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Direct Brønsted Acid-Catalyzed Dehydration of Glucose to HMF in Methyl Isobutyl Ketone
Not provided.
Manganese Carbonate/Laser-Induced Graphene Composite for Glucose Sensing
Not Available
Femtosecond laser-induced non-thermal welding for a single Cu nanowire glucose sensor
Experiments and simulations of FS laser induced nonthermal welding for single Cu nanowires on a flexible substrate.
Bioprocess development and scale-up for cis , cis -muconic acid production from glucose and xylose by Pseudomonas putida
Bioprocess development enhanced muconate titers and productivities from mixed sugars, leading to reduced production costs and a significant decrease in GHG emissions compared to fossil carbon-based adipic acid production. Created with BioRender.com.
Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor
Abstract not provided
Functional Analysis of H + -Pumping Membrane-Bound Pyrophosphatase, ADP-Glucose Synthase, and Pyruvate Phosphate Dikinase as Pyrophosphate Sources in Clostridium thermocellum
Increased understanding of the central metabolism of C. thermocellum is important from a fundamental as well as from a sustainability and industrial perspective. In addition to showing that H + -pumping membrane-bound PPase, glycogen cycling, a Ppdk–malate shunt cycle, and acetate cycling are not significant sources of PP i supply, this study adds functional annotation of four genes and availability of an updated PP i stoichiometry from biosynthesis to the scientific domain.
Precipitant-Free Crystallization of Lysozyme and Glucose Isomerase by Drying
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Stable isotope probing of the glucose added soils(total DNA)
The objective of this project is to investigate the effect of plant diversity and the soil pore sizes on the active microorganisms utilizing the newly added carbon.
Stable isotope probing of the glucose added soils (fraction)
The objective of this study is to investigate the effect of plant diversity and soil pore sizes on the active microorganisms utilizing the newly added carbon.
Cell-free metabolic pathway for glucose metabolism with a molecular purge valve
Provided is an engineered pathway that can function in a cell-free system, cellular system or a combination thereof to convert a sugar to a chemical or biofuel.
Metabolomic profiles are reflective of hypoxia-induced insulin resistance during exercise in healthy young adult males
Hypoxia-induced insulin resistance appears to suppress exogenous glucose oxidation during metabolically matched aerobic exercise during acute (<8 h) high-altitude (HA) exposure. However, a better understanding of this metabolic dysregulation is needed to identify interventions to mitigate these effects. The objective of this study was to determine if differences in metabolomic profiles during exercise at sea level (SL) and HA are reflective of hypoxia-induced insulin resistance. Native lowlanders ( n = 8 males) consumed 145 g (1.8 g/min) of glucose while performing 80-min of metabolically matched treadmill exercise at SL (757 mmHg) and HA (460 mmHg) after 5-h exposure. Exogenous glucose oxidation and glucose turnover were determined using indirect calorimetry and dual tracer technique ([ 13 C]glucose and [6,6- 2 H 2 ]glucose). Metabolite profiles were analyzed in serum as change (Δ), calculated by subtracting postprandial/exercised state SL (ΔSL) and HA (ΔHA) from fasted, rested conditions at SL. Compared with SL, exogenous glucose oxidation, glucose rate of disappearance, and glucose metabolic clearance rate (MCR) were lower ( P < 0.05) during exercise at HA. One hundred and eighteen metabolites differed between ΔSL and ΔHA ( P < 0.05, Q < 0.10). Differences in metabolites indicated increased glycolysis, tricarboxylic acid cycle, amino acid catabolism, oxidative stress, and fatty acid storage, and decreased fatty acid mobilization for ΔHA. Branched-chain amino acids and oxidative stress metabolites, Δ3-methyl-2-oxobutyrate ( r = -0.738) and Δγ-glutamylalanine ( r = -0.810), were inversely associated ( P < 0.05) with Δexogenous glucose oxidation. Δ3-Hydroxyisobutyrate ( r = -0.762) and Δ2-hydroxybutyrate/2-hydroxyisobutyrate ( r = -0.738) were inversely associated ( P < 0.05) with glucose MCR. Coupling global metabolomics and glucose kinetic data suggest that the underlying cause for diminished exogenous glucose oxidative capacity during aerobic exercise is acute hypoxia-mediated peripheral insulin resistance.
C fluxes from incubations of California upland soil with and without synthetic iron (hydr)oxide associations
There is a growing understanding that interactions with soil mineral phases contribute to the accumulation and retention of otherwise degradable organic matter in soils and sediments. However, the bioavailability of organic compounds in mineral-organic-associations, especially under varying environmental conditions is not well known. To assess the impact of mineral association and warming on the decomposition of an easily respirable organic substrate (glucose), we conducted a series of laboratory incubations at different temperatures with field-collected soils from 10 to 20 cm, 50–60 cm, and 80–90 cm depth at the Blodgett Forest Research Station. We added 13C-labeled glucose either directly to native soil or sorbed to one of two synthetic iron (hydr)oxide phases (goethite and ferrihydrite) that differ in crystallinity and affinity for sorbing glucose. We incubated the soils at 25 deg C. This dataset comprises the added glucose C and the cumulative fluxes over 72 and 1896 hours. We found that: (1) association with the Fe (hydr)oxide minerals reduced the decomposition rate of glucose by > 99.5% relative to rate of decomposition for free glucose in soil; (2) the respiration rate per gram carbon did not differ appreciably with depth, suggesting a similar degree of decomposability for native C across depths and that under the incubation conditions total carbon availability represents the principal limitation on respiration under these conditions as opposed to reduced abundance of decomposers or moisture and oxygen limitations; (3) addition of free glucose enhanced native carbon respiration at all soil depths with the largest effect at 50–60 cm; (4) in general respiration of the organo-mineral complex (glucose and iron-(hydr)oxide) was less temperature sensitive than was respiration of native carbon; (5) the addition of organic free mineral decreased the rate of soil respiration in the intermediate 50–60 cm depth soil. The results emphasize the key role of MOAs in regulating the fluxes of carbon from soils to the atmosphere and in turn the stocks of soil carbon.This dataset lists the glucose additions made to soils with and without added geothite or ferrihidrite and the C respired over the timespan of the incubations.
Assessing microbial residues in soil as a potential carbon sink and moderator of carbon use efficiency
Abstract A longstanding assumption of glucose tracing experiments is that all glucose is microbially utilized during short incubations of ≤2 days to become microbial biomass or carbon dioxide. Carbon use efficiency (CUE) estimates have consequently ignored the formation of residues (non-living microbial products) although such materials could represent an important sink of glucose that is prone to stabilization as soil organic matter. We examined the dynamics of microbial residue formation from a short tracer experiment with frequent samplings over 72 h, and conducted a meta-analysis of previously published glucose tracing studies to assess the generality of these experimental results. Both our experiment and meta-analysis indicated 30–34% of amended glucose-C ( 13 C or 14 C) was in the form of residues within the first 6 h of substrate addition. We expand the conventional efficiency calculation to include residues in both the numerator and denominator of efficiency, thereby deriving a novel metric of the potential persistence of glucose-C in soil as living microbial biomass plus residues (‘carbon stabilization efficiency’). This new metric indicates nearly 40% of amended glucose-C persists in soil 180 days after amendment, the majority as non-biomass residues. Starting microbial biomass and clay content emerge as critical factors that positively promote such long term stabilization of labile C. Rapid residue production supports the conclusion that non-growth maintenance activity can illicit high demands for C in soil, perhaps equaling that directed towards growth, and that residues may have an underestimated role in the cycling and sequestration potential of C in soil.