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NASA NTRS2010

Fluorogenic Cell-Based Biosensors for Monitoring Microbes

Fluorogenic cell-based sensor systems for detecting microbes (especially pathogenic ones) and some toxins and allergens are undergoing development. These systems harness the natural signaltransduction and amplification cascades that occur in mast cells upon activation with antigens. These systems include (1) fluidic biochips for automated containment of samples, reagents, and wastes and (2) sensitive, compact fluorometers for monitoring the fluorescent responses of mast cells engineered to contain fluorescent dyes. It should be possible to observe responses within minutes of adding immune complexes. The systems have been shown to work when utilizing either immunoglobulin E (IgE) antibodies or traditionally generated rat antibodies - a promising result in that it indicates that the systems could be developed to detect many target microbes. Chimeric IgE antibodies and rat immunoglobulin G (IgG) antibodies could be genetically engineered for recognizing biological and chemical warfare agents and airborne and food-borne allergens. Genetic engineering efforts thus far have yielded (1) CD14 chimeric antibodies that recognize both Grampositive and Gram-negative bacteria and bind to the surfaces of mast cells, eliciting a degranulation response and (2) rat IgG2a antibodies that act similarly in response to low levels of canine parvovirus.

Curtis, Theresa↗

NASA NTRS2010

Use of Dynamic Models and Operational Architecture to Solve Complex Navy Challenges

The United States Navy established 8 Maritime Operations Centers (MOC) to enhance the command and control of forces at the operational level of warfare. Each MOC is a headquarters manned by qualified joint operational-level staffs, and enabled by globally interoperable C41 systems. To assess and refine MOC staffing, equipment, and schedules, a dynamic software model was developed. The model leverages pre-existing operational process architecture, joint military task lists that define activities and their precedence relations, as well as Navy documents that specify manning and roles per activity. The software model serves as a "computational wind-tunnel" in which to test a MOC on a mission, and to refine its structure, staffing, processes, and schedules. More generally, the model supports resource allocation decisions concerning Doctrine, Organization, Training, Material, Leadership, Personnel and Facilities (DOTMLPF) at MOCs around the world. A rapid prototype effort efficiently produced this software in less than five months, using an integrated process team consisting of MOC military and civilian staff, modeling experts, and software developers. The work reported here was conducted for Commander, United States Fleet Forces Command in Norfolk, Virginia, code N5-0LW (Operational Level of War) that facilitates the identification, consolidation, and prioritization of MOC capabilities requirements, and implementation and delivery of MOC solutions.

Grande, Darby↗

NASA NTRS2010

Serious Games that Improve Performance

Serious games can help people function more effectively in complex settings, facilitate their role as team members, and provide insight into their team's mission. In such games, coordination and cooperation among team members are foundational to the mission's success and provide a preview of what individuals and the team as a whole could choose to do in a real scenario. Serious games often model events requiring life-or-death choices, such as civilian rescue during chemical warfare. How the players communicate and what actions they take can determine the number of lives lost or saved. However, merely playing a game is not enough to realize its most practical value, which is in learning what actions and communication methods are closest to what the mission requires. Teams often play serious games in isolation, so when the game is complete, an analytical stage is needed to extract the strategies used and examine each strategy's success relative to the others chosen. Recognizing the importance of this next stage, Noblis has been developing Game Analysis, software that parses individual game play into meaningful units and generates a strategic analysis. Trainers create a custom game-specific grammar that reflects the objects and range of actions allowable in a particular game, which Game Analysis then uses to parse the data and generate a practical analysis. Trainers have then enough information to represent strategies in tools, such as Gantt and heat map charts. First-responder trainees in North Carolina have already partnered Hot-Zone and Game Analysis with great success.

McGowan, Clement, III↗

NASA NTRS2003

The MASSE Project: Applications of Biotechnology for Planetary Exploration

Automated life-detection experiments for solar system exploration have been previously. proposed and used onboard the. Viking, Mars lander,s, although. with ambiguous results. The recent advances in biotechnology such as biosensors, protein microarrays, and microfluidics alongside increased. knowledge in biomarker science have led to vastly improved sophistication and sensitivity for a new approach in life detection. The MASSE project has taken the challenge of integrating all of this knowledge into a new generation of interplanetary flight instrumentation for the main purpose.ot combining several mutually. confirming tests for life, organic/microbial contamination, prebiotic and abiotic chemicals into a small low powered instrument. Although the primary goal is interplanetary exploration, several terrestrial applications have become apparent specifically in point-of-care medical technology, bio-warfare, environmental sensing and microbial monitoring of manned space-flight vehicles.

Lynch, Kennda↗

NASA NTRS2010

A Biomathematical Model of Lymphopoiesis and Its Application to Acute and Chronic Irradiation Assessment

After the events of September 11, 2001, there is an increasing concern of the occurrence of radiological terrorism that may result in significant casualties in densely populated areas. Much effort has been made to establish various biomarkers to rapidly assess radiation dose in mass-casualty and population-monitoring scenarios, which are demanded for effective medical management and treatment of the exposed victims. Among these the count of lymphocytes in peripheral blood and their depletion kinetics are the most important early indicators of the severity of the radiation injury. In this study, we examine a biomathematical model of lymphopoiesis which has been successfully utilized to simulate and interpret experimental data of acute and chronic irradiations on rodents [1]. With revised parameters for humans, we find this model can reproduce several sets of clinical lymphocyte data of accident victims over a wide range of absorbed doses. In addition, the absolute lymphocyte counts and the depletion rate constants calculated by this model also show good correlation with the Guskova formula and the Goans model, the two empirical tools which have been widely recognized for early estimation of the exposed dose after radiation accidents [2]. We also use the model to analyze the hematological data of the Techa River residents which were exposed to chronic low-dose irradiation during 1950-1956 [3]. This model can serve as a computational tool in radiation accident management, military operations involving nuclear warfare, radiation therapy, and space radiation risk assessment.

Hu, Shaowen↗

NASA NTRS2010

Hand-Held Devices Detect Explosives and Chemical Agents

Ion Applications Inc., of West Palm Beach, Florida, partnered with Ames Research Center through Small Business Innovation Research (SBIR) agreements to develop a miniature version ion mobility spectrometer (IMS). While NASA was interested in the instrument for detecting chemicals during exploration of distant planets, moons, and comets, the company has incorporated the technology into a commercial hand-held IMS device for use by the military and other public safety organizations. Capable of detecting and identifying molecules with part-per-billion sensitivity, the technology now provides soldiers with portable explosives and chemical warfare agent detection. The device is also being adapted for detecting drugs and is employed in industrial processes such as semiconductor manufacturing.

Source record↗

NASA NTRS2010

Lithium Ion Testing at NSWC Crane in Support of NASA Goddard Space Flight Center

This viewgraph presentation reviews Lithium Ion Cell testing at the Naval Surface Warfare Center in Crane, India. The contents include: 1) Quallion 15 Ahr Lithium-Ion Cells, LEO Life Cycle Test; 2) Lithion 50 Ahr Lithium-Ion Cells, LEO Life Cycle Test; 3) ABSL 5 Ahr Lithium-Ion Battery, LRO-LLO Life Cycle Test, SDO-GEO Life Cycle Test; and 4) A123 40 Ahr Lithium-Ion Battery, GPM Life Cycle Test, MMS Life Cycle Test.

Brown, Harry↗

NASA NTRS2011

Virginia Demonstration Project Encouraging Middle School Students in Pursuing STEM Careers

Encouraging students at all grade levels to consider pursuing a career in Science, Technology, Engineering, and Mathematics (STEM) fields i s a national focus. In 2005, the Naval Surface Warfare Center, Dahlgren Division (NSWCDD), a Department of Defense laboratory located in Da hlgren, Virginia, began work on the Virginia Demonstration Project (VDP) with the goal of increasing more student interest in STEM educatio n and pursuing STEM careers. This goal continues as the program enters its sixth year. This project has been successful through the partici pation of NSWCDD's scientists and engineers who are trained as mentor s to work in local middle school classrooms throughout the school year, As an extension of the in-class activities, several STEM summer aca demies have been conducted at NSWCDD, These academies are supported by the Navy through the VDP and the STEM Learning Module Project. These projects are part of more extensive outreach efforts offered by the National Defense Education Program (NDEP), sponsored by the Director, Defense Research and Engineering. The focus of this paper is on the types of activities conducted at the summer academy, an overview of the academy planning process, and recommendations to help support a nati onal plan of integrating modeling and simulation-based engineering and science into all grade levels. based upon the lessons learned

Bachman, Jane T.↗

NASA NTRS2005

Miniature Laboratory for Detecting Sparse Biomolecules

A miniature laboratory system has been proposed for use in the field to detect sparsely distributed biomolecules. By emphasizing concentration and sorting of specimens prior to detection, the underlying system concept would make it possible to attain high detection sensitivities without the need to develop ever more sensitive biosensors. The original purpose of the proposal is to aid the search for signs of life on a remote planet by enabling the detection of specimens as sparse as a few molecules or microbes in a large amount of soil, dust, rocks, water/ice, or other raw sample material. Some version of the system could prove useful on Earth for remote sensing of biological contamination, including agents of biological warfare. Processing in this system would begin with dissolution of the raw sample material in a sample-separation vessel. The solution in the vessel would contain floating microscopic magnetic beads coated with substances that could engage in chemical reactions with various target functional groups that are parts of target molecules. The chemical reactions would cause the targeted molecules to be captured on the surfaces of the beads. By use of a controlled magnetic field, the beads would be concentrated in a specified location in the vessel. Once the beads were thus concentrated, the rest of the solution would be discarded. This procedure would obviate the filtration steps and thereby also eliminate the filter-clogging difficulties of typical prior sample-concentration schemes. For ferrous dust/soil samples, the dissolution would be done first in a separate vessel before the solution is transferred to the microbead-containing vessel.

Lin, Ying↗

NASA NTRS2013

Testing Small CPAS Parachutes Using HIVAS

The High Velocity Airflow System (HIVAS) facility at the Naval Air Warfare Center (NAWC) at China Lake was successfully used as an alternative to flight test to determine parachute drag performance of two small Capsule Parachute Assembly System (CPAS) canopies. A similar parachute with known performance was also tested as a control. Realtime computations of drag coefficient were unrealistically low. This is because HIVAS produces a non-uniform flow which rapidly decays from a high central core flow. Additional calibration runs were performed to characterize this flow assuming radial symmetry from the centerline. The flow field was used to post-process effective flow velocities at each throttle setting and parachute diameter using the definition of the momentum flux factor. Because one parachute had significant oscillations, additional calculations were required to estimate the projected flow at off-axis angles. The resulting drag data from HIVAS compared favorably to previously estimated parachute performance based on scaled data from analogous CPAS parachutes. The data will improve drag area distributions in the next version of the CPAS Model Memo.

Ray, Eric S.↗

NASA NTRS2012

Implementing the Mars Science Laboratory Terminal Descent Sensor Field Test Campaign

The Mars Science Laboratory (MSL) will deliver a 900 kg rover to the surface of Mars in August 2012. MSL will utilize a new pulse-Doppler landing radar, the Terminal Descent Sensor (TDS). The TDS employs six narrow-beam antennas to provide unprecedented slant range and velocity performance at Mars to enable soft touchdown of the MSL rover using a unique sky crane Entry, De-scent, and Landing (EDL) technique. Prior to use on MSL, the TDS was put through a rigorous verification and validation (V&V) process. A key element of this V&V was operating the TDS over a series of field tests, using flight-like profiles expected during the descent and landing of MSL over Mars-like terrain on Earth. Limits of TDS performance were characterized with additional testing meant to stress operational modes outside of the expected EDL flight profiles. The flight envelope over which the TDS must operate on Mars encompasses such a large range of altitudes and velocities that a variety of venues were neces-sary to cover the test space. These venues included an F/A-18 high performance aircraft, a Eurocopter AS350 AStar helicopter and 100-meter tall Echo Towers at the China Lake Naval Air Warfare Center. Testing was carried out over a five year period from July 2006 to June 2011. TDS performance was shown, in gen-eral, to be excellent over all venues. This paper describes the planning, design, and implementation of the field test campaign plus results and lessons learned.

Mars Science Laboratory (MSL)↗

NASA NTRS2013

High-Speed Data Recorder for Space, Geodesy, and Other High-Speed Recording Applications

A high-speed data recorder and replay equipment has been developed for reliable high-data-rate recording to disk media. It solves problems with slow or faulty disks, multiple disk insertions, high-altitude operation, reliable performance using COTS hardware, and long-term maintenance and upgrade path challenges. The current generation data recor - ders used within the VLBI community are aging, special-purpose machines that are both slow (do not meet today's requirements) and are very expensive to maintain and operate. Furthermore, they are not easily upgraded to take advantage of commercial technology development, and are not scalable to multiple 10s of Gbit/s data rates required by new applications. The innovation provides a softwaredefined, high-speed data recorder that is scalable with technology advances in the commercial space. It maximally utilizes current technologies without being locked to a particular hardware platform. The innovation also provides a cost-effective way of streaming large amounts of data from sensors to disk, enabling many applications to store raw sensor data and perform post and signal processing offline. This recording system will be applicable to many applications needing realworld, high-speed data collection, including electronic warfare, softwaredefined radar, signal history storage of multispectral sensors, development of autonomous vehicles, and more.

Taveniku, Mikael↗

NASA NTRS2014

Combustion Stability Assessments of the Black Brant Solid Rocket Motor

The Black Brant variation of the Standard Brant developed in the 1960's has been a workhorse motor of the NASA Sounding Rocket Project Office (SRPO) since the 1970's. In March 2012, the Black Brant Mk1 used on mission 36.277 experienced combustion instability during a flight at White Sands Missile Range, the third event in the last four years, the first occurring in November, 2009, the second in April 2010. After the 2010 event the program has been increasing the motor's throat diameter post-delivery with the goal of lowering the chamber pressure and increasing the margin against combustion instability. During the most recent combustion instability event, the vibrations exceeded the qualification levels for the Flight Termination System. The present study utilizes data generated from T-burner testing of multiple Black Brant propellants at the Naval Air Warfare Center at China Lake, to improve the combustion stability predictions for the Black Brant Mk1 and to generate new predictions for the Mk2. Three unique one dimensional (1-D) stability models were generated, representing distinct Black Brant flights, two of which experienced instabilities. The individual models allowed for comparison of stability characteristics between various nozzle configurations. A long standing "rule of thumb" states that increased stability margin is gained by increasing the throat diameter. In contradiction to this experience based rule, the analysis shows that little or no margin is gained from a larger throat diameter. The present analysis demonstrates competing effects resulting from an increased throat diameter accompanying a large response function. As is expected, more acoustic energy was expelled through the nozzle, but conversely more acoustic energy was generated due to larger gas velocities near the propellant surfaces.

Fischbach, Sean↗

NASA NTRS2013

Rocket Sled Propelled Testing of a Supersonic Inflatable Aerodynamic Decelerator

Decelerators (IADs) have traditionally been tested in wind tunnels. As the limitations of these test facilities are reached, other avenues must be pursued. The IAD being tested is a Supersonic IAD (SIAD), which attaches just aft of the heatshield around the perimeter of an entry body. This 'attached torus' SIAD is meant to improve the accuracy of landing for robotic class missions to Mars and allow for potentially increased payloads. The SIAD Design Verification (SDV) test aims to qualify the SIAD by applying a targeted aerodynamic load to the vehicle. While many test architectures were researched, a rocket sled track was ultimately chosen to be the most cost effective way to achieve the desired dynamic pressures. The Supersonic Naval Ordnance Research Track (SNORT) at the Naval Air Warfare Center Weapons Division (NAWCWD) China Lake is a four mile test track, traditionally used for warhead and ejection seat testing. Prior to SDV, inflatable drag bodies have been tested on this particular track. Teams at Jet Propulsion Laboratory (JPL) and NAWCWD collaborate together to design and fabricate one of the largest sleds ever built. The SDV sled is comprised of three individual sleds: a Pusher Sled which holds the solid booster rockets, an Item Sled which supports the test vehicle, and a Camera Sled that is pushed in front for in-situ footage and measurements. The JPL-designed Test Vehicle has a full-scale heatshield shape and contains all instrumentation and inflation systems necessary to inflate and test a SIAD. The first campaign that is run at SNORT tested all hardware and instrumentation before the SIAD was ready to be tested. For each of the three tests in this campaign, the number of rockets and top speed was increased and the data analyzed to ensure the hardware is safe at the necessary accelerations and aerodynamic loads.

Supersonic Inflatable Aerodynamic Decelerators (SI↗

NASA NTRS1939

A Glimpse of Scientific Research on Fundamental Problems of Military and Civil Aeronautics

Among the outstanding accomplishments of the last century is man's conquest of the air. That conquest began in 1903 when the Wright brothers made the first successful flight of an airplane at Kitty Hawk, N. C. Five years later the United States Government purchased its first airplane for the use of the Army, and began the training of officers for military flying. During the years immediately preceding the outbreak of the World War the Government and a meager aircraft industry had made important progress, but the Government, practically the only customer, had purchased less than 100 airplanes. In the meantime, leading European nations, sensing acutely the potentialities of aircraft in warfare, had made greater progress and had begun laying the foundations for the new science of aeronautics. The World War gave a remarkable impetus to the development of aeronautics and emphasized the need for organized research on the fundamental problems of flight. By act of Congress approved March 3, 1915, the National Advisory Committee for Aeronautics was created and charged with the duty of supervising, directing, and conducting fundamental scientific research and experiment in aeronautics. With the farsighted support of the Congress the Committee has led the world in the development of unique aeronautical research facilities in its laboratories at Langley Field, Va. The research programs include problems initiated by the Committee and its subcommittees and also investigations requested by the Army, the Navy, and the Civil Aeronautics Authority. The results of researches conducted under one control, serve without duplication of effort, the needs of all branches of aviation, civil and military, and exert a profound influence on the progress of aeronautics by improving the performance, efficiency, and safety of aircraft. A brief description of the results of some of the committee's researches and of the equipment employed will be found in the following pages.

Source record↗

NASA NTRS2015

Dynamic Open-Rotor Composite Shield Impact Test Report

The Federal Aviation Administration (FAA) is working with the European Aviation Safety Agency to determine the certification base for proposed new engines that would not have a containment structure on large commercial aircraft. Equivalent safety to the current fleet is desired by the regulators, which means that loss of a single fan blade will not cause hazard to the aircraft. NASA Glenn and Naval Air Warfare Center (NAWC) China Lake collaborated with the FAA Aircraft Catastrophic Failure Prevention Program to design and test a shield that would protect the aircraft passengers and critical systems from a released blade that could impact the fuselage. This report documents the live-fire test from a full-scale rig at NAWC China Lake. NASA provided manpower and photogrammetry expertise to document the impact and damage to the shields. The test was successful: the blade was stopped from penetrating the shield, which validates the design analysis method and the parameters used in the analysis. Additional work is required to implement the shielding into the aircraft.

Shielding↗

NASA NTRS2015

Analysis and Testing of a Composite Fuselage Shield for Open Rotor Engine Blade-Out Protection

The Federal Aviation Administration is working with the European Aviation Safety Agency to determine the certification base for proposed new engines that would not have a containment structure on large commercial aircraft. Equivalent safety to the current fleet is desired by the regulators, which means that loss of a single fan blade will not cause hazard to the Aircraft. The NASA Glenn Research Center and The Naval Air Warfare Center (NAWC), China Lake, collaborated with the FAA Aircraft Catastrophic Failure Prevention Program to design and test lightweight composite shields for protection of the aircraft passengers and critical systems from a released blade that could impact the fuselage. In the test, two composite blades were pyrotechnically released from a running engine, each impacting a composite shield with a different thickness. The thinner shield was penetrated by the blade and the thicker shield prevented penetration. This was consistent with pre-test predictions. This paper documents the live fire test from the full scale rig at NAWC China Lake and describes the damage to the shields as well as instrumentation results.

safety↗

NASA NTRS2016

Science and Technology (S and T) Roadmap Collaboration between SMC, NASA, and Government Partners

National Security Space (NSS) presents multi-faceted S and T challenges. We must continually innovate enterprise and information management; provide decision support; develop advanced materials; enhance sensor technology; transform communication technology; develop advanced propulsion and resilient space architectures and capabilities; and enhance multiple additional S and T domains. These challenges are best met by leveraging advanced S and T research and technology development from a number of DoD agencies and civil agencies such as NASA. The authors of this paper have engaged in these activities since 2006 and over the past decade developed multiple strategic S and T relationships. This paper highlights the Office of the Space Missile Systems Center (SMC) Chief Scientist (SMC/ST) collaboration with the NASA Office of Chief Technologist (NASA OCT), which has multiple S and T activities that are relevant to NSS. In particular we discuss the development of the Technology Roadmaps that benefit both Civil Space and NSS. Our collaboration with NASA OCT has been of mutual benefit to multiple participants. Some of the other DoD components include the Defense Advanced Research Projects agency (DARPA), Air Force Research Laboratory (AFRL), Naval Research Laboratory (NRL), The USAF Office of Chief Scientist, the USAF Science Advisory Board (SAB), Space and Naval Warfare Systems Command (SPAWAR), and a number of other services and agencies. In addition, the human talent is a key enabler of advanced S and T activities; it is absolutely critical to have a strong supply of talent in the fields of Science Technology, Engineering, and Mathematics (STEM). Consequently, we continually collaborate with the USAF Institute of Technology (AFIT), other service academies and graduate schools, and other universities and colleges. This paper highlights the benefits that result from such strategic S and T partnerships and recommends a way forward that will continually build upon these achievements into the future.

Science Technology Collaboration↗