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At least 109 records · Page 6

Osmosensor-mediated control of Ca 2+ spiking in pollen germination

Higher plants survive terrestrial water deficiency and fluctuation by arresting cellular activities (dehydration) and resuscitating processes (rehydration). However, how plants monitor water availability during rehydration is unknown. Although increases in hypo-osmolarity-induced cytosolic Ca 2+ concentration (HOSCA) have long been postulated to be the mechanism for sensing hypo-osmolarity in rehydration, the molecular basis remains unknown. Because osmolarity triggers membrane tension and the osmosensing specificity of osmosensing channels can only be determined in vivo, these channels have been classified as a subtype of mechanosensors. Here we identify bona fide cell surface hypo-osmosensors in Arabidopsis and find that pollen Ca 2+ spiking is controlled directly by water through these hypo-osmosensors—that is, Ca 2+ spiking is the second messenger for water status. We developed a functional expression screen in Escherichia coli for hypo-osmosensitive channels and identified OSCA2.1, a member of the hyperosmolarity-gated calcium-permeable channel (OSCA) family of proteins. We screened single and high-order OSCA mutants, and observed that the osca2.1/osca2.2 double-knockout mutant was impaired in pollen germination and HOSCA. OSCA2.1 and OSCA2.2 function as hypo-osmosensitive Ca 2+ -permeable channels in planta and in HEK293 cells. Decreasing osmolarity of the medium enhanced pollen Ca 2+ oscillations, which were mediated by OSCA2.1 and OSCA2.2 and required for germination. OSCA2.1 and OSCA2.2 convert extracellular water status into Ca 2+ spiking in pollen and may serve as essential hypo-osmosensors for tracking rehydration in plants.

59 BASIC BIOLOGICAL SCIENCES↗

Citation network datasets for benchmarking spiking graph neural networks on experimental neuromorphic hardware

Spiking neural networks (SNNs) running on neuromorphic computers offer an energy-efficient alternative for AI tasks. Recently, spiking graph neural networks (S-GNNs) have been shown to produce encouraging results on benchmark citation network datasets such as Cora, CiteSeer, and PubMed for node classification tasks. These S-GNNs were run on SNN simulators only because they contain up to tens of thousands of neurons and up to millions of synapses, translating poorly to neuromorphic hardware. Therefore, in this paper, we create a suite of benchmark datasets from the CiteSeer dataset that can be accommodated on current neuromorphic hardware platforms. Our contribution consists of a collection of three datasets. First, we have an induced subgraph of CiteSeer, which we call MiniSeer, containing 2110 papers, 3604 binary features, and 6 topics. Second, MicroSeer is a very small dataset consisting of 84 papers, 1227 features, and 6 topics. Lastly, BiteSeer is a collection of 15 binary classification datasets. We present creation of these datasets along with accuracies, running times, and spike counts when simulated. We believe that our results in this paper will be used by the neuromorphic community to benchmark, test, and develop neuromorphic hardware and simulators.

Zhu, Kevin [George Mason University, Virginia]↗

Easy-plane spin Hall nano-oscillators as spiking neurons for neuromorphic computing

Here we show analytically using a macrospin approximation that easy-plane spin Hall nano-oscillators excited by a spin current polarized perpendicularly to the easy plane have phase dynamics analogous to that of Josephson junctions. Similarly to Josephson junctions, they can reproduce the spiking behavior of biological neurons that is appropriate for neuromorphic computing. To take advantage of typical spin-orbit torques, we use a nanoconstriction geometry, in which the magnetostatic interaction and magnetocrystalline anisotropy are tuned to create an easy plane that includes the interface normal direction. We perform micromagnetic simulations of such oscillators realized in this geometry and show that the easy-plane spiking dynamics is preserved in this experimentally feasible architecture. Finally we simulate two elementary neural network blocks that implement operations essential for neuromorphic computing. First, we show that output spikes energies from two neurons can be summed and injected into a following layer neuron and second, we demonstrate that outputs can be multiplied by synaptic weights implemented by locally modifying the anisotropy.

36 MATERIALS SCIENCE↗

Resilience and Robustness of Spiking Neural Networks for Neuromorphic Systems

Though robustness and resilience are commonly quoted as features of neuromorphic computing systems, the expected performance of neuromorphic systems in the face of hardware failures is not clear. In this work, we study the effect of failures on the performance of four different training algo-rithms for spiking neural networks on neuromorphic systems: two back-propagation-based training approaches (Whetstone and SLAYER), a liquid state machine or reservoir computing approach, and an evolutionary optimization-based approach (EONS). We show that these four different approaches have very different resilience characteristics with respect to simulated hardware failures. We then analyze an approach for training more resilient spiking neural networks using the evolutionary optimization approach. We show how this approach produces more resilient networks and discuss how it can be extended to other spiking neural network training approaches as well.

Schuman, Catherine↗

Spike-based graph centrality measures

We derive several spike-based routines that compute or establish bounds on radial centrality measures for undirected graphs and trees without the use of matrix multiplication. These spike-based centrality measures utilize a direct embedding of graph nodes and edges into neurons and synapses, can be implemented with static synapses or plastic synapses, and rely on minimal post-processing of spike rasters. This work contributes to the growing set of graphical applications for neuromorphic hardware.

Hamilton, Kathleen↗

Mapping Spiking Neural Networks to Heterogeneous Crossbar Architectures using Integer Linear Programming

Advances in novel hardware devices and architectures allow Spiking Neural Network (SNN) evaluation using ultra-low power, mixed-signal, memristor crossbar arrays. As individual network sizes quickly scale beyond the dimensional capabilities of single crossbars, networks must be mapped onto multiple crossbars. Crossbar sizes within modern Memristor Crossbar Architectures (MCAs) are determined predominately not by device technology but by network topology; more, smaller crossbars consume less area thanks to the high structural sparsity found in larger, brain-inspired SNNs. Motivated by continuing increases in SNN sparsity due to improvements in training methods, we propose utilizing heterogeneous crossbar sizes to further reduce area consumption. This approach was previously unachievable as prior compiler studies only explored solutions targeting homogeneous MCAs. Our work improves on the state-of-the-art by providing Integer Linear Programming (ILP) formulations supporting arbitrarily heterogeneous architectures. By modeling axonal interactions between neurons, our methods produce better mappings while removing inhibitive a priori knowledge requirements. We first show a 16.7-27.6% reduction in area consumption for square-crossbar homogeneous architectures. Then, we demonstrate 66.9-72.7% further reduction when using a reasonable configuration of heterogeneous crossbar dimensions. Next, we present a new optimization formulation capable of minimizing the number of inter-crossbar routes. When applied to solutions already near-optimal in area, an 11.9-26.4% routing reduction is observed without impacting area consumption. Finally, we present a profile-guided optimization capable of minimizing the number of runtime spikes between crossbars. Compared to the best-area-then-route optimized solutions, we observe a further 0.5-14.8% inter-crossbar spike reduction while requiring 1–3 orders of magnitude less solver time.

Pohl, Devin [ORNL] (ORCID:0009000040149027)↗

Investigation of the Effect of Temperature on the Structure of SARS-CoV-2 Spike Protein by Molecular Dynamics Simulations

Statistical and epidemiological data imply temperature sensitivity of the SARS-CoV2 coronavirus. However, the molecular level understanding of the virus structure at different temperature is still not clear. Spike protein is the outermost structural protein of the SARS-CoV-2 virus which interacts with the Angiotensin Converting Enzyme 2 (ACE2), a human receptor, and enters the respiratory system. In this study, we performed an all atom molecular dynamics simulation to study the effect of temperature on the structure of the Spike protein. After 200 ns of simulation at different temperatures, we came across some interesting phenomena exhibited by the protein. We found that the solvent exposed domain of Spike protein, namely S1, is more mobile than the transmembrane domain, S2. Structural studies implied the presence of several charged residues on the surface of N-terminal Domain of S1 which are optimally oriented at 10– 30°C. Bioinformatics analyses indicated that it is capable of binding to other human receptors and should not be disregarded. Additionally, we found that receptor binding motif (RBM), present on the receptor binding domain (RBD) of S1, begins to close around temperature of 40°C and attains a completely closed conformation at 50°C. We also found that the presence of glycan moieties did not influence the observed protein dynamics. Nevertheless, the closed conformation disables its ability to bind to ACE2, due to the burying of its receptor binding residues. Our results clearly show that there are active and inactive states of the protein at different temperatures. This would not only prove beneficial for understanding the fundamental nature of the virus, but would be also useful in the development of vaccines and therapeutics.

59 BASIC BIOLOGICAL SCIENCES↗

Latent Tracks in Ion-Irradiated LiTaO 3 Crystals: Damage Morphology Characterization and Thermal Spike Analysis

Systematic research on the response of crystal materials to the deposition of irradiation energy to electrons and atomic nuclei has attracted considerable attention since it is fundamental to understanding the behavior of various materials in natural and manmade radiation environments. This work examines and compares track formation in LiTaO3 induced by separate and combined effects of electronic excitation and nuclear collision. Under 0.71–6.17 MeV/u ion irradiation with electronic energy loss ranging from 6.0 to 13.8 keV/nm, the track damage morphologies evolve from discontinuous to continuous cylindrical zone. Based on the irradiation energy deposited via electronic energy loss, the subsequently induced energy exchange and temperature evolution processes in electron and lattice subsystems are calculated through the inelastic thermal spike model, demonstrating the formation of track damage and relevant thresholds of lattice energy and temperature. Combined with a disorder accumulation model, the damage accumulation in LiTaO3 produced by nuclear energy loss is also experimentally determined. The damage characterizations and inelastic thermal spike calculations further demonstrate that compared to damage-free LiTaO3, nuclear-collision-damaged LiTaO3 presents a more intense thermal spike response to electronic energy loss owing to the decrease in thermal conductivity and increase in electron–phonon coupling, which further enhance track damage.

36 MATERIALS SCIENCE↗

Stellar occultation spikes as probes of atmospheric structure and composition

The characteristics of spikes observed in occultation light curves of Beta Scorpii by Jupiter are discussed in terms of the gravity-gradient model. The occultation of Beta Sco by Jupiter on May 13, 1971, is reviewed, and the gravity-gradient model is defined as an isothermal atmosphere of constant composition in which the refractivity is a function only of the radial coordinate from the center of refraction, which is assumed to lie parallel to the local gravity gradient. The derivation of the occultation light curve in terms of the atmosphere, the angular diameter of the occulted star, and the occultation geometry is outlined. It is shown that analysis of the light-curve spikes can yield the He/H2 concentration ratio in a well-mixed atmosphere, information on fine-scale atmospheric structure, high-resolution images of the occulted star, and information on ray crossing. Observational limits are placed on the magnitude of horizontal refractivity gradients, and it is concluded that the spikes are the result of local atmospheric density variations: atmospheric layers, density waves, or turbulence.

Elliot, J. L.↗

Bright, rapid, highly polarized radio spikes from the M dwarf AD Leonis

A rapid sequence of highly polarized spikes was observed during the gradual rise of a longer lasting event in an Arecibo Observatory study of a radio burst at 1400 MHz from the main sequence radio star AD Leo. The maximum flux density of the spikes was 130 mJy, and they had rise times of less than about 200 msec. The rise times provide an upper limit to the linear size of the emitter of 6 billion cm, and an area of less than 0.03 of the star's surface area is inferred, for a spike brightness temperature of more than about 10 to the 13th K. The high brightness temperatures and high degrees of circular polarization are explained in terms of electron-cyclotron maser emission at the second harmonic of the gyrofrequency, in longitudinal magnetic fields of about 250 G.

Lang, K. R.↗

Extremely rapid radio spikes in flares: A review

Radio spikes of a few to tens of milliseconds of the solar radio emission have recently seen a surge of interest of theoreticians who are fascinated by their high brightness temperature of up to 10 to the 15th power K, their association with hard X-ray bursts, and a possibly very intimate relation to electron acceleration. Their bandwidth and global distribution in frequency were quantitatively measured only recently. This review is intended to emphasize the considerable extend of old and new observational knowledge which is hardly touched upon by theory. The wide range of spike observations is summarized and brought into perspective of recent models. It is concluded that spikes yield a considerable potential for the diagnostics of energetic particles, their origin, and history in astrophysical plasmas.

Benz, A. O.↗

The role of narrowband dm-spikes in solar flares

The main observational characteristics of narrowband dm-spikes are summarized. Since the spikes are observed in typical sequences of radio bursts, a global model of these bursts is presented. The intensity of the magnetic field in the spike source region, which is of principal importance, is discussed.

Karlicky, Marian↗

The microwave spectrum of solar millisecond spikes

The microwave radiation from solar flares sometimes shows short and intensive spikes which are superimposed on the burst continuum. In order to determine the upper frequency limit of their occurrence and the circular polarization, a statistical analysis was performed on digital microwave observations from 3.2 to 92.5 GHz. Additionally, fine structures were investigated with a fast 32-channel spectrometer at 3.47 GHz. It was found that about 10 percent of the bursts show fine structures at 3.2 and 5.2 GHz, whereas none occurred above 8.4 GHz. Most of the observed spikes were very short and their bandwidth varied from below 0.5 MHz to more than 200 MHz. Simultaneous observations at two further frequencies showed no coincident spikes at the second and third harmonic. The observations can be explained by the theory of electron cyclotron masering if the observed bandwidths are determined by magnetic field inhomogeneities or if the rise times are independent of the source diameters. The latter would imply source sizes between 50 and 100 km.

Staehli, M.↗

Sunward spike and equatorial plane of Halley's Comet

Photographs from late April until at least early June 1986 of comet Halley show a narrow spike in the Sun's direction. It extends to distances of at least 700,000 km from the nucleus in projection onto the sky on computer processed photographs. The spike is composed of dust and its enormous sunward extent (compared to other dust features) suggests an anomalously high ratio of particle ejection velocity to solar radiation pressure. The implied grains are either dielectric or slightly absorbing and much less than 1 micron in size, which are undetectable optically, unless Earth is located in or very near a plane of their concentration. The only plane to which these grains can possibly be confined for long is the equatorial plane of the nucleus, especially when the obliquity is small. Accordingly, the spike's position as a function of time contains information on the comet's spin axis.

Sekanina, Z.↗

Spike: Artificial intelligence scheduling for Hubble space telescope

Efficient utilization of spacecraft resources is essential, but the accompanying scheduling problems are often computationally intractable and are difficult to approximate because of the presence of numerous interacting constraints. Artificial intelligence techniques were applied to the scheduling of the NASA/ESA Hubble Space Telescope (HST). This presents a particularly challenging problem since a yearlong observing program can contain some tens of thousands of exposures which are subject to a large number of scientific, operational, spacecraft, and environmental constraints. New techniques were developed for machine reasoning about scheduling constraints and goals, especially in cases where uncertainty is an important scheduling consideration and where resolving conflicts among conflicting preferences is essential. These technique were utilized in a set of workstation based scheduling tools (Spike) for HST. Graphical displays of activities, constraints, and schedules are an important feature of the system. High level scheduling strategies using both rule based and neural network approaches were developed. While the specific constraints implemented are those most relevant to HST, the framework developed is far more general and could easily handle other kinds of scheduling problems. The concept and implementation of the Spike system are described along with some experiments in adapting Spike to other spacecraft scheduling domains.

Johnston, Mark↗

Computational studies of a fluid spike as a leading edge protection device for shock-shock interference heating

The effectiveness of a fluid spike as a device to protect leading edges of hypersonic atmospheric flight vehicles from high aerothermal loads produced by complex shock-shock interference is studied. The two-dimensional Navier-Stokes equations are solved using an unstructured cell-centered, fully implicit, flux-difference split algorithm. Adaptively generated unstructured meshes are employed. A type IV shock-shock interference for Mach 8 flow on a cylindrical leading edge with and without a small contraflow supersonic jet (fluid spike) placed at two different locations on the body is solved. A typical flow past a blunt body with a type IV shock-shock interference produces very high pressures and heat fluxes on the leading edge. Present results indicate that a fluid spike displaces the bow shock further in front of the body and modifies the shock-shock interference pattern. This leads to reduced peak pressures and heat fluxes on the body.

Prabhu, Ramadas K.↗

SPIKE: AI scheduling techniques for Hubble Space Telescope

AI (Artificial Intelligence) scheduling techniques for HST are presented in the form of the viewgraphs. The following subject areas are covered: domain; HST constraint timescales; HTS scheduling; SPIKE overview; SPIKE architecture; constraint representation and reasoning; use of suitability functions by scheduling agent; SPIKE screen example; advantages of suitability function framework; limiting search and constraint propagation; scheduling search; stochastic search; repair methods; implementation; and status.

Johnston, Mark D.↗

Anomalous TWTA output power spikes and their effect on a digital satellite communications system

Several 30 GHz, 60 W traveling wave tube amplifiers (TWTA) were manufactured for the NASA Lewis Research Center's High Burst Rate Link Evaluation Terminal Project. An unusual operating problem characterized by anomalous nonperiodic output power spikes, common to all of the TWTAs proved during testing to significantly affect the performance of a digitally-modulated data transmission test system. Modifications made to the TWTAs significantly curtailed the problem and allowed acceptable system performance to be obtained. This paper presents a discussion of the TWTA output power spike problem, possible causes of the problem, and the solutions implemented by the manufacturer which improved the TWTA performance to an acceptable level. The results of the testing done at NASA Lewis on the TWTAs both before and after the improvement made by Hughes are presented, and the effects of the output power spikes on the performance of the test system are discussed.

May, Brian D.↗