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At least 1,099 records · Page 61

Cluster Method Analysis of K. S. C. Image

Information obtained from satellite-based systems has moved to the forefront as a method in the identification of many land cover types. Identification of different land features through remote sensing is an effective tool for regional and global assessment of geometric characteristics. Classification data acquired from remote sensing images have a wide variety of applications. In particular, analysis of remote sensing images have special applications in the classification of various types of vegetation. Results obtained from classification studies of a particular area or region serve towards a greater understanding of what parameters (ecological, temporal, etc.) affect the region being analyzed. In this paper, we make a distinction between both types of classification approaches although, focus is given to the unsupervised classification method using 1987 Thematic Mapped (TM) images of Kennedy Space Center.

Rodriguez, Joe, Jr.↗

SU-E-I-40: Phantom Research On Monochromatic Images Taken by Dual CBCT with Multiple Energy Sets

Purpose: To evaluate the quality of monochromatic images at the same virtual monochromatic energy using dual cone-beam computed tomography (CBCT) with either kV/kV or MV/kV or MV/MV energy sets. Methods: CT images of Catphan 504 phantom were acquired using four different KV and MV settings: 80kV, 140kV, 4MV, 6MV. Three sets of monochromatic images were calculated: 80kV-140kV, 140kV-4MV and 4MV-6MV. Each set of CBCT images were reconstructed from the same selected virtual monochromatic energy of 1MeV. Contrast-to-Noise Ratios (CNRs) were calculated and compared between each pair of images with different energy sets. Results: Between kV/MV and MV/MV images, the CNRs are comparable for all inserts. However, differences of CNRs were observed between the kV/kV and kV/MV images. Delrin’s CNR ratio between kV/kV image and kV/MV image is 1.634. LDPE’s (Low-Density Polyethylene) CNR ratio between kV/kV and kV/MV images is 0.509. Polystyrene’s CNR ratio between kV/kV image and kV/MV image is 2.219. Conclusion: Preliminary results indicated that the CNRs calculated from CBCT images reconstructed from either kV/MV projections or MV/MV projections for the same selected virtual monochromatic energy may be comparable.

60 APPLIED LIFE SCIENCES↗

Beyond maximum entropy: Fractal pixon-based image reconstruction

We have developed a new Bayesian image reconstruction method that has been shown to be superior to the best implementations of other methods, including Goodness-of-Fit (e.g. Least-Squares and Lucy-Richardson) and Maximum Entropy (ME). Our new method is based on the concept of the pixon, the fundamental, indivisible unit of picture information. Use of the pixon concept provides an improved image model, resulting in an image prior which is superior to that of standard ME.

Puetter, R. C.↗

SU-F-T-242: A Method for Collision Avoidance in External Beam Radiation Therapy

Purpose: We proposed a method for collision avoidance (CA) in external beam radiation therapy (EBRT). The method encompasses the analysis of all positions of the moving components of the beam delivery system such as the treatment table and gantry, including patient specific information obtained from the CT images. This method eliminates the need for time-consuming dry-runs prior to the actual treatments. Methods: The QA procedure for EBRT requires that the collision should be checked prior to treatment. We developed a system capable of a rigorous computer simulation of all moving components including positions of the couch and gantry during the delivery, position of the patients, and imaging equipment. By running this treatment simulation it is possible to quantify and graphically represent all positions and corresponding trajectories of all points of the moving parts during the treatment delivery. The development of the workflow for implementation of the CA includes several steps: a) derivation of combined dynamic equation of motion of the EBRT delivery systems, b) developing the simulation model capable of drawing the motion trajectories of the specific points, c) developing the interface between the model and the treatment plan parameters such as couch and gantry parameters for each field. Results: The patient CT images were registered to the treatment couch so the patient dimensions were included into the simulation. The treatment field parameters were structured in the xml-file which was used as the input into the dynamic equations. The trajectories of the moving components were plotted on the same graph using the dynamic equations. If the trajectories intersect that was the signal that collision exists. Conclusion: This CA method was proved to be effective in the simulation of treatment delivery. The proper implementation of this system can potentially improve the QA program and increase the efficacy in the clinical setup.

60 APPLIED LIFE SCIENCES↗

Communication: Time- and space-sliced velocity map electron imaging

We develop a new method to achieve slice electron imaging using a conventional velocity map imaging apparatus with two additional components: a fast frame complementary metal-oxide semiconductor camera and a high-speed digitizer. The setup was previously shown to be capable of 3D detection and coincidence measurements of ions. Here, we show that when this method is applied to electron imaging, a time slice of 32 ps and a spatial slice of less than 1 mm thick can be achieved. Each slice directly extracts 3D velocity distributions of electrons and provides electron velocity distributions that are impossible or difficult to obtain with a standard 2D imaging electron detector.

37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CH↗

High-Resolution Momentum Imaging—From Stern’s Molecular Beam Method to the COLTRIMS Reaction Microscope [Book Chapter]

Multi-particle momentum imaging experiments are now capable of providing detailed information on the properties and the dynamics of quantum systems in Atomic, Molecular and Photon (AMO) physics. Historically, Otto Stern can be considered the pioneer of high-resolution momentum measurements of particles moving in a vacuum and he was the first to obtain sub-atomic unit (a.u.) momentum resolution (Schmidt-Böcking et al. in The precision limits in a single-event quantum measurement of electron momentum and position, these proceedings). A major contribution to modern experimental atomic and molecular physics was his so-called molecular beam method, which Stern developed and employed in his experiments. With this method he discovered several fundamental properties of atoms, molecules and nuclei. As corresponding particle detection techniques were lacking during his time, he was only able to observe the averaged footprints of large particle ensembles. Today it is routinely possible to measure the momenta of single particles, because of the tremendous progress in single particle detection and data acquisition electronics. A “state-of-the-art” COLTRIMS reaction microscope can measure, for example, the momenta of several particles ejected in the same quantum process in coincidence with sub-a.u. momentum resolution. Such setups can be used to visualize the dynamics of quantum reactions and image the entangled motion of electrons inside atoms and molecules. This review will briefly summarize Stern’s work and then present in longer detail the historic steps of the development of the COLTRIMS reaction microscope. Furthermore, some benchmark results are shown which initially paved the way for a broad acceptance of the COLTRIMS approach. Finally, a small selection of milestone work is presented which has been performed during the last two decades.

Jahnke, T.↗

SU-E-I-11: A New Cone-Beam CT System for Bedside Head Imaging

Purpose: To design and develop a new mobile cone-beam CT (CBCT) system for head imaging with good soft-tissue visibility, to be used bedside in ICU and neurosurgery department to monitor treatment and operation outcome in brain patients. Methods: The imaging chain consists of a 30cmx25cm amorphous silicon flat panel detector and a pulsed, stationary anode monoblock x-ray source of 100kVp at a maximal tube current of 10mA. The detector and source are supported on motorized mechanisms to provide detector lateral shift and source angular tilt, enabling a centered digital radiographic imaging mode and half-fan CBCT, while maximizing the use of the x-ray field and keep the source to detector distance short. A focused linear anti-scatter grid is mounted on the detector, and commercial software with scatter and other corrective algorithms is used for data processing and image reconstruction. The gantry rotates around a horizontal axis, and is able to adjust its height for different patient table positions. Cables are routed through a custom protective sleeve over a large bore with an in-plane twister band, facilitating single 360-degree rotation without a slip-ring at a speed up to 5 seconds per rotation. A UPS provides about 10 minutes of operation off the battery when unplugged. The gantry is on locked casters, whose brake is control by two push handles on both sides for easy reposition. The entire system is designed to have a light weight and a compact size for excellent maneuverability. Results: System design is complete and main imaging components are tested. Initial results will be presented and discussed later in the presentation. Conclusion: A new mobile CBCT system for head imaging is being developed. With its compact size, a large bore, and quality design, it is expected to be a useful imaging tool for bedside uses. The work is supported by a grant from Chinese Academy of Sciences.

60 APPLIED LIFE SCIENCES↗

Obtaining the Grobner Initialization for the Ground Flash Fraction Retrieval Algorithm

At optical wavelengths and from the vantage point of space, the multiple scattering cloud medium obscures one's view and prevents one from easily determining what flashes strike the ground. However, recent investigations have made some progress examining the (easier, but still difficult) problem of estimating the ground flash fraction in a set of N flashes observed from space In the study by Koshak, a Bayesian inversion method was introduced for retrieving the fraction of ground flashes in a set of flashes observed from a (low earth orbiting or geostationary) satellite lightning imager. The method employed a constrained mixed exponential distribution model to describe the lightning optical measurements. To obtain the optimum model parameters, a scalar function of three variables (one of which is the ground flash fraction) was minimized by a numerical method. This method has formed the basis of a Ground Flash Fraction Retrieval Algorithm (GoFFRA) that is being tested as part of GOES-R GLM risk reduction.

Solakiewicz, R.↗

Approaches to reducing photon dose calculation errors near metal implants

Purpose: Dose calculation errors near metal implants are caused by limitations of the dose calculation algorithm in modeling tissue/metal interface effects as well as density assignment errors caused by imaging artifacts. The purpose of this study was to investigate two strategies for reducing dose calculation errors near metal implants: implementation of metal-based energy deposition kernels in the convolution/superposition (C/S) dose calculation method and use of metal artifact reduction methods for computed tomography (CT) imaging. Methods: Both error reduction strategies were investigated using a simple geometric slab phantom with a rectangular metal insert (composed of titanium or Cerrobend), as well as two anthropomorphic phantoms (one with spinal hardware and one with dental fillings), designed to mimic relevant clinical scenarios. To assess the dosimetric impact of metal kernels, the authors implemented titanium and silver kernels in a commercial collapsed cone C/S algorithm. To assess the impact of CT metal artifact reduction methods, the authors performed dose calculations using baseline imaging techniques (uncorrected 120 kVp imaging) and three commercial metal artifact reduction methods: Philips Healthcare’s O-MAR, GE Healthcare’s monochromatic gemstone spectral imaging (GSI) using dual-energy CT, and GSI with metal artifact reduction software (MARS) applied. For the simple geometric phantom, radiochromic film was used to measure dose upstream and downstream of metal inserts. For the anthropomorphic phantoms, ion chambers and radiochromic film were used to quantify the benefit of the error reduction strategies. Results: Metal kernels did not universally improve accuracy but rather resulted in better accuracy upstream of metal implants and decreased accuracy directly downstream. For the clinical cases (spinal hardware and dental fillings), metal kernels had very little impact on the dose calculation accuracy (<1.0%). Of the commercial CT artifact reduction methods investigated, the authors found that O-MAR was the most consistent method, resulting in either improved dose calculation accuracy (dental case) or little impact on calculation accuracy (spine case). GSI was unsuccessful at reducing the severe artifacts caused by dental fillings and had very little impact on calculation accuracy. GSI with MARS on the other hand gave mixed results, sometimes introducing metal distortion and increasing calculation errors (titanium rectangular implant and titanium spinal hardware) but other times very successfully reducing artifacts (Cerrobend rectangular implant and dental fillings). Conclusions: Though successful at improving dose calculation accuracy upstream of metal implants, metal kernels were not found to substantially improve accuracy for clinical cases. Of the commercial artifact reduction methods investigated, O-MAR was found to be the most consistent candidate for all-purpose CT simulation imaging. The MARS algorithm for GSI should be used with caution for titanium implants, larger implants, and implants located near heterogeneities as it can distort the size and shape of implants and increase calculation errors.

60 APPLIED LIFE SCIENCES↗

Multicomponent Convection Induced by Fronts in the Chlorate-Sulfite Reaction

An application of a new method is presented for the measurement of the temperature profiles of chemical waves propagating through a solution. Using solutions of thermocolor materials, the temperature distribution caused by the heat released in the propagating chlorate oxidation of sulfite was visualized and recorded using digital image processing methods. After calibration, the temperature gradient was calculated from the gray scale value in a digitized image. Extensive multicomponent convection ('fingering') was induced by descending fronts. Only ascending fingers were observed because of the large thermal gradient that suppressed descending ones. The characteristics of the temperature profile were determined as a function of initial sulfite and chlorate concentration, and tube diameter. Unusual behavior was observed when the fronts propagated under conditions of continuously changing diameter in a conical vessel. Fingering occurred periodically in a front descending in a flask with an increasing diameter. However, when a front propagated down in flask whose diameter decreased, no multicomponent convection was observed.

Nagy, Istvan P.↗

SU-C-209-02: 3D Fluoroscopic Image Generation From Patient-Specific 4DCBCT-Based Motion Models Derived From Clinical Patient Images

Purpose: We develop a method to generate time varying volumetric images (3D fluoroscopic images) using patient-specific motion models derived from four-dimensional cone-beam CT (4DCBCT). Methods: Motion models are derived by selecting one 4DCBCT phase as a reference image, and registering the remaining images to it. Principal component analysis (PCA) is performed on the resultant displacement vector fields (DVFs) to create a reduced set of PCA eigenvectors that capture the majority of respiratory motion. 3D fluoroscopic images are generated by optimizing the weights of the PCA eigenvectors iteratively through comparison of measured cone-beam projections and simulated projections generated from the motion model. This method was applied to images from five lung-cancer patients. The spatial accuracy of this method is evaluated by comparing landmark positions in the 3D fluoroscopic images to manually defined ground truth positions in the patient cone-beam projections. Results: 4DCBCT motion models were shown to accurately generate 3D fluoroscopic images when the patient cone-beam projections contained clearly visible structures moving with respiration (e.g., the diaphragm). When no moving anatomical structure was clearly visible in the projections, the 3D fluoroscopic images generated did not capture breathing deformations, and reverted to the reference image. For the subset of 3D fluoroscopic images generated from projections with visibly moving anatomy, the average tumor localization error and the 95th percentile were 1.6 mm and 3.1 mm respectively. Conclusion: This study showed that 4DCBCT-based 3D fluoroscopic images can accurately capture respiratory deformations in a patient dataset, so long as the cone-beam projections used contain visible structures that move with respiration. For clinical implementation of 3D fluoroscopic imaging for treatment verification, an imaging field of view (FOV) that contains visible structures moving with respiration should be selected. If no other appropriate structures are visible, the images should include the diaphragm. This project was supported, in part, through a Master Research Agreement with Varian Medical Systems, Inc, Palo Alto, CA.

60 APPLIED LIFE SCIENCES↗

Maskless Fourier transform holography

Fourier transform holography is a lensless imaging technique that retrieves an object's exit-wave function with high fidelity. It has been used to study nanoscale phenomena and spatio-temporal dynamics in solids, with sensitivity to the phase component of electronic and magnetic textures. However, the method requires an invasive and labor-intensive nanopatterning of a holography mask directly onto the sample, which can alter the sample properties, forces a fixed field-of-view, and leads to a low signal-to-noise ratio at high resolution. In this work, we propose using wavefront-shaping diffractive optics to create a structured probe with full control of its phase at the sample plane, circumventing the need for a mask. We demonstrate in silico that the method can image nanostructures and magnetic textures and validate our approach with a visible light-based experiment. The method enables investigation of a plethora of phenomena at the nanoscale including magnetic and electronic phase coexistence in solids, with further uses in soft and biological matter research.

Keskinbora, Kahraman↗

Evaluation of pebble scanning strategies for fuel qualification by simple simulated radiography

Reactor designs using tristructural-isotropic (TRISO) particles in pebble fuel forms have been developed in multiple programs and are now being designed and deployed by several companies around the world. Fuel pebbles for these designs commonly contain an inner fueled zone packed with TRISO particles and a fuel-free zone on the surface of the pebble to protect the particles within. Therefore, qualification of pebbles for use in a reactor commonly requires determination that there are no TRISO particles within a given minimum distance to the pebble surface. This determination may be made non-destructively by pebble radiography, in which a series of x-ray projections of the pebble are acquired. In this work, a method to create and image representative digital pebbles was developed to allow for rapid testing of various pebble radiography strategies to evaluate their effectiveness in detecting escapee particles. Using this method, imaging strategies in two and three dimensions were tested with fixed and adaptive angular distributions. Here it was found that an adaptive two-dimensional pebble scanning strategy was the most effective for fuel pebble qualification.

11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS↗

TU-G-204-04: A Unified Strategy for Bi-Factorial Optimization of Radiation Dose and Contrast Dose in CT Imaging

Purpose: To substantiate the interdependency of contrast dose, radiation dose, and image quality in CT towards the patient- specific optimization of the imaging protocols Methods: The study deployed two phantom platforms. A variable sized (12, 18, 23, 30, 37 cm) phantom (Mercury-3.0) containing an iodinated insert (8.5 mgI/ml) was imaged on a representative CT scanner at multiple CTDI values (0.7–22.6 mGy). The contrast and noise were measured from the reconstructed images for each phantom diameter. Linearly related to iodine-concentration, contrast-to-noise ratio (CNR), were calculated for 16 iodine-concentration levels (0–8.5 mgI/ml). The analysis was extended to a recently developed suit of 58 virtual human models (5D XCAT) with added contrast dynamics. Emulating a contrast-enhanced abdominal image procedure and targeting a peak-enhancement in aorta, each XCAT phantom was “imaged” using a simulation platform (CatSim, GE). 3D surfaces for each patient/size established the relationship between iodine-concentration, dose, and CNR. The ratios of change in iodine-concentration versus dose (IDR) to yield a constant change in CNR were calculated for each patient size. Results: Mercury phantom results show the image-quality size- dependence on CTDI and IC levels. For desired image-quality values, the iso-contour-lines reflect the trade off between contrast-material and radiation doses. For a fixed iodine-concentration (4 mgI/mL), the IDR values for low (1.4 mGy) and high (11.5 mGy) dose levels were 1.02, 1.07, 1.19, 1.65, 1.54, and 3.14, 3.12, 3.52, 3.76, 4.06, respectively across five sizes. The simulation data from XCAT models confirmed the empirical results from Mercury phantom. Conclusion: The iodine-concentration, image quality, and radiation dose are interdependent. The understanding of the relationships between iodine-concentration, image quality, and radiation dose will allow for a more comprehensive optimization of CT imaging devices and techniques, providing the methodology to balance iodine-concentration and dose based on patient’s attributes.

60 APPLIED LIFE SCIENCES↗

Sci-Thur AM: YIS – 01: New technologies for astatine-211 targeted alpha therapy research

Purpose: The short-range, densely ionizing α-particles emitted by {sup 211}At (t{sub 1/2}=7.2h) are well suited for the treatment of diffuse microscopic disease, using cancer targeting biomolecules. {sup 211}At availability is limited by the rarity of α-cyclotrons required for standard production. Image-based dosimetry is also limited for {sup 211}At, which emits low intensity X-rays. Our goal was to leverage state-of-the-art infrastructure at TRIUMF to produce and evaluate two related isotopes, {sup 211}Rn (t{sub 1/2}=14.6h, 73% decay to {sup 211}At) as a generator for {sup 211}At, and {sup 209}At (t{sub 1/2}=5.4h, X-ray/gamma-ray emitter) as a novel 211At surrogate for preclinical imaging studies. Methods: Produced by spallation of uranium with 480 MeV protons, mass separated ion beams of short-lived francium isotopes were implanted into NaCl targets where {sup 211}Rn or {sup 209}At were produced by radioactive decay, in situ. {sup 211}Rn was transferred to dodecane from which {sup 211}At was efficiently extracted and evaluated for clinical applicability. High energy SPECT/CT was evaluated for measuring {sup 209}At activity distributions in mice and phantoms. Results: Our small scale {sup 211}Rn/{sup 211}At generator system provided high purity {sup 211}At samples. The methods are immediately scalable to the level of radioactivity required for in vivo experiments with {sup 211}At. {sup 209}At-based high energy SPECT imaging was determined suitable for pursuing image-based dosimetry in mouse tumour models. In the future, we will utilize quantitative {sup 209}At-SPECT for image-based dose calculations. Conclusion: These early studies provided a foundation for future endeavours with {sup 211}At-based α-therapy. Canada is now significantly closer to clinical targeted α-therapy of cancer.

60 APPLIED LIFE SCIENCES↗

Hubble Space Telescope Imaging of the Circumnuclear Environments of the CfA Seyfert Galaxies: Nuclear Spirals and Fueling

We present archival Hubble Space Telescope (HST) images of the nuclear regions of 43 of the 46 Seyfert galaxies found in the volume limited,spectroscopically complete CfA Redshift Survey sample. Using an improved method of image contrast enhancement, we created detailed high-quality " structure maps " that allow us to study the distributions of dust, star clusters, and emission-line gas in the circumnuclear regions (100-1000 pc scales) and in the associated host galaxy. Essentially all of these Seyfert galaxies have circumnuclear dust structures with morphologies ranging from grand-design two-armed spirals to chaotic dusty disks. In most Seyfert galaxies there is a clear physical connection between the nuclear dust spirals on hundreds of parsec scales and large-scale bars and spiral arms in the host galaxies proper. These connections are particularly striking in the interacting and barred galaxies. Such structures are predicted by numerical simulations of gas flows in barred and interacting galaxies and may be related to the fueling of active galactic nuclei by matter inflow from the host galaxy disks. We see no significant differences in the circumnuclear dust morphologies of Seyfert 1s and 2s, and very few Seyfert 2 nuclei are obscured by large-scale dust structures in the host galaxies. If Sevfert 2s are obscured Sevfert Is, then the obscuration must occur on smaller scales than those probed by HST.

Pogge, Richard W.↗

A Grobner Basis Solution for Lightning Ground Flash Fraction Retrieval

A Bayesian inversion method was previously introduced for retrieving the fraction of ground flashes in a set of flashes observed from a (low earth orbiting or geostationary) satellite lightning imager. The method employed a constrained mixed exponential distribution model to describe the lightning optical measurements. To obtain the optimum model parameters, a scalar function was minimized by a numerical method. In order to improve this optimization, we introduce a Grobner basis solution to obtain analytic representations of the model parameters that serve as a refined initialization scheme to the numerical optimization. Using the Grobner basis, we show that there are exactly 2 solutions involving the first 3 moments of the (exponentially distributed) data. When the mean of the ground flash optical characteristic (e.g., such as the Maximum Group Area, MGA) is larger than that for cloud flashes, then a unique solution can be obtained.

Solakiewicz, Richard↗

SkyFACT: high-dimensional modeling of gamma-ray emission with adaptive templates and penalized likelihoods

We present SkyFACT (Sky Factorization with Adaptive Constrained Templates), a new approach for studying, modeling and decomposing diffuse gamma-ray emission. Like most previous analyses, the approach relies on predictions from cosmic-ray propagation codes like GALPROP and DRAGON. However, in contrast to previous approaches, we account for the fact that models are not perfect and allow for a very large number (∼> 10{sup 5}) of nuisance parameters to parameterize these imperfections. We combine methods of image reconstruction and adaptive spatio-spectral template regression in one coherent hybrid approach. To this end, we use penalized Poisson likelihood regression, with regularization functions that are motivated by the maximum entropy method. We introduce methods to efficiently handle the high dimensionality of the convex optimization problem as well as the associated semi-sparse covariance matrix, using the L-BFGS-B algorithm and Cholesky factorization. We test the method both on synthetic data as well as on gamma-ray emission from the inner Galaxy, |ℓ|<90{sup o} and | b |<20{sup o}, as observed by the Fermi Large Area Telescope. We finally define a simple reference model that removes most of the residual emission from the inner Galaxy, based on conventional diffuse emission components as well as components for the Fermi bubbles, the Fermi Galactic center excess, and extended sources along the Galactic disk. Variants of this reference model can serve as basis for future studies of diffuse emission in and outside the Galactic disk.

79 ASTRONOMY AND ASTROPHYSICS↗