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NASA NTRSDate not supplied

Using Systems Engineering to Develop an Integrated Crew Health and Performance System to Mitigate Risk for Human Exploration Missions

New space exploration missions are currently being designed to take humanity beyond low Earth orbit (LEO) to cis-lunar space, the lunar surface, and eventually to Mars. These missions carry increased risks due to a number of factors, including distance from Earth, exposure to deep space hazards, reduced capacity and ability to resupply and evacuate, and increased communication delays. As distance from Earth grows and mission length increases, a growing proportion of mission risk can be attributed to the “human system.” Almost twenty years ago, the Institute of Medicine in the United States recommended the early and complete integration of the human system into the spacecraft and mission design process to mitigate this increased risk inherent in exploration missions. Exploration missions will require increasing levels of crew self-sufficiency that will challenge the current operational paradigms established in LEO. Enabling progressive Earth independence requires management of the increasingly complex interactions among spacecraft systems and integration of all the data and functions that affect human health and performance into one coordinated system –the Crew Health and Performance (CHP) system. This system is a critical spacecraft system that is analogous to other systems such as propulsion, guidance and navigation, or avionics. Design and integration of the CHP system requires the evidence-based merger of typically disparate disciplines such as medicine, human factors, and life support system design, using systems engineering (SE) practices. SE provides traceability of spacecraft requirements and enables reliable and repeatable trade space analysis of the many competing options for hardware and software to be included in the mission architecture. The approach described here enables spacecraft and mission designers to align the scope of a CHP system with mission specific requirements, decrease risk to the crew, and increase the probability of mission success.

Kerry McGuire↗

NASA NTRS2001

Exploring the Unknown: Selected Documents in the History of the US Civil Space Program: Exploring the Cosmos - Volume 5

The documents selected for inclusion in this volume are presented in three major sections, each covering a particular aspect of the origins, evolution, and execution of the US space science program. Chapter 1 deals with the origins, evolution, and organization of the space science program. Chapter 2 deals with the solar system exploration. Chapter 3 deals with NASA's astronomy and astrophysics efforts. Each chapter in the present volume is introduced by an overview essay. In the main, these essays are intended to introduce and complement the documents in the chapter and to place them in a chronological and substantive context. Each essay contains references to the documents in the chapter it introduces, and may also contain references to documents in other chapters of the collection

Logsdon, John M.↗

NASA NTRSDate not supplied

Using Systems Engineering to Develop an Integrated Crew Health and Performance System to Mitigate Risk for Human Exploration Missions

New space exploration missions are currently being designed to take humanity beyond Low EarthOrbit (LEO) to cis-lunar space, the lunar surface, and eventually to Mars. These missions carryincreased risks due to a number of factors, including distance from Earth, exposure to deep spacehazards, reduced capacity and ability to resupply and evacuate, and increased communication delays.As distance from Earth grows and mission length increases, a growing proportion of overall missionrisk can be attributed to the “human system.” Almost twenty years ago, the Institute of Medicine in theUnited States recommended the early and complete integration of the human system into thespacecraft and mission design process to mitigate this increased risk inherent in exploration missions.Exploration missions will require increasing levels of crew self-sufficiency that will challenge thecurrent operational paradigms established in LEO. Enabling progressive Earth independence requiresmanagement of the increasingly complex interactions among spacecraft systems and integration of allthe data and functions that affect human health and performance into one coordinated system – theCrew Health and Performance (CHP) system. This system is a critical spacecraft system that isanalogous to other systems such as propulsion, guidance and navigation, or avionics. Design andintegration of the CHP system requires the evidence-based merger of typically disparate disciplinessuch as medicine, human factors, and physiological support system design, using systems engineering(SE) practices. The approach described here enables spacecraft and mission designers to align thescope of a CHP system with mission specific requirements, decrease risk to the crew, and increase theprobability of mission success.

Kerry Mcguire↗

NASA NTRS2023

LunaNet Position, Navigation, and Timing Services and Signal, Enabling the Future of Lunar Exploration

The International Space Exploration Coordination Group established in 2018 the 3rd edition of the Global Exploration Roadmap (ISECG, 2018) that aims to achieve Mars human surface activities and identifies the exploration of the Moon as a critical intermediate step. A supplement covering updates on surface exploration scenarios was released in 2020 (ISECG, 2020). The Artemis Accords (NASA Artemis, 2020), first signed in October 2020, now includes over two dozen nations, in an agreement on the principles for best practices, including interoperability. September 2022 introduced the National Aeronautics and Space Administration’s (NASA) Moon to Mars Objectives highlighting recurring tenets of collaboration with international and industry partners and interoperability, along with infrastructure objectives for Position, Navigation, and Timing (PNT). The successful Artemis 1 mission paved the way to the ambitious plans to establish a sustainable human presence on the Moon. Just a few months after Artemis 1 launch (NASA, 2022), iSpace HAKUTO-R Mission1 (iSpace, 2022) launched, being the first-ever commercial mission, launched by a commercial launch service provider, aiming to land on the lunar surface. The NASA Artemis programme plans initial crewed landings and traverses in 2025, supported by the Lunar Gateway, followed by regular launches to build the lunar systems (NASA Artemis Plan, 2020), (NASA, 2022). NASA’s contracts with Commercial Lunar Payload Services (CLPS, (NASA, n.d.)) to deliver science and technology to the Moon, with launches starting in November 2023. The European Space Agency (ESA) Argonaut (ESA Argonaut, 2022) programme plans to have recurrent missions to bring payloads to the lunar surface, supporting lunar exploration. These are just a few examples of planned missions that will target the Earth’s natural satellite in the next decade, with forecasts of tens of missions per year (NSR, 2022), (Euroconsult, 2020). The large number of missions and the complexity of landing and operating are expected to demand a change of paradigm from the current Earth-based communication and navigation services. In recent years, several agencies have proposed to deploy cislunar communication and navigation services to support lunar missions (NASA LCRNS, 2022), (ESA Moonlight, 2022), (JAXA, 2022)). All these proposals seek to deploy service-providing satellites in lunar orbit to ease the user missions’ operations. The PNT services objective is to support all types of lunar users (e.g.: orbiters, landers, ascent vehicles, and surface crew and rovers). At the same time, NASA and ESA initiated an effort to define a common framework to ensure interoperability among different service providers: the LunaNet framework. The LunaNet Interoperability Specification (NASA and ESA, 2023) covers communication, PNT, and auxiliary services, by establishing a common set of requirements to ensure interoperability. This conference contribution will present the LunaNet PNT services, focusing on the Lunar Augmented Navigation Service (LANS) that resembles the Global Navigation Satellite System (GNSS) concept on Earth: constellations of satellites broadcasting a radio navigation signal synchronized to a common reference clock, with augmentations to accommodate users’ needs in an environment away from Earth. This includes a description of the high-level LANS concept and the basic principles defined to ensure interoperability. In addition, it will describe the common S-band PNT Augmented Forward Signal (AFS) and common messages to be adopted for compliance with the LunaNet framework, and the justification of the selected approach.

LunaNet↗

NASA NTRS2023

Lunanet Position, Navigation, and Timing Services and Signals, Enabling the Future of Lunar Exploration

The International Space Exploration Coordination Group established in 2018 the 3rd edition of the Global Exploration Roadmap (ISECG, 2018) that aims to achieve Mars human surface activities and identifies the exploration of the Moon as a critical intermediate step. A supplement covering updates on surface exploration scenarios was released in 2020 (ISECG, 2020). The Artemis Accords (NASA Artemis, 2020), first signed in October 2020, now includes over two dozen nations, in an agreement on the principles for best practices, including interoperability. In September 2022 the National Aeronautics and Space Administration (NASA) introduced the Moon to Mars Objectives highlighting recurring tenets of collaboration with international and industry partners and interoperability, along with infrastructure objectives for Position, Navigation, and Timing (PNT). The successful Artemis 1 mission paved the way to the ambitious plans to establish a sustainable human presence on the Moon. Just a few months after Artemis 1 launch (NASA, 2022), iSpace HAKUTO-R Mission1 (iSpace, 2022) launched, being the first-ever mission launched by a commercial launch service provider aiming to land on the lunar surface. The NASA Artemis program plans initial crewed landings and surface traverses in 2025, supported by the Lunar Gateway. Regular launches will follow to build the lunar systems for a sustained presence as presented in the Artemis Plan (NASA Artemis Plan, 2020), (NASA, 2022). NASA’s contracts with commercial providers through the Commercial Lunar Payload Services program (CLPS, (NASA, n.d.)) will deliver science and technology demonstration missions to the Moon starting in November 2023. The European Space Agency (ESA) Argonaut (ESA Argonaut, 2022) program plans to have recurrent missions to bring payloads to the lunar surface, supporting lunar exploration. These are just a few examples of planned missions that will target Earth’s natural satellite in the next decade, with forecasts of tens of missions per year (NSR, 2022), (Euroconsult, 2020). The large number of missions and the complexity of landing and operating are expected to demand a change of paradigm from the current Earth-based communication and navigation services, that may be combined with onboard sensors. In recent years, several agencies have proposed to deploy cislunar communication and navigation services to support lunar missions (NASA LCRNS, 2022), (ESA Moonlight, 2022), (JAXA, 2022)). All these proposals seek to deploy service-providing satellites in lunar orbit to ease the user missions’ operations. The PNT services objective is to support all types of lunar users (e.g.: orbiters, landers, ascent vehicles, surface crew, rovers, and deployed science payloads). At the same time, NASA and ESA initiated an effort to define a common framework to ensure interoperability among different service providers: the LunaNet framework. The LunaNet Interoperability Specification (NASA and ESA, 2023) covers communication, PNT, and auxiliary services, by establishing a common set of requirements to ensure interoperability. This conference contribution will present the LunaNet PNT services, focusing on the Lunar Augmented Navigation Service (LANS) that would be provided by a system that resembles the Global Navigation Satellite System (GNSS) concept on Earth: constellations of satellites broadcasting a radio navigation signal synchronized to a common reference clock, with augmentations to accommodate users’ needs in an environment away from Earth. This paper includes a description of the high-level LANS concept, and the basic principles defined to ensure interoperability. In addition, it will describe the common S-band PNT Augmented Forward Signal (AFS) and common messages to be adopted for compliance with the LunaNet framework, and the justification of the selected approach.

LunaNet↗

NASA NTRS2011

Human Research Program Integrated Research Plan

Crew health and performance are critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) is essential to enabling extended periods of space exploration because it provides knowledge and tools to mitigate risks to human health and performance. Risks include physiological effects from radiation and hypogravity environments, as well as unique challenges in medical support, human factors, and behavioral or psychological factors. The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies and tools to enable safe, reliable, and productive human space exploration. Without HRP results, NASA will face unknown and unacceptable risks for mission success and post-mission crew health. This Integrated Research Plan (IRP) describes (1) HRP's approach and research activities that are intended to address the needs of human space exploration and serve HRP customers and (2) the method of integration for risk mitigation. The scope of the IRP is limited to the activities that can be conducted with the resources available to the HRP; it does not contain activities that would be performed if additional resources were available. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration.

Steinberg, Susan↗

NASA NTRS2009

Human Research Program Integrated Research Plan

The Integrated Research Plan (IRP) describes the portfolio of Human Research Program (HRP) research and technology tasks. The IRP is the HRP strategic and tactical plan for research necessary to meet HRP requirements. The need to produce an IRP is established in HRP-47052, Human Research Program - Program Plan, and is under configuration management control of the Human Research Program Control Board (HRPCB). Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) is essential to enabling extended periods of space exploration because it provides knowledge and tools to mitigate risks to human health and performance. Risks include physiological and behavioral effects from radiation and hypogravity environments, as well as unique challenges in medical support, human factors, and behavioral or psychological factors. The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies and tools to enable safe, reliable, and productive human space exploration. Without HRP results, NASA will face unknown and unacceptable risks for mission success and post-mission crew health. This Integrated Research Plan (IRP) describes HRP s approach and research activities that are intended to address the needs of human space exploration and serve HRP customers and how they are integrated to provide a risk mitigation tool. The scope of the IRP is limited to the activities that can be conducted with the resources available to the HRP; it does not contain activities that would be performed if additional resources were available. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration.

Source record↗

NASA NTRS2012

Collaborative Business Models for Exploration: - The Expansion of Public-Private Partnerships to Enable Exploration and Improve the Quality of Life on Earth

In May of 2007, The Space Life Sciences Strategy was published, launching a series of efforts aimed at driving human health and performance innovations that both meet space flight needs and benefit life on Earth. These efforts, led by the Space Life Science Directorate (SLSD) at the NASA Johnson Space Center, led to the development and implementation of the NASA Human Health and Performance Center (NHHPC) in October 2010. The NHHPC now has over 100 members including seven NASA centers; other federal agencies; some of the International Space Station partners; industry; academia and non-profits. The NHHPC seeks to share best practices, develop collaborative projects and experiment with open collaboration techniques such as crowdsourcing. Using this approach, the NHHPC collaborative projects are anticipated to be at the earliest possible stage of development utilizing the many possible public-private partnerships in this center. Two workshops have been successfully conducted in 2011 (January and October) with a third workshop planned for the spring of 2012. The challenges of space flight are similar in many respects to providing health care and environmental monitoring in challenging settings on the earth. These challenges to technology development include the need for low power consumption, low weight, in-situ analysis, operator independence (i.e., minimal training), robustness, and limited resupply or maintenance. When similar technology challenges are identified (such as the need to provide and monitor a safe water supply or develop a portable medical diagnostic device for remote use), opportunities arise for public-private partnerships to engage in co-creation of novel approaches for space exploration and health and environmental applications on earth. This approach can enable the use of shared resources to reduce costs, engage other organizations and the public in participatory exploration (solving real-world problems), and provide technologies with multiple uses for space exploration and life on earth. Several examples will be provided that demonstrate the application of a technology to solve a space exploration need and to provide a positive impact to the quality of life on earth.

Davis, Jeffrey R.↗

NASA NTRS1959

Global Aspects of the Exploration of Space

The interest of man in outer space began long ago among uncivilized peoples to whom the face of the sky was clock and almanac; the celestial bodies, objects of worship. Exploration was at first by visual observation, later aided by armillary spheres and quadrants, and still later by more precise measuring instruments, telescopes, and spectroscopes. The information obtained was that borne by the light that was transmitted from the distant celestial object through the atmosphere to the observing instrument on the ground. In recent years the light waves have been supplemented by radio waves as carriers of information from the stars and planets. Men of many nations have contributed through the centuries to the exploration of space by the methods of astronomy. The history of advances in astronomical knowledge and technique includes the records of Chinese, Babylonians, Greeks, Arabians, and of nearly every nation of the modern world. International cooperation was early recognized as essential and beneficial; the countless number of the stars and the vastness of space present mankind with a truly global task. The picture of the universe obtained by the astronomers early stirred the imagination of men to speculate about the existence of life elsewhere in the universe, about means of communication with distant stars, and in the last centuries about the possibility of the travel of man to the moon and planets. Some sought to apply the science and engineering of their day to describe the vehicles to be used. For example, Jules Verne published in 1865 in "From the Earth to the Moon" a description of a gun-launched projectile carrying passengers to orbit the moon. Today we have taken the first steps to bring this inspired vision to reality. The exploration of space by unmanned vehicles carrying scientific apparatus began on October 4, 1957; exploration by man will follow in due course.

Dryden, Hugh L.↗

NASA NTRS2006

Crew Launch Vehicle (CLV) Avionics and Software Integration Overview

On January 14, 2004, the President of the United States announced a new plan to explore space and extend a human presence across our solar system. The National Aeronautics and Space Administration (NASA) established the Exploration Systems Mission Directorate (ESMD) to develop and field a Constellation Architecture that will bring the Space Exploration vision to fruition. The Constellation Architecture includes a human-rated Crew Launch Vehicle (CLV) segment, managed by the Marshall Space Flight Center (MSFC), comprised of the First Stage (FS), Upper Stage (US), and Upper Stage Engine (USE) elements. The CLV s purpose is to provide safe and reliable crew and cargo transportation into Low Earth Orbit (LEO), as well as insertion into trans-lunar trajectories. The architecture's Spacecraft segment includes, among other elements, the Crew Exploration Vehicle (CEV), managed by the Johnson Space Flight Center (JSC), which is launched atop the CLV. MSFC is also responsible for CLV and CEV stack integration. This paper provides an overview of the Avionics and Software integration approach (which includes the Integrated System Health Management (ISHM) functions), both within the CLV, and across the CEV interface; it addresses the requirements to be met, logistics of meeting those requirements, and the roles of the various groups. The Avionics Integration and Vehicle Systems Test (ANST) Office was established at the MSFC with system engineering responsibilities for defining and developing the integrated CLV Avionics and Software system. The AIVST Office has defined two Groups, the Avionics and Software Integration Group (AVSIG), and the Integrated System Simulation and Test Integration Group (ISSTIG), and four Panels which will direct trade studies and analyses to ensure the CLV avionics and software meet CLV system and CEV interface requirements. The four panels are: 1) Avionics Integration Panel (AIP), 2) Software Integration Panel, 3) EEE Panel, and 4) Systems Simulation and Test Panel. Membership on the groups and panels includes the MSFC representatives from the requisite engineering disciplines, the First Stage, the Upper Stage, the Upper Stage Engine projects, and key personnel from other NASA centers. The four panels will take the results of trade studies and analyses and develop documentation in support of Design Analysis Cycle Reviews and ultimately the System Requirements Review.

Monell, Donald W.↗

NASA NTRS1992

Universe exploration vision

U.S. space policy is discussed in terms of present and planned activities in the solar system and beyond to develop a concept for expanding space travel. The history of space exploration is briefly reviewed with references to the Mariner II, Apollo, and Discoverer programs. Attention is given to the issues related to return trips to the moon, sprint vs repetitive missions to Mars, and the implications of propulsion needs. The concept of terraforming other bodies within the solar system so that they can support human activity is identified as the next major phase of exploration. The following phase is considered to be the use of robotic or manned missions that extend beyond the solar system. Reference is given to a proposed Thousand Astronomical Units mission as a precursor to exploratory expansion into the universe, and current robotic mission activities are mentioned.

O'Handley, D.↗

NASA NTRS2018

NASA's Space Launch System and Deep Space Opportunities for Smallsats

Overview of the agency’s plans for deep space exploration: NASA has a phased approach to successful human exploration of deep space; We began LEO (Low Earth Orbit), where we’ve lived aboard the ISS continuously for more than 17 years; What have we learned in those years that will help us put boots on the moon with eyes toward Mars? And also help us on Earth? - Advances in materials research - 3D printing in space - Engineered life support systems for sustained stays in space - Better understanding of the effects of microgravity on the human body - We deploy CubeSats from the ISS (International Space Station) - We’ve cooperate with international partners - We’ve opened transportation to LEO to commercial vehicles; Allowing commercial companies to take over LEO frees NASA to explore deep space - next step is back to the Moon; NASA will establish a lunar Gateway near the moon (near rectilinear halo orbit);The Gateway will be crew tended (30-90 day missions); Gateway will communicate with Earth and lunar surface; Will open new opportunities for robotic exploration of the moon, especially far side of the moon and poles; Prospecting for volatiles will be high on the list of priorities; SLS (Space Launch System)/Orion will participate in gateway assembly and operation; Will serve as a testbed for new technologies and inform future Mars missions; After learning how to live and work in deep space like we did in LEO, NASA will move on Mars missions; SLS’s capability to accommodate primary, co-manifested and secondary payloads (when available) is a key component in making this vision a reality.

Bookout, Paul S.↗

NASA NTRS2006

Cool and Quiet: Partnering to Enhance the Aerodynamic and Acoustic Performance of Installed Electronics Cooling Fans: A White Paper

Breathtaking images of distant planets. Spacewalks to repair a telescope in orbit. Footprints on the moon. The awesome is made possible by the mundane. Every achievement in space exploration has relied on solid, methodical advances in engineering. Space exploration fuels economic development like no other endeavor can. But which advances will make their way into our homes and businesses? And how long will it take? Answers to these questions are dependent upon industrial involvement in government sponsored research initiatives, market demands, and timing. Recognizing an opportunity is half the battle. This proposal describes the framework for a collaborative research program aimed at improving the aerodynamic and acoustic performance of electronics cooling fans. At its best, the program would involve NASA and academic researchers, as well as corporate researchers representing the Information Technology (IT) and fan manufacturing industries. The momentum of space exploration, the expertise resultant from the nation's substantial investment in turbofan noise reduction research, and the competitiveness of the IT industry are intended to be catalysts of innovation.

Koch, L. Danielle↗

NASA NTRS2006

NASA Crew Launch Vehicle Flight Test Process

Davis, Stephan R.↗

NASA NTRS2007

Ares I-X Flight Test Philosophy

In response to the Vision for Space Exploration, the National Aeronautics and Space Administration (NASA) has defined a new space exploration architecture to return humans to the Moon and prepare for human exploration of Mars. One of the first new developments will be the Ares I Crew Launch Vehicle (CLV), which will carry the Orion Crew Exploration Vehicle (CEV), into Low Earth Orbit (LEO) to support International Space Station (ISS) missions and, later, support lunar missions. As part of Ares I development, NASA will perform a series of Ares I flight tests. The tests will provide data that will inform the engineering and design process and verify the flight hardware and software. The data gained from the flight tests will be used to certify the new Ares/Orion vehicle for human space flight. The primary objectives of this first flight test (Ares I-X) are the following: Demonstrate control of a dynamically similar integrated Ares CLV/Orion CEV using Ares CLV ascent control algorithms; Perform an in-flight separation/staging event between an Ares I-similar First Stage and a representative Upper Stage; Demonstrate assembly and recovery of a new Ares CLV-like First Stage element at Kennedy Space Center (KSC); Demonstrate First Stage separation sequencing, and quantify First Stage atmospheric entry dynamics and parachute performance; and Characterize the magnitude of the integrated vehicle roll torque throughout the First Stage (powered) flight. This paper will provide an overview of the Ares I-X flight test process and details of the individual flight tests.

Davis, S. R.↗

NASA NTRS2011

Development of Methodologies, Metrics, and Tools for Investigating Human-Robot Interaction in Space Robotics

Human-robot systems are expected to have a central role in future space exploration missions that extend beyond low-earth orbit [1]. As part of a directed research project funded by NASA s Human Research Program (HRP), researchers at the Johnson Space Center have started to use a variety of techniques, including literature reviews, case studies, knowledge capture, field studies, and experiments to understand critical human-robot interaction (HRI) variables for current and future systems. Activities accomplished to date include observations of the International Space Station s Special Purpose Dexterous Manipulator (SPDM), Robonaut, and Space Exploration Vehicle (SEV), as well as interviews with robotics trainers, robot operators, and developers of gesture interfaces. A survey of methods and metrics used in HRI was completed to identify those most applicable to space robotics. These methods and metrics included techniques and tools associated with task performance, the quantification of human-robot interactions and communication, usability, human workload, and situation awareness. The need for more research in areas such as natural interfaces, compensations for loss of signal and poor video quality, psycho-physiological feedback, and common HRI testbeds were identified. The initial findings from these activities and planned future research are discussed. Human-robot systems are expected to have a central role in future space exploration missions that extend beyond low-earth orbit [1]. As part of a directed research project funded by NASA s Human Research Program (HRP), researchers at the Johnson Space Center have started to use a variety of techniques, including literature reviews, case studies, knowledge capture, field studies, and experiments to understand critical human-robot interaction (HRI) variables for current and future systems. Activities accomplished to date include observations of the International Space Station s Special Purpose Dexterous Manipulator (SPDM), Robonaut, and Space Exploration Vehicle (SEV), as well as interviews with robotics trainers, robot operators, and developers of gesture interfaces. A survey of methods and metrics used in HRI was completed to identify those most applicable to space robotics. These methods and metrics included techniques and tools associated with task performance, the quantification of human-robot interactions and communication, usability, human workload, and situation awareness. The need for more research in areas such as natural interfaces, compensations for loss of signal and poor video quality, psycho-physiological feedback, and common HRI testbeds were identified. The initial findings from these activities and planned future research are discussed.

Ezer, Neta↗

NASA NTRSDate not supplied

Yeast strain development to test in-space bioproduction in the Lunar Explorer Instrument for space biology Applications (LEIA) mission

The Lunar Explorer Instrument for space biology Applications (LEIA) is investigating the effects of lunar radiation and gravity on yeast viability, growth, and metabolism. LEIA is part of the CP-22 Commercial Lunar Payload Services (CLPS) surface mission to the south polar region of the Moon. The biological payload will test genetic factors that are likely to influence the tolerance of yeast for deep space and lunar surface radiation. LEIA is also investigating in-space production of β-carotene in bioengineered yeast. This carotenoid is both an antioxidant and pro-vitamin A- an essential human micronutrient. We report progress on engineering carotenoid-expressing strains to test the impacts of strain background and specific genetic variants on growth and production of β-carotene. To test for enhanced sensitivity to the LEIA mission environment, we generated gene knockouts for the RAD51 DNA damage repair locus as well as the SOD1, SOD2, and TSA1 reactive oxygen species (ROS) defense enzymes. We are also generating strains expected to increase tolerance to abiotic stressors and ROS. To be included in the biology payload, each strain needs to satisfy a series of requirements to be compatible with the mission concept of operations. The LEIA mission will conduct experiments using an autonomous light emitting diode optical detection system and microfluidics incubator to quantify growth, metabolism, and carotenoid production. Strains must produce sufficient carotenoids for bioproduction to be detectable with this optical system. Cells will be loaded into microfluidics cards, desiccated, and stored for 8-12 months prior to the initiation of lunar surface operations. The CLPS lander will operate for one lunar day, and strains will need to grow to stationary phase within 96 hours to ensure that telemetry of LEIA data to Earth can be completed. Genetic variants also need to display expected phenotypes within these optical detection, storage, and growth cycle constraints.

Yeast Engineering↗

NASA NTRS2004

Transitioning a Fundamental Research Program to Align with the NASA Exploration Initiative-Perspectives from Microgravity Combustion Science and Fluid Physics

A new Vision for Space Exploration was announced earlier this year by U.S. President George W. Bush. NASA has evaluated on-going programs for strategic alignment with this vision. The evaluation proceeded at a rapid pace and is resulting in changes to the scope and focus of experimental research that will be conducted in support of the new vision. The existing network of researchers in the physical sciences - a highly capable, independent, and loosely knitted community - typically have shared conclusions derived from their work within appropriate discipline-specific peer reviewed journals and publications. The initial result of introducing this Vision for Space Exploration has been to shift research focus from a broad coverage of numerous, widely varying topics into a research program focused on a nearly-singular set of supporting research objectives to enable advances in space exploration. Two of these traditional physical science research disciplines, Combustion Science and Fluid Physics, are implementing a course adjustment from a portfolio dominated by "Fundamental Science Research" to one focused nearly exclusively on supporting the Exploration Vision. Underlying scientific and engineering competencies and infrastructure of the Microgravity Combustion Science and Fluid Physics disciplines do provide essential research capabilities to support the contemporary thrusts of human life support, radiation countermeasures, human health, low gravity research for propulsion and materials and, ultimately, research conducted on the Moon and Mars. A perspective on how these two research disciplines responded to the course change will be presented. The relevance to the new NASA direction is provided, while demonstrating through two examples how the prior investment in fundamental research is being brought to bear on solving the issues confronting the successful implementation of the exploration goals.

Sutliff, Thomas J.↗