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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 109 records · Page 6
All sourcesNASA NTRSDOE OSTI
DOE OSTI2019

Perioperative Gemcitabine + Erlotinib Plus Pancreaticoduodenectomy for Resectable Pancreatic Adenocarcinoma: ACOSOG Z5041 (Alliance) Phase II Trial

Background: There is considerable interest in a neoadjuvant approach for resectable pancreatic ductal adenocarcinoma (PDAC). This study evaluated perioperative gemcitabine + erlotinib (G+E) for resectable PDAC. Methods: A multicenter, cooperative group, single-arm, phase II trial was conducted between April 2009 and November 2013 (ACOSOG Z5041). Patients with biopsy-confirmed PDAC in the pancreatic head without evidence of involvement of major mesenteric vessels (resectable) were eligible. Patients (n = 123) received an 8-week cycle of G+E before and after surgery. The primary endpoint was 2-year overall survival (OS), and secondary endpoints included toxicity, response, resection rate, and time to progression. Resectability was assessed retrospectively by central review. The study closed early due to slow accrual, and no formal hypothesis testing was performed. Results: Overall, 114 patients were eligible, consented, and initiated protocol treatment. By central radiologic review, 97 (85%) of the 114 patients met the protocol-defined resectability criteria. Grade 3+ toxicity was reported in 60% and 79% of patients during the neoadjuvant phase and overall, respectively. Twenty-two of 114 (19%) patients did not proceed to surgery; 83 patients (73%) were successfully resected. R0 and R1 margins were obtained in 67 (81%) and 16 (19%) resected patients, respectively, and 54 patients completed postoperative G+E (65%). The 2-year OS rate for the entire cohort (n = 114) was 40% (95% confidence interval [CI] 31–50), with a median OS of 21.3 months (95% CI 17.2–25.9). The 2-year OS rate for resected patients (n = 83) was 52% (95% CI 41–63), with a median OS of 25.4 months (95% CI 21.8–29.6). Conclusions: For resectable PDAC, perioperative G+E is feasible. Further evaluation of neoadjuvant strategies in resectable PDAC is warranted with more active systemic regimens.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2026

Mono-mix strategy enables comparative proteomics of a cross-kingdom microbial symbiosis

Cross-kingdom microbial symbioses, such as those between algae and bacteria, are key players in biogeochemical cycles. The molecular changes during initiation and establishment of symbiosis are of great interest, but quantitatively monitoring such changes can be challenging, particularly when the microorganisms differ greatly in size or are intimately associated. Here, we analyze output from label-free, data-dependent acquisition (DDA) LC-MS/MS proteomics experiments investigating the well-studied interaction between the alga Chlamydomonas reinhardtii and the heterotrophic bacterium Mesorhizobium japonicum. We found that detection of bacterial proteins decreased in coculture by 50% proteome-wide due to the abundance of algal proteins. As a result, standard differential expression analysis led to numerous false-positive reports of significantly downregulated proteins, where it was not possible to distinguish meaningful biological responses to symbiosis from artifacts of the reduced protein detection in coculture relative to monoculture. We show that data normalization alone does not eliminate the impact of altered detection on differential expression analysis of the cross-kingdom symbiosis. We assessed two additional strategies to overcome this methodological artifact inherent to DDA proteomics. In the first, we combined algal and bacterial monocultures at a relative abundance that mimicked the coculture, creating a “mono-mix” control to which the coculture could be compared. This approach enabled comparable detection of bacterial proteins in the coculture and the monoculture control. In the second strategy, we enhanced detection of lowly abundant bacterial proteins by using sample fractionation upstream of LC-MS/MS analysis. When these simple approaches were combined, they allowed for meaningful comparisons of nearly 10,000 algal proteins and over 4,000 bacterial proteins in response to symbiosis by DDA. They successfully recovered expected changes in the bacterial proteome in response to algal coculture, including upregulation of sugar-binding proteins and transporters. They also revealed novel proteomic responses to coculture that guide hypotheses about algal-bacterial interactions.

Dupuis, Sunnyjoy [University of California, Berkel↗
DOE OSTI2024

Long-Term Infrasound Sensor Calibration and Characterization

Previous testing has shown that infrasound sensors deployed in the field can exhibit notable deviations from their nominal, lab-based calibrations. These variations may be due to changes in environmental conditions, long-term sensor drift, or other unresolved features. In early 2018, we installed two identical infrasound elements with five infrasound sensors at each element (Chaparral M50A, Chaparral M64LN, CEA/Martec MB2005, CEA/Seismowave MB3a, and Hyperion IFS-5113A). These sensors were accepted or under consideration for use in the International Monitoring System network of the Comprehensive Nuclear-Test-Ban Treaty. Each element had all sensors connected to a single digitizer and port to the atmosphere. We also recorded instrument enclosure air temperature and humidity and external air temperature. Using the MB2005 as the reference, we examine the relative sensor response (both magnitude and phase) as a function of time and frequency and compare it with quarterly laboratory calibrations and environmental conditions. Here, we find that the magnitude response for all sensors exhibits some variability in both the lab and field, with the amplitude variations often >5%. The field-based variations are more severe and occur on both long-term (months) and short-term (hours) timescales. Short-term variability correlates with changes in environmental conditions and is considerable (up to 25%) for the Chaparral M50A and noticeable (∼5%) for the French Alternative Energies and Atomic Energy Commission (CEA) MB3a. Long-term magnitude variability for the Chaparral M50A was up to 50% and does not clearly correlate with environmental conditions. The other sensors show some long-term magnitude offsets, but they have relatively stable responses in the conditions we examined. The MB3a also displays some frequency-dependent magnitude variability and shows a minor dependence on temperature. Phase estimates are stable and near zero for all sensors tested. These results strongly suggest sensor response and variability due to environmental conditions should be considered in future infrasound data interpretation and sensor selection and development.

Fee, David↗
DOE OSTI2020

2019 Hyperion 5313A and 5119A Infrasound Sensor Type Approval Evaluation

Sandia National Laboratories has tested and evaluated two variations of a new model of infrasound sensor, the Hyperion 5313A and 5119A. The purpose of this infrasound sensor evaluation is to measure the performance characteristics in such areas as power consumption, sensitivity, full scale, self-noise, dynamic range, response, passband, sensitivity variation due to changes in static pressure and temperature, and sensitivity to vertical acceleration. The Hyperion infrasound sensors are being evaluated for potential use in the International Monitoring System (IMS) of the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO).

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2020

Evaluation of the Nanometrics Centaur Digitizer

Sandia National Laboratories has tested and evaluated a new digitizer, the Centaur, manufactured by Nanometrics, Inc. This digitizer is used to record sensor output for seismic and infrasound monitoring applications. The purpose of the digitizer evaluation was to measure the performance characteristics in such areas as power, sensitivity, self-noise, dynamic range, system noise, modified noise power ration, relative transfer function, analog bandwidth, harmonic distortion, common mode, cross talk, timing tag accuracy and timing drift. The Centaur provides six channels of 24 bit digitization, three of which may be transmitted utilizing CD1.1 protocol.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2020

Kinemetrics Q330M+ Digitizer Evaluation

Sandia National Laboratories has tested and evaluated a new digitizer, the Q330M+, manufactured by Quanterra, a division of Kinemetrics Inc. This digitizer is used to record sensor output for seismic and infrasound monitoring applications. The purpose of the digitizer evaluation was to measure the performance characteristics in such areas as sensitivity, input impedance, power consumption, self noise, dynamic range, system noise, relative transfer function, analog bandwidth, modified noise power ratio, harmonic distortion, common mode, cross talk, timing tag accuracy and timing drift. The Q330M+ provides six channels of 24 bit digitization, all of which may be transmitted utilizing CD1.1 protocol, at multiple sample rates.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2020

Guralp Affinity Digitizer Evaluation

Sandia National Laboratories has tested and evaluated a new digitizer, the Affinity, manufactured by Guralp Systems. This digitizer is used to record sensor output for seismic and infrasound monitoring applications. The purpose of the digitizer evaluation was to measure the performance characteristics in such areas as sensitivity, power, self-noise, dynamic range, system noise, relative transfer function, modified noise power ratio, analog bandwidth, harmonic distortion, common mode, cross talk, timing tag accuracy and timing drift. The Affinity provides eight, rather the typical six, channels of 24 bit high sample rate digitization, all of which may be transmitted utilizing the CD1.1 protocol, at multiple sample rates.

46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
DOE OSTI2020

Comparison of DTRA/NACT Next Generation Digitizer Evaluations

Sandia National Laboratories has tested and evaluated three digitizers, the Affinity, manufactured by Guralp Systems, the Centaur, manufactured by Nanometrics, and the Q330M+, manufactured by Quanterra, a division of Kinemetrics. These digitizers are used to record sensor output for seismic and infrasound monitoring applications. The purpose of this document is to highlight various results and observations collected during comprehensive evaluations conducted on each unit.

42 ENGINEERING↗
DOE OSTI2021

Guidelines for Broadband Seismometer Testing

The Comprehensive Nuclear-Test-Ban Treaty mandates the four verification technologies to be used by the International Monitoring System (IMS) to monitor compliance to the Treaty. These technologies are seismic, hydroacoustic, infrasound, and radionuclide. Operational manuals for each of these technologies specify the requirements that equipment installed at IMS stations must meet for data from said stations to be accepted by the International Data Center. Following a model in which a revised set of infrasound sensor specifications and accompanying test procedures were developed in an international collaboration overseen by the Comprehensive Nuclear-Test-Ban Treaty Organization, the same process was recently followed for seismometers potentially of use by the IMS. This document, a product of that collaboration, defines key concepts and recommends test procedures to be followed to characterize broadband seismometers in a consistent and standardized way. Results from these test procedures can be used to verify that a seismometer meets the manufacturers stated specifications and IMS requirements. ACKNOWLEDGEMENTS The writers of this document would like to acknowledge Charles R. Hutt, John R. Evans, Fred Followill, Robert L. Nigbor, and Erhard Wielandt, the authors of the 2009 Guidelines for Standardized Testing of Broadband Seismometers and Accelerometers funded by the U.S. Department of Interior, on which this document is based. Although this document is limited in scope to seismometers and much of the document has been updated, the structure remains essentially the same.

58 GEOSCIENCES↗
DOE OSTI2021

2020 Hyperion Infrasound Sensor Equilibration Evaluation

Sandia National Laboratories has performed testing on several Hyperion 5313A infrasound sensors in order to determine the length of time it takes for the sensors to thermally equilibrate under a variety of environmental conditions. The motivation for performing these tests is to aid in determining suitable procedures for station operators to follow when installing these sensors. The desired outcome is for the station operators to be able to determine more quickly and reliably whether the sensors are performing correctly at the time of installation.

47 OTHER INSTRUMENTATION↗
DOE OSTI2021

Evaluation of Low Cost Infrasound Sensor Packages

Sandia National Laboratories has tested and evaluated the performance of the following five models of low-cost infrasound sensors and sensor packages: Camas microphone, Gem Infrasound Logger, InfraBSU sensor, Raspberry Boom, and the Samsung S10 smartphone utilizing the Redvox app. The purpose of this infrasound sensor evaluation is to measure the performance characteristics in such areas as power consumption, sensitivity, self-noise, dynamic range, response, passband, linearity, sensitivity variation due to changes in static pressure and temperature, and sensitivity to vertical acceleration. The infrasound monitoring community has leveraged such sensors and integrated packages in novel ways; better understanding the performance of these units serves the geophysical monitoring community.

42 ENGINEERING↗
DOE OSTI2022

2022 MB3a Infrasound Sensor Type Approval Evaluation

Sandia National Laboratories has tested and evaluated an updated version of the MB3a infrasound sensor, designed by CEA and manufactured by SeismoWave. The purpose of this infrasound sensor evaluation is to measure the performance characteristics in such areas as power consumption, sensitivity, full scale, self-noise, dynamic range, response, passband, sensitivity variation due to changes in barometric pressure and temperature, and sensitivity to acceleration. The MB3a infrasound sensors are being evaluated for use in the International Monitoring System (IMS) of the Preparatory Commission to the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO).

47 OTHER INSTRUMENTATION↗
DOE OSTI2022

2022 Chaparral 64S Infrasound Sensor Type Approval Evaluation

Sandia National Laboratories has tested and evaluated a new version of the Chaparral 64S infrasound sensor, designed and manufactured by Chaparral Physics. The purpose of this infrasound sensor evaluation is to measure the performance characteristics in such areas as power consumption, sensitivity, full scale, self-noise, dynamic range, response, passband, sensitivity variation due to changes in barometric pressure and temperature, and sensitivity to acceleration. The Chaparral 64S infrasound sensors are being evaluated for use in the International Monitoring System (IMS) of the Preparatory Commission to the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO).

47 OTHER INSTRUMENTATION↗