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At least 1,117 records · Page 62

Test Report - Fault Current Through Graphite Filament Reinforced Plastic

Tests were performed to determine the damage to samples of composite material when a current carrying wire is shorted to the surface of the composite material, and to determine whether enough current can flow through the material to blow a fuse before damage can occur. Fault current tests were performed on samples of graphite epoxy materials. Samples consisted of six layers of IM7 graphite fiber mat in Hercules 8552 epoxy resin. A variable power supply provided up to 35 amps of current. The high voltage side of the power supply was attached to a wire at the end of a hinged arm, and the low side was attached to the edge of the sample. To test joints, the return was connected to the edge of one sample, and the high side was shorted to the top of the other sample. Tests show that when current exceeds approximately 5 amps, the graphite glows, and the epoxy melts out at the shorted contact. At higher current levels the epoxy burns. At voltages above 15 volts the epoxy outer coat is easily broken, and fire, flame, and a rise in current occur suddenly. When joints are introduced, resistance is increased, and the maximum current resulting from a short circuit to the graphite epoxy is reduced. This condition can easily result in fault current lower than the circuit breaker limit and higher than the 5 amp ignition level. The shorting contact and the joint become hot spots with melting epoxy, smoke, and fire.

Evans, R. W.↗

Evidence for Black Holes in Green Peas from WISE Colors and Variability

We explore the presence of active galactic nuclei (AGNs)/black holes in Green Pea galaxies (GPs), motivated by the presence of high-ionization emission lines such as He ii and [Ne iii] in their optical spectra. In order to identify AGN candidates, we used mid-infrared (MIR) photometric observations from the all-sky Wide-field Infrared Survey Explorer (WISE) mission for a sample of 1004 GPs. Considering only >5σ detections with no contamination from neighboring sources in AllWISE, we select 31 GPs out of 134 as candidate AGNs based on a stringent three-band WISE color diagnostic. Using multi-epoch photometry in W1 and W2 bands based on time-resolved unWISE coadd images, we find two sources exhibiting variability in both the WISE bands among 112 GPs with W1 ≤16 mag and no contamination from neighboring sources in unWISE. These two variable sources were selected as AGNs by the WISE three-band color diagnostic as well. Compared to variable AGN fractions observed among low-mass galaxy samples in previous studies, we find a higher fraction (~1.8%) of MIR variable sources among GPs, which demonstrates the uniqueness and importance of studying these extreme objects. Through this work, we demonstrate that MIR diagnostics are promising tools to select AGNs that may be missed by other selection techniques (including optical emission-line ratios and X-ray emission) in star formation-dominated, low-mass, low-metallicity galaxies.

79 ASTRONOMY AND ASTROPHYSICS↗

Spatial and temporal variability of VAS radiance measurements by structure and correlation analysis

The statistical structure function analysis presently applied to VISSR Atmospheric Sounder (VAS) measurements has been extended to include time, and yields structure plots in either two spatial dimensions or one spatial dimension and time that indicate three-dimensional measurement variability. The analyses that include time as a coordinate also yield an indication of the mean speed and direction of the analyzed data. Results for three-hourly VAS data indicate that sampling at a high, approximately 1-hour, frequency is required in order to correctly monitor VAS measurements' temporal variability in a way equivalent to high spatial resolution.

Hillger, Donald W.↗

A machine learning approach for identifying variables associated with risk of developing neutralizing antidrug antibodies to factor VIII

A key unmet need in the management of hemophilia A (HA) is the lack of clinically validated markers that are associated with the development of neutralizing antibodies to Factor VIII (FVIII) (commonly referred to as inhibitors). This study aimed to identify relevant biomarkers for FVIII inhibition using Machine Learning (ML) and Explainable AI (XAI) using the My Life Our Future (MLOF) research repository. The dataset includes biologically relevant variables such as age, race, sex, ethnicity, and the variants in the F8 gene. In addition, we previously carried out Human Leukocyte Antigen Class II (HLA-II) typing on samples obtained from the MLOF repository. Using this information, we derived other patient-specific biologically and genetically important variables. These included identifying the number of foreign FVIII derived peptides, based on the alignment of the endogenous FVIII and infused drug sequences, and the foreign-peptide HLA-II molecule binding affinity calculated using NetMHCIIpan. The data were processed and trained with multiple ML classification models to identify the top performing models. The top performing model was then chosen to apply XAI via SHAP, (SHapley Additive exPlanations) to identify the variables critical for the prediction of FVIII inhibitor development in a hemophilia A patient. Using XAI we provide a robust and ranked identification of variables that could be predictive for developing inhibitors to FVIII drugs in hemophilia A patients. These variables could be validated as biomarkers and used in making clinical decisions and during drug development. The top five variables for predicting inhibitor development based on SHAP values are: (i) the baseline activity of the FVIII protein, (ii) mean affinity of all foreign peptides for HLA DRB 3, 4, & 5 alleles, (iii) mean affinity of all foreign peptides for HLA DRB1 alleles), (iv) the minimum affinity among all foreign peptides for HLA DRB1 alleles, and (v) F8 mutation type.

60 APPLIED LIFE SCIENCES↗

Variable Iron K(alpha) Lines in Seyfert 1 Galaxies

We find that variability of the iron K alpha line is common in Seyfert 1 galaxies. Using data from the ASCA archive for objects that have been observed more than once during the mission, we study the time-averaged spectra from individual observations, thereby probing variability on timescales that range from days to years. Since the statistics of the data do not warrant searches for line variability in terms of a complex physical model, we use a simple Gaussian to model the gross shape of the line and then use the centroid energy, intensity, and equivalent width as robust indicators of changes in the line profile. We find that approximately 70% of Seyfert 1 galaxies (10 out of 15) show variability in at least one of these parameters: the centroid energy, intensity, and equivalent width vary in six, four, and eight sources, respectively. Because of the low signal-to-noise ratio, limited sampling, and time averaging, we consider these results to represent lower limits to the rate of incidence of variability. In most cases changes in the line do not appear to track changes in the continuum. In particular, we find no evidence for variability of the line intensity in NGC 4151, suggesting an origin in a region larger than the putative accretion disk, where most of the iron line has been thought to originate. Mrk 279 is investigated on short timescales. The time-averaged effective line energy (as measured by the Gaussian center energy, which is weighted by emission in the entire line profile) is 6.5 keV in the galaxy rest frame. As the continuum flux increases by 20% in a few hours, the Fe K line responds within approximately 10,000 seconds with the effective line energy increasing by 0.22 keV (approximately 10,500 kilometers per second). We also examine the ROSAT PSPC spectrum of Mrk 279 but find inconsistencies with ASCA. Problems with the ASCA and ROSAT calibration that affect simultaneous spectral fits at low energies are discussed in an appendix.

Weaver, K. A.↗

Stable-carbon isotope ratios for sourcing the nerve-agent precursor methylphosphonic dichloride and its products

The ability to connect a chemical threat agent to a specific batch of a synthetic precursor can provide a fingerprint to contribute to effective forensic investigations. Stable isotope analysis can leverage intrinsic, natural isotopic variability within the molecules of a threat agent to unlock embedded chemical fingerprints in the material. Methylphosphonic dichloride (DC) is a chemical precursor to the nerve agent sarin. It is converted to methylphosphonic difluoride (DF) as part of the sarin synthesis process. We used a suite of commercially available DC stocks to both evaluate the potential for δ13C analysis to be used as a fingerprinting tool in sarin-related investigations and to develop sample preparation techniques (using chemical hydrolysis) that can simplify isotopic analysis of DC and its synthetic products. We demonstrate that natural isotopic variability in DC results in at least three distinct, isotope-resolved clusters within the thirteen stocks we analyzed. Isotopic variability in the carbon feedstock (i.e., methanol) used for DC synthesis is likely inherited by the DC samples we measured. We demonstrate that the hydrolysis of DC and DF to methylphosphonic acid (MPA) can be used as a preparative step for isotopic analysis because the reaction does not impart a measureable isotopic fractionation. MPA is more chemically stable, less toxic, and easier to handle than DC or DF. Further, the hydrolysis method we demonstrated can be applied to a suite of other precursors or to sarin itself, thereby providing a potentially valuable forensic tool.

Moran, James J.↗

Assessing the Influence of Climate on the Spatial Pattern of West Nile Virus Incidence in the United States

West Nile virus (WNV) is the leading cause of mosquito-borne disease in humans in the United States. Since the introduction of the disease in 1999, incidence levels have stabilized in many regions, allowing for analysis of climate conditions that shape the spatial structure of disease incidence. Our goal was to identify the seasonal climate variables that influence the spatial extent and magnitude of WNV incidence in humans. We developed a predictive model of contemporary mean annual WNV incidence using U.S. county-level case reports from 2005 to 2019 and seasonally averaged climate variables. We used a random forest model that had an out-of-sample model performance of R 2 =0.61. Our model accurately captured the V-shaped area of higher WNV incidence that extends from states on the Canadian border south through the middle of the Great Plains. It also captured a region of moderate WNV incidence in the southern Mississippi Valley. The highest levels of WNV incidence were in regions with dry and cold winters and wet and mild summers. The random forest model classified counties with average winter precipitation levels <23.3 mm/month as having incidence levels over 11 times greater than those of counties that are wetter. Among the climate predictors, winter precipitation, fall precipitation, and winter temperature were the three most important predictive variables. We consider which aspects of the WNV transmission cycle climate conditions may benefit the most and argued that dry and cold winters are climate conditions optimal for the mosquito species key to amplifying WNV transmission. Our statistical model may be useful in projecting shifts in WNV risk in response to climate change.

60 APPLIED LIFE SCIENCES↗

Investigating the impacts of solid phase extraction on dissolved organic matter optical signatures and the pairing with high‐resolution mass spectrometry data across a freshwater stream network

Abstract Advancing our understanding of dissolved organic matter (DOM) chemistry in aquatic systems necessitates the integration of data streams from multiple analytical platforms. Some measurements require pretreatment with solid phase extraction (SPE), while others are performed directly on whole water samples. Evidence has suggested that SPE will be biased against select DOM fractions, leading to concerns over the ability to establish data linkages across platforms with variable needs for SPE pretreatment, such as those from optical measurements and those that provide high‐resolution molecular information. Here, we directly addressed this concern by assessing the impact of SPE on DOM optical properties through excitation–emission matrices with parallel factor analysis (PARAFAC) for 47 samples across a stream network within a single watershed reflective of variable DOM sources. PARAFAC data was further paired with molecular information obtained by Fourier transform ion cyclotron resonance mass spectrometry (FTICR‐MS). A comparison of PARAFAC models first revealed no systematic qualitative differences in major components between whole water DOM and DOM isolated by SPE (SPE‐DOM); however, quantitative biases against select components were observed. Further linkages with FTICR‐MS data revealed that the molecular fingerprint associated with each PARAFAC component was consistent between the whole water DOM and SPE‐DOM. Our results suggest that bulk scale linkages across these analytical platforms could be inferred irrespective of the observed quantitative biases resulting from SPE for samples within this example watershed. This work represents a key step toward the systematic evaluation of linkages between optical and high‐resolution mass spectrometry datasets in freshwater lotic environments.

59 BASIC BIOLOGICAL SCIENCES↗

Effects of cardiac phase on diameter measurements from coronary cineangiograms

The measurement variability of end-diastolic frames is compared with frames taken from the other portions of the cardiac cycle. Two computer measurements, average diameter and minimum, are obtained for every frame of two complete cardiac cycles in angiograms of 20 subjects. Six schemes for sampling frames in various portions of the cardiac cycle are defined and the standard deviation is calculated for pairs of measurements from each scheme. The results suggest that the best strategy for frame selection is to use sequential frames in end-diastole. However, it is noted that if random samples are taken anywhere in the cardiac cycle instead of sequentially in end-diastole, the variability of two vessel edge measures changes from 4.9 percent to 6.3 percent, which is considered to be a small penalty.

Selzer, Robert H.↗

ColorMap ND : A Data-Driven Approach and Tool for Mapping Multivariate Data to Color

A wide variety of color schemes have been devised for mapping scalar data to color. We address the challenge of color-mapping multivariate data. While a number of methods can map low-dimensional data to color, for example, using bilinear or barycentric interpolation for two or three variables, these methods do not scale to higher data dimensions. Likewise, schemes that take a more artistic approach through color mixing and the like also face limits when it comes to the number of variables they can encode. Our approach does not have these limitations. It is data driven in that it determines a proper and consistent color map from first embedding the data samples into a circular interactive multivariate color mapping display (ICD) and then fusing this display with a convex (CIE HCL) color space. The variables (data attributes) are arranged in terms of their similarity and mapped to the ICD’s boundary to control the embedding. Using this layout, the color of a multivariate data sample is then obtained via modified generalized barycentric coordinate interpolation of the map. In conclusion, the system we devised has facilities for contrast and feature enhancement, supports both regular and irregular grids, can deal with multi-field as well as multispectral data, and can produce heat maps, choropleth maps, and diagrams such as scatterplots.

97 MATHEMATICS AND COMPUTING↗

Extravehicular Activity Asteroid Exploration and Sample Collection Capability

NASA's Asteroid Redirect Crewed Mission (ARCM) is challenged with primary mission objectives of demonstrating deep space Extravehicular Activity (EVA) and tools, and obtaining asteroid samples to return to Earth for further study. Although the Modified Advanced Crew Escape Suit (MACES) is used for the EVAs, it has limited mobility which increases fatigue and decreases the crews' capability to perform EVA tasks. Furthermore, previous Shuttle and International Space Station (ISS) spacewalks have benefited from EVA interfaces which have been designed and manufactured on Earth. Rigid structurally mounted handrails, and tools with customized interfaces and restraints optimize EVA performance. For ARCM, some vehicle interfaces and tools can leverage heritage designs and experience. However, when the crew ventures onto an asteroid capture bag to explore the asteroid and collect rock samples, EVA complexity increases due to the uncertainty of the asteroid properties. The variability of rock size, shape and composition, as well as bunching of the fabric bag will complicate EVA translation, tool restraint and body stabilization. The unknown asteroid hardness and brittleness will complicate tool use. The rock surface will introduce added safety concerns for cut gloves and debris control. Feasible solutions to meet ARCM EVA objectives were identified using experience gained during Apollo, Shuttle, and ISS EVAs, terrestrial mountaineering practices, NASA Extreme Environment Mission Operations (NEEMO) 16 mission, and during Neutral Buoyancy Laboratory testing in the MACES suit. The proposed concept utilizes expandable booms and integrated features of the asteroid capture bag to position and restrain the crew at the asteroid worksite. These methods enable the capability to perform both finesse, and high load tasks necessary to collect samples for scientific characterization of the asteroid. This paper will explore the design trade space and options that were examined for EVA, the overall concept for the EVAs including translation paths and body restraint methods, potential tools used to extract the samples, design implications for the Asteroid Redirect Vehicle (ARV) for EVA, the results of early development testing of potential EVA tasks, and extensibility of the EVA architecture to NASA's exploration missions.

Scoville, Zebulon↗

Abnormal Transport and Magnetic Properties Induced by Change of the Phase Volume Ratio for YBa{sub 2}Cu{sub 3}O{sub 7-δ}/La{sub 0.67}Sr{sub 0.33}MnO{sub 3} Hybrids

Two elaborately designed hybrids consisting of superconducting YBa{sub 2}Cu{sub 3}O{sub 7-δ} (YBCO) and ferromagnetic La{sub 0.67}Sr{sub 0.33}MnO{sub 3} (LSMO), namely 20 × (YBCO(m)/LSMO(100 − m)) are prepared on single crystal SrTiO{sub 3} (STO) by pulsed laser deposition (PLD) with 20 being repetition periods and m = 90 and 10, respectively, which represents YBCO pulse number in a period. The films show highly c-oriented and epitaxial quality, suggested by XRD 𝜃–2𝜃 scans and pole figures. The 20 × (YBCO90/LSMO10) sample with a large YBCO volume fraction exhibits the typical character of a metal superconductor at about 90 K, while its transition width reaches 9.1 K, which is nearly eight times of that of the pure YBCO film. Above the superconducting transition temperature, a superparamagnetic signal rather than ferromagnetic behavior is observed, which may be associated with a diluted system consisting of the ferromagnetic nanoparticles embedded in the superconducting films. For the hybrid with a small YBCO volume fraction, i.e., the 20 × (YBCO10/LSMO90) sample, its transport behavior at normal state is insulating, and it is found that the Mott variable range hopping conduction dominates in this insulating phase in the temperature range 70–310 K. Obviously distinguishable insulator to superconductor (IS) transition occurs at 52 K, but the superconducting diamagnetic signals are very weak in the magnetic measurements below the IS temperature. For this sample, the magnetization loop at 100 K is ferromagnetic, yet manifested by a reduced coercive field and residual magnetization as compared with a pure LSMO film. In fact, both hybrids represent two kinds of nanocomposites, i.e., superconducting nanoparticles in a ferromagnetic matrix and ferromagnetic nanoparticles in a superconducting matrix, which benefits to study interfacial interactions due to an increased interface to value ratio and reduced size effect.

75 CONDENSED MATTER PHYSICS, SUPERCONDUCTIVITY AND↗

Leaf chlorophyll content as a proxy for leaf photosynthetic capacity

Improving the accuracy of estimates of forest carbon exchange is a central priority for understanding ecosystem response to increased atmospheric CO 2 levels and improving carbon cycle modelling. However, the spatially continuous parameterization of photosynthetic capacity (Vcmax) at global scales and appropriate temporal intervals within terrestrial biosphere models (TBMs) remains unresolved. This research investigates the use of biochemical parameters for modelling leaf photosynthetic capacity within a deciduous forest. Particular attention is given to the impacts of seasonality on both leaf biophysical variables and physiological processes, and their interdependent relationships. Four deciduous tree species were sampled across three growing seasons (2013-2015), approximately every 10 days for leaf chlorophyll content (Chl Leaf ) and canopy structure. Leaf nitrogen (N Area ) was also measured during 2014. Leaf photosynthesis was measured during 2014-2015 using a Li-6400 gas-exchange system, with A-Ci curves to model Vcmax. Results showed that seasonality and variations between species resulted in weak relationships between Vcmax normalized to 25°C (Vcmax 25 ) and N Area ( R 2 = 0.62, P < 0.001), whereas Chl Leaf demonstrated a much stronger correlation with Vcmax 25 ( R 2 = 0.78, P < 0.001). The relationship between Chl Leaf and N Area was also weak ( R 2 = 0.47, P < 0.001), possibly due to the dynamic partitioning of nitrogen, between and within photosynthetic and nonphotosynthetic fractions. The spatial and temporal variability of Vcmax 25 was mapped using Landsat TM/ETM satellite data across the forest site, using physical models to derive Chl Leaf . TBMs largely treat photosynthetic parameters as either fixed constants or varying according to leaf nitrogen content. This research challenges assumptions that simple N Area - Vcmax 25 relationships can reliably be used to constrain photosynthetic capacity in TBMs, even within the same plant functional type. It is suggested that Chl Leaf provides a more accurate, direct proxy for Vcmax 25 and is also more easily retrievable from satellite data. These results have important implications for carbon modelling within deciduous ecosystems.

59 BASIC BIOLOGICAL SCIENCES↗

Three Dimensional Variable-Wavelength X-Ray Bragg Coherent Diffraction Imaging

Here, we present and demonstrate a formalism by which three-dimensional (3D) Bragg x-ray coherent diffraction imaging (BCDI) can be implemented without moving the sample by scanning the energy of the incident x-ray beam. This capability is made possible by introducing a 3D Fourier transform that accounts for x-ray wavelength variability. We also demonstrate the approach by inverting coherent Bragg diffraction patterns from a gold nanocrystal measured with an x-ray energy scan. Furthermore, variable-wavelength BCDI will expand the breadth of feasible in situ 3D strain imaging experiments towards more diverse materials environments, especially where sample manipulation is difficult.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

The Exosat spectral survey of AGN

Results are presented from Exosat observations of 48 hard X-ray selected Seyfert-type active galactic nuclei (AGN). These include all 30 of the emission line AGN in the Piccinotti (1981) sample. Combining Exosat LE and ME data has yielded X-ray spectra over the broad energy range 0.1-10 keV. Spectra in the about 2-10 keV range are found to be well described by a simple power law, with a narrow distribution of spectral indices across the sample about a mean energy index alpha = 0.70. Exosat has also revealed a substantial number of sources with complex soft X-ray spectra. Evidence that soft emission components occur in many Seyferts, together with detection of rapid variability in the soft component, provides a quantitative support for an accretion disk model for AGN. Approximately half of the present sample of AGN show low-energy absorption attributable to substantial cold matter within the host galaxy. A few cases show evidence for column variability and reduced low-energy opacity (by photo-ionization). These results and the observed rarity of intrinsic absorption in the higher luminosity sources suggest the absorbing matter lies close to the central continuum source.

Turner, T. J.↗

Near-infrared Variability in the 2MASS Calibration Fields: A Search for Planetary Transit Candidates

The Two Micron All Sky Survey (2MASS) photometric calibration observations cover approximately 6 square degrees on the sky in 35 'calibration fields,' each sampled in nominal photometric conditions between 562 and 3692 times during the 4 years of the 2MASS mission. We compile a catalog of variables from the calibration observations to search for M dwarfs transited by extrasolar planets. We present our methods for measuring periodic and nonperiodic flux variability. From 7554 sources with apparent K(sub s) magnitudes between 5.6 and 16.1, we identify 247 variables, including extragalactic variables and 23 periodic variables. We have discovered three M dwarf eclipsing systems, including two candidates for transiting extrasolar planets.

statistical methods↗

Detectability of minerals on desert alluvial fans using reflectance spectra

The visible and near-infrared reflectance spectra of soil samples collected from desert alluvial and colluvial surfaces in the Cuprite mining district, Nevada, were analyzed. These surfaces are downslope from hydrothermally altered volcanic rocks that contain spectrally characteristic minerals such as alunite and kaolinite. Coarse fractions of the soils on the alluvial fans are mineralogically variable and express the upslope lithologies; fine fractions are remarkably similar mineralogically and spectrally in all samples because of dilution of local mineral components by regionally derived windblown dust. Theoretical models for spectral mixing and for particle-size effects were used to model the observed spectral variations. Diagnostic mineral absorption bands in the spectra of fan materials were enhanced by computationally removing the spectrum of the homogeneous fine-soil component. Results show that spectral mixing models are useful for analyzing data with high spectral resolution obtained by field and aircraft spectrometers.

Shipman, Hugh↗

Lead exposure to children from consumption of backyard chicken eggs

Highlights: • Backyard chicken eggs from most households providing egg samples (98%) contained detectable concentrations of lead. • IIn prediction models, backyard egg consumption increased overall blood lead levels in children • Infants < 1 year of age experience the greatest increase in predicted blood lead levels from backyard egg consumption. • Mean household egg lead concentration was strongly positively correlated with coop soil lead concentrations. Backyard chicken ownership is rapidly increasing in urban areas in the United States, largely as a way to provide eggs for household consumption. Despite elevated levels of environmental lead contamination in many US cities, the role of backyard chicken eggs as a pathway for lead exposure, particularly for children, has received limited scrutiny. To characterize lead exposure from consumption of backyard chicken eggs for children and predict related effects on blood lead level (BLL), we conducted a cross-sectional study of backyard chicken owners in the Greater Boston area (n = 51). We interviewed participants regarding egg consumption by household members and collected backyard eggs (n = 201) and coop soil samples (n = 48) for analysis. Inductively coupled plasma mass spectrometry (ICP-MS) was used to evaluate lead concentration in homogenized eggs and an X-ray fluorescence (XRF) portable device was used to assess soil lead levels in the laboratory. We used the USEPA's Integrated Exposure Uptake Biokinetic Model for Lead in Children (IEUBK) to assess the relative contribution of backyard egg consumption to aggregate BLL in children. Four scenarios were developed in the IEUBK model to address variability in egg consumption rates and egg lead contamination. Lead was detected in egg samples from 98% of the households that provided egg samples. Mean household lead concentration was 0.10 μg/g (SD: 0.18). Egg lead concentrations ranged from below the limit of detection (0.0014 μg/g) to 1.798 μg/g (<1.4–1198 ppb). Egg lead levels were strongly positively correlated with lead concentration in coop soil (r = 0.64; p < 0.001). In modeled scenarios where a child < 7 years frequently ate eggs highly contaminated with lead, BLLs are predicted to increase by 0.9–1.5 μg/dL. In three other scenarios reflecting more moderate egg lead contamination and consumption rates, BLLs were predicted to increase from 0.1 to 0.8 μg/dL. Consumption of backyard chicken eggs can contribute to lead exposure in children. Soil lead remediation prior to chicken ownership may reduce lead exposure from backyard eggs.

54 ENVIRONMENTAL SCIENCES↗