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At least 1,081 records · Page 60

Image Guided Radiation Therapy (IGRT) Practice Patterns and IGRT's Impact on Workflow and Treatment Planning: Results From a National Survey of American Society for Radiation Oncology Members

Purpose: To survey image guided radiation therapy (IGRT) practice patterns, as well as IGRT's impact on clinical workflow and planning treatment volumes (PTVs). Methods and Materials: A sample of 5979 treatment site–specific surveys was e-mailed to the membership of the American Society for Radiation Oncology (ASTRO), with questions pertaining to IGRT modality/frequency, PTV expansions, method of image verification, and perceived utility/value of IGRT. On-line image verification was defined as images obtained and reviewed by the physician before treatment. Off-line image verification was defined as images obtained before treatment and then reviewed by the physician before the next treatment. Results: Of 601 evaluable responses, 95% reported IGRT capabilities other than portal imaging. The majority (92%) used volumetric imaging (cone-beam CT [CBCT] or megavoltage CT), with volumetric imaging being the most commonly used modality for all sites except breast. The majority of respondents obtained daily CBCTs for head and neck intensity modulated radiation therapy (IMRT), lung 3-dimensional conformal radiation therapy or IMRT, anus or pelvis IMRT, prostate IMRT, and prostatic fossa IMRT. For all sites, on-line image verification was most frequently performed during the first few fractions only. No association was seen between IGRT frequency or CBCT utilization and clinical treatment volume to PTV expansions. Of the 208 academic radiation oncologists who reported working with residents, only 41% reported trainee involvement in IGRT verification processes. Conclusion: Consensus guidelines, further evidence-based approaches for PTV margin selection, and greater resident involvement are needed for standardized use of IGRT practices.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

TU-G-BRA-03: Predicting Radiation Therapy Induced Ventilation Changes Using 4DCT Jacobian Calculations

Purpose: Longitudinal changes in lung ventilation following radiation therapy can be mapped using four-dimensional computed tomography(4DCT) and image registration. This study aimed to predict ventilation changes caused by radiation therapy(RT) as a function of pre-RT ventilation and delivered dose. Methods: 4DCT images were acquired before and 3 months after radiation therapy for 13 subjects. Jacobian ventilation maps were calculated from the 4DCT images, warped to a common coordinate system, and a Jacobian ratio map was computed voxel-by-voxel as the ratio of post-RT to pre-RT Jacobian calculations. A leave-one-out method was used to build a response model for each subject: post-RT to pre-RT Jacobian ratio data and dose distributions of 12 subjects were applied to the subject’s pre-RT Jacobian map to predict the post-RT Jacobian. The predicted Jacobian map was compared to the actual post-RT Jacobian map to evaluate efficacy. Within this cohort, 8 subjects had repeat pre-RT scans that were compared as a reference for no ventilation change. Maps were compared using gamma pass rate criteria of 2mm distance-to-agreement and 6% ventilation difference. Gamma pass rates were compared using paired t-tests to determine significant differences. Further analysis masked non-radiation induced changes by excluding voxels below specified dose thresholds. Results: Visual inspection demonstrates the predicted post-RT ventilation map is similar to the actual map in magnitude and distribution. Quantitatively, the percentage of voxels in agreement when excluding voxels receiving below specified doses are: 74%/20Gy, 73%/10Gy, 73%/5Gy, and 71%/0Gy. By comparison, repeat scans produced 73% of voxels within the 6%/2mm criteria. The agreement of the actual post-RT maps with the predicted maps was significantly better than agreement with pre-RT maps (p<0.02). Conclusion: This work validates that significant changes to ventilation post-RT can be predicted. The differences between the predicted and actual outcome are similar to differences between repeat scans with equivalent ventilation. This work was supported by NIH grant CA166703 and a Pilot Grant from University of Iowa Carver College of Medicine.

60 APPLIED LIFE SCIENCES↗

SU-E-I-87: Calibrating Cherenkov Emission to Match Superficial Dose in Tissue

Purpose: Through Monte Carlo simulations and phantom studies, the dominant factors affecting the calibration of superficial Cherenkov intensity to absolute surface dose was investigated, including tissue optical properties, curvatures, beam properties and imaging angle. Methods: The phasespace files for the TrueBeam system from Varian were used in GAMOS (a GEANT4 based Monte Carlo simulation toolkit) to simulate surface emission Cherenkov signals and the correlated deposited dose. The parameters examined were: i) different tissue optical properties (skin color from light to dark), ii) beam types (X-ray and electron beam), iii) beam energies, iv) thickness of tissues (2.5 cm to 20 cm), v) SSD (80 cm to 120 cm), vi) field sizes (0.5×0.5 cm2 to 20×20 cm2), vii) entrance/exit sides, viii) curvatures (cylinders with diameters from 2.5 cm to 20cm) and ix) imaging angles (0 to 90 degrees). In a specific case, for any Cherenkov photon emitted from the surface, the original position and direction, final position and direction and energy were recorded. Similar experimental measurements were taken in a range of the most pertinent parameters using tissue phantoms. Results: Combining the dose distribution and sampling sensitivity of Cherenkov emission, quantitatively accurate calibration factors (the amount of radiation dose represented by a single Cherenkov photon) were calculated. The data showed relatively large dependence upon different optical properties, curvature, entrance/exit and beam types. For a diffusive surface, the calibration factor was insensitive to imaging angles smaller than 60 degrees. Normalization with the reflectance image was experimentally validated as a simple and accurate method for calibrations of different optical properties. Conclusion: This study sheds light on how and to what extent different conditions affect the calibration from Cherenkov intensity to absolute superficial dose and provides practical solutions to allow quantitative Cherenkov imaging to be used as a dose surrogate for imaging.

60 APPLIED LIFE SCIENCES↗

A reconnaissance space sensing investigation of crustal structure for a strip from the eastern Sierra Nevada to the Colorado Plateau

There are no author-identified significant results in this report. Research progress in applications of ERTS-1 MSS imagery in study of Basin-Range tectonics is summarized. Field reconnaissance of ERTS-1 image anomalies has resulted in recognition of previously unreported fault zones and regional structural control of volcanic and plutonic activity. NIMBUS, Apollo 9, X-15, U-2, and SLAR imagery are discussed with specific applications, and methods of image enhancement and analysis employed in the research are summarized. Areas studied and methods employed in geologic field work are outlined.

Bechtold, I. C.↗

Adaptive Patching for High-resolution Image Segmentation with Transformers

Attention-based models are proliferating in the space of image analytics, including segmentation. The standard method of feeding images to transformer encoders is to divide the images into patches and then feed the patches to the model as a linear sequence of tokens. For high-resolution images, e.g. microscopic pathology images, the quadratic compute and memory cost prohibits the use of an attention-based model, if we are to use smaller patch sizes that are favorable in segmentation. The solution is to either use custom complex multi-resolution models or approximate attention schemes. We take inspiration from Adapative Mesh Refinement (AMR) methods in HPC by adaptively patching the images, as a pre-processing step, based on the image details to reduce the number of patches being fed to the model, by orders of magnitude. This method has a negligible overhead, and works seamlessly with any attention-based model, i.e. it is a pre-processing step that can be adopted by any attention-based model without friction. We demonstrate superior segmentation quality over SoTA segmentation models for realworld pathology datasets while gaining a geomean speedup of 6.9× for resolutions up to 64K2, on up to 2, 048 GPUs.

Zhang, Enzhi↗

Volume of interest CBCT and tube current modulation for image guidance using dynamic kV collimation

Purpose: The focus of this work is the development of a novel blade collimation system enabling volume of interest (VOI) CBCT with tube current modulation using the kV image guidance source on a linear accelerator. Advantages of the system are assessed, particularly with regard to reduction and localization of dose and improvement of image quality. Methods: A four blade dynamic kV collimator was developed to track a VOI during a CBCT acquisition. The current prototype is capable of tracking an arbitrary volume defined by the treatment planner for subsequent CBCT guidance. During gantry rotation, the collimator tracks the VOI with adjustment of position and dimension. CBCT image quality was investigated as a function of collimator dimension, while maintaining the same dose to the VOI, for a 22.2 cm diameter cylindrical water phantom with a 9 mm diameter bone insert centered on isocenter. Dose distributions were modeled using a dynamic BEAMnrc library and DOSXYZnrc. The resulting VOI dose distributions were compared to full-field CBCT distributions to quantify dose reduction and localization to the target volume. A novel method of optimizing x-ray tube current during CBCT acquisition was developed and assessed with regard to contrast-to-noise ratio (CNR) and imaging dose. Results: Measurements show that the VOI CBCT method using the dynamic blade system yields an increase in contrast-to-noise ratio by a factor of approximately 2.2. Depending upon the anatomical site, dose was reduced to 15%–80% of the full-field CBCT value along the central axis plane and down to less than 1% out of plane. The use of tube current modulation allowed for specification of a desired SNR within projection data. For approximately the same dose to the VOI, CNR was further increased by a factor of 1.2 for modulated VOI CBCT, giving a combined improvement of 2.6 compared to full-field CBCT. Conclusions: The present dynamic blade system provides significant improvements in CNR for the same imaging dose and localization of imaging dose to a predefined volume of interest. The approach is compatible with tube current modulation, allowing optimization of the imaging protocol.

60 APPLIED LIFE SCIENCES↗

Photodissociation of aligned CH3I and C6H3F2I molecules probed with time-resolved Coulomb explosion imaging by site-selective extreme ultraviolet ionization

We explore time-resolved Coulomb explosion induced by intense, extreme ultraviolet (XUV) femtosecond pulses from a free-electron laser as a method to image photo-induced molecular dynamics in two molecules, iodomethane and 2,6-difluoroiodobenzene. At an excitation wavelength of 267 nm, the dominant reaction pathway in both molecules is neutral dissociation via cleavage of the carbon–iodine bond. This allows investigating the influence of the molecular environment on the absorption of an intense, femtosecond XUV pulse and the subsequent Coulomb explosion process. We find that the XUV probe pulse induces local inner-shell ionization of atomic iodine in dissociating iodomethane, in contrast to non-selective ionization of all photofragments in difluoroiodobenzene. The results reveal evidence of electron transfer from methyl and phenyl moieties to a multiply charged iodine ion. In addition, indications for ultrafast charge rearrangement on the phenyl radical are found, suggesting that time-resolved Coulomb explosion imaging is sensitive to the localization of charge in extended molecules.

74 ATOMIC AND MOLECULAR PHYSICS↗

Detecting an underground tunnel by applying joint traveltime and waveform inversion

Underground tunnel and void detection is a challenging geophysical problem, and many methods have been proposed. Seismic techniques are promising because of the large seismic velocity contrasts between the air-filled void and the surrounding sediment and concrete. We apply a joint seismic traveltime and waveform inversion method to image a buried tunnel with concrete walls and a void space inside. The joint inversion images the top of the concrete tunnel as a high-velocity anomaly and the void space as a low-velocity anomaly. The location of the velocity anomalies predicted by the method agrees with the known location of the tunnel. As a comparison, the stand-alone full waveform inversion is also applied to the data. The first-arrival traveltime tomography shows weak nonlinearity but fails to image the hidden low-velocity layer. Full waveform inversion is able to image complex near-surface structures, but fitting waveforms may not honor the traveltime fit, especially when the data contain noise. Synthetic and real data tests show that the joint inversion method retains the advantages of both traveltime inversion and full waveform inversion and overcomes their respective drawbacks at the same time. The field example shows the joint inversion provides a better reconstruction of the high-velocity feature representing the top of the concrete wall in terms of its magnitude and location.

58 GEOSCIENCES↗

A reconnaissance space sensing investigation of crustal structure for a strip from the eastern Sierra Nevada to the Colorado Plateau

The author has identified the following significant results. Research progress in applications of ERTS-1 MSS imagery to study of Basin-Range tectonics is summarized. Field reconnaissance of ERTS-1 image anomalies has resulted in recognition of previously unreported fault zones and regional structural control of volcanic and plutonic activity. Nimbus, Apollo 9, X-15, U-2, and SIAR imagery are discussed with specific applications, and methods of image enhancement and analysis employed in the research are summarized. Field areas studied and methods employed in geologic field work are outlined.

Liggett, M. A.↗

Multidimensional images and aberrations in STEM

Recent advances in scanning transmission electron microscopy (STEM) have led to increased development of multi-dimensional STEM imaging modalities and novel image reconstruction methods. This interest arises because the main electron lens in a modern transmission electron microscope usually has a diffraction-space information limit that is significantly better than the real-space resolution of the same lens. This state-of-affairs is sometimes shared by other scattering methods in modern physics and contributes to a broader excitement surrounding multidimensional techniques that scan a probe while recording diffraction-space images, such as ptychography and scanning nano-beam diffraction. However, the contrasting resolution in the two spaces raises the question as to what is limiting their effective performance. Here, we examine this paradox by considering the effects of aberrations in both image and diffraction planes, and likewise separate the contributions of pre- and post-sample aberrations. In conclusion, this consideration provides insight into aberration-measurement techniques and might also indicate improvements for super-resolution techniques.

Hoglund, Eric R.↗

High resolution images of P/Tempel 1 and P/Tempel 2 constructed from IRAS survey data

Infrared images of P/Tempel 1 and P/Tempel 2 were constructed from IRAS survey data using a computer algorithm based on the Maximum Correlation Method for Image Construction (Aumann et al, 1990). The resulting images are of sufficiently high quality and resolution to delineate coma and tail morphology, and permit accurate photometry of the total dust complex. Comparisons of the infrared colors and photometric profiles of Tempel 1 and Tempel 2 at similar heliocentric distances show that the grains produced by the two comets are quite similar in radiometric and dynamic properties. Tempel 1 is found to produce about 30 percent more dust in its coma and tail than Tempel 2. The comae of Tempel 1 and Tempel 2 are expanding with mean velocities of 5.8 plus or minus 0.07 and 6.1 plus or minus 0.17 m/sec respectively, indicative of the ejection of large grains. The IRAS cataloged infrared fluxes (Walker, 1986) are found to be underestimated by as much as a factor of three for the comets. Therefore, it is essential to create images of the comets to obtain meaningful IRAS photometry.

Walker, Russell G.↗

Discorpy : algorithms and software for camera calibration and correction

Camera or lens-based detector calibration is essential for spatial accuracy in applications like dimensional tomography, optical metrology, and computer vision. Many methods and software exist yet there is still a lack of approaches that achieve both high accuracy and robustness while being easy to use and capable of handling a wide range of distortions. Radial lens distortion is common in high-resolution X-ray detector optics used in parallel-beam tomography at synchrotrons. Achieving sub-pixel accuracy requires calibrating with an optical target image. Although methods for characterizing radial distortion are well established, acquired images often also include perspective distortion and optical center offset. Here, we present our approaches to individually characterize and correct both types of distortion using a single calibration image, implemented in the Discorpy software.

36 MATERIALS SCIENCE↗

Reconstructing magnetic deflections from sets of proton images using differential evolution

Proton imaging is a powerful technique for imaging electromagnetic fields within an experimental volume, in which spatial variations in proton fluence are a result of deflections to proton trajectories due to interaction with the fields. When deflections are large, proton trajectories can overlap, and this nonlinearity creates regions of greatly increased proton fluence on the image, known as caustics. The formation of caustics has been a persistent barrier to reconstructing the underlying fields from proton images. We have developed a new method for reconstructing the path-integrated magnetic fields, which begins to address the problem posed by caustics. Our method uses multiple proton images of the same object, each image at a different energy, to fill in the information gaps and provide some uniqueness when reconstructing caustic features. We use a differential evolution algorithm to iteratively estimate the underlying deflection function, which accurately reproduces the observed proton fluence at multiple proton energies simultaneously. We test this reconstruction method using synthetic proton images generated for three different, cylindrically symmetric field geometries at various field amplitudes and levels of proton statistics and present reconstruction results from a set of experimental images. Here, the method we propose requires no assumption of deflection linearity and can reliably solve for fields underlying linear, nonlinear, and caustic proton image features for the selected geometries and is shown to be fairly robust to noise in the input proton intensity.

47 OTHER INSTRUMENTATION↗

TU-F-CAMPUS-J-03: Elasticity Functions Based On 4DCT Images to Predict Tumor and Normal Tissue Response to Radiation for Patients with Lung Cancers

Purpose: To investigate radiotherapy outcomes by incorporating 4DCT-based physiological and tumor elasticity functions for lung cancer patients. Methods: 4DCT images were acquired from 28 lung SBRT patients before radiation treatment. Deformable image registration (DIR) was performed from the end-inhale to the end-exhale using a B-Spline-based algorithm (Elastix, an open source software package). The resultant displacement vector fields (DVFs) were used to calculate a relative Jacobian function (RV) for each patient. The computed functions in the lung and tumor regions represent lung ventilation and tumor elasticity properties, respectively. The 28 patients were divided into two groups: 16 with two-year tumor local control (LC) and 12 with local failure (LF). The ventilation and elasticity related RV functions were calculated for each of these patients. Results: The LF patients have larger RV values than the LC patients. The mean RV value in the lung region was 1.15 (±0.67) for the LF patients, higher than 1.06 (±0.59) for the LC patients. In the tumor region, the elasticity-related RV values are 1.2 (±0.97) and 0.86 (±0.64) for the LF and LC patients, respectively. Among the 16 LC patients, 3 have the mean RV values greater than 1.0 in the tumors. These tumors were located near the diaphragm, where the displacements are relatively large.. RV functions calculated in the tumor were better correlated with treatment outcomes than those calculated in the lung. Conclusion: The ventilation and elasticity-related RV functions in the lung and tumor regions were calculated from 4DCT image and the resultant values showed differences between the LC and LF patients. Further investigation of the impact of the displacements on the computed RV is warranted. Results suggest that the RV images might be useful for evaluation of treatment outcome for lung cancer patients.

60 APPLIED LIFE SCIENCES↗

The application of nonintrusive optical methods for physical measurements in combustion

Laser optical diagnostic techniques have proven to be effective for making physical measurements in hostile combustion environments. Two major and complementary approaches have been applied; namely, single event imaging and multi-signal detection methods. Single event imaging methods (e.g., pulsed laser holography) can provide the essentially instantaneous observation of physical events, e.g., fuel atomization, droplet breakup, particle and surface combustion, condensed phase formation, and flow field visualization. Multi-signal detection methods, which involve the processing of signals produced by the light scattered from the interaction of particles and/or droplets with an incident coherent ray, can provide information on flow velocity, turbulence, fluid shear stresses, and particle/droplet size and velocity. Recent results using both approaches are presented.

Wuerer, J. E.↗

Cluster Method Analysis of K. S. C. Image

Information obtained from satellite-based systems has moved to the forefront as a method in the identification of many land cover types. Identification of different land features through remote sensing is an effective tool for regional and global assessment of geometric characteristics. Classification data acquired from remote sensing images have a wide variety of applications. In particular, analysis of remote sensing images have special applications in the classification of various types of vegetation. Results obtained from classification studies of a particular area or region serve towards a greater understanding of what parameters (ecological, temporal, etc.) affect the region being analyzed. In this paper, we make a distinction between both types of classification approaches although, focus is given to the unsupervised classification method using 1987 Thematic Mapped (TM) images of Kennedy Space Center.

Rodriguez, Joe, Jr.↗

SU-E-I-40: Phantom Research On Monochromatic Images Taken by Dual CBCT with Multiple Energy Sets

Purpose: To evaluate the quality of monochromatic images at the same virtual monochromatic energy using dual cone-beam computed tomography (CBCT) with either kV/kV or MV/kV or MV/MV energy sets. Methods: CT images of Catphan 504 phantom were acquired using four different KV and MV settings: 80kV, 140kV, 4MV, 6MV. Three sets of monochromatic images were calculated: 80kV-140kV, 140kV-4MV and 4MV-6MV. Each set of CBCT images were reconstructed from the same selected virtual monochromatic energy of 1MeV. Contrast-to-Noise Ratios (CNRs) were calculated and compared between each pair of images with different energy sets. Results: Between kV/MV and MV/MV images, the CNRs are comparable for all inserts. However, differences of CNRs were observed between the kV/kV and kV/MV images. Delrin’s CNR ratio between kV/kV image and kV/MV image is 1.634. LDPE’s (Low-Density Polyethylene) CNR ratio between kV/kV and kV/MV images is 0.509. Polystyrene’s CNR ratio between kV/kV image and kV/MV image is 2.219. Conclusion: Preliminary results indicated that the CNRs calculated from CBCT images reconstructed from either kV/MV projections or MV/MV projections for the same selected virtual monochromatic energy may be comparable.

60 APPLIED LIFE SCIENCES↗