating formulas to test and optimize the autonomous corrosion detection, inhibition, and self-healing functions of the coatings. This paper provides an overview of progress made to date and highlights recent technical developments, such as improved corrosion detection sensitivity, inhibitor test results in various types of coatings, and highly effective self-healing coatings based on green chemistry. The NASA Kennedy Space Centers Corrosion Technology Lab at the Kennedy Space Center in Florida, U.S.A. has been developing multifunctional smart coatings based on the microencapsulation of environmentally friendly corrosion indicators, inhibitors and self-healing agents. This allows the incorporation of autonomous corrosion control functionalities, such as corrosion detection and inhibition as well as the self-healing of mechanical damage, into coatings. This paper presents technical details on the characterization of inhibitor-containing particles and their corrosion inhibitive effects using electrochemical and mass loss methods.Three organic environmentally friendly corrosion inhibitors were encapsulated in organic microparticles that are compatible with desired coatings. The release of the inhibitors from the microparticles in basic solution was studied. Fast release, for immediate corrosion protection, as well as long-term release for continued protection, was observed.The inhibition efficacy of the inhibitors, incorporated directly and in microparticles, on carbon steel was evaluated. Polarization curves and mass loss measurements showed that, in the case of 2MBT, its corrosion inhibition effectiveness was greater when it was delivered from microparticles.

Corrosion Control↗
NASA NTRS1996

RSRM Chamber Pressure Oscillations: Transit Time Models and Unsteady CFD

Space Shuttle solid rocket motor low frequency internal pressure oscillations have been observed since early testing. The same type of oscillations also are present in the redesigned solid rocket motor (RSRM). The oscillations, which occur during RSRM burn, are predominantly at the first three motor cavity longitudinal acoustic mode frequencies. Broadband flow and combustion noise provide the energy to excite these modes at low levels throughout motor burn, however, at certain times during burn the fluctuating pressure amplitude increases significantly. The increased fluctuations at these times suggests an additional excitation mechanism. The RSRM has inhibitors on the propellant forward facing surface of each motor segment. The inhibitors are in a slot at the segment field joints to prevent burning at that surface. The aft facing segment surface at a field joint slot burns and forms a cavity of time varying size. Initially the inhibitor is recessed in the field joint cavity. As propellant burns away the inhibitor begins to protrude into the bore flow. Two mechanisms (transit time models) that are considered potential pressure oscillation excitations are cavity-edge tones, and inhibitor hole-tones. Estimates of frequency variation with time of longitudinal acoustic modes, cavity edge-tones, and hole-tones compare favorably with frequencies measured during motor hot firing. It is believed that the highest oscillation amplitudes occur when vortex shedding frequencies coincide with motor longitudinal acoustic modes. A time accurate computational fluid dynamic (CFD) analysis was made to replicate the observations from motor firings and to observe the transit time mechanisms in detail. FDNS is the flow solver used to detail the time varying aspects of the flow. The fluid is approximated as a single-phase ideal gas. The CFD model was an axisymmetric representation of the RSRM at 80 seconds into burn.Deformation of the inhibitors by the internal flow was determined through an iterative structural and CFD analysis. The analysis domain ended just upstream of the nozzle throat. This is an acoustic boundary condition that caused the motor to behave as a closed-open organ pipe. This differs from the RSRM which behaves like a closed-closed organ pipe. The unsteady CFD solution shows RSRM chamber pressure oscillations predominately at the longitudinal acoustic mode frequencies of a closed-open organ pipe. Vortex shedding in the joint cavities and at the inhibitors contribute disturbances to the flow at the second longitudinal acoustic mode frequency. Further studies are planned using an analysis domain that extends downstream of the nozzle throat.

Nesman, Tom↗
NASA NTRS1990

Effects of ethylene on the kinetics of curvature and auxin redistribution in gravistimulated roots of Zea mays

We tested the involvement of ethylene in maize (Zea mays L.) root gravitropism by measuring the kinetics of curvature and lateral auxin movement in roots treated with ethylene, inhibitors of ethylene synthesis, or inhibitors of ethylene action. In the presence of ethylene the latent period of gravitropic curvature appeared to be increased somewhat. However, ethylene-treated roots continued to curve after control roots had reached their final angle of curvature. Consequently, maximum curvature in the presence of ethylene was much greater in ethylene-treated roots than in controls. Inhibitors of ethylene biosynthesis or action had effects on the kinetics of curvature opposite to that of ethylene, i.e. the latent period appeared to be shortened somewhat while total curvature was reduced relative to that of controls. Label from applied 3H-indole-3-acetic acid was preferentially transported toward the lower side of stimulated roots. In parallel with effects on curvature, ethylene treatment delayed the development of gravity-induced asymmetric auxin movement across the root but extended its duration once initiated. The auxin transport inhibitor, 1-N-naphthylphthalamic acid reduced both gravitropic curvature and the effect of ethylene on curvature. Since neither ethylene nor inhibitors of ethylene biosynthesis or action prevented curvature, we conclude that ethylene does not mediate the primary differential growth response causing curvature. Because ethylene affects curvature and auxin transport in parallel, we suggest that ethylene modifies curvature by affecting gravity-induced lateral transport of auxin, perhaps by interfering with adaptation of the auxin transport system to the gravistimulus.

Non-NASA Center↗
NASA NTRS1994

Abrogation of TNF-mediated cytotoxicity by space flight involves protein kinase C

Experiments conducted on STS-50 indicated that space flight significantly inhibited tumor necrosis factor (TNF)-mediated killing of LM929 cells compared to ground controls. In ground-based studies, activation of protein kinase C (PKC) with phorbol 12-myristate 13-acetate (PMA) also inhibited TNF-mediated killing of LM929 cells. Therefore, we used PKC inhibitors to determine if the inhibitory effects of spaceflight on TNF-mediated cytotoxicity involved the activation of PKC. In experiments conducted onboard space shuttle mission STS-54, we saw that in the presence of the protein kinase C inhibitors H7 and H8, TNF-mediated cytotoxicity was restored to levels of those observed in the ground controls. Subsequent experiments done during the STS-57 mission tested the dose response of two protein kinase inhibitors, H7 and HA1004. We again saw that killing was restored in a dose-dependent manner, with inhibitor concentrations known to inhibit PKC being most effective. These data suggest that space flight ameliorates the action of TNF by affecting PKC in target cells.

STS-54 Shuttle Project↗
NASA NTRS1980

Fouling and the inhibition of salt corrosion

In an attempt to reduce fouling while retaining the beneficial effects of alkaline earth inhibitors on the hot corrosion of superalloys, the use of both additives and the intermittent application of the inhibitors were evaluated. Additions of alkaline earth compounds to combustion gases containing sodium sulfate were shown to inhibit hot corrosion. However, sulfate deposits can lead to turbine fouling in service. For that reason, dual additives and intermittant inhibitor applications were evaluated to reduce such deposit formation. Silicon in conjunction with varium showed some promise. Total deposition was apparently reduced while the inhibition of hot corrosion by barium was unimpaired. The intermittant application of the inhibitor was found to be more effective and controllable.

Deadmore, D. L.↗