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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 109 records · Page 6

Biology

Exobiological studies of blood circulation, and radiation and acceleration tolerances in rabbits and mice

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Late effects of 2.2 GeV protons on the central nervous system.

Investigation of late pathological effects of high-energy (2.2 GeV) protons on the brain of rabbits, in a postirradiation period of up to 16 months following exposure at fluxes of 30, 100, and 1000 billion protons per sq cm. At the latter two irradiation-intensity levels, the kinds of brain lesions inflicted include large venous dilatation, thickening of vessel walls with deposit of amorphous PAS positive substance, thrombosis, perivascular infiltration of leukocytes and macrophages, mobilization of microglia cells, gliosis, demyelinization, and multiple small pseudocyst formation.

Lippincott, S. W.↗

Effects of oxygen-augmented atmosphere on the immune response.

Antibovine serum albumin antibody and nonspecific protein production was evaluated in female rabbits (11-14.5 kg) housed in special cages ventilated with 20% or 40% oxygen at normal barometric pressure. Animals exposed to 40% oxygen do not show normal steady increase of serum antibody. Instead, their titers show a pattern of undershoot, overshoot, undershoot, and finally equilibration at a subnormal level; they have a depressed popliteal node polysome level and have an abnormally low proportion of membrane-bound polysomes. They also show reduced capability of popliteal nodes to synthesize protein (as expected from the reduced number of polysomes). However, the ratio of newly-synthesized specific antibody: nonspecific protein remains normal.

Guttman, H. N.↗

Optokinetic stimulation of an immobilized eye in the monkey.

Quantitative investigation of the optokinetic nystagmus effect in rhesus monkeys. The results obtained are shown to parallel those found for the rabbit by Ter Braak (1936). Quantitative findings pertaining to the ratio between slow velocity of nystagmus and stimulus speed as a power function of pattern motion velocity and to other parameters are presented graphically and discussed.

Korner, F.↗

Evaluation of possible interaction among drugs contemplated for use during manned space flights

Possible interactions among drugs contemplated for use during manned spaceflights have been studied in several animal species. The following seven drugs were investigated: nitrofurantoin, chloral hydrate, hexobarbital, phenobarbital, flurazepam, diphenoxylate, and phenazopyridine. Particular combinations included: chloral hydrate, hexabarbital or flurazepam with nitrofurantoin; phenobarbital or flurazepam with phenazopyridine; and diphenoxylate with two does formulations of nitrofurantoin. Studies were carried out in several species to determine whether induction of liver microsomal enzymes would increase the tendency of phenazopyridine to produce methemoglobin in vivo. Animals were premedicated with phenobarbital, a known inducer of azoreductase, and in a separate experiment with flurazepam, before administration of phenazopyridine. Methemoglobin production was determined in each animal after receiving phenazopyridine. No evidence was found for increased production of methemoglobin in the rat, dog, or rabbit that could be attributed to increased amounts of microsomal enzymes.

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An analysis of the circuitry of the visual pathway of the lateral eye of limullus

The methodology is discussed for three-dimensional analysis of the nervous system on the basis of electron micrographs of serial sections. An analysis is presented of a part of the circuitry of the rabbit retina. In addition, some exploratory work is reported with respect to the visual cortex of the cat brain. A proper technique for preservation of the visual cortex was worked out and a technique to localize microelectrode tips in the tissue in connection with electron microscopy was partially worked out.

Sjoestrand, F. S.↗

The 1973 Ethiopian-Rift geodimeter survey

Remeasurement of the Adama, Lake Langana, and Arba Minch (Lake Margherita) geodimeter networks in 1973 has enabled Mohr's interpretation concerning possible surface ground deformation in the Ethiopian rift to be considerably developed. Extension appears to have occurred across the Mojjo-Adama horst at a rate of about 1 cm yr/1. The opposing rims of the Adama graben have not moved significantly relative to one another (between 1969 and 1973), but stations on the sliced graben floor show possible movement with a large rift-trend component. In the Wolenchiti quadrilateral, significant movement of station RABBIT is confirmed, but the radical change of vector (that of 1970-1971 to that of 1971-1973) casts doubt on a tectonic cause and seems to indicate that stations on steep hillslopes are liable to be unstable. South of the quadrilateral and east of the Adama graben, alternating rift-trend zones of extension and shortening appear to coexist. In the Lake Langana network, significant movements of the order of 0.5 cm yr/1 are directed perpendicular to the rift floor faulting.

Mohr, P. A.↗

The influence of a constant magnetic field on the coagulatory system of the blood in an experiment

The influence of a constant magnetic field with a strength of 2500 oersteds on the coagulatory system of the blood in rabbits was studied; the animals were subjected to this field for one and five hours. The magnetic field acts on the coagulatory system of the blood after only one hour exposure. Repeated 5-hour exposures cause activation of the anticoagulatory system in the blood and causes distinctive effects on the subsequent changes in the coagulatory system of the blood. It is quite likely that in this instance the adaptational properties of the organism make themselves felt.

Zabrodina, L. V.↗

Repeated action of a constant magnetic field on the blood coagulation system in artificially produced anemia

Changes are discussed in the coagulatory system of the blood in rabbits under the influence of a constant magnetic field of an intensity of 2500 oersteds against the background of artificially induced anemia. Reversibility of the changes produced and the presence of the adaptational effect are noted. Taking all this into consideration, the changes involving the coagulatory system of the blood which arise under the influence of a constant magnetic field may be considered to have a nerve-reflex nature.

Zabrodina, L. V.↗