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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 109 records · Page 6
All sourcesNASA NTRSDOE OSTI
NASA NTRS2018

Stress-Induced Heat Shock Protein 40 and Immune Function in Altered Gravity

In space, astronauts are more susceptible to pathogens, viral reactivation and immunosuppression, which poses limits to their health and the mission. Interestingly, during space flight, stress-inducible heat shock proteins (HSP) are robustly induced, and the overexpression of HSPs have been implicated in immune dysregulation, therefore HSPs may be critically involved in regulating immune homeostasis. HSP40/DNAJ1 plays a major role in proper protein translation and folding. Its loss of function has been implicated in susceptibility to microbial infection, while its overexpression has been implicated in autoimmunity, collectively suggesting its complicated, but necessary, role in maintaining immunological function. To determine the role of HSP40 during stress-induced altered gravity conditions, wild-type and Hsp40 mutant Drosophila melanogaster were exposed to ground-based chronic hypergravity conditions, followed by quantitative PCR (qPCR) analysis of immune gene expression. In addition, larval hemocytes were collected to determine the functional output in response to E. coli bioparticle phagocytosis. Preliminary data indicates a required role for Hsp40 in strengthening immune function during stress-induced spaceflight in flies. In short, a critical need to evaluate the relationship between HSPs and immune suppression during space flight is necessary. Since space travel may become available to the general public in the not too distant future, and for the possibility of long-term space missions, a more comprehensive evaluation of the molecules responsible for immune dysfunction observed during space flight is required.

hypergravity↗
NASA NTRS2018

Heat Shock Protein 40 and Immune Function in Altered Gravity

In space, astronauts are more susceptible to pathogens, viral reactivation and immunosuppression, which poses limits to their health and the mission. Interestingly, during space flight, stress-inducible heat shock proteins (HSP) are robustly induced, and the overexpression of HSPs have been implicated in immune dysregulation, therefore HSPs may be critically involved in regulating immune homeostasis. HSP40/DNAJ1 plays a major role in proper protein translation and folding. Its loss of function has been implicated in susceptibility to microbial infection, while its overexpression has been implicated in autoimmunity, collectively suggesting its complicated, but necessary, role in maintaining immunological function. To determine the role of HSP40 during stress-induced altered gravity conditions, wild-type and Hsp40 mutant Drosophila melanogaster were exposed to ground-based chronic hypergravity conditions, followed by quantitative PCR (qPCR) analysis of immune gene expression. In addition, larval hemocytes were collected to determine the functional output in response to E. coli bioparticle phagocytosis. Preliminary data indicates a required role for Hsp40 in strengthening immune function during stress-induced spaceflight in flies. In short, a critical need to evaluate the relationship between HSPs and immune suppression during space flight is necessary. Since space travel may become available to the general public in the not too distant future, and for the possibility of long-term space missions, a more comprehensive evaluation of the molecules responsible for immune dysfunction observed during space flight is required.

hypergravity↗
NASA NTRS2000

NASA's Long Term Space Astrophysics Program

We have carried out a comprehensive, multiwavelength study of interstellar molecules using data obtained from the Infrared Space Observatory (ISO), the Hubble Space Telescope (HST), and the Submillimeter Wave Astronomy Satellite (SWAS). Molecular observations provide a unique probe of the astrophysical Universe and yield information of general astronomical importance that can obtained in no other way. Molecules are also of importance because they can dominate the cooling of astrophysical media. The key topics addressed by our study have been: (1) the cooling of the interstellar gas; (2) the chemistry and excitation of molecular hydrogen in shocks, diffuse molecular clouds, and X-ray heated regions; (3) the chemistry and excitation of interstellar halides in dense molecular clouds, and the discovery of interstellar hydrogen fluoride; (4) the chemistry and excitation of water vapor in shocks, circumstellar outflows, translucent molecular clouds, and dense molecular clouds; (5) future prospects for probing the high-redshift Universe with molecular and other spectroscopic observations.

Source record↗
NASA NTRS2009

Detection of presence of chemical precursors

Methods and systems for determining if one or more target molecules are present in a gas, by exposing a functionalized carbon nanostructure (CNS) to the gas and measuring an electrical parameter value EPV(n) associated with each of N CNS sub-arrays. In a first embodiment, a most-probable concentration value C(opt) is estimated, and an error value, depending upon differences between the measured values EPV(n) and corresponding values EPV(n;C(opt)) is computed. If the error value is less than a first error threshold value, the system interprets this as indicating that the target molecule is present in a concentration C.apprxeq.C(opt). A second embodiment uses extensive statistical and vector space analysis to estimate target molecule concentration.

Li, Jing↗
NASA NTRS2017

Enzymatic Activity Detection via Electrochemistry for Enceladus

Electrochemical detection of biological molecules is a pertinent topic and application in many fields such as medicine, environmental spills, and life detection in space. Proteases, a class of molecules of interest in the search for life, catalyze the hydrolysis of peptides. Trypsin, a specific protease, was chosen to investigate an optimized enzyme detection system using electrochemistry. This study aims at providing the ideal functionalization of an electrode that can reliably detect a signal indicative of an enzymatic reaction from an Enceladus sample.

astrobiolog↗
NASA NTRS1979

Collimation of high-speed flow with thermal spread losses

The operation of the neutral beam collimator designed for the mass spectrometer inlet system of the Space Shuttle Induced Environment Contamination Monitor system is discussed. The collimator will allow selective views of a 10 deg half-angle conical volume of space so that backscattered molecules from within this volume can be measured and related to the column densities of outgassing species. Gas molecules which enter the collimator but do not have a view from the entrance orifice to the exit are directed to a gas getter and eliminated. The loss of properly directed molecules in the collimator due to their thermal distribution is calculated for the case of a directed flow, which would occur when the collimator is pointed in the direction of motion of the spacecraft. Inlet to outlet flux ratios are also computed as a function of angle of attack.

Taeusch, D. R.↗
NASA NTRS1981

Three new 'nonterrestrial' molecules

Eight new interstellar lines have been detected from three molecules not previously observed spectroscopically in space or in the laboratory. One is a linear or nearly linear molecule with microwave constants B0 equals 21,337.15 plus or minus 0.06 MHz, D0 equals 21.4 plus or minus 1.5 kHz. This is the thioformyl ion HCS(plus), first identified because B0 and D0 are close to those calculated, and now confirmed by laboratory detection of one of the present lines (Gudeman et al.). The second molecule, also linear or nearly so, has microwave constants B0 equals 10,691,406 plus or minus 0.043 MHz, D0 equals 1.84 plus or minus 0.91 kHz close to those expected for the isoelectronic systems HOCO(plus) and HOCN; a choice between the two cannot be made on the basis of the available astronomical data. The existence of a third molecule is deduced from an unidentified line at 85,338 MHz that has been found in many sources, is fairly intense in several, and may be self-absorbed in Sgr B2.

Thaddeus, P.↗
NASA NTRS1986

The nature of the bonding in the transition metal trimers

The electronic structure of the transition metal (TM) trimers was studied by comparing the bonding in the Ca3, Sc3, and Cu3 molecules. The complete active space SCF/externally contracted configuration interaction (CI) ratio for the low-lying states of Sc3 and Sc3(+) and the SCF/CI ratio for Ca3 and Cu3 trimers, all for near equilateral triangle geometries, were calculated. In addition, vertical excitation energies for Cu3 were computed, leading to a new assignment of the upper state in the resonant two-photon ionization spectrum. Based on these studies, bonding in other TM trimers was discussed.

Walch, Stephen P.↗
NASA NTRS1990

DSMC calculations for the double ellipse

The direct simulation Monte Carlo (DSMC) method involves the simultaneous computation of the trajectories of thousands of simulated molecules in simulated physical space. Rarefied flow about the double ellipse for test case 6.4.1 has been calculated with the DSMC method of Bird. The gas is assumed to be nonreacting nitrogen flowing at a 30 degree incidence with respect to the body axis, and for the surface boundary conditions, the wall is assumed to be diffuse with full thermal accommodation and at a constant wall temperature of 620 K. A parametric study is presented that considers the effect of variations of computational domain, gas model, cell size, and freestream density on surface quantities.

Moss, James N.↗
NASA NTRS2004

Modeling of Radiation Risks for Human Space Missions

Prior to any human space flight, calculations of radiation risks are used to determine the acceptable scope of astronaut activity. Using the supercomputing facilities at NASA Ames Research Center, Ames researchers have determined the damage probabilities of DNA functional groups by space radiation. The data supercede those used in the current Monte Carlo model for risk assessment. One example is the reaction of DNA with hydroxyl radical produced by the interaction of highly energetic particles from space radiation with water molecules in the human body. This reaction is considered an important cause of DNA mutations, although its mechanism is not well understood.

Fletcher, Graham↗
NASA NTRS2012

Walk Through Solar System Times: An Exhibit with an Astrobiology Emphasis

In this astrobiology outreach project, we attempt to present the research of the Goddard Center for Astrobiology (GCA) in the context of the history of the Solar System. GCA research emphasizes the origin and formation of complex pre-biotic organic materials in extraterrestrial environments and explores whether the delivery of these primordial materials and water to the early Earth enabled the emergence and evolution of life. The content expounds on areas that are usually not touched upon in a timeline of the Earth's formation. The exhibit addresses the questions: How did our solar system form? How is the formation of our solar systems similar or different from others? How did the organic molecules we observe in space get to the Earth? What conditions are most suitable for life? We will address the issues and challenges of designing the exhibit and of explaining advanced astrobiology research topics to the public.

Cheung, C. Y.↗
NASA NTRS2016

Airborne Measurements of Atmospheric Methane Using Pulsed Laser Transmitters

Atmospheric methane (CH4) is the second most important anthropogenic greenhouse gas with approximately 25 times the radiative forcing of carbon dioxide (CO2) per molecule. At NASA Goddard Space Flight Center (GSFC) we have been developing a laser-based technology needed to remotely measure CH4 from orbit. We report on our development effort for the methane lidar, especially on our laser transmitters and recent airborne demonstration. Our lidar transmitter is based on an optical parametric process to generate near infrared laser radiation at 1651 nanometers, coincident with a CH4 absorption. In an airborne flight campaign in the fall of 2015, we tested two kinds of laser transmitters --- an optical parametric amplifier (OPA) and an optical parametric oscillator (OPO). The output wavelength of the lasers was rapidly tuned over the CH4 absorption by tuning the seed laser to sample the CH4 absorption line at several wavelengths. This approach uses the same Integrated Path Differential Absorption (IPDA) technique we have used for our CO2 lidar for ASCENDS. The two laser transmitters were successfully operated in the NASAs DC-8 aircraft, measuring methane from 3 to 13 kilometers with high precision.

optical radar↗
NASA NTRS2017

The Diffuse Interstellar Bands: Solving a Century Old Problem

The Diffuse Interstellar Bands (DIBs) are a set of apporoximately 500 absorption bands that are seen in the spectra of reddened stars (i.e., stars obscured by the presence of interstellar clouds in their line of sight). The first DIBs were detected in the visible over a century ago. Diffuse Interstellar Bands are now detected from the near ultraviolet to the near infrared in the spectra of reddened stars spanning a variety of interstellar environments in our local, and in other galaxies. Although DIB carriers are a significant part of the interstellar chemical inventory as they account for a noticeable fraction of the interstellar extinction, the nature of their carriers is still unknown over a century after the detection of the first bands. DIB carriers are stable and ubiquitous in a broad variety of interstellar environments and play a unique role in interstellar physics and chemistry. It has long been realized that the solving of the DIB problem requires a strong synergy between astronomical observations, laboratory astrophysics and astrochemistry, quantum chemistry calculations and astrophysical modeling of line-of-sights. In this review, we'll present and discuss the current state of this perplexing problem. We'll review the progress and the failures that have been encountered in the long quest for the identification of the carriers of these ubiquitous interstellar bands.

Molecules in Space↗
NASA NTRS2015

Fiat Lux, Let There Be Light!

Most of us think of light as helping us see things, but it is so much more important than that. Light is electromagnetic energy moving in waves through space, interacting with atoms and molecules as it goes. So are radio waves, microwaves, infrared light, ultraviolet, x-rays and gamma rays - all of them are electromagnetic energy, and the only real difference is the spacing between the wave crests. So light gives us communications with each other with radio and TV, and it gives us the ability to travel through the universe using telescopes and our imagination. But light also gives us access to scientific questions, such as: what holds the atoms and molecules together? How does the mysterious quantum mechanics work? And understanding all these, how can we build electronic devices for modern life? And if we are very ambitious, we build accelerators like the Large Hadron Collider, and particles collide and concentrate electromagnetic energy into tiny spaces, and according to Einstein's E equals mc squared, we turn energy into new particles to learn, perhaps what the universe was like when it was a tiny fraction of a second old.

telescopes↗
NASA NTRS2015

Strategic Map for Exploring the Ocean-World Enceladus

Among the many "ocean worlds" of our solar system, Enceladus appears unique in its combination of astrobiologically relevant, exploration-worthy attributes: extensive liquid-water ocean with high-temperature hydrothermal activity, containing salts and organics expressed predictably into space. The Enceladus south polar plume allows direct access to telltale molecules, ions, isotopes, and potential cytofragments in space. Plume mass spectroscopy and sample return, in situ investigation of surface fallback deposits, direct vent exploration, and eventually oceanographic exploration can all be envisioned. However, building consensus to fund such ambitious exploration hinges on acquiring key new data. A roadmap is essential. It could start with cost-capped onramps: 1) flythrough analysis of the plume, following up on Cassini measurements with modern instruments; 2) sample return of plume material for analysis on Earth. A methodical mission sequence in which each step depends on emergent results from prior missions would push in situ oceanographic exploration into the second half of this century. Even for this scenario, prioritization by the next planetary Decadal Survey would be pivotal.

Cassini↗
NASA NTRS1987

High resolution infrared spectroscopy from space: A preliminary report on the results of the Atmospheric Trace Molecule Spectroscopy (ATMOS) experiment on Spacelab 3

The ATMOS (Atmospheric Trace Molecule Spectroscopy) experiment has the broad purpose of investigating the physical structure, chemistry, and dynamics of the upper atmosphere through the study of the distributions of the neutral minor and trace constituents and their seasonal and long-term variations. The technique used is high-resolution infrared absorption spectroscopy using the Sun as the radiation source, observing the changes in the transmission of the atmosphere as the line-of-sight from the Sun to the spacecraft penetrates the atmosphere close to the Earth's limb at sunrise and sunset. During these periods, interferograms are generated at the rate of one each second which yield, when transformed, high resolution spectra covering the 2.2 to 16 micron region of the infrared. Twenty such occultations were recorded during the Spacelab 3 flight, which have produced concentration profiles for a large number of minor and trace upper atmospheric species in both the Northern and Southern Hemispheres. Several of these species have not previously been observed in spectroscopic data. The data reduction and analysis procedures used following the flight are discussed; a number of examples of the spectra obtained are shown, and a bar graph of the species detected thus far in the analysis is given which shows the altitude ranges for which concentration profiles were retrieved.

Farmer, Crofton B.↗
NASA NTRS2001

Spectroscopic diagnostics of organic chemistry in the protostellar environment

A combination of astronomical observations, laboratory studies, and theoretical modelling is necessary to determine the organic chemistry of dense molecular clouds. We present spectroscopic evidence for the composition and evolution of organic molecules in protostellar environments. The principal reaction pathways to complex molecule formation by catalysis on dust grains and by reactions in the interstellar gas are described. Protostellar cores, where warming of dust has induced evaporation of icy grain mantles, are excellent sites in which to study the interaction between gas phase and grain-surface chemistries. We investigate the link between organics that are observed as direct products of grain surface reactions and those which are formed by secondary gas phase reactions of evaporated surface products. Theory predicts observable correlations between specific interstellar molecules, and also which new organics are viable for detection. We discuss recent infrared observations obtained with the Infrared Space Observatory, laboratory studies of organic molecules, theories of molecule formation, and summarise recent radioastronomical searches for various complex molecules such as ethers, azaheterocyclic compounds, and amino acids.

Ethers/analysis/chemical synthesis/chemistry↗
NASA NTRS2007

Fabry-Perot Based Radiometers for Precise Measurement of Greenhouse Gases

Differential radiometers based upon the Fabry-Perot interferometer have been developed and demonstrated that exhibit very great sensitivity to changes in the atmospheric column of carbon dioxide, oxygen, and water vapor. These instruments employ a solid Fabry-Perot etalon that is tuned to the proper wavelength by changing the temperature. By choosing the thickness of the etalon its multiple pass bands can be made to align with regularly space absorption features of the molecule under investigation. Use of multiple absorption features improves the optical throughput of the instrument and improves the stability of the instrument response with respect to environmental changes. Efforts are underway at Goddard to extend this technique to the carbon 13 isotope of carbon dioxide and to methane. These instruments are intrinsically rugged and can be made rather small and inexpensively. They therefore hold promise for widespread use in ground based networks for calibration of satellite instruments such as OCO and GOSAT. Results will be presented for ground based and airborne operations for these systems. The effects of atmospheric scattering, pointing errors, pressure broadening and temperature effects will be discussed with regard to achieving precision better than .5% required for validation of carbon dioxide column measured from space. Designs permitting the extension of the technique to an even larger number of atmospheric species will be discussed along with theoretical analysis of potential system performance.

Heaps, William S.↗