Improving the In Vivo Stability of [ 52 Mn]Mn(II) Complexes with 18-Membered Macrocyclic Chelators for PET Imaging
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60 APPLIED LIFE SCIENCES↗
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Results for “actionable science”
Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.
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A GeoHealth Call to Action: Moving Beyond Identifying Environmental Injustices to Co-Creating Solutions
As marginalized communities continue to bear disproportionate impacts from environmental hazards, we urgently call for researchers and institutions to elevate the principles of Environmental Justice. The American Geophysical Union (AGU) GeoHealth section supports members' engagement in health-related community-engaged and community-led transdisciplinary research. We highlight intersectional research that provides examples and actions for both individuals and organizations on community science and trust building, removing barriers created by scientific agency priorities and career expectations, and opportunities in education and policy. Justice does not start or end at one meeting; this is ongoing work that is active, evolving, and an ethical responsibility of AGU's membership.
59 BASIC BIOLOGICAL SCIENCES↗
River systems under peaked stress
The change in the global energy production mix towards variable renewable energy sources requires efficient utilization of regulated rivers to optimise hydropower operations meet the needs of a changing energy market. However, the flexible operation of hydropower plants causes non-natural, sub-daily fluctuating flows in the receiving water bodies, often referred to as ‘hydropeaking’. Drastic changes in sub-daily flow regimes undermine attempts to improve river system health. Environmental decision makers, including permitting authorities and river basin managers facing the intense and increasing pressure on river environments, should consider ecosystem services and biodiversity issues more thoroughly. The need for research innovations in hydropeaking operation design to fulfil both the water and energy security responsibilities of hydropower is highlighted. Our paper outlines optimized hydropeaking design as a future research direction to help researchers, managers, and decision-makers prioritize actions that could enable better integration of river science and energy system planning. The goal of this is to find a balanced hydropower operation strategy.
54 ENVIRONMENTAL SCIENCES↗
Nuclear Physics Network Requirements Review: One-Year Update
A Nuclear Physics Network Requirements Review, conducted by ESnet in collaboration with the DOE SC, was held on May 8 and 9, 2019. A continuation of this process involves “checkup” procedures to be conducted after one and two years have passed. ESnet and the DOE SC, in collaboration with the previous participants, held a virtual meeting on September 2, 2020, to continue the review process. Topics of discussion included the following: Programmatic updates from the DOE SC ASCR. Programmatic updates from the DOE SC NP. Programmatic updates from ESnet. Brief updates from case study authors. A general discussion and Q&A on findings and actions from the review. This report outlines the areas of discussion, new findings and actions, and updates to the overall process of science for several key NP initiatives since 2019 and looking into 2021.
73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗
Implementing the Provisions of the National Environmental Policy Act
This handbook provides guidance and assistance to NASA officials in carrying out their responsibilities under the National Environmental Policy Act and the applicable NASA procedures (14 CFR 1216.3, Attachment A to NMI 8800.7). The handbook, as was contemplated by the regulations of the Council on Environmental Quality, stresses the need for environmental analysis from the time of early planning through environmental assessment and environmental impact statement preparation to implementation of the subject action, and provides for necessary follow up. It stresses the need for NASA officials to draw upon all the appropriate disciplines from the natural and social sciences plus the environmental design arts in planning and decision making on actions which may have an impact on the human environment. The handbook is applicable to NASA Headquarters and field installations.
Source record↗
Robot Science Autonomy in the Atacama Desert and Beyond
Science-guided autonomy augments rovers with reasoning to make observations and take actions related to the objectives of scientific exploration. When rovers can directly interpret instrument measurements then scientific goals can inform and adapt ongoing navigation decisions. These autonomous explorers will make better scientific observations and collect massive, accurate datasets. In current astrobiology studies in the Atacama Desert we are applying algorithms for science autonomy to choose effective observations and measurements. Rovers are able to decide when and where to take follow-up actions that deepen scientific understanding. These techniques apply to planetary rovers, which we can illustrate with algorithms now used by Mars rovers and by discussing future missions.
robotic surface exploration↗
NASA ESTO Advanced Information Systems Technology (AIST)
"(Only Talk/No Publication) NASA’s Advanced Information Systems Technology (AIST) Program identifies, develops, and supports adoption of software and information systems, as well as novel computer science technologies expected to be needed by the Earth Science Division in the 5-10-year timeframe. This presentation gives an overview of the AIST Program. AIST’s previous thrusts have been New Observing Strategies (NOS) and Analytic Collaborative Frameworks (ACF). The current vision is to connect these two thrusts and integrate them into the larger concept of Earth System Digital Twins (ESDT). To implement this new vision, the AIST Program is focusing on technologies and innovative concepts with three main objectives: O1. Enable new observation measurements and new observing systems design and operations through intelligent, timely, dynamic, and coordinated distributed sensing; O2. Enable agile science investigations that fully utilize the large amount of diverse observations using advanced analytic tools, visualizations, and computing environments, and that interact seamlessly with relevant observing systems; O3. Enable the development of integrated Earth Science frameworks that mirror the Earth with state-of-the-art models (Earth system models and others), timely and relevant observations, and analytic tools. This thrust will provide technology for enabling near- and long-term science and policy decisions (“science decisions” including planning for the acquisition of new measurements; the development of new models or science analysis; the integration of Earth observations in novel ways; applications to inform choices, support decisions, and guide actions for societal benefit; etc.)."
Mathematical and Computer Sciences (General)↗
Closure Report for Corrective Action Unit 168: Area 25 and 26 Contaminated Materials and Waste Dumps, Nevada Test Site, Nevada, Revision 0, with ROTCs 1-2
The purpose of this CR is to provide a summary of the completed closure activities, documentation of waste disposal, and analytical data to confirm that the remediation goals were met.
54 ENVIRONMENTAL SCIENCES↗
The Making of a Metric: Co-Producing Decision-Relevant Climate Science
Developing decision-relevant science for adaptation requires the identification of climatic parameters that are both actionable for practitioners as well as tractable for modelers. In many sectors, these decision-relevant climatic metrics and the approaches that enable their identification remain largely unknown. “Co-production” of science with scientists and decision-makers is one potential way to identify these metrics, but there is little research describing specific and successful co-production approaches. This paper examines the negotiations and outcomes from Project Hyperion, wherein scientists and water managers jointly developed decision-relevant climatic metrics for adaptive water management. We identify successful co-production strategies by analyzing the project’s numerous back-and-forth engagements and tracing the evolution of the science during these engagements. We found that effective mediation between scientists and managers needed dedicated “boundary spanners” with significant modeling expertise. Translating practitioners’ information needs into tractable climatic metrics required direct and indirect methods of eliciting knowledge. We identified four indirect methods that were particularly salient for extracting tacitly held knowledge and enabling shared learning: developing a hierarchical framework linking management issues with metrics, starting discussions from the planning challenges, collaboratively exploring the planning relevance of new scientific capabilities, and using analogies of other “good” metrics. The decision-relevant metrics we developed provide insights into advancing adaptation-relevant climate science in the water sector. The co-production strategies we identified can be used to design and implement productive scientist–decision-maker interactions. Overall, the approaches and metrics we developed can help climate science to expand in new and more use-inspired directions.
Planning↗
Residential Façade Upgrades: Market Assessment and Recommendations
In support of DOE’s move toward transformational whole-building upgrades and enclosure solutions, the Pacific Northwest National Laboratory (PNNL) and National Renewable Energy Laboratory (NREL) are partnering and collaborating with leading building science researchers and home-performance entities to identify and characterize technical and economic barriers to façade retrofits in an effort to identify market-viable façade solutions and opportunities for an actionable plan to transform the market. The project includes partnerships with Building Science Corporation (BSC) and a combination of strategic implementation partners with home-performance and retrofit expertise and industry contacts. The project will include expert advisory and review consultation from Lawrence Berkeley National Laboratory’s (LBNL’s) Residential Windows & Attachments team and Oak Ridge National Laboratory’s Building Envelope team. The project consists of three parts: 1. a market analysis that captures the current state of the façade retrofit market and includes housing characteristics and retrofit costs, façade retrofit approaches and materials, contractor business models and workforce requirements to support advanced façade approaches; 2. an economic analysis focused on the viability of advanced façade retrofit approaches and materials; and 3. field demonstration of façade retrofits that include enhanced insulation/air-sealing and window technologies in multiple climate zones. This report represents the market analysis, as outlined in item 1 above. The goal of this analysis is to provide a techno-economic study that supports comprehensive retrofits of residential enclosures that include traditional approaches, and integrated wall assemblies and windows that result in durable, energy efficient, and marketable strategies. This study will provide a better knowledge base regarding the viable market for façade retrofit strategies, identify the barriers to uptake, analyze economic opportunities, and develop documentation specifically aimed to overcome technical and market barriers associated with installation.
29 ENERGY PLANNING, POLICY, AND ECONOMY↗
Selective inhibition of human translation termination by a drug-like compound
Methods to directly inhibit gene expression using small molecules hold promise for the development of new therapeutics targeting proteins that have evaded previous attempts at drug discovery. Among these, small molecules including the drug-like compound PF-06446846 (PF846) selectively inhibit the synthesis of specific proteins, by stalling translation elongation. These molecules also inhibit translation termination by an unknown mechanism. Using cryo-electron microscopy (cryo-EM) and biochemical approaches, we show that PF846 inhibits translation termination by arresting the nascent chain (NC) in the ribosome exit tunnel. The arrested NC adopts a compact α-helical conformation that induces 28 S rRNA nucleotide rearrangements that suppress the peptidyl transferase center (PTC) catalytic activity stimulated by eukaryotic release factor 1 (eRF1). These data support a mechanism of action for a small molecule targeting translation that suppresses peptidyl-tRNA hydrolysis promoted by eRF1, revealing principles of eukaryotic translation termination and laying the foundation for new therapeutic strategies.
59 BASIC BIOLOGICAL SCIENCES↗
Closure Report for Corrective Action Unit 116: Area 25 Test Cell C Facility, Nevada National Security Site, Nevada with ROTC-1
CR loaded to this OSTI record. Just adding new file which includes CR plus new ROTC 1 and update the metadata to the following: This Closure Report (CR) presents information supporting closure of Corrective Action Unit (CAU) 116, Area 25 Test Cell C Facility. This CR complies with the requirements of the Federal Facility Agreement and Consent Order (FFACO) that was agreed to by the State of Nevada; the U.S. Department of Energy (DOE), Environmental Management; the U.S. Department of Defense; and DOE, Legacy Management (FFACO, 1996 [as amended March 2010]). CAU 116 consists of the following two Corrective Action Sites (CASs), located in Area 25 of the Nevada National Security Site: (1) CAS 25-23-20, Nuclear Furnace Piping and (2) CAS 25-41-05, Test Cell C Facility. CAS 25-41-05 consisted of Building 3210 and the attached concrete shield wall. CAS 25-23-20 consisted of the nuclear furnace piping and tanks. Closure activities began in January 2007 and were completed in August 2011. Activities were conducted according to Revision 1 of the Streamlined Approach for Environmental Restoration Plan for CAU 116 (U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office [NNSA/NSO], 2008). This CR provides documentation supporting the completed corrective actions and provides data confirming that closure objectives for CAU 116 were met. Site characterization data and process knowledge indicated that surface areas were radiologically contaminated above release limits and that regulated and/or hazardous wastes were present in the facility. The Record of Technical Change 1 updated the use restriction information.
54 ENVIRONMENTAL SCIENCES↗
Data preservation in high energy physics
Data preservation is a mandatory specification for any present and future experimental facility and it is a cost-effective way of doing fundamental research by exploiting unique data sets in the light of the continuously increasing theoretical understanding. This document summarizes the status of data preservation in high energy physics. The paradigms and the methodological advances are discussed from a perspective of more than ten years of experience with a structured effort at international level. The status and the scientific return related to the preservation of data accumulated at large collider experiments are presented, together with an account of ongoing efforts to ensure long-term analysis capabilities for ongoing and future experiments. Transverse projects aimed at generic solutions, most of which are specifically inspired by open science and FAIR principles, are presented as well. A prospective and an action plan are also indicated.
72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗
The Office of Space Science and Applications strategic plan, 1990: A strategy for leadership in space through excellence in space science and applications
A strategic plan for the U.S. space science and applications program during the next 5 to 10 years was developed and published in 1988. Based on the strategies developed by the advisory committees of both the National Academy of Science and NASA, the plan balances major, moderate, and small mission initiatives, the utilization of the Space Station Freedom, and the requirements for a vital research base. The Office of Space Science and Applications (OSSA) strategic plan is constructed around five actions: establish a set of programmatic themes; establish a set of decision rules; establish a set of priorities for missions and programs within each theme; demonstrate that the strategy will yield a viable program; and check the strategy for consistency within resource constraints. The OSSA plan is revised annually. This OSSA 1990 Strategic Plan refines the 1989 Plan and represents OSSA's initial plan for fulfilling its responsibilities in two major national initiatives. The Plan is now built on interrelated, complementary strategies for the core space science and applications program, for the U.S. Global Change Research Program, and for the Space Exploration Initiative. The challenge is to make sure that the current level of activity is sustained through the end of this century and into the next. The 1990 Plan presents OSSA's strategy to do this.
Source record↗
The AdS 5 × S 5 superstring
The duality between the type IIB superstring theory in an AdS 5 × S 5 background with N units of five-form flux and N = 4 super Yang–Mills theory with a U ( N ) gauge group has been studied extensively. My version of the construction of the superstring world-sheet action is reviewed here.
Science & Technology - Other Topics↗
Supporting Growth of a Skilled Workforce in the Building Energy Efficiency Industry (Final Technical Report)
The Interstate Renewable Energy Council (IREC), having worked for well over a decade to develop national networks and best practices focused on attracting and training high quality workers for the clean energy industries, sought to address shortfalls in skilled workers who build, retrofit, operate, and maintain energy efficient buildings. Through this project, IREC created and promoted a Green Buildings Career Map (GBCM)—a career awareness and recruitment tool—that seeks to boost the nationwide growth of workers entering the energy efficiency (EE) industry. Working with a team of subject matter experts and our partner organizations—Building Performance Association (BPA), Building Performance Institute (BPI), Community Action Partnership (CAP), and the National Institute of Building Sciences (NIBS)—IREC produced an interactive, engaging career map to attract and motivate individuals into pursuing careers in energy efficiency, and in support of the Weatherization Assistance Program. The GBCM was designed for a broad audience including educators, career advisors, employers, policymakers, workforce professionals, and jobseekers who may otherwise have little or no awareness of the exciting and rewarding opportunities within targeted industry sectors. Most individuals seeking careers do not know about the breadth of careers awaiting them in the built environment and the same is true for most career and guidance counselors, educators, and parents. The GBCM provides this broad audience with a vision of the myriad jobs that could lead to a long-standing career in energy efficiency. The GBCM describes diverse occupations across the EE industry, charts possible progression between those occupations, and identifies the training, skills, and credentials necessary to do them well.
32 ENERGY CONSERVATION, CONSUMPTION, AND UTILIZATI↗
Hanford Site Post-Fire Vegetation Monitoring Report for Calendar Year 2021
The Hanford Site presents an expanse of shrub-steppe habitat that provides exceptional value to plants and animals located on the Site and in the surrounding greater Columbia Basin. The greatest threat to this habitat is fire-related conversion to a cheatgrass-dominated monoculture. In order to decrease future fire risk and to disrupt the positive feedback cycle between cheatgrass and fire, land managers can make efforts to restore native vegetation following a fire. The goal of this report is to analyze vegetation recovery post-fire in both restored and unrestored areas to inform future post-fire response actions.
54 ENVIRONMENTAL SCIENCES↗
Extreme Weather and Climate: Workshop Report
Extreme events are the aspects of climate to which human society is most sensitive. Due to both their severity and their rarity, extreme events can challenge the capacity of physical, social, economic and political infrastructures, turning natural events into human disasters. Yet, because they are low frequency events, the science of extreme events is very challenging. Among the challenges is the difficulty of connecting extreme events to longer-term, large-scale variability and trends in the climate system, including anthropogenic climate change. How can we best quantify the risks posed by extreme weather events, both in the current climate and in the warmer and different climates to come? How can we better predict them? What can we do to reduce the harm done by such events? In response to these questions, the Initiative on Extreme Weather and Climate has been created at Columbia University in New York City (extreme weather.columbia.edu). This Initiative is a University-wide activity focused on understanding the risks to human life, property, infrastructure, communities, institutions, ecosystems, and landscapes from extreme weather events, both in the present and future climates, and on developing solutions to mitigate those risks. In May 2015,the Initiative held its first science workshop, entitled Extreme Weather and Climate: Hazards, Impacts, Actions. The purpose of the workshop was to define the scope of the Initiative and tremendously broad intellectual footprint of the topic indicated by the titles of the presentations (see Table 1). The intent of the workshop was to stimulate thought across disciplinary lines by juxtaposing talks whose subjects differed dramatically. Each session concluded with question and answer panel sessions. Approximately, 150 people were in attendance throughout the day. Below is a brief synopsis of each presentation. The synopses collectively reflect the variety and richness of the emerging extreme event research agenda.
extreme weather events↗