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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 109 records · Page 6

How do we get from cell and animal data to risks for humans from space radiations?

After four decades of human exploration in space, many scientists consider the medical consequences from radiation exposures to be the major biological risk associated with long-term missions. This conclusion is based upon results from a research program that has evolved over the past thirty years. Despite the diversity in both opinions and approaches that necessarily arise in research endeavors such as this, a commonality has emerged from our community. We need epidemiological data for humans, animal data in areas where no human data exist, and data on mechanisms to get from animal to humans. We need a programmatic infrastructure that addresses specific goals as well as basic research. These concepts might be deemed overly simplistic and even tautologous were it not for the fact that they are frequently underutilized and even ignored. This article examines the goals, premises, and infrastructures proposed by expert panels and agencies to address radiation risks in space. It is proposed that the required level of effort and the resources available demand a unified, focused international effort that is, at the same time, subjected to rigorous peer review if it is to be successful. There is a plan; let us implement it.

Non-NASA Center↗

Enhanced animal growth via ligand-regulated GHRH myogenic-injectable vectors

Regulated animal growth occurred following a single electroporated injection of a mixture of two plasmids (10 microg of DNA), one expressing the GeneSwitch regulator protein, the other an inducible growth hormone releasing hormone (GHRH) gene, into the tibialis anterior muscles of adult SCID mice. Administration of the ligand mifepristone (MFP) up-regulated GHRH expression, as shown by elevations of IGF-I levels, and when MFP dosing was withdrawn, IGF-I returned to baseline levels. Five cycles of IGF-I induction were observed during a five-month period. Chronic MFP dosing for 25 days increased lean body mass, weight gain, and bone mineral density significantly compared with non-MFP treated controls. In summary, long-term drug-regulated GHRH expression was achieved following plasmid-based gene therapy, and chronic induction of GHRH expression in adult animals led to improvements in weight gain and body composition.

NASA Discipline Musculoskeletal↗

Introduction: an overview of gravity sensing, perception, and signal transduction in animals and plants

The antiquity of biological sensitivity and response to gravity can be traced through the ubiquity of morphology, mechanisms, and cellular events in gravity sensing biological systems in the most diverse species of both plants and animals. Further, when we examine organisms at the cellular level to elucidate the molecular mechanism by which a gravitational signal is transduced into a biochemical response, the distinction between plants and animals becomes blurred.

NASA Center HQS↗

The evolution of embryonic patterning mechanisms in animals

Animals exhibit an enormous diversity of life cycles and larval morphologies. The developmental basis for this diversity is not well understood. It is clear, however, that mechanisms of pattern formation in early embryos differ significantly among and within groups of animals. These differences show surprisingly little correlation with phylogenetic relationships; instead, many are correlated with ecological factors, such as changes in life histories. Copyright 2000 Academic Press.

Review, Tutorial↗

A compendium of fossil marine animal families, 2nd edition

A comprehensive listing of 4075 taxonomic families of marine animals known from the fossil record is presented. This listing covers invertebrates, vertebrates, and animal-like protists, gives time intervals of apparent origination and extinction, and provides literature sources for these data. The time intervals are mostly 81 internationally recognized stratigraphic stages; more than half of the data are resolved to one of 145 substage divisions, providing more highly resolved data for studies of taxic macroevolution. Families are classified by order, class, and phylum, reflecting current classifications in the published literature. This compendium is a new edition of the 1982 publication, correcting errors and presenting greater stratigraphic resolution and more current ideas about acceptable families and their classification.

Non-NASA Center↗

Memory monitoring by animals and humans

The authors asked whether animals and humans would use similarly an uncertain response to escape indeterminate memories. Monkeys and humans performed serial probe recognition tasks that produced differential memory difficulty across serial positions (e.g., primacy and recency effects). Participants were given an escape option that let them avoid any trials they wished and receive a hint to the trial's answer. Across species, across tasks, and even across conspecifics with sharper or duller memories, monkeys and humans used the escape option selectively when more indeterminate memory traces were probed. Their pattern of escaping always mirrored the pattern of their primary memory performance across serial positions. Signal-detection analyses confirm the similarity of the animals' and humans' performances. Optimality analyses assess their efficiency. Several aspects of monkeys' performance suggest the cognitive sophistication of their decisions to escape.

NASA Discipline Space Human Factors↗

The uncertain response in humans and animals

There has been no comparative psychological study of uncertainty processes. Accordingly, the present experiments asked whether animals, like humans, escape adaptively when they are uncertain. Human and animal observers were given two primary responses in a visual discrimination task, and the opportunity to escape from some trials into easier ones. In one psychophysical task (using a threshold paradigm), humans escaped selectively the difficult trials that left them uncertain of the stimulus. Two rhesus monkeys (Macaca mulatta) also showed this pattern. In a second psychophysical task (using the method of constant stimuli), some humans showed this pattern but one escaped infrequently and nonoptimally. Monkeys showed equivalent individual differences. The data suggest that escapes by humans and monkeys are interesting cognitive analogs and may reflect controlled decisional processes prompted by the perceptual ambiguity at threshold.

Non-NASA Center↗

Immune changes in test animals during spaceflight

Over the past two decades, it has become apparent that changes in immune parameters occur in cosmonauts and astronauts after spaceflight. Therefore, interest has been generated in the use of animal surrogates to better understand the nature and extent of these changes, the mechanism of these changes, and to allow the possible development of countermeasures. Among the changes noted in animals after spaceflight are alterations in lymphocytic blastogenesis, cytokine function, natural killer cell activity, and colony-stimulating factors. The nature and significance of spaceflight-induced changes in immune responses will be the focus of this review.

Cosmos Project↗

Reproduction in the space environment: Part I. Animal reproductive studies

Mankind's exploration and colonization of the frontier of space will ultimately depend on men's and women's ability to live, work, and reproduce in the space environment. This paper reviews animal studies, from microorganisms to mammals, done in space or under space-simulated conditions, which identify some of the key areas which might interfere with human reproductive physiology and/or embryonic development. Those space environmental factors which impacted almost all species included: microgravity, artificial gravity, radiation, and closed life support systems. These factors may act independently and in combination to produce their effects. To date, there have been no studies which have looked at the entire process of reproduction in any animal species. This type of investigation will be critical in understanding and preventing the problems which will affect human reproduction. Part II will discuss these problems directly as they relate to human physiology.

Review, Tutorial↗

An Astro-Animation Class: Optimizing Artistic, Educational and Outreach Outcomes

The authors investigate how teaching art and astronomy together has the potential to inspire new art forms, enhance scientific public outreach, and promote art and science education. The authors teach an astro-animation class at the Maryland Institute College of Art in partnership with NASA scientists. The animations explore science in creative ways. Astrophysicists, educators, students, and the general public were surveyed to evaluate the experiences, and benefits from this project. The responses were very positive -the program is an effective way to stimulate art students to learn science, share an artist’s viewpoint beyond the classroom, and engage with the public.

Animation↗

MAGIK Animation of Robotic Operations for Flight SpaceX-31 to ISS

The MAGIK Robotics analysis team provides kinematic feasibility assessments for the ISS and has produced an animation to showcase Extravehicular Robotics (EVR) activities for Flight SpaceX (SpX)-31. Shown EVR activities were developed by Flight Operations Directorate (FOD) Robotics (ROBO). The animation also displays the current ISS configuration at the time of the flight in Increment 72. Flight SpX-31 includes a SpaceX Cargo Dragon vehicle docked to Node 2 Forward (N2F) and consists of the delivery of the Coronal Observation Experiment (CODEX) payload. Robotic operations shown include utilization the Special Purpose Dexterous Manipulator (SPDM) based on the Space Station Remote Manipulator System (SSRMS), survey of the cargo trunk, extraction of CODEX from the trunk, stow of SPDM, SSRMS walkoff to the Mobile Remote Servicer (MRS) Base System (MBS), SSRMS grapple of SPDM, translate of the Mobile Transporter (MT), and install of CODEX to Express Logistics Carrier 3 (ELC-3) Site 3. There is no disposal payload for this flight.

ISS↗

Telemetry with unrestrained animals.

Telemetry with unrestrained animals, discussing radio tracking of game animals and instrumentation requirements for studying green sea turtle goal finding ability

Baldwin, H. A.↗

Real-time pair-feeding of animals

Automatic pair-feeding system was developed which immediately dispenses same amount of food to control animal as has been consumed by experimental animal that has free access to food. System consists of: master feeding system; slave feeding station; and control mechanism. Technique performs real time pair-feeding without attendant time lag.

Leon, H. A.↗

Use of the Doppler technique to track free roaming animals from satellites

The application of the Doppler effect to track wild animals is discussed, with artificial satellites used to provide wide range coverage. The limitations of radiotelemetry for the purpose of tracking animals are presented. The advantages of the artificial satellite, with specific reference to the Nimbus satellite, are examined.

Maxwell, J. C.↗

Bio-medical telemetry: Sensing and transmitting biological information from animals to man

The application of small radio transmitters for monitoring biological activity in animals and humans is discussed. The microminiaturization of the electronic transmitters makes it possible for them to be swallowed and to operate within the body with no external connections. The small size also makes it possible for the transmitters to be surgically implanted or carried externally to monitor specific bodily functions. The use of satellites to monitor the activity of birds and animals carrying small transmitters is described. Photographs of birds, fish, and reptiles which were equipped with miniature electronic monitors are provided.

Mackay, S.↗

A preliminary investigation of the environmental Control and Life Support Subsystems (EC/LSS) for animal and plant experiment payloads

A preliminary study of the environmental control and life support subsystems (EC/LSS) necessary for an earth orbital spacecraft to conduct biological experiments is presented. The primary spacecraft models available for conducting these biological experiments are the space shuttle and modular space station. The experiments would be housed in a separate module that would be contained in either the shuttle payload bay or attached to the modular space station. This module would be manned only for experiment-related tasks, and would contain a separate EC/LSS for the crew and animals. Metabolic data were tabulated on various animals that are considered useful for a typical experiment program. The minimum payload for the 30-day space shuttle module was found to require about the equivalent of a one-man EC/LSS; however, the selected two-man shuttle assemblies will give a growth and contingency factor of about 50 percent. The maximum payloads for the space station mission will require at least a seven-man EC/LSS for the laboratory colony and a nine-man EC/LSS for the centrifuge colony. There is practically no room for growth or contingencies in these areas.

Wells, H. B.↗