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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 1,135 records · Page 63
All sourcesNASA NTRSDOE OSTI
DOE OSTI2015

MO-AB-BRA-02: A Novel Scatter Imaging Modality for Real-Time Image Guidance During Lung SBRT

Purpose: A novel scatter imaging modality is developed and its feasibility for image-guided radiation therapy (IGRT) during stereotactic body radiation therapy (SBRT) for lung cancer patients is assessed using analytic and Monte Carlo models as well as experimental testing. Methods: During treatment, incident radiation interacts and scatters from within the patient. The presented methodology forms an image of patient anatomy from the scattered radiation for real-time localization of the treatment target. A radiographic flat panel-based pinhole camera provides spatial information regarding the origin of detected scattered radiation. An analytical model is developed, which provides a mathematical formalism for describing the scatter imaging system. Experimental scatter images are acquired by irradiating an object using a Varian TrueBeam accelerator. The differentiation between tissue types is investigated by imaging simple objects of known compositions (water, lung, and cortical bone equivalent). A lung tumor phantom, simulating materials and geometry encountered during lung SBRT treatments, is fabricated and imaged to investigate image quality for various quantities of delivered radiation. Monte Carlo N-Particle (MCNP) code is used for validation and testing by simulating scatter image formation using the experimental pinhole camera setup. Results: Analytical calculations, MCNP simulations, and experimental results when imaging the water, lung, and cortical bone equivalent objects show close agreement, thus validating the proposed models and demonstrating that scatter imaging differentiates these materials well. Lung tumor phantom images have sufficient contrast-to-noise ratio (CNR) to clearly distinguish tumor from surrounding lung tissue. CNR=4.1 and CNR=29.1 for 10MU and 5000MU images (equivalent to 0.5 and 250 second images), respectively. Conclusion: Lung SBRT provides favorable treatment outcomes, but depends on accurate target localization. A comprehensive approach, employing multiple simulation techniques and experiments, is taken to demonstrate the feasibility of a novel scatter imaging modality for the necessary real-time image guidance.

60 APPLIED LIFE SCIENCES↗
NASA NTRS1984

A comparison of two photogrammetric algorithms for the measurement of model deformation in the National Transonic Facility

A comparison was made of two photogrammetric measurement techniques which can be used for the determination of the spatial loctions of targets. One technique is known as the Direct Linear Transformation (DLT), and the other is referred to as the Bundle method. Each technique utilizes triangulation of image data from two or more cameras, but they differ in their method of determining camera parameters. While the study was performed with simulated data, the geometries, image data accuracies and other parameters were set to simulate conditions for a two-camera, photogrammetric system which will be used at the National Transonic Facility at the NASA's Langley Research Center. For the conditions studied the Bundle technique was found to have smaller errors. Both methods were sensitive to the spatial distribution of control-point targets, but this effected the accuracy of the Bundle algorithm less than that of the DLT algorithm.

Monteith, J. H.↗
DOE OSTI2016

HIDING IN THE SHADOWS. II. COLLISIONAL DUST AS EXOPLANET MARKERS

Observations of the youngest planets (∼1–10 Myr for a transitional disk) will increase the accuracy of our planet formation models. Unfortunately, observations of such planets are challenging and time-consuming to undertake, even in ideal circumstances. Therefore, we propose the determination of a set of markers that can preselect promising exoplanet-hosting candidate disks. To this end, N-body simulations were conducted to investigate the effect of an embedded Jupiter-mass planet on the dynamics of the surrounding planetesimal disk and the resulting creation of second-generation collisional dust. We use a new collision model that allows fragmentation and erosion of planetesimals, and dust-sized fragments are simulated in a post-process step including non-gravitational forces due to stellar radiation and a gaseous protoplanetary disk. Synthetic images from our numerical simulations show a bright double ring at 850 μm for a low-eccentricity planet, whereas a high-eccentricity planet would produce a characteristic inner ring with asymmetries in the disk. In the presence of first-generation primordial dust these markers would be difficult to detect far from the orbit of the embedded planet, but would be detectable inside a gap of planetary origin in a transitional disk.

79 ASTRONOMY AND ASTROPHYSICS↗
DOE OSTI2015

WE-G-BRD-06: Volumetric Cine MRI (VC-MRI) Estimated Based On Prior Knowledge for On-Board Target Localization

Purpose: To develop a technique to generate on-board VC-MRI using patient prior 4D-MRI, motion modeling and on-board 2D-cine MRI for real-time 3D target verification of liver and lung radiotherapy. Methods: The end-expiration phase images of a 4D-MRI acquired during patient simulation are used as patient prior images. Principal component analysis (PCA) is used to extract 3 major respiratory deformation patterns from the Deformation Field Maps (DFMs) generated between end-expiration phase and all other phases. On-board 2D-cine MRI images are acquired in the axial view. The on-board VC-MRI at any instant is considered as a deformation of the prior MRI at the end-expiration phase. The DFM is represented as a linear combination of the 3 major deformation patterns. The coefficients of the deformation patterns are solved by matching the corresponding 2D slice of the estimated VC-MRI with the acquired single 2D-cine MRI. The method was evaluated using both XCAT (a computerized patient model) simulation of lung cancer patients and MRI data from a real liver cancer patient. The 3D-MRI at every phase except end-expiration phase was used to simulate the ground-truth on-board VC-MRI at different instances, and the center-tumor slice was selected to simulate the on-board 2D-cine images. Results: Image subtraction of ground truth with estimated on-board VC-MRI shows fewer differences than image subtraction of ground truth with prior image. Excellent agreement between profiles was achieved. The normalized cross correlation coefficients between the estimated and ground-truth in the axial, coronal and sagittal views for each time step were >= 0.982, 0.905, 0.961 for XCAT data and >= 0.998, 0.911, 0.9541 for patient data. For XCAT data, the maximum-Volume-Percent-Difference between ground-truth and estimated tumor volumes was 1.6% and the maximum-Center-of-Mass-Shift was 0.9 mm. Conclusion: Preliminary studies demonstrated the feasibility to estimate real-time VC-MRI for on-board target localization before or during radiotherapy treatments. National Institutes of Health Grant No. R01-CA184173; Varian Medical System.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2013

Investigation of realistic PET simulations incorporating tumor patient's specificity using anthropomorphic models: Creation of an oncology database

Purpose: The GATE Monte Carlo simulation toolkit is used for the implementation of realistic PET simulations incorporating tumor heterogeneous activity distributions. The reconstructed patient images include noise from the acquisition process, imaging system's performance restrictions and have limited spatial resolution. For those reasons, the measured intensity cannot be simply introduced in GATE simulations, to reproduce clinical data. Investigation of the heterogeneity distribution within tumors applying partial volume correction (PVC) algorithms was assessed. The purpose of the present study was to create a simulated oncology database based on clinical data with realistic intratumor uptake heterogeneity properties.Methods: PET/CT data of seven oncology patients were used in order to create a realistic tumor database investigating the heterogeneity activity distribution of the simulated tumors. The anthropomorphic models (NURBS based cardiac torso and Zubal phantoms) were adapted to the CT data of each patient, and the activity distribution was extracted from the respective PET data. The patient-specific models were simulated with the Monte Carlo Geant4 application for tomography emission (GATE) in three different levels for each case: (a) using homogeneous activity within the tumor, (b) using heterogeneous activity distribution in every voxel within the tumor as it was extracted from the PET image, and (c) using heterogeneous activity distribution corresponding to the clinical image following PVC. The three different types of simulated data in each case were reconstructed with two iterations and filtered with a 3D Gaussian postfilter, in order to simulate the intratumor heterogeneous uptake. Heterogeneity in all generated images was quantified using textural feature derived parameters in 3D according to the ground truth of the simulation, and compared to clinical measurements. Finally, profiles were plotted in central slices of the tumors, across lines with heterogeneous activity distribution for visual assessment.Results: The accuracy of the simulated database was assessed against the original clinical images. The PVC simulated images matched the clinical ones best. Local, regional, and global features extracted from the PVC simulated images were closest to the clinical measurements, with the exception of the size zone variability and the mean intensity values, where heterogeneous tumors showed better reproducibility. The profiles on PVC simulated tumors after postfiltering seemed to represent the more realistic heterogeneous regions with respect to the clinical reference.Conclusions: In this study, the authors investigated the input activity map heterogeneity in the GATE simulations of tumors with heterogeneous activity distribution. The most realistic heterogeneous tumors were obtained by inserting PVC activity distributions from the clinical image into the activity map of the simulation. Partial volume effect (PVE) can play a crucial role in the quantification of heterogeneity within tumors and have an important impact on applications such as patient follow-up during treatment and assessment of tumor response to therapy. The development of such a database incorporating patient anatomical and functional variability can be used to evaluate new image processing or analysis algorithms, while providing control of the ground truth, which is not available when dealing with clinical datasets. The database includes all images used and generated in this study, as well as the sinograms and the attenuation phantoms for further investigation. It is freely available to the interested reader of the journal at http://www.med.upatras.gr/oncobase/.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2024

A Stereo Camera Simulator for Large-Eddy Simulations of Continental Shallow Cumulus Clouds Based on Three-Dimensional Path-Tracing

The complex spatial and temporal structure of cumulus clouds complicates their representation in weather and climate models. Classic meteorological instrumentation struggles to fully capture these features. Networks of multiple high-resolution hemispheric cameras are increasingly used to fill this data gap, and provide information on this missing multi-dimensional spatial information. In this study, a path-tracing algorithm is used to generate virtual camera images of resolved clouds in large-eddy simulations (LES). These images are then used as a camera network simulator, allowing reconstructions of three-dimensional cloud edges from the model output. Because the actual LES cloud field is fully known, the combined path-tracing and reconstruction method can be statistically analyzed. The method is applied to LES realizations of summertime shallow cumulus at the Jülich Observatory for Cloud Evolution (JOYCE), Germany, which also routinely operates a camera network. We find that the path-tracing method allows accurate reconstruction of up to 70% of the visible cloud edges. Additional sensitivity tests show that the method is robust for changes in its hyperparameters. The sensitivity to cloud optical thickness is also investigated, finding a cloud boundary placement error of approximately 182 m. This error can be considered typical for cloud boundary reconstruction using real stereo camera imagery. The results provide proof of principle for future use of the method for evaluating LES clouds against camera network imagery, and for further optimizing the configuration of such camera networks.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2014

Observation of early shell-dopant mix in OMEGA direct-drive implosions and comparisons with radiation-hydrodynamic simulations

Temporally, spatially, and spectrally resolved x-ray image data from direct-drive implosions on OMEGA were interpreted with the aid of radiation-hydrodynamic simulations. Neither clean calculations nor those using a turbulent mix model can explain fully the observed migration of shell-dopant material (titanium) into the core. Shell-dopant migration was observed via time-dependent, spatially integrated spectra, and spatially and spectrally resolved x-ray images of capsule implosions and resultant dopant emissions. The titanium emission was centrally peaked in narrowband x-ray images. In post-processed clean simulations, the peak titanium emission forms in a ring in self-emission images as the capsule implodes. Post-processed simulations with mix reproduce trends in time-dependent, spatially integrated spectra, as well having centrally peaked Ti emission in synthetic multiple monochromatic imager. However, mix simulations still do not transport Ti to the core as is observed in the experiment. This suggests that phenomena in addition to the turbulent mix must be responsible for the transport of Ti. Simple diffusion estimates are unable to explain the early Ti mix into the core. Mechanisms suggested for further study are capsule surface roughness, illumination non-uniformity, and shock entrainment.

70 PLASMA PHYSICS AND FUSION TECHNOLOGY↗
DOE OSTI2025

High fidelity simulations of contaminant dispersion in an urban environment with comparison to magnetic resonance imaging measurements

The dispersion of a contaminant in an urban environment has the potential to impact a large population of people. In this work, a complex urban canopy flow based on the Oklahoma City downtown business district circa 2003 is studied using Magnetic Resonance Imaging (MRI) and high-fidelity Large Eddy Simulations (LES). MRI is a novel experimental technique that can provide high-resolution measurements in four dimensions (three spatial and temporal) for lab scale models. The experiments and simulations use the same geometry and boundary conditions providing a one-to-one comparison of the two methods. Results are presented on the time-averaged velocity and concentration fields, the temporal dynamics of the concentration plumes for a transient release, and a novel Cloud Identification Algorithm that can separate plumes produced by periodic contaminant releases used for ensemble averaging over many releases. The MRI and LES datasets both include millions of measurement voxels and the comparisons highlight the complex 3D nature of the flow including strong vertical velocities in spanwise street canyons and flow acceleration in streamwise street canyons. The concentration fields are qualitatively similar albeit the LES shows larger dispersion. A quantitative analysis with performance measures compares the datasets pointwise and demonstrates that the two 3D datasets are similar with respect to many measures including a fractional bias of 0.02 (ideal=0.0), correlation coefficient of 0.87 (ideal = 1.0), and the fraction points within a factor of 2 is 0.98 (ideal = 1.0). Plume analysis compares the arrival and residence time of contaminant and is found to vary significantly with location within the urban environment with arrival times between 0 and 1.25 and differences within the contaminant cloud less than 10% at most locations.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2019

Particle/Ray Interaction Simulation Manager (PRISM) Assessment Report

The Particle/Ray Interaction Simulation Manager (PRISM) is a software tool developed by Triple Ring Technologies (TRT), http://www.tripleringtech.com/, under a Small Business Innovation Research Award from the Department of Homeland Security (DHS) to investigate the utility of simulations in X-ray-based explosive detection systems. The PRISM tool is intended to provide a standardized and intuitive user interface to control and configure realistic simulations of X-ray imaging systems. It includes a command-line interface that enables the user to configure simulated X-ray radiography and computed tomography (CT) systems. It allows the import of computer-aided design (CAD) models of objects and it supports Monte Carlo simulation engines such as GEANT4. PRISM is designed to simulate realistic X-ray projection images including scatter, noise, and various detector effects such as quantum efficiency, lag, and veiling glare. At the request of DHS, the authors assessed PRISM’s capabilities to simulate data generated by a Micro-CT test-bed system (MCT-TB) housed at the Lawrence Livermore National Laboratory (LLNL). This document describes the results of that assessment.

42 ENGINEERING↗
DOE OSTI2023

Bayesian merging of numerical modeling and remote sensing for saltwater intrusion quantification in the Vietnamese Mekong Delta

Saltwater intrusion has become one of the most concerning issues in the Vietnamese Mekong Delta (VMD) due to its increasing impacts on agriculture and food security of Vietnam. Reliable estimation of salinity plays a crucial role to mitigate the impacts of saltwater intrusion. Here, this study developed a hybrid technique that merges satellite imagery with numerical simulations to improve the estimation of salinity in the VMD. The salinity derived from Landsat images and by numerical simulations was fused using the Bayesian inference technique. The results indicate that our technique significantly reduces the uncertainties and improves the accuracy of salinity estimates. The Nash–Sutcliffe coefficient is 0.74, which is much higher than that of numerical simulation (0.63) and Landsat estimation (0.6). The correlation coefficient between the ensemble and measured salinity is relatively high (0.88). The variance of the ensemble salinity errors (5.0 ppt 2 ) is lower than that of Landsat estimation (10.4 ppt 2 ) and numerical simulations (9.6 ppt 2 ). The proposed approach shows a great potential to combine multiple data sources of a variable of interest to improve its accuracy and reliability wherever these data are available.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2016

Sci-Thur AM: YIS – 07: Optimizing dual-energy x-ray parameters using a single filter for both high and low-energy images to enhance soft-tissue imaging

Objective: To optimize dual-energy parameters of ExacTrac stereoscopic x-ray imaging system for lung SBRT patients Methods: Simulated spectra and a lung phantom were used to optimize filter material, thickness, kVps, and weighting factors to obtain bone subtracted dual-energy images. Spektr simulations were used to identify material in the atomic number (Z) range [3–83] based on a metric defined to separate spectrums of high and low energies. Both energies used the same filter due to time constraints of image acquisition in lung SBRT imaging. A lung phantom containing bone, soft tissue, and a tumor mimicking material was imaged with filter thicknesses range [0–1] mm and kVp range [60–140]. A cost function based on contrast-to-noise-ratio of bone, soft tissue, and tumor, as well as image noise content, was defined to optimize filter thickness and kVp. Using the optimized parameters, dual-energy images of anthropomorphic Rando phantom were acquired and evaluated for bone subtraction. Imaging dose was measured with dual-energy technique using tin filtering. Results: Tin was the material of choice providing the best energy separation, non-toxicity, and non-reactiveness. The best soft-tissue-only image in the lung phantom was obtained using 0.3 mm tin and [140, 80] kVp pair. Dual-energy images of the Rando phantom had noticeable bone elimination when compared to no filtration. Dose was lower with tin filtering compared to no filtration. Conclusions: Dual-energy soft-tissue imaging is feasible using ExacTrac stereoscopic imaging system utilizing a single tin filter for both high and low energies and optimized acquisition parameters.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2016

Accuracy of UTE-MRI-based patient setup for brain cancer radiation therapy

Purpose: Radiation therapy simulations solely based on MRI have advantages compared to CT-based approaches. One feature readily available from computed tomography (CT) that would need to be reproduced with MR is the ability to compute digitally reconstructed radiographs (DRRs) for comparison against on-board radiographs commonly used for patient positioning. In this study, the authors generate MR-based bone images using a single ultrashort echo time (UTE) pulse sequence and quantify their 3D and 2D image registration accuracy to CT and radiographic images for treatments in the cranium. Methods: Seven brain cancer patients were scanned at 1.5 T using a radial UTE sequence. The sequence acquired two images at two different echo times. The two images were processed using an in-house software to generate the UTE bone images. The resultant bone images were rigidly registered to simulation CT data and the registration error was determined using manually annotated landmarks as references. DRRs were created based on UTE-MRI and registered to simulated on-board images (OBIs) and actual clinical 2D oblique images from ExacTrac™. Results: UTE-MRI resulted in well visualized cranial, facial, and vertebral bones that quantitatively matched the bones in the CT images with geometric measurement errors of less than 1 mm. The registration error between DRRs generated from 3D UTE-MRI and the simulated 2D OBIs or the clinical oblique x-ray images was also less than 1 mm for all patients. Conclusions: UTE-MRI-based DRRs appear to be promising for daily patient setup of brain cancer radiotherapy with kV on-board imaging.

61 RADIATION PROTECTION AND DOSIMETRY↗
NASA NTRS1989

Ground evaluation of seeding an in-flight wingtip vortex using infrared imaging flow visualization technique

An experimental simulation of an in-flight wingtip vortical flow visualization technique uses infrared imaging to observe strong and concentrated vortices. This experiment is phase 1 of a two-phase infrared evaluation program. The system includes a vortex generator (model 320 Vortec Vortex Tube) which generates the required vortex. The mouth of the unit is mounted close to the free end of a half-inch diameter, sixteen and a half foot long stainless steel tubing (sized after tubing currently installed in the wings of an experimental Beechcraft Sundowner 180 aircraft). Dichloro difluoromethane (Freon-12) is entrained into the generated vortex. A breakdown of the vortices is indicated by the rapid diffusion and the resulting pattern is tracked using the infrared imager and video systems. Flow rates (volume and mass) are estimated at the laboratory and proposed flight conditions. The nominal flight altitude is expected to be 2500 feet.

Akinyanju, Ted↗
DOE OSTI2015

Microcalcification detectability using a bench-top prototype photon-counting breast CT based on a Si strip detector

Purpose: To investigate the feasibility of detecting breast microcalcification (μCa) with a dedicated breast computed tomography (CT) system based on energy-resolved photon-counting silicon (Si) strip detectors. Methods: The proposed photon-counting breast CT system and a bench-top prototype photon-counting breast CT system were simulated using a simulation package written in MATLAB to determine the smallest detectable μCa. A 14 cm diameter cylindrical phantom made of breast tissue with 20% glandularity was used to simulate an average-sized breast. Five different size groups of calcium carbonate grains, from 100 to 180 μm in diameter, were simulated inside of the cylindrical phantom. The images were acquired with a mean glandular dose (MGD) in the range of 0.7–8 mGy. A total of 400 images was used to perform a reader study. Another simulation study was performed using a 1.6 cm diameter cylindrical phantom to validate the experimental results from a bench-top prototype breast CT system. In the experimental study, a bench-top prototype CT system was constructed using a tungsten anode x-ray source and a single line 256-pixels Si strip photon-counting detector with a pixel pitch of 100 μm. Calcium carbonate grains, with diameter in the range of 105–215 μm, were embedded in a cylindrical plastic resin phantom to simulate μCas. The physical phantoms were imaged at 65 kVp with an entrance exposure in the range of 0.6–8 mGy. A total of 500 images was used to perform another reader study. The images were displayed in random order to three blinded observers, who were asked to give a 4-point confidence rating on each image regarding the presence of μCa. The μCa detectability for each image was evaluated by using the average area under the receiver operating characteristic curve (AUC) across the readers. Results: The simulation results using a 14 cm diameter breast phantom showed that the proposed photon-counting breast CT system can achieve high detection accuracy with an average AUC greater than 0.89 ± 0.07 for μCas larger than 120 μm in diameter at a MGD of 3 mGy. The experimental results using a 1.6 cm diameter breast phantom showed that the prototype system can achieve an average AUC greater than 0.98 ± 0.01 for μCas larger than 140 μm in diameter using an entrance exposure of 1.2 mGy. Conclusions: The proposed photon-counting breast CT system based on a Si strip detector can potentially offer superior image quality to detect μCa with a lower dose level than a standard two-view mammography.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2016

Technical Note: Multipurpose CT, ultrasound, and MRI breast phantom for use in radiotherapy and minimally invasive interventions

Purpose: To develop a multipurpose gel-based breast phantom consisting of a simulated tumor with realistic imaging properties in CT, ultrasound and MRI, or a postsurgical cavity on CT. Applications for the phantom include: deformable image registration (DIR) quality assurance (QA), autosegmentation validation, and localization testing and training for minimally invasive image-guided procedures such as those involving catheter or needle insertion. Methods: A thermoplastic mask of a typical breast patient lying supine was generated and then filled to make an array of phantoms. The background simulated breast tissue consisted of 32.4 g each of ballistic gelatin (BG) powder and Metamusil™ (MM) dissolved in 800 ml of water. Simulated tumors were added using the following recipe: 12 g of barium sulfate (1.4% v/v) plus 0.000 14 g copper sulfate plus 0.7 g of MM plus 7.2 g of BG all dissolved in 75 ml of water. The phantom was evaluated quantitatively in CT by comparing Hounsfield units (HUs) with actual breast tissue. For ultrasound and MRI, the phantoms were assessed based on subjective image quality and signal-difference to noise (SDNR) ratio, respectively. The stiffness of the phantom was evaluated based on ultrasound elastography measurements to yield an average Young’s modulus. In addition, subjective tactile assessment of phantom was performed under needle insertion. Results: The simulated breast tissue had a mean background value of 24 HU on CT imaging, which more closely resembles fibroglandular tissue (40 HU) as opposed to adipose (−100 HU). The tumor had a mean CT number of 45 HU, which yielded a qualitatively realistic image contrast relative to the background either as an intact tumor or postsurgical cavity. The tumor appeared qualitatively realistic on ultrasound images, exhibiting hypoechoic characteristics compared to background. On MRI, the tumor exhibited a SDNR of 3.7. The average Young’s modulus was computed to be 15.8 ± 0.7 kPa (1 SD). Conclusions: We have developed a process to efficiently and inexpensively produce multipurpose breast phantoms containing simulated tumors visible on CT, ultrasound, and MRI. The phantoms have been evaluated for image quality and elasticity and can serve as a medium for DIR QA, autosegmentation QA, and training for minimally invasive procedures.

60 APPLIED LIFE SCIENCES↗
NASA NTRS2015

System and Method for Null-Lens Wavefront Sensing

A method of measuring aberrations in a null-lens including assembly and alignment aberrations. The null-lens may be used for measuring aberrations in an aspheric optic with the null-lens. Light propagates from the aspheric optic location through the null-lens, while sweeping a detector through the null-lens focal plane. Image data being is collected at locations about said focal plane. Light is simulated propagating to the collection locations for each collected image. Null-lens aberrations may extracted, e.g., applying image-based wavefront-sensing to collected images and simulation results. The null-lens aberrations improve accuracy in measuring aspheric optic aberrations.

Hill, Peter C.↗
DOE OSTI2014

SU-E-T-35: An Investigation of the Accuracy of Cervical IMRT Dose Distribution Using 2D/3D Ionization Chamber Arrays System and Monte Carlo Simulation

Purpose: The purpose of this work is to compare the verification results of three solutions (2D/3D ionization chamber arrays measurement and Monte Carlo simulation), the results will help make a clinical decision as how to do our cervical IMRT verification. Methods: Seven cervical cases were planned with Pinnacle 8.0m to meet the clinical acceptance criteria. The plans were recalculated in the Matrixx and Delta4 phantom with the accurate plans parameters. The plans were also recalculated by Monte Carlo using leaf sequences and MUs for individual plans of every patient, Matrixx and Delta4 phantom. All plans of Matrixx and Delta4 phantom were delivered and measured. The dose distribution of iso slice, dose profiles, gamma maps of every beam were used to evaluate the agreement. Dose-volume histograms were also compared. Results: The dose distribution of iso slice and dose profiles from Pinnacle calculation were in agreement with the Monte Carlo simulation, Matrixx and Delta4 measurement. A 95.2%/91.3% gamma pass ratio was obtained between the Matrixx/Delta4 measurement and Pinnacle distributions within 3mm/3% gamma criteria. A 96.4%/95.6% gamma pass ratio was obtained between the Matrixx/Delta4 measurement and Monte Carlo simulation within 2mm/2% gamma criteria, almost 100% gamma pass ratio within 3mm/3% gamma criteria. The DVH plot have slightly differences between Pinnacle and Delta4 measurement as well as Pinnacle and Monte Carlo simulation, but have excellent agreement between Delta4 measurement and Monte Carlo simulation. Conclusion: It was shown that Matrixx/Delta4 and Monte Carlo simulation can be used very efficiently to verify cervical IMRT delivery. In terms of Gamma value the pass ratio of Matrixx was little higher, however, Delta4 showed more problem fields. The primary advantage of Delta4 is the fact it can measure true 3D dosimetry while Monte Carlo can simulate in patients CT images but not in phantom.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2013

Validation of velocity map imaging conditions over larger areas

We have established through simulations and experiments the area over which Velocity Map Imaging (VMI) conditions prevail. We designed a VMI setup in which we can vary the ionization position perpendicular to the center axis of the time-of-flight spectrometer. We show that weak extraction conditions are far superior over standard three-plate setups if the aim is to increase the ionization volume without distorting VMI conditions. This is important for a number of crossed molecular beam experiments that already utilize weak extraction conditions, but to a greater extent for surface studies where fragments are desorbed or scattered off a surface in all directions. Our results on the dissociation of NO{sub 2} at 226 nm show that ionization of the fragments can occur up to {+-}5.5 mm away from the center axis of the time-of-flight spectrometer without affecting resolution or arrival position.

43 PARTICLE ACCELERATORS↗