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Reactivation of latent Epstein-Barr virus (EBV) may be an important threat to crew health during extended space missions. Cellular immunity, which is decreased during and after space flight, is responsible for controlling EBV replication in vivo. In this study, we investigated the effects of short-term space flight on latent EBV reactivation.
We are developing high-energy grazing-incidence replicated optics for a balloon-borne hard-x-ray telescope. When completed, the instrument will have 170 cm2 of effective collecting area at 40 keV and 130 square cm at 60 keV with <= 30 arc seconds half power diameter. This payload will offer unprecedented sensitivity in the hard-x-ray region, with around 250 microCrab sensitivity on long-duration flights and 50-100 microCrab on ultra- long-duration balloon missions The payload consists of 16 mirror modules, each with 14 nested mirrors made from a high-strength nickel alloy, and a corresponding array of 16 focal plane detectors. An engineering demonstration flight is scheduled for the Spring of 2000, using just two mirror modules each with 3 shells, above a pair of gas-scintillation-proportional counters. This flight is intended to test a newly designed gondola pointing and aspect system and the stability of the optical bench design. The first scientific flight of the full payload is scheduled for the Fall of 2002. Full details of the payload and its capabilities will be presented together with data from various mirror-module tests. If available data from the first flight will also be presented.
This presentation discuss ground-based simulation, and flight-tests study (HAVE PIO). The purpose of this study is to determine if the amount of platform motion affects ability to replicate in-flight results.
In support of the Constellation X mission the Optics Branch at Goddard Space Flight Center is developing technology for precision figuring and polishing of mandrels used to produce replicated mirrors that will be used in X-Ray telescopes. Employing a specially built machine controlled in 2 axes by a computer, we are doing automated polishing/figuring of 15 cm long, 20 cm diameter cylindrical, conical and Wolter mandrels. A battery of tests allow us to fully characterize all important aspects of the mandrels, including surface figure and finish, mid-frequency errors, diameters and cone angle. Parts are currently being produced with surface roughnesses at the .5nm RMS level, and half-power diameter slope error less than 2 arcseconds.
We are developing grazing incidence x-ray optics for a balloon-borne hard-x-ray telescope (HERO). The HERO mirror shells are fabricated using electroform-nickel replication off super-polished cylindrical mandrels. One of the sources for mirror resolution error is departure of the shell figure from prescription. We have modified a Vertical-scan Long Trace Profilometer (VLTP) in order to measure the figure of the inner surface of the HERO mirror shells for diameters as small as 76 mm. Mirror alignment method and sources for systematic errors will be discussed. Comparison of figure metrology of the mandrel and the shells will be presented together with results from x-ray tests.
Replicated nickel optics has been used extensively in x-ray astronomy, most notable for the XMM/Newton mission. Thc combination of relative ease of fabrication and the inherent stability of full shell optics, make them FIJI attractive approach for medium-resolution, high-throughput applications. MSFC has been developing these optics for use in the hard-x-ray region. Efforts at improving the resolution of these, particularly the very-thin shells required to meet thc weight budget of future missions, will be described together with the prospects for significant improvements down to the 5-arcsec level.
Surface replication has been proposed as a method for crack detection in space shuttle main engine flowliner slots. The results of a feasibility study show that examination of surface replicas with a scanning electron microscope can result in the detection of cracks as small as 0.005 inch, and surface flaws as small as 0.001 inch, for the flowliner material.
We are developing grazing-incidence x-ray optics for astronomy. The optics are full-cylinder mirror shells fabricated using electroformed-nickel replication off super-polished mandrels. For space-based applications where weight is at a premium, very-thin-walled, light-weight mirrors are required. Such shells have been fabricated at MSFC with greater than 15 arcsec resolution. The challenge, however, is to preserve this resolution during mounting and assembly. We present here a status report on a mounting and alignment system currently under development at Marshall Space Flight Center to meet this challenge.
High resolution B-mode ultrasound images of the common carotid artery are obtained with an ultrasound transducer using a standardized methodology. Subjects are supine with the head counter-rotated 45 degrees using a head pillow. The jugular vein and carotid artery are located and positioned in a vertical stacked orientation. The transducer is rotated 90 degrees around the centerline of the transverse image of the stacked structure to obtain a longitudinal image while maintaining the vessels in a stacked position. A computerized methodology assists operators to accurately replicate images obtained over several spaced-apart examinations. The methodology utilizes a split-screen display in which the arterial ultrasound image from an earlier examination is displayed on one side of the screen while a real-time live ultrasound image from a current examination is displayed next to the earlier image on the opposite side of the screen. By viewing both images, whether simultaneously or alternately, while manually adjusting the ultrasound transducer, an operator is able to bring into view the real-time image that best matches a selected image from the earlier ultrasound examination. Utilizing this methodology, measurement of vascular dimensions such as carotid arterial IMT and diameter, the coefficient of variation is substantially reduced to values approximating from about 1.0% to about 1.25%. All images contain anatomical landmarks for reproducing probe angulation, including visualization of the carotid bulb, stacking of the jugular vein above the carotid artery, and initial instrumentation settings, used at a baseline measurement are maintained during all follow-up examinations.
A passive replicator comprising a plurality of elongated bars interposed between an input propagation path and a plurality of output propagation paths.
We are developing grazing-incidence x-ray optics for high-energy astrophysical applications using the electroformnickel replication process. For space-based applications these optics must be light-weight yet stable, which dictates the use of very-thin-walled full-shell mirrors. Such shells have been fabricated with resolution as good as 11 arcsec for hard x-rays, and technology enhancements under development at MSFC are aimed at producing mirrors with resolution better than 10 arcsec. The challenge, however, is to preserve this resolution during mounting and assembly. We present here a status report on a mounting and alignment system currently under development at Marshall Space Flight Center designed to meet this challenge.
Phase change materials (PCM) may be useful for thermal control systems that involve cyclical heat loads or cyclical thermal environments such as Low Earth Orbit (LEO) and Low Lunar Orbit (LLO). Thermal energy can be stored in the PCM during peak heat loads or in adverse thermal environments. The stored thermal energy can then be released later during minimum heat loads or in more favorable thermal environments. One advantage that PCM s have over evaporators in this scenario is that they do not use a consumable. Wax PCM units have been baselined for the Orion thermal control system and also provide risk mitigation for the Altair Lander. However, the use of water as a PCM has the potential for significant mass reduction since the latent heat of formation of water is approximately 70% greater than that of wax. One of the potential drawbacks of using ice as a PCM is its potential to rupture its container as water expands upon freezing. In order to develop a space qualified ice PCM heat exchanger, failure mechanisms must first be understood. Therefore, a methodical experimental investigation has been undertaken to demonstrate and document specific failure mechanisms due to ice expansion in the PCM. An ice PCM heat exchanger that replicates the thermal energy storage capacity of an existing wax PCM unit was fabricated and tested. Additionally, methods for controlling void location in order to reduce the risk of damage due to ice expansion are investigated. This paper presents the results to date of this investigation.
Phase change materials (PCM) may be useful for thermal control systems that involve cyclical heat loads or cyclical thermal environments such as Low Earth Orbit (LEO) and Low Lunar Orbit (LLO). Thermal energy can be stored in the PCM during peak heat loads or in adverse thermal environments. The stored thermal energy can then be released later during minimum heat loads or in more favorable thermal environments. One advantage that PCM's have over evaporators in this scenario is that they do not use a consumable. Wax PCM units have been baselined for the Orion thermal control system and also provide risk mitigation for the Altair Lander. However, the use of water as a PCM has the potential for significant mass reduction since the latent heat of formation of water is approximately 70% greater than that of wax. One of the potential drawbacks of using ice as a PCM is its potential to rupture its container as water expands upon freezing. In order to develop a space qualified ice PCM heat exchanger, failure mechanisms must first be understood. Therefore, a methodical experimental investigation has been undertaken to demonstrate and document specific failure mechanisms due to ice expansion in the PCM. An ice PCM heat exchanger that replicates the thermal energy storage capacity of an existing wax PCM unit was fabricated and tested. Additionally, methods for controlling void location in order to reduce the risk of damage due to ice expansion are investigated. This paper presents the results to date of this investigation. Nomenclature
The role of variance in a Modern Design of Experiments analysis of wind tunnel data is reviewed, with distinctions made between explained and unexplained variance. The partitioning of unexplained variance into systematic and random components is illustrated, with examples of the elusive systematic component provided for various types of real-world tests. The importance of detecting and defending against systematic unexplained variance in wind tunnel testing is discussed, and the random and systematic components of unexplained variance are examined for a representative wind tunnel data set acquired in a test in which a missile is used as a test article. The adverse impact of correlated (non-independent) experimental errors is described, and recommendations are offered for replication strategies that facilitate the quantification of random and systematic unexplained variance.
Life can be defined as a self-sustaining chemical system capable of undergoing Darwinian evolution; a self-bounded, self-replicating, and self-perpetuating entity [1]. This definition should hold for terrestrial as well as extraterrestrial life-forms. Although, it is reasonable to expect that a Mars life-form would be more adaptable to Mars-like conditions than to Earth-like environments, it remains possible that negative ecological or host interactions might occur if Mars microbiota were to be inadvertently released into the terrestrial environment. A biogenic infectious agent can be defined as a self-sustaining chemical system capable of undergoing Darwinian evolution and derives its sustenance from a living cell or from the by-products of cell death. Disease can be de-fined as the detrimental alteration of one or more ordered metabolic processes in a living host caused by the continued irritation of a primary causal factor or factors; disease is a dynamic process [2]. In contrast, an injury is due to an instantaneous event; injury is not a dynamic process [2]. A causal agent of disease is defined as a pathogen, and can be either abiotic or biotic in nature. Diseases incited by biotic pathogens are the exceptions, not the norms, in terrestrial host-microbe interactions. Disease induction in a plant host can be conceptually characterized using the Disease Triangle (Fig. 1) in which disease occurs only when all host, pathogen, and environ-mental factors that contribute to the development of disease are within conducive ranges for a necessary minimum period of time. For example, plant infection and disease caused by the wheat leaf rust fungus, Puccinia recondita, occur only if virulent spores adhere to genetically susceptible host tissues for at least 4-6 hours under favorable conditions of temperature and moisture [3]. As long as one or more conditions required for disease initiation are not available, disease symptoms will not develop.
A new approach for arc jet testing of thermal protection materials at conditions approximating the time-varying conditions of atmospheric entry was developed and demonstrated. The approach relies upon the spatial variation of heat flux and pressure over a cylindrical test model. By slowly rotating a cylindrical arc jet test model during exposure to an arc jet stream, each point on the test model will experience constantly changing applied heat flux. The predicted temporal profile of heat flux at a point on a vehicle can be replicated by rotating the cylinder at a prescribed speed and direction. An electromechanical test model mechanism was designed, built, and operated during an arc jet test to demonstrate the technique.
On September 21-22, 2013, the High Energy Replicated Optics to Explore the Sun (HEROES) hard X-ray telescope, flew as a balloon payload from Ft. Sumner, N.M. HEROES observed the Sun, the black hole binary GRS 1915+105, and the Crab Nebula during its 27 hour flight. In this paper we describe laboratory calibration measurements of the HEROES detectors using line and continuum sources, applications of these measurements to define channel to energy (gain) corrections for observed events and to define detector response matrices. We characterize the HEROES X-ray grazing incidence optics using measurements taken in the Stray-Light (SLF) Facility in Huntsville, AL, and using ray traces.
A new approach to arc jet testing that replicates the time-varying conditions of atmospheric entry heating was demonstrated. The concept relies on the spatial variation of heat flux and pressure around a cylindrical test article. The spatial variation is transformed to a temporal variation at one location by rotating the test article during exposure to the arc jet stream. The test article rotation mechanism is based on a programmable stepper motor. An entry heat flux profile was mapped to the cylinders heat flux distribution to determine the rotation angle vs. time executed by the mechanism. A series of arc jet tests with instrumented cylindrical TPS test articles was conducted to prove the concept.