Search NASA⌕ Search

SEARCH · Search NASA

Results for “analyzable function”

Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 1,099 records · Page 61

Algorithms and file structures to extend and enhance liquid chromatography and ion mobility mass spectrometry workflows (CRADA Final Report)

The purpose of this project was to continue supporting customizations of algorithms and raw data file structures to enhance software workflows for liquid chromatography (LC), mass spectrometry (MS) and ion mobility mass spectrometry (IM-MS)-based protein and metabolite characterization. PNNL worked with Agilent to design, implement, evaluate, and demonstrate new algorithms and integrated them as functionalities into the PNNL-PreProcessor software. The project augmented PNNL’s capabilities to analyze complex proteomics and metabolomics samples. These capabilities are directly beneficial to DOE and PNNL efforts to characterize and analyze these compounds in microbial and plant communities. The project assisted Agilent in further developing improved instrument-software solutions combining liquid chromatography and ion mobility with mass spectrometry for widespread applications in life sciences and other fields.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

THE ROLE OF QUENCHING TIME IN THE EVOLUTION OF THE MASS–SIZE RELATION OF PASSIVE GALAXIES FROM THE WISP SURVEY

We analyze how passive galaxies at z ∼ 1.5 populate the mass–size plane as a function of their stellar age, to understand if the observed size growth with time can be explained with the appearance of larger quenched galaxies at lower redshift. We use a sample of 32 passive galaxies extracted from the Wide Field Camera 3 Infrared Spectroscopic Parallel (WISP) survey with spectroscopic redshift 1.3 ≲ z ≲ 2.05, specific star formation rates lower than 0.01 Gyr{sup −1}, and stellar masses above 4.5 × 10{sup 10} M {sub ⊙}. All galaxies have spectrally determined stellar ages from fitting of their rest-frame optical spectra and photometry with stellar population models. When dividing our sample into young (age ≤2.1 Gyr) and old (age >2.1 Gyr) galaxies we do not find a significant trend in the distributions of the difference between the observed radius and that predicted by the mass–size relation. This result indicates that the relation between the galaxy age and its distance from the mass–size relation, if it exists, is rather shallow, with a slope α ≳ −0.6. At face value, this finding suggests that multiple dry and/or wet minor mergers, rather than the appearance of newly quenched galaxies, are mainly responsible for the observed time evolution of the mass–size relation in passive galaxies.

79 ASTRONOMY AND ASTROPHYSICS↗

Low-frequency Carbon Radio Recombination Lines. II. The Diffuse Interstellar Medium

In the second paper of the series, we have modeled low-frequency carbon radio recombination lines (CRRLs) from the interstellar medium. Anticipating the Low Frequency Array survey of Galactic CRRLs, we focus our study on the physical conditions of the diffuse, cold neutral medium. We have used the improved departure coefficients computed in the first paper of the series to calculate line-to-continuum ratios. The results show that the line width and integrated optical depths of CRRLs are sensitive probes of the electron density, gas temperature, and emission measure of the cloud. Furthermore, the ratio of CRRL to the [C ii] at the 158 μ m line is a strong function of the temperature and density of diffuse clouds. Guided by our calculations, we analyze CRRL observations and illustrate their use with data from the literature.

79 ASTRONOMY AND ASTROPHYSICS↗

First Global Extraction of the Worm-gear TMD g 1 T

In these proceedings, we report on the first simultaneous extraction of the worm-gear function g 1 T , one of the eight leading-twist TMDs. The study analyzes COMPASS, HERMES and JLab semi-inclusive deep-inelastic scattering data using Monte Carlotechniques. We also provide a comparison of g 1 T obtained from this experimental data with a large N c analysis, the Wandzura–Wilczek-type approximation, and lattice QCD.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Operando FTIR Studies of Electrolyte Solution Structures and Dynamics at Electrode-Electrolyte Interfaces

The well-stabilized electrode-electrolyte interface (EEI) is critical to battery performance and safety, thus understanding the electrolyte solution structures (e.g., ion solvation and ionic association) and dynamics within EEI is an important area of study. Unfortunately, due to the sensitive nature of the electrodes, ex-situ characterization methods are limited and challenging to interpret as chemical and structural changes occur upon deconstructing the cell. In this work, we present operando characterization of near-surface electrolyte solution structures and dynamics by ATR-FTIR spectroscopy during battery cycling. We studied two selected model electrodes, a lithium nickel manganese cobalt oxide (NMC) or a planar silicon (Si), in a standard Gen2 electrolyte of 1.2 M LiPF6 in ethylene carbonate (EC):ethyl methyl carbonate (EMC) (3:7 wt%). In the former case, the composite cathode on aluminum foil is placed face-down on an ATR crystal. A ring of lithium metal serves as the counter/reference electrode and no separator is required. In the latter case, a lightly doped p-type silicon wafer is phosphorous-doped at the surface to increase the conductivity of the sample without compromising infrared transparency. The ATR crystal is then pressed on the back of the silicon with a minimal air gap to ensure sufficient optical contact between the two materials. The front of wafer is then placed in a modified coin-type cell geometry with a minimal electrolyte, a separator, and a lithium metal counter/reference electrode. In both experiments, we analyze the electrolyte solution structures within the EEI and find similar patterns as a function of potential. Firstly, we find that EMC decomposes faster than EC -suggesting that EMC plays a greater role in the electrochemical reactions on the electrode surface (e.g., formation of a protective layer to prevent further electrolyte decomposition). Secondly, we monitor the increase/decrease of the vibrational absorption peaks attributed to carbonates coordinated with Li+ ions relative to the decrease/increase of their uncoordinated counterparts, as expected when changing the local concentration of Li+ ions near the electrode surface during deintercalation/intercalation into the electrode. Finally, we observe that the features assigned to the Li+-PF6 -/-solvent molecules contact ion pair relative to the uncoordinated PF6 - anion. These observations give important information regarding the electrolyte solution structures and dynamics near the electrode surfaces. We look forward to applying these techniques to additional lithiumion battery systems with different cathode or anode materials and beyond lithium-ion systems to characterize surface chemistry/evolution (on-going research) and solution structures/dynamics (in particular, (de)solvation behaviors) within the EEI, which can be a bottleneck to efficient ion transfer from the electrolyte to the electrode.

14 SOLAR ENERGY↗

Nonstationary model of an axisymmetric mirror trap with nonequilibrium plasma

The DOL nonstationary model intended to describe plasma processes in axisymmetric magnetic mirror traps is considered. The model uses averaging over the bounce period in order to take into account the dependence of plasma parameters on the coordinate along the facility axis. Examples of calculations of trap parameters by means of the DOL code based on this model are presented. Among the features of the DOL model, one can single out two points: first, the capability of calculating the terms of the collision integral with the use of a non-Maxwellian scattering function while evaluating the distribution function of fast ions and, second, concerning the background plasma, the capability of calculating the longitudinal particle and energy fluxes in confinement modes with the particle mean free path being on the order of the trap length. The influence of the scattering function approximation used to calculate the collision integral on the solution to the kinetic equation is analyzed. The dependences of plasma parameters on the power of heating injectors and the length of the fast-ion turning zone are presented as calculation examples. The longitudinal profile of the fusion reaction rate in the case of a trap with a long fast-ion turning zone is shown to depend strongly on the input parameters of the model.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗

Predictors of Liver Toxicity Following Stereotactic Body Radiation Therapy for Hepatocellular Carcinoma

Purpose: To identify risk factors associated with a decline in liver function after stereotactic body radiation therapy (SBRT) for hepatocellular carcinoma. Methods and Materials: Data were analyzed from patients with hepatocellular carcinoma treated on clinical trials of 6-fraction SBRT. Liver toxicity was defined as an increase in Child-Pugh (CP) score ≥2 three months after SBRT. Clinical factors, SBRT details, and liver dose-volume histogram (DVH) parameters were tested for association with toxicity using logistic regression. CP class B patients were analyzed separately. Results: Among CP class A patients, 101 were evaluable, with a baseline score of A5 (72%) or A6 (28%). Fifty-three percent had portal vein thrombus. The median liver volume was 1286 cc (range, 766-3967 cc), and the median prescribed dose was 36 Gy (range, 27-54 Gy). Toxicity was seen in 26 patients (26%). Thrombus, baseline CP of A6, and lower platelet count were associated with toxicity on univariate analysis, as were several liver DVH-based parameters. Absolute and spared liver volumes were not significant. On multivariate analysis for CP class A patients, significant associations were found for baseline CP score of A6 (odds ratio [OR], 4.85), lower platelet count (OR, 0.90; median, 108 × 10{sup 9}/L vs 150 × 10{sup 9}/L), higher mean liver dose (OR, 1.33; median, 16.9 Gy vs 14.7 Gy), and higher dose to 800 cc of liver (OR, 1.11; median, 14.3 Gy vs 6.0 Gy). With 13 CP-B7 patients included or when dose to 800 cc of liver was replaced with other DVH parameters (eg, dose to 700 or 900 cc of liver) in the multivariate analysis, effective volume and portal vein thrombus were associated with an increased risk. Conclusions: Baseline CP scores and higher liver doses (eg, mean dose, effective volume, doses to 700-900 cc) were strongly associated with liver function decline 3 months after SBRT. A lower baseline platelet count and portal vein thrombus were also associated with an increased risk.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Modeling Liquid Water by Climbing up Jacob’s Ladder in Density Functional Theory Facilitated by Using Deep Neural Network Potentials

Within the framework of Kohn–Sham density functional theory (DFT), the ability to provide good predictions of water properties by employing a strongly constrained and appropriately normed (SCAN) functional has been extensively demonstrated in recent years. Here, we further advance the modeling of water by building a more accurate model on the fourth rung of Jacob’s ladder with the hybrid functional, SCAN0. In particular, we carry out both classical and Feynman path-integral molecular dynamics calculations of water with the SCAN0 functional and the isobaric–isothermal ensemble. To generate the equilibrated structure of water, a deep neural network potential is trained from the atomic potential energy surface based on ab initio data obtained from SCAN0 DFT calculations. For the electronic properties of water, a separate deep neural network potential is trained by using the Deep Wannier method based on the maximally localized Wannier functions of the equilibrated trajectory at the SCAN0 level. The structural, dynamic, and electric properties of water were analyzed. The hydrogen-bond structures, density, infrared spectra, diffusion coefficients, and dielectric constants of water, in the electronic ground state, are computed by using a large simulation box and long simulation time. For the properties involving electronic excitations, we apply the GW approximation within many-body perturbation theory to calculate the quasiparticle density of states and bandgap of water. Compared to the SCAN functional, mixing exact exchange mitigates the self-interaction error in the meta-generalized-gradient approximation and further softens liquid water toward the experimental direction. For most of the water properties, the SCAN0 functional shows a systematic improvement over the SCAN functional. However, some important discrepancies remain. The H-bond network predicted by the SCAN0 functional is still slightly overstructured compared to the experimental results.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

Two symmetric n-type interfaces SrTiO{sub 3}/LaAlO{sub 3} in perovskite: Electronic properties from density functional theory

The first principles study of the (001) two symmetric n-type interfaces between two insulating perovskites, the nonpolar SrTiO{sub 3} (STO), and the polar LaAlO{sub 3} (LAO) was performed. We have analyzed the formation of metallic interface states between the STO and LAO heterointerfaces by using the all-electron full-potential linearized augmented plane-wave approach based on the density functional theory, within the local density approximation, the Perdew-Burke-Ernzerhof generalized gradient approximation (PBE-GGA), and the Engel-Vosko GGA (EVGGA) formalism. It has been found that some bands cross the Fermi energy level (E{sub F}), forming a metallic nature of two symmetric n-type 6.5STO/1.5LAO interfaces with density of states at E{sub F}, N(E{sub F}) of about 3.56 (state/eV/unit cell), and bare electronic specific heat coefficient (γ) of about 0.62 mJ/(mol cell K{sup 2}). The electronic band stature and the partial density of states in the vicinity of E{sub F} are mainly originated from Ti1,2,3,4-3dxy orbitals. These bands are responsible for the metallic behavior and the forming of the Fermi surface of the two symmetric n-type 6.5STO/1.5LAO interfaces. To obtain a clear map of the valence band electronic charge density distribution of the two symmetric n-type 6.5STO/1.5LAO interfaces, we have investigated the bond's nature and the interactions between the atoms. It reveals that the charge is attracted towards O atoms as it is clear that the O atoms are surrounded by uniform blue spheres which indicate the maximum charge accumulation.

71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗

Productive interactions: heavy particles and non-Gaussianity

We analyze the shape and amplitude of oscillatory features in the primordial power spectrum and non-Gaussianity induced by periodic production of heavy degrees of freedom coupled to the inflaton Φ. We find that non-adiabatic production of particles can contribute effects which are detectable or constrainable using cosmological data even if their time-dependent masses are always heavier than the scale Φ 1/2 , much larger than the Hubble scale. This provides a new role for UV completion, consistent with the criteria from effective field theory for when heavy fields cannot be integrated out. This analysis is motivated in part by the structure of axion monodromy, and leads to an additional oscillatory signature in a subset of its parameter space. At the level of a quantum field theory model that we analyze in detail, the effect arises consistently with radiative stability for an interesting window of couplings up to of order ≲ 1. The amplitude of the bispectrum and higher-point functions can be larger than that for Resonant Non-Gaussianity, and its signal/noise may be comparable to that of the corresponding oscillations in the power spectrum (and even somewhat larger within a controlled regime of parameters). Its shape is distinct from previously analyzed templates, but was partly motivated by the oscillatory equilateral searches performed recently by the Planck collaboration. As a result, we also make some general comments about the challenges involved in making a systematic study of primordial non-Gaussianity.

72 PHYSICS OF ELEMENTARY PARTICLES AND FIELDS↗

Contribution to Spin Tubes Study

In this work, we aim to study both analytically and numerically the behavior of triangular spin tubes made by three chains which are connected to one another by exchange, in the presence of single-ion anisotropy. By diagonalizing the spin Hamiltonian, the partition function was exactly calculated within the transfer matrix approach and several relevant physical quantities were derived and analyzed. Depending on the sign and strengths of the exchange and anisotropy constants, the system reveals a rich variety of features such as frustration and steplikes in the magnetization curves arising from both geometry and conflicting interactions.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Comparison of CZT SPECT and conventional SPECT for assessment of contractile function, mechanical synchrony and myocardial scar in patients with heart failure

Aim: The aim of this study was to compare CZT-SPECT (CZT SPECT) to conventional SPECT (C-SPECT) in the assessment of left ventricular myocardial scar, contractile function, and mechanical synchrony in patients with heart failure (HF). Methods: Fifty-nine patients with HF who were referred for myocardial perfusion/metabolism imaging were enrolled. All patients underwent resting {sup 99m}Tc-MIBI gated myocardial perfusion imaging using a CZT SPECT camera and a C-SPECT camera, respectively, and {sup 18}F-FDG PET myocardial metabolism imaging within three days. Summed rest score (SRS) and total perfusion defect (TPD) (as indices of perfusion abnormality), left ventricular (LV), end diastolic volume (EDV), end systolic volume (ESV), and ejection fraction (EF) (as indices of LV systolic function), and histogram band width (BW) and standard deviation (SD) (as indices of mechanical synchrony) were analyzed by automated software while the perfusion/metabolism patterns were analyzed visually. Results: There was a good correlation between CZT SPECT and C-SPECT for SRS and TPD. CZT SPECT tended to underestimate SRS and TPD compared to C-SPECT. CZT-SPECT and C-SPECT showed excellent agreement in assessing the perfusion/metabolism pattern though a small proportion of normal segments (6.6%) identified by CZT/PET exhibited mismatch pattern on C-SPECT/PET. CZT SPECT also showed excellent correlation with C-SPECT in measuring EDV, ESV, and EF. Finally, BW and SD measured by CZT SPECT correlated well with C-SPECT but CZT SPECT tended to overestimate BW and SD compared to C-SPECT. Conclusion: CZT SPECT provided comparable data to C-SPECT for measuring LV scar, function and synchrony at a considerable reduction in imaging time. CZT SPECT holds a promise for comprehensive evaluation of myocardial performance in patients with HF.

62 RADIOLOGY AND NUCLEAR MEDICINE↗

Protein carbamylation and proteomics: from artifacts to elucidation of biological functions

Lysine carbamylation is a non-enzymatic protein post-translational modification (PTM) that plays important roles in regulating enzymatic activity and the pathogenesis of diseases such as atherosclerosis, rheumatoid arthritis, and uremia. The progress of understanding the roles of carbamylation in biological systems has been delayed due to lack of systematic assays to study its functions. To aggravate this scenario, carbamylation is a major artifact in proteomics analysis given that urea, which is used during sample preparation, induces carbamylation. In addition, anti-acetyllysine antibodies co-purify carbamylated and acetylated peptides. In a recent paper, we leveraged co-purification with anti-acetyllysine antibodies to develop a method for analyzing carbamylated proteomes. In this perspective article, we discuss how this method may be applied to characterize the physiological functions of carbamylation in humans and other biological models, as well as the utility of establishing novel disease biomarkers.

59 BASIC BIOLOGICAL SCIENCES↗

Solving numerically nonlinear systems of balance laws by multivariate sigmoidal functions approximation

A numerical method for solving systems of nonlinear one-dimensional balance laws, based on multivariate sigmoidal functions approximation, is developed. Constructive approximation theorems are first established in both, uniform and L{sup p} norms. A priori as well as a posteriori error estimates are derived for the numerical solutions, when various kinds of sigmoidal functions, such as unit step, logistic and Gompertz functions, are chosen. The residual of the numerical method is also estimated. Numerical examples are given to test the performance of the algorithm, a comparison with the Godunov method is made concerning accuracy and computational cost. Finally, the numerical stability of the method is analyzed.

97 MATHEMATICS AND COMPUTING↗

Targeting safety improvements through identification of incident origination and detection in a near-miss incident learning system

Purpose: Radiation treatment planning involves a complex workflow that has multiple potential points of vulnerability. This study utilizes an incident reporting system to identify the origination and detection points of near-miss errors, in order to guide their departmental safety improvement efforts. Previous studies have examined where errors arise, but not where they are detected or applied a near-miss risk index (NMRI) to gauge severity. Methods: From 3/2012 to 3/2014, 1897 incidents were analyzed from a departmental incident learning system. All incidents were prospectively reviewed weekly by a multidisciplinary team and assigned a NMRI score ranging from 0 to 4 reflecting potential harm to the patient (no potential harm to potential critical harm). Incidents were classified by point of incident origination and detection based on a 103-step workflow. The individual steps were divided among nine broad workflow categories (patient assessment, imaging for radiation therapy (RT) planning, treatment planning, pretreatment plan review, treatment delivery, on-treatment quality management, post-treatment completion, equipment/software quality management, and other). The average NMRI scores of incidents originating or detected within each broad workflow area were calculated. Additionally, out of 103 individual process steps, 35 were classified as safety barriers, the process steps whose primary function is to catch errors. The safety barriers which most frequently detected incidents were identified and analyzed. Finally, the distance between event origination and detection was explored by grouping events by the number of broad workflow area events passed through before detection, and average NMRI scores were compared. Results: Near-miss incidents most commonly originated within treatment planning (33%). However, the incidents with the highest average NMRI scores originated during imaging for RT planning (NMRI = 2.0, average NMRI of all events = 1.5), specifically during the documentation of patient positioning and localization of the patient. Incidents were most frequently detected during treatment delivery (30%), and incidents identified at this point also had higher severity scores than other workflow areas (NMRI = 1.6). Incidents identified during on-treatment quality management were also more severe (NMRI = 1.7), and the specific process steps of reviewing portal and CBCT images tended to catch highest-severity incidents. On average, safety barriers caught 46% of all incidents, most frequently at physics chart review, therapist’s chart check, and the review of portal images; however, most of the incidents that pass through a particular safety barrier are not designed to be capable of being captured at that barrier. Conclusions: Incident learning systems can be used to assess the most common points of error origination and detection in radiation oncology. This can help tailor safety improvement efforts and target the highest impact portions of the workflow. The most severe near-miss events tend to originate during simulation, with the most severe near-miss events detected at the time of patient treatment. Safety barriers can be improved to allow earlier detection of near-miss events.

60 APPLIED LIFE SCIENCES↗

ESR1 mediated circ{sub 0}004018 suppresses angiogenesis in hepatocellular carcinoma via recruiting FUS and stabilizing TIMP2 expression

Angiogenesis has been certified to account for tumor pathobiology. Circular RNAs (circRNAs) have been demonstrated to be involved in angiogenesis-related diseases, including hepatocellular carcinoma (HCC). Nevertheless, the regulatory roles of most circRNAs remain obscure. This study aims to uncover the function of hsa{sub c}irc{sub 0}004018 on angiogenesis in HCC. Firstly, quantitative real-time RT-PCR (RT-qPCR) analyzed that circ{sub 0}004018 was definitely down-regulated in HCC. Western blot analysis was conducted to detect the protein level of fused protein in sarcoma (FUS) and TIMP metallopeptidase inhibitor 2 (TIMP2). Functional assays were carried out to assess the impacts of circ{sub 0}004018 on HCC. From the experimental results, we found that overexpression of circ{sub 0}004018 significantly inhibited angiogenesis in HCC. The regulatory mechanism of circ{sub 0}004018 in HCC was determined by chromatin immunoprecipitation (ChIP), luciferase reporter assays and RNA immunoprecipitation (RIP) assay. Therefore, we proved that estrogen receptor 1 (ESR1) mediated circ{sub 0}004018 regulated TIMP2 by recruiting FUS. A series of rescue assays verified that circ{sub 0}004018 participated in angiogenesis in HCC via modulating TIMP2. In summary, this paper disclosed that ESR1 activated circ{sub 0}004018 inhibited angiogenesis in HCC via binding to FUS and stabilizing TIMP2 expression.

60 APPLIED LIFE SCIENCES↗

Cumulant methods for electron-phonon problems. I. Perturbative expansions

Here in this work, we investigate the ability of the cumulant expansion (CE) to capture one-particle spectral information in electron-phonon coupled systems at both zero and finite temperatures. In particular, we present a comprehensive study of the second- and fourth-order CEs for the one-dimensional Holstein model as compared with numerically exact methods. We investigate both finite sized systems as well as the approach to the thermodynamic limit, drawing distinctions, and connections between the behavior of systems in and away from the thermodynamic limit that enable a greater understanding of the ability of the CE to capture real-frequency information across the full range of wave vectors. We find that for zero electronic momentum, the spectral function is well described by the second-order CE at low and high temperatures. However, for nonzero electronic momenta, the CE is only accurate at high temperature. We analyze the fourth-order cumulant and find that while it improves the description of the short-time dynamics encoded in the one-particle Green's function, it can introduce divergences in the time domain as well as unphysical negative spectral weight in the spectral function. When well-behaved, the fourth-order CE does provide notable accurate corrections to the second-order CE. Finally, we use our results to comment on the use of the CE as a tool for calculating transport behavior in the realistic ab initio modeling of materials.

36 MATERIALS SCIENCE↗

Composition-Dependent Functionality of Copper Vanadate Photoanodes

To understand functional roles of constituent elements in ternary metal oxide photoanodes, essential photoelectrochemical (PEC) properties are systematically analyzed on a series of copper vanadate compounds with different Cu:V elemental ratios. Here, homogeneous and highly continuous thin films of β-Cu 2 V 2 O 7 , γ-Cu 3 V 2 O 8 , Cu 11 V 6 O 26 , and Cu 5 V 2 O 10 are grown via reactive co-sputtering and their performance characteristics for the light-driven oxygen evolution reaction are evaluated. All four compounds have similar bandgaps in the range of 1.83-2.03 eV, though Cu-rich phases exhibit stronger optical absorption and higher charge separation efficiencies. Transient photocurrent analysis reveals a reduction of surface catalytic activity with increasing Cu:V elemental ratio due to competitive charge recombination at Cu-related surface states. This comprehensive analysis of PEC functionalities - including photon absorption, carrier separation, and heterogeneous charge transfer - informs strategies for improving PEC activity in the copper vanadate materials system and reveals insights that may aid discovery, design, and engineering of new photoelectrode materials.

36 MATERIALS SCIENCE↗