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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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All sourcesNASA NTRSDOE OSTI
NASA NTRS2003

National Aeronautics and Space Administration Biological and Physical Research Enterprise Strategy

As the 21st century begins, NASA's new Vision and Mission focuses the Agency's Enterprises toward exploration and discovery.The Biological and Physical Research Enterprise has a unique and enabling role in support of the Agency's Vision and Mission. Our strategic research seeks innovations and solutions to enable the extension of life into deep space safely and productively. Our fundamental research, as well as our research partnerships with industry and other agencies, allow new knowledge and tech- nologies to bring improvements to life on Earth. Our interdisciplinary research in the unique laboratory of microgravity addresses opportunities and challenges on our home planet as well as in space environments. The Enterprise maintains a key role in encouraging and engaging the next generation of explorers from primary school through the grad- uate level via our direct student participation in space research.The Biological and Physical Research Enterprise encompasses three themes. The biological sciences research theme investigates ways to support a safe human presence in space. This theme addresses the definition and control of physiological and psychological risks from the space environment, including radiation,reduced gravity, and isolation. The biological sciences research theme is also responsible for the develop- ment of human support systems technology as well as fundamental biological research spanning topics from genomics to ecologies. The physical sciences research theme supports research that takes advantage of the space environment to expand our understanding of the fundamental laws of nature. This theme also supports applied physical sciences research to improve safety and performance of humans in space. The research partnerships and flight support theme establishes policies and allocates space resources to encourage and develop entrepreneurial partners access to space research.Working together across research disciplines, the Biological and Physical Research Enterprise is performing vital research and technology development to extend the reach of human space flight.

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NASA NTRSDate not supplied

Destination: Mars. Biology Research to Support Human Space Exploration

This is a public talk about astronaut health risks during deep space exploration, including exposure to deep space radiation (galactic cosmic rays and solar particle events), microgravity and other stressors, and about the research currently being done at NASA Ames and other institutions to investigate and mitigate these risks. I will specifically focus on the risk posed by exposure to deep space radiation, and will briefly describe my own research on developing human brain-on-a-chip models to investigate its impact on the central nervous system.

human spaceflight, space radiation, organ-on-a-chi↗
NASA NTRS1990

The CELSS Test Facility - A foundation for crop research in space

Under the NASA Space Biology Initiative, a CELSS Test Facility (CTF) is being planned for installation on Space Station Freedom. The CTF will be used to study the productivity of typical CELSS higher plant crops under the microgravity conditions of the Space Station Freedom (SSF). Such science studies will be supported under the CELSS Space Research Project. The CTF will be used to evaluate fundamental issues of crop productivity, such as the production rates of O2, food and transpired water, and CO2 uptake. A series of precursor tests that are essential to the development of the CTF will be flown on Space Shuttle flights. The tests will be used to validate and qualify technology concepts and to answer specific questions regarding seed germination, root/shoot orientation, water condensation and recycling, nutrient delivery, and liquid/gas phase interactions.

Straight, C. L.↗
NASA NTRS2018

Stem Cell-Based Regenerative Health in Microgravity

The research of Dr. Almeida's Lab at NASA Ames focuses on the effects of microgravity mechanical unloading on stem-cell-based tissue regeneration. The research focuses on testing the broad hypothesis that mechanical load from gravity at 1 g is required for normal adult stem cell proliferation and differentiation during tissue regeneration. Research from the lab has provides evidence supporting the hypothesis in various biological models, including newt tail regeneration, mouse bone and bone marrow in whole animals, and mouse embryonic stem cells all exposed to microgravity during spaceflight. Using these models, the lab has identified overexpression of the cell cycle inhibitor p21/CDKN1a as a candidate molecular mediator mechanism of bone marrow mesenchymal and hematopoietic lineage tissue regenerative arrest in microgravity. The labis currently focused on using p21/CDKN1a null mouse and cell culture approaches in microgravity to test the gravity tissue regeneration hypothesis.

stem cells microgravity regeneration↗
NASA NTRS1996

STS-78 Space Shuttle Mission Report

The STS-78 Space Shuttle Program Mission Report summarizes the Payload activities as well as the Orbiter, External Tank (ET), Solid Rocket Booster (SRB), Reusable Solid Rocket Motor (RSRM), and the Space Shuttle main engine (SSME) systems performance during the seventy-eighth flight of the Space Shuttle Program, the fifty-third flight since the return-to-flight, and the twentieth flight of the Orbiter Columbia (OV-102). In addition to the Orbiter, the flight vehicle consisted of an ET that was designated ET-79; three SSME's that were designated as serial numbers 2041, 2039, and 2036 in positions 1, 2, and 3, respectively; and two SRB's that were designated BI-081. The RSRM's, designated RSRM-55, were installed in each SRB and the individual RSRM's were designated as 360L055A for the left SRB, and 360L055B for the right SRB. The STS-78 Space Shuttle Program Mission Report fulfills the Space Shuttle Program requirement as documented in NSTS 07700, Volume 7, Appendix E. The requirement stated in that document is that each organizational element supporting the Program will report the results of their hardware (and software) evaluation and mission performance plus identify all related in-flight anomalies. The primary objective of this flight was to successfully perform the planned operations of the Life and Microgravity Spacelab experiments. The secondary objectives of this flight were to complete the operations of the Orbital Acceleration Research Experiment (OARE), Biological Research in Canister Unit-Block II (BRIC), and the Shuttle Amateur Radio Experiment II-Configuration C (SAREX-II). The STS-78 mission was planned as a 16-day, plus one day flight plus two contingency days, which were available for weather avoidance or Orbiter contingency operations. The sequence of events for the STS-78 mission is shown in Table 1, and the Space Shuttle Vehicle Management Office Problem Tracking List is shown in Table 2. The Government Furnished Equipment/Flight Crew Equipment (GFE/FCE) Problem Tracking List is shown in Table 3. The Marshall Space Flight Center (MSFC) Problem Tracking List is shown in Table 4. Appendix A lists the sources of data, both formal and informal, that were used to prepare this report. Appendix B provides the definition of acronyms and abbreviations used throughout the report. All times during the flight are given in Greenwich mean time (G.m.t.) and mission elapsed time (MET).

Fricke, Robert W., Jr.↗
NASA NTRS1997

Biological Bases of Space Radiation Risk

In this session, Session JP4, the discussion focuses on the following topics: Hematopoiesis Dynamics in Irradiated Mammals, Mathematical Modeling; Estimating Health Risks in Space from Galactic Cosmic Rays; Failure of Heavy Ions to Affect Physiological Integrity of the Corneal Endothelial Monolayer; Application of an Unbiased Two-Gel CDNA Library Screening Method to Expression Monitoring of Genes in Irradiated Versus Control Cells; Detection of Radiation-Induced DNA Strand Breaks in Mammalian Cells By Enzymatic Post-Labeling; Evaluation of Bleomycin-Induced Chromosome Aberrations Under Microgravity Conditions in Human Lymphocytes, Using "Fish" Techniques; Technical Description of the Space Exposure Biology Assembly Seba on ISS; and Cytogenetic Research in Biological Dosimetry.

Source record↗
NASA NTRS2000

Microgravity Sciences Program Overview

This overview presents in viewgraph form, the NASA Program organization regarding fluid physics, physical sciences research in space and the connection to biology, the dual thrust of the fluid physics program, and the immediate and future plans of the physical science research division.

Trinh, E.↗
NASA NTRS1992

Toward a microgravity research strategy

Recommendations of the Committee on Microgravity Research (CMGR) of the Space Studies Board of the National Research Council are found in the Summary and Recommendations in the front of the report. The CMGR recommends a long-range research strategy. The main rationale for the microgravity research program should be to improve our fundamental scientific and technical knowledge base, particularly in the areas that are likely to lead to improvements in processing and manufacturing on earth. The CMGR recommends research be categorized as Biological science and technology, Combustion, Fluid science, Fundamental phenomena, Materials, and Processing science and technology. The committee also recommends that NASA apply a set of value criteria and measurement indicators to define the research and analysis program more clearly. The CMGR recommends that the funding level for research and analysis in microgravity science be established as a fixed percentage of the total program of NASA's Microgravity Science and Applications Division in order to build a strong scientific base for future experiments. The committee also recommends a cost-effective approach to experiments. Finally the CMGR recommends that a thorough technical review of the centers for commercial development of space be conducted to determine the quality of their activities and to ascertain to what degree their original mission has been accomplished.

Source record↗
NASA NTRS2021

Customized Science Carrier Modules and Accessories Developed for Microgravity Simulation Devices

Because the access to the true weightless environment of the ISS and other Low Earth Orbit (LEO) vehicles is limited and cost prohibitive, the need for ground-based microgravity simulation analogs to bridge the gravity continuum gap between 1g gravity and costly space flight studies with true weightlessness was realized. As such, the Microgravity Simulation Support Facility (MSSF) was established at NASA John F. Kennedy Space Center (KSC) to fulfill the need of the scientific community. Our facility provides the US science community with a focal point in the field of gravitational research by granting access to an array of two-dimensional(2D) and three-dimensional (3D)clinostats, and Random Positioning Machine (RPM) platforms developed by teams throughout the world. The availability of these capabilities will allow further understanding the role of altered gravity vectors from “functional weightlessness”, partial gravity conditions (1 x 10-3to 0.9g, and Moon and Mars ‘g vectors), to hypergravity (up to3g) on biological processes. We have designed and 3D printed a variety of specialized attachments(and associated “static control” hardware)to allow researchers to mount their samples onto these microgravity simulation devices to meet their unique science requirements. A summary of each attachment module will be presented below. Note: All software or code information should be requested to the author Ye Zhang, Kennedy Space Center ye.zhang-1@nasa.gov

Ye Zhang↗
NASA NTRS1999

Novel Approaches to Cellular Transplantation from the US Space Program

Research in the treatment of type I diabetes is entering a new era that takes advantage of our knowledge in an ever increasing variety of scientific disciplines. Some may originate from very diverse sources, one of which is the Space Program at National Aeronautics and Space Administration (NASA). The Space Program contributes to diabetes-related research in several treatment modalities. As an ongoing effort for medical monitoring of personnel involved in space exploration activities NASA and the extramural scientific community investigate strategies for noninvasive estimation of blood glucose levels. Part of the effort in the space protein crystal growth program is high-resolution structural analysis insulin as a means to better understand the interaction with its receptor and with host immune components and as a basis for rational design of a "better" insulin molecule. The Space Program is also developing laser technology for potential early cataract detection as well as a noninvasive analyses for addressing preclinical diabetic retinopathy. Finally, NASA developed an exciting cell culture system that affords some unique advantages in the propagation and maintenance of mammalian cells in vitro. The cell culture system was originally designed to maintain cell suspensions with a minimum of hydrodynamic and mechanical sheer while awaiting launch into microgravity. Currently the commercially available NASA bioreactor (Synthecon, Inc., Houston, TX) is used as a research tool in basic and applied cell biology. In recent years there is continued strong interest in cellular transplantation as treatment for type I diabetes. The advantages are the potential for successful long-term amelioration and a minimum risk for morbidity in the event of rejection of the transplanted cells. The pathway to successful application of this strategy is accompanied by several substantial hurdles: (1) isolation and propagation of a suitable uniform donor cell population; (2) management of host immune rejection; (3) protection from the autoimmune component of the disease; and (4) anatomic placement of the engrafted cells that permits timely response to blood sugar levels as well as effective release and deployment of insulin. Bioreactor technology may provide some critical advances for surmounting some of these scientific hurdles. The NASA bioreactor is a horizontally rotating cylinder that is completely filled with culture medium. Gaseous exchange is maintained by a concentric cylinder of permeable silicon. In slow rotation (15-25 rpm) particles of small mass such as cells and tissue aggregates remain suspended in the rotating body of fluid. This novel approach suspends cells without stirring thus, allowing objects of different size mass to colocate and interact in a very low shear environment. In fact, analysis of the forces acting on individual cells in the rotating bioreactor reveals that the cells are continuously falling through the fluid medium. The conditions in the bioreactor permit assembly of cells into aggregates. three-dimensional tissue growth, synthesis of intercellular matrix,10 differentiation, and some sinusoid formations that may serve as a surrogate vasculature for larger tissue segments.

Pellis, Neal R.↗
NASA NTRSDate not supplied

NASA’s Ground-Based Microgravity Simulation Facility

Since opportunities to conduct experiments in space are scarce, various microgravity simulators and analogs have been widely used in space biology ground studies. Even though microgravity simulators do not produce all of the biological effects observed in the true microgravity environment, they provide alternative test platforms that are effective, affordable, and readily available to facilitate microgravity research. The Microgravity Simulation Support Facility (MSSF) at the National Aeronautics and Space Administration (NASA) John F. Kennedy Space Center (KSC) has been established for conducting short duration experiments, typically less than 1 month, utilizing a variety of microgravity simulation devices for research at different gravity levels. The simulators include, but are not limited to, 2D Clinostats, 3D Clinostats, Random Positioning Machines, and Rotating Wall Vessels. In this presentation, we will provide an overview of current MSSF capabilities, research conducted in MSSF, new technology developments, customized sample holder designs, and the physical characteristics of these microgravity simulators.

Ye Zhang↗
NASA NTRSDate not supplied

NASA's Ground-Based Microgravity Simulation Facility

Since opportunities to conduct experiments in space are scarce, various microgravity simulators and analogs have been widely used in space biology ground studies. Even though microgravity simulators do not produce all of the biological effects observed in the true microgravity environment, they provide alternative test platforms that are effective, affordable, and readily available to facilitate microgravity research. The Microgravity Simulation Support Facility (MSSF) at the National Aeronautics and Space Administration (NASA) John F. Kennedy Space Center (KSC) has been established for conducting short duration experiments, typically less than 1 month, utilizing a variety of microgravity simulation devices for research at different gravity levels. The simulators include, but are not limited to, 2D Clinostats, 3D Clinostats, Random Positioning Machines, and Rotating Wall Vessels. In this chapter, we will discuss current MSSF capabilities, development concepts, customized sample holder designs, and the physical characteristics of these microgravity simulators.

Ye Zhang↗
NASA NTRSDate not supplied

A Pair of Trans-Golgi Network/Early Endosome-Localized Proteins Facilitate Cytoskeletal-Mediated Root Skewing in Arabidopsis Thaliana

Roots treated with the actin-disrupting compound Latrunculin B (LatB) show stronger gravitropic responses on Earth and dampened straightening responses on a 2-D clinostat. In related experiments using the Biological Research in Canisters (BRIC) hardware, it was found that knockouts to vegetative actin isoforms in Arabidopsis thaliana had more robust root skewing in microgravity and waved more strongly than wild type on hard agar surfaces. These results indicate that the actin cytoskeleton mediates directional root growth in space and on the ground. To gain new insights into the role of actin in directional root growth, we identified mutants that showed differential growth responses to low doses of LatB. In-depth studies of one mutant led to the identification of a trans-Golgi Network (TGN)/Early Endosome (EE)- localized protein that associates with actin. This protein called hypersensitive to LatB 1 (HLB1) colocalized with the ADP-ribosylation-factor guanine nucleotide exchange factor, MIN7/BEN1 (HOPM INTERACTOR7/BREFELDIN A-VISUALIZED ENDOCYTIC TRAFFICKING DEFECTIVE1), at the TGN/EE. HLB1 and MIN7/BEN1 were found to regulate exocytosis and endocytosis, respectively, suggesting that both proteins are involved in actin-mediated membrane traffic. Microtubules, another component of the cytoskeleton, is known to be involved in root skewing. Both hlb1 and min7/ben1 mutants exhibited dampened root skewing on the microtubule stabilizing compound taxol. Taken together, our results support the conclusion that cytoskeletal-membrane interactions contribute to directional root skewing in A. thaliana and is facilitated in part by the TGN/EE-localized HLB1 and MIN7/BEN1 proteins.

Plant Space Biology↗
NASA NTRS2005

Microfabricated Genomic Analysis System

Genetic sequencing and many genetic tests and assays require electrophoretic separation of DNA. In this technique, DNA fragments are separated by size as they migrate through a sieving gel under the influence of an applied electric field. In order to conduct these analyses on-orbit, it is essential to acquire the capability to efficiently perform electrophoresis in a microgravity environment. Conventional bench top electrophoresis equipment is large and cumbersome and does not lead itself to on-orbit utilization. Much of the previous research regarding on-orbit electrophoresis involved altering conventional electrophoresis equipment for bioprocessing, purification, and/or separation technology applications. A new and more efficient approach to on-orbit electrophoresis is the use of a microfabricated electrophoresis platform. These platforms are much smaller, less expensive to produce and operate, use less power, require smaller sample sizes (nanoliters), and achieve separation in a much shorter distance (a few centimeters instead of 10 s or 100 s of centimeters.) In contrast to previous applications, this platform would be utilized as an analytical tool for life science/medical research, environmental monitoring, and medical diagnoses. Identification of infectious agents as well as radiation related damage are significant to NASA s efforts to maintain, study, and monitor crew health during and in support of near-Earth and interplanetary missions. The capability to perform genetic assays on-orbit is imperative to conduct relevant and insightful biological and medical research, as well as continuing NASA s search for life elsewhere. This technology would provide an essential analytical tool for research conducted in a microgravity environment (Shuttle, ISS, long duration/interplanetary missions.) In addition, this technology could serve as a critical and invaluable component of a biosentinel system to monitor space environment genotoxic insults to include radiation.

Gonda, Steve↗
NASA NTRS2003

2002 Microgravity Materials Science Conference

The 2002 Microgravity Materials Science Conference was held June 25-26, 2002, at the Von Braun Center, Huntsville, Alabama. Organized by the Microgravity Materials Science Discipline Working Group, sponsored by the Physical Sciences Research Division, NASA Headquarters, and hosted by NASA Marshall Space Flight Center and member institutions under the Cooperative Research in Biology and Materials Science (CORBAMS) agreement, the conference provided a forum to review the current research and activities in materials science, discuss the envisioned long-term goals, highlight new crosscutting research areas of particular interest to the Physical Sciences Research Division, and inform the materials science community of research opportunities in reduced gravity. An abstracts book was published and distributed at the conference to the approximately 240 people attending, who represented industry, academia, and other NASA Centers. This CD-ROM proceedings is comprised of the research reports submitted by the Principal Investigators in the Microgravity Materials Science program.

Gillies, Donald↗
NASA NTRS2021

Mitigation and Use of Biofilms in Space for the Benefit of Human Space Exploration

Biofilms are groups of cells of the same or different species living in communities. Such structures are usually attached to surfaces, and on Earth, they have been found in diverse and extreme environments. Such agglomerations have been described as recalcitrant or protective when facing adversity. In space systems, biofilms have been found on a multitude of hardware surfaces. Different studies have identified genetic changes that may impact human health. The insufficiency of consistent research may return inconclusive arguments as to what extent microgravity encourages virulence and how biofilms could exacerbate crewed spaceflight–especially ones to remote areas with a lack of resupply and service missions. However, biofilms are also beneficial to plant biology, and they may supply in metabolic pathways that produce useful organic and inorganic components to maintain life in other celestial bodies. There are expansive areas of research that look into biofilms in space and scientific recommendations that reflect on expanding the aerospace industry’s knowledge of biofilms, how to mitigate, or use them to the advantage of spaceflight.

Yo-ann Velez Justiniano↗
NASA NTRS2018

Semi-Autonomous Rodent Habitat for Deep Space Exploration

NASA has flown animals to space as part of trailblazing missions and to understand the biological responses to spaceflight. Mice traveled in the Lunar Module with the Apollo 17 astronauts and now mice are frequent research subjects in LEO on the ISS. The ISS rodent missions have focused on unravelling biological mechanisms, better understanding risks to astronaut health, and testing candidate countermeasures. A critical barrier for longer-duration animal missions is the need for humans-in-the-loop to perform animal husbandry and perform routine tasks during a mission. Using autonomous or telerobotic systems to alleviate some of these tasks would enable longer-duration missions to be performed at the Deep Space Gateway. Rodent missions performed using the Gateway as a platform could address a number of critical risks identified by the Human Research Program (HRP), as well as Space Biology Program questions identified by NRC Decadal Survey on Biological and Physical Sciences in Space, (2011). HRP risk areas of potentially greatest relevance that the Gateway rodent missions can address include those related to visual impairment (VIIP) and radiation risks to central nervous system, cardiovascular disease, as well as countermeasure testing. Space Biology focus areas addressed by the Gateway rodent missions include mechanisms and combinatorial effects of microgravity and radiation. The objectives of the work proposed here are to 1) develop capability for semi-autonomous rodent research in cis-lunar orbit, 2) conduct key experiments for testing countermeasures against low gravity and space radiation. The hardware and operations system developed will enable experiments at least one month in duration, which potentially could be extended to one year in duration. To gain novel insights into the health risks to crew of deep space travel (i.e., exposure to space radiation), results obtained from Gateway flight rodents can be compared to ground control groups and separate groups of mice exposed to simulated Galactic Cosmic Radiation (at the NASA Space Radiation Lab). Results can then be compared to identical experiments conducted on the ISS. Together results from Gateway, ground-based, and ISS rodent experiments will provide novel insight into the effects of space radiation.

deep space gateway↗
NASA NTRS2020

Electromagnetic Compatibility Considerations for International Space Station Payload Developers

The International Space Station (ISS) is a laboratory for scientific research, innovative technology development, and global education. The ISS provides a number of facilities and platforms for payload developers and investigators to conduct biological, microgravity, and Earth and space observation science, as well as for performing technology development. Due to the unique nature of the ISS vehicle and its electrical power and data systems, achieving electromagnetic compatibility (EMC) with the vehicle requires special considerations by the payload developer. The ISS electromagnetic interference (EMI) requirements and test methods are based on MIL-STD-461, “Electromagnetic Emissions and Susceptibility Requirements for the Control of Electromagnetic Interference”, Revision C, and MIL-STD-462, “Electromagnetic Interference Characteristics, Measurement of,” respectively. The low source impedance of the test setup requires special considerations when designing or selecting EMI power filters and switched mode power supplies. Many filters, suited for later revisions of MIL-STD-461, will result in non-compliant designs. ISS electrical power system power quality requirements, imposed to protect the stability of the system, can also affect EMI filter design. The selection and use of commercial-off-the-shelf (COTS) equipment for ISS applications requires special considerations to meet both EMC and crew safety requirements. Furthermore, the ISS environment can provide unique immunity challenges; if the payload developer ignores these challenges, the result is a possible loss of science or impact to technology demonstration. The ISS provides a unique opportunity for the science and technology development community. However, in order to be successful, the payload developer must incorporate special EMC considerations, many of which will be presented.

McCollum, Matthew↗