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At least 1,225 records · Page 68

Expression and function of FGF10 in mammalian inner ear development

We have investigated the expression of FGF10 during ear development and the effect of an FGF10 null mutation on ear development. Our in situ hybridization data reveal expression of FGF10 in all three canal crista sensory epithelia and the cochlea anlage as well as all sensory neurons at embryonic day 11.5 (E11.5). Older embryos (E18.5) displayed strong graded expression in all sensory epithelia. FGF10 null mutants show complete agenesis of the posterior canal crista and the posterior canal. The posterior canal sensory neurons form initially and project rather normally by E11.5, but they disappear within 2 days. FGF10 null mutants have no posterior canal system at E18.5. In addition, these mutants have deformations of the anterior and horizontal cristae, reduced formation of the anterior and horizontal canals, as well as altered position of the remaining sensory epithelia with respect to the utricle. Hair cells form but some have defects in their cilia formation. No defects were detected in the organ of Corti at the cellular level. Together these data suggest that FGF10 plays a major role in ear morphogenesis. Most of these data are consistent with earlier findings on a null mutation in FGFR2b, one of FGF10's main receptors. Copyright 2003 Wiley-Liss, Inc.

NASA Discipline Developmental Biology↗

Traction in smooth muscle cells varies with cell spreading

Changes in cell shape regulate cell growth, differentiation, and apoptosis. It has been suggested that the regulation of cell function by the cell shape is a result of the tension in the cytoskeleton and the distortion of the cell. Here we explore the association between cell-generated mechanical forces and the cell morphology. We hypothesized that the cell contractile force is associated with the degree of cell spreading, in particular with the cell length. We measured traction fields of single human airway smooth muscle cells plated on a polyacrylamide gel, in which fluorescent microbeads were embedded to serve as markers of gel deformation. The traction exerted by the cells at the cell-substrate interface was determined from the measured deformation of the gel. The traction was measured before and after treatment with the contractile agonist histamine, or the relaxing agonist isoproterenol. The relative increase in traction induced by histamine was negatively correlated with the baseline traction. On the contrary, the relative decrease in traction due to isoproterenol was independent of the baseline traction, but it was associated with cell shape: traction decreased more in elongated than in round cells. Maximum cell width, mean cell width, and projected area of the cell were the parameters most tightly coupled to both baseline and histamine-induced traction in this study. Wide and well-spread cells exerted larger traction than slim cells. These results suggest that cell contractility is controlled by cell spreading.

Non-NASA Center↗

Equivariant graph convolutional neural networks for the representation of homogenized anisotropic microstructural mechanical response

Composite materials with different microstructural material symmetries are common in engineering applications where grain structure, alloying and particle/fiber packing are optimized via controlled manufacturing. In fact these microstructural tunings can be done throughout a part to achieve functional gradation and optimization at a structural level. To predict the performance of particular microstructural configuration and thereby overall performance, constitutive models of materials with microstructure are needed. In this work we provide neural network architectures that provide effective homogenization models of materials with anisotropic components. These models satisfy equivariance and material symmetry principles inherently through a combination of equivariant and tensor basis operations. We demonstrate them on datasets of stochastic volume elements with different textures and phases where the material undergoes elastic and plastic deformation, and show that the these network architectures provide significant performance improvements.

anisotropy↗

A novel fiber-fretting test for tribological characterization of the fiber/matrix interface

Ceramic matrix composites exhibit excellent high temperature properties and are candidate materials for structural applications from jet engines to nuclear fuel cladding. The strength and deformation behavior of these composites are intrinsically tied to the properties of the fiber/matrix interface. This research introduces a novel technique to evaluate the fundamental friction and wear characteristics of these interfaces. A case study on SiC f /PyC/SiC m composites applies in situ fiber fretting to investigate the kinetic friction coefficient and cyclic wear characteristics of the interphase. The experimental methodology is presented in explicit detail to encourage other researchers to explore the capabilities of this technique. Additionally, testing was carried out as a function of fiber roughness, PyC thickness (≈10, 500, 1200 nm), cycle count (10, 100, 1000), and frequency (1, 5, and 10 Hz). The friction coefficient and wear behavior changed with cycle length due to a transition from adhesive to abrasive mechanisms. SEM fractography provided insights to tribological evolution from adhesive sliding to three-body abrasive wear. The structural disorder at the tribo-surface relating to graphitic content and dangling bond density was investigated using Raman spectroscopy. Properties are contextualized with comparison to uniaxial tensile behavior of the parent composite.

36 MATERIALS SCIENCE↗

Modeling Jupiter's current disc - Pioneer 10 outbound

A model of the magnetic field of the Jovian current disk is presented. The model uses Euler functions and the Biot-Savart law applied to a series of concentric, but not necessarily coplanar current rings. It was found that the best fit to the Pioneer 10 outbound perturbation magnetic field data is obtained if the current disk is twisted, and also bent to tend toward parallelism with the Jovigraphic equator. The inner and outer radii of the disk appear to be about 7 and 150 Jovian radii, respectively; because of the observed current disk penetrations, the bent disk also requires a deformation in the form of a bump or wrinkle whose axis tends to exhibit spiraling. Modeling of the azimuthal field shows that it is due to a thin radial current sheet, but it may actually be due in large part to penetration of a tail current sheet as suggested by Voyager observations.

Jones, D. E.↗

Crustal Deformation and the Seismic Cycle across the Kodiak Islands, Alaska

The Kodiak Islands are located approximately 130 to 250 km from the Alaska-Aleutian Trench where the Pacific plate is underthrusting the North American plate at a rate of about 57 mm/yr. The southern extent of the 1964 Prince William Sound (${M-w}$ = 9.2) earthquake rupture occurred offshore and beneath the eastern portion of the Kodiak Islands. Here we report GPS results (1993-2001) from northern Kodiak Island that span the transition between the 1964 uplift region along the eastern coast and the region of coseismic subsidence further inland. The horizontal velocity vectors range from 22.9 $\pm$ 2.2 mm/yr at N26.3$\deg$W $\pm$ 2.5$\deg$, about 150 km from the trench, to 5.9 $\pm$ 1.3 mm/yr at N65.9$\deg$W $\pm$ 6.6$\deg$, about 190 km from the trench. Near the northeastern coast of Kodiak the velocity vector above the shallow, locked main thrust zone is between the orientation of PCFC-NOAM plate motion (N22$/deg$W) and the trench-normal (N3O$\deg$W). Further west, our geodetic results suggest the accumulation of shear strain that will be released eventually as left-lateral motion on upper plate faults such as the Kodiak Island fault. These results are consistent with the hypothesis that the difference between the Pacific-North American plate motion and the orientation of the down going slab would lead to 4-8 mm/yr of left-lateral slip. Short-term geodetic uplift rates range from 2 - 14 mm/yr, with the maximum uplift located near the axis of maximum subsidence during the 1964 earthquake. We evaluated alternate interseismic models for Kodiak to test the importance of various mechanisms responsible for crustal deformation rates. These models are based on the plate interface slip history inferred from earlier modeling of coseismic and post-seismic geodetic results. The horizontal (trench perpendicular) and vertical deformation rates across Kodiak are consistent with a model that includes the viscoelastic response to : (1) a downgoing Pacific plate interface that is locked at shallow depths,(2) coseismic slip in the 1964 and (3) interseismic creep below the seismogenic zone. The change in orientation of the horizontal velocity vector occurs down-dip from the locked main thrust zone. In southern Kodiak, the coseismic slip in the 1964 earthquake was smaller than in the northern Kodiak region; yet, the horizontal, interseismic velocities as a function of distance from the trench are comparable to those in northern Kodiak. Based on the earthquake history prior to, and following the 1964 earthquake, we hypothesize that the plate interface in southern Kodiak slips in more frequent large earthquakes than in northern Kodiak.

Sauber, Jeanne↗

Luminescence from Self‐Trapped Excitons and Energy Transfers in Vacancy‐Ordered Hexagonal Halide Perovskite Cs 2 HfF 6 Doped with Rare Earths for Radiation Detection

Abstract Compared to halides Cs 2 HfX 6 (X = Cl, Br, I) with a vacancy‐ordered cubic double perovskite structure, the halide Cs 2 HfF 6 (CHF), with a hexagonal Bravais lattice, possesses a higher mass density and chemical stability for radiation detection. Luminescence properties and energy transfer mechanisms of rare‐earths‐doped CHF materials are studied here. The structure of CHF is identified as a new type of vacancy‐ordered hexagonal perovskite, with the same type of building blocks of the double perovskite but stacked with single layers. Density‐functional theory calculations reveal a large bandgap of CHF. A broad emission is observed from the pristine CHF host, which is suggested to be associated with self‐trapped excitons (STEs). A series of rare‐earths‐doped materials are designed utilizing the STE emissions, and efficient energy transfers from STEs and Tb 3+ to Eu 3+ are achieved for tunable emissions. The codoped material shows stable emission under X‐ray irradiation, with 10.2% reduction from its initial emission intensity, associated with possible structural evolution by radiation‐induced deformation of the soft host. The radiation responses of singly and codoped materials are evaluated, and the codoped material is found to be more sensitive to the radiation energy than the singly doped or pristine CHF for radiation detection.

36 MATERIALS SCIENCE↗

Celestial amplitudes as AdS-Witten diagrams

Both celestial and momentum space amplitudes in four dimensions are beset by divergences resulting from spacetime translation and sometimes scale invariance. In this paper we consider a (linearized) marginal deformation of the celestial CFT for Yang-Mills theory which preserves 2D conformal invariance but breaks both spacetime translation and scale invariance and involves a chirally coupled massive scalar. The resulting MHV celestial amplitudes are completely finite (apart from the usual soft and collinear divergences and isolated poles in the sum of the weights) and take the canonical CFT form. Moreover, we show they can be simply rewritten in terms of AdS 3 -Witten contact diagrams which evaluate to the well-known D-functions, thereby forging a direct connection between flat and AdS holography.

79 ASTRONOMY AND ASTROPHYSICS↗

Mechanical performance of co-deposited immiscible Cu–Ta thin films

Abstract The immiscible alloy Cu–Ta has the potential for enhanced mechanical performance in applications as a functional coating. To establish baseline mechanical properties, four Cu–Ta films were co-sputtered at the temperatures 23, 400, 600, and 800 °C and tested with nanoindentation at strain rates 5 $$\times $$ × 10 −3 s −1 to 10 s −1 . Each film had a unique microstructure morphology. The hardness and elastic modulus of the four films were insensitive to strain rate changes. Instead, the measured properties were spatially dependent, particularly in the 600 and 800 °C films. In those two films, there is a bimodal deformation behavior due to Cu-agglomeration under protruding grains and planar Ta-rich regions. Increasing the indentation depth revealed shear band suppression which is related to a homogenous distribution of flow stresses for all four microstructure morphologies. Finally, the Cu–Ta hardness appeared to follow a rule-of-mixtures when compared to extrapolated data of Cu and Ta monolithic films.

36 MATERIALS SCIENCE↗

Fabrication of Scaffold-Based 3D Magnetic Nanowires for Domain Wall Applications

Three-dimensional magnetic nanostructures hold great potential to revolutionize information technologies and to enable the study of novel physical phenomena. In this work, we describe a hybrid nanofabrication process combining bottom-up 3D nano-printing and top-down thin film deposition, which leads to the fabrication of complex magnetic nanostructures suitable for the study of new 3D magnetic effects. First, a non-magnetic 3D scaffold is nano-printed using Focused Electron Beam Induced Deposition; then a thin film magnetic material is thermally evaporated onto the scaffold, leading to a functional 3D magnetic nanostructure. Scaffold geometries are extended beyond recently developed single-segment geometries by introducing a dual-pitch patterning strategy. Additionally, by tilting the substrate during growth, low-angle segments can be patterned, circumventing a major limitation of this nano-printing process; this is demonstrated by the fabrication of ‘staircase’ nanostructures with segments parallel to the substrate. The suitability of nano-printed scaffolds to support thermally evaporated thin films is discussed, outlining the importance of including supporting pillars to prevent deformation during the evaporation process. Employing this set of methods, a set of nanostructures tailored to precisely match a dark-field magneto-optical magnetometer have been fabricated and characterized. This work demonstrates the versatility of this hybrid technique and the interesting magnetic properties of the nanostructures produced, opening a promising route for the development of new 3D devices for applications and fundamental studies.

36 MATERIALS SCIENCE↗

Gravity and suspension effects on the dynamics of controlled structures

The effects of gravity on the actuators, sensors and structural plant of a controlled flexible structure are investigated. These influences include gravity stiffening, gravity induced deformations, gravity influence on inertial sensors and actuators, and the interaction with the suspension system. For each of the four influences, a simplified model is derived, from which the appropriate non-dimensional parameter can be identified, and the magnitude of the influence estimated. The construction of a detailed numerical model, which includes the four gravity influences, is outlined. This modeling procedure is then applied to a simplified model of the Middeck Active Control Eperiment (MACE). The influence on the poles and input-output transfer function is examined for several variations in the plant. The modeling procedure is also applied to the MACE experimental hardware. Experimental and model-based transfer functions are compared to demonstrate the significant improvement by incorporating gravity effects.

Rey, Daniel A.↗

Deformation Behaviors in Single BCC‐Phase Refractory Multi‐Principal Element Alloys under Dynamic Conditions

The mechanical behavior and microstructural evolution of a BCC-phase NbTaTiV refractory multi-principal element alloy (RMPEA) is studied over a wide range of strain rates (10 −3 to 10 3 s −1 ) and temperatures (room temperature to 850 °C). The mechanical property of present RMPEA shows less strain-rate dependence and strong resistance to softening at high temperatures. Under high strain-rate loading, the formation of thin type-I twins is observed, which could lead to an increase in strain-hardening rates. However, this hardening mechanism competes with adiabatic heating effects, resulting in the deterrence of strain-hardening behaviors. In contrast, substantial strain-hardening occurs at cryogenic temperatures due to the formation of twins, which act as stronger barriers to dislocation motion and interact with each other. To further understand the different strain-hardening behaviors, density functional theory (DFT) calculations predict relatively low stacking fault energies and high twinning stress for the NbTaTiV RMPEA.

36 MATERIALS SCIENCE↗

Effects of low-temperature neutron irradiation on the microstructure and tensile properties of duplex 2304 stainless steel and its electron-beam welds

A lean duplex stainless steel material (2304-grade) in its base metal and electron beam (e-beam) welded conditions were studied microstructurally and mechanically as a function of irradiation conditions to evaluate its use as a structural material at low temperatures (60–100 °C). Neutron irradiation up to a fluence of 1.40 × 10 19 n/cm 2 (E > 0.1 MeV) or ~0.011 dpa decreased the total elongation of both base metal and e-beam welded samples. Overall, radiation hardening was observed in all the samples. The transversely cut irradiated samples showed some nonuniform quasi-cleavage and shearing in their fracture surfaces, indicating the variance of ductile nature of the two-phased (deformable austenite and harder ferrite) duplex structure. The e-beam welded samples also showed quasi-cleavage fracture, which is a characteristic of radiation-induced embrittlement. Furthermore, these observations of the e-beam welded samples were attributed to the formation of coarse ferrites, grain boundary and intragranular phases such as γ 2 and γ 3 , and minor impurity phases such as CrN and Cr 2 N in the weld pool and/or heat-affected zone of the samples. Radiation-induced elemental segregation was also identified in the post-irradiated base metal.

36 MATERIALS SCIENCE↗

Ultrafast Formation of Jahn–Teller Polarons Revealed by State-Selective Excitation in Correlated Spinel Co 3 O 4

Jahn–Teller polarons are quasiparticles that stem from symmetry breaking and strong local electron–phonon coupling. They originate from an excess charge carrier being dressed by a local lattice distortion, caused by the Jahn–Teller effect, and they critically impact electrical, structural, and magnetic properties in transition metal oxides. The observation of the microscopic steps involved in their formation is essential for enabling control over material properties through the targeted activation of local, site-specific modifications with light pulses. While Jahn–Teller distortion associated with polaron formation was predicted to contribute significantly to changes in electronic band gap and optical properties in Co 3 O 4 , its experimental observation remains elusive, requiring signatures of local symmetry reduction. In this work, we demonstrate Jahn–Teller polaron formation in spinel Co 3 O 4 . By exciting electronic transitions at 3.10 eV and 1.55 eV, we target either the Oh Cobalt(III) or the Td Cobalt(II) ions, and drive the subsequent coherent responses of the system through two different pathways. For the former, we demonstrate that ligand-to-metal charge transfer leads to Jahn–Teller polaron formation, which is linked to the deformation potential and magnetoelastic coupling. For the latter, we identify the coherent excitation of a T 2g phonon mode launched by on-site d-d electronic transitions. Key to our observations is the ability to target site-specific electronic excitations in spinel Co 3 O 4 using ultrafast optical pulses, while monitoring the ensuing low-energy collective modes through the coherent time-domain response of the material. Our approach, which combines the comparative analysis of experimental fingerprints with the support from density functional theory calculations, is broadly applicable to systems in which Jahn–Teller polaron physics has been theoretically predicted but remains experimentally unverified, and it underscores the potential of electronic-state targeting as a route to selectively excite and probe quasiparticle dynamics in solids.

Lattices↗

Linking electronic structure calculations to generalized stacking fault energies in multicomponent alloys

Abstract The generalized stacking fault energy is a key ingredient to mesoscale models of dislocations. Here we develop an approach to quantify the dependence of generalized stacking fault energies on the degree of chemical disorder in multicomponent alloys. We introduce the notion of a “configurationally-resolved planar fault” (CRPF) energy and extend the cluster expansion method from alloy theory to express the CRPF as a function of chemical occupation variables of sites surrounding the fault. We apply the approach to explore the composition and temperature dependence of the unstable stacking fault energy (USF) in binary Mo–Nb alloys. First-principles calculations are used to parameterize a formation energy and CRPF cluster expansion. Monte Carlo simulations show that the distribution of USF energies is significantly affected by chemical composition and temperature. The formalism is broadly applicable to arbitrary crystal structures and alloy chemistries and will enable the development of rigorous models for deformation mechanisms in high-entropy alloys.

Natarajan, Anirudh Raju (ORCID:0000000202529480)↗

CFT and lattice correlators near an RG domain wall between minimal models

Conformal interfaces separating two conformal field theories (CFTs) provide maps between different CFTs, and naturally exist in nature as domain walls between different phases. One particularly interesting construction of a conformal interface is the renormalization group (RG) domain wall between CFTs. For a given Virasoro minimal model \mathcal{M}_{k+3,k+2} ℳ k + 3 , k + 2 , an RG domain wall can be generated by a specific deformation which triggers an RG flow towards its adjacent Virasoro minimal model \mathcal{M}_{k+2,k+1} ℳ k + 2 , k + 1 with the deformation turned on over part of the space. An algebraic construction of this domain wall was proposed by Gaiotto in [J. High Energy Phys. 12, 103 (2012)]. In this paper, we will provide a study of this RG domain wall for the minimal case k=2 k = 2 , which can be thought of as a nonperturbative check of the construction. In this case the wall is separating the Tricritical Ising Model (TIM) CFT and the Ising Model (IM) CFT. We will check the analytical results of correlation functions from the RG brane construction with the numerical density matrix renormalization group (DMRG) calculation using a lattice model proposed in [arXiv.1206.1332, Science 344, 280 (2014)], and find a perfect agreement. We comment on possible experimental realizations of this RG domain wall.

Cogburn, Cameron V.↗

Oceanic lithosphere and asthenosphere - Thermal and mechanical structure

A coupled thermomechanical subsolidus model of the oceanic lithosphere and asthenosphere is developed which includes vertical heat conduction, a temperature-dependent thermal conductivity, heat advection by a horizontal and vertical mass flow that depends on depth and age, contributions of viscous dissipation or shear heating, a linear or nonlinear deformation law relating shear stress and strain rate, as well as a temperature- and pressure-dependent viscosity. The model requires a constant horizontal velocity and temperature at the surface, but zero horizontal velocity and constant temperature at great depths. The depth- and age-dependent temperature, horizontal and vertical velocities, and viscosity structure of the lithosphere and asthenosphere are determined along with the age-dependent shear stress in those two zones. The ocean-floor topography, oceanic heat flow, and lithosphere thickness are deduced as functions of ocean-floor age; seismic velocity profiles which exhibit a marked low-velocity zone are constructed from the age-dependent geotherms and assumed values of the elastic parameters. It is found that simple boundary-layer cooling determines the thermal structure at young ages, while effects of viscous dissipation become more important at older ages.

Schubert, G.↗

Demonstration of a Segment Alignment Maintenance System on a Seven-Segment Sub-Array of the Hobby-Eberly Telescope

NASA's Marshall Space Flight Center, in collaboration with Blue Line Engineering of Colorado Springs, Colorado, is developing a Segment Alignment Maintenance System (SAMS) for McDonald Observatory's Hobby-Eberly Telescope (HET). The SAMS shall sense motions of the 91 primary mirror segments and send corrections to HET's primary mirror controller as the mirror segments misalign due to thermo-elastic deformations of the mirror support structure. The SAMS consists of inductive edge sensors supplemented by inclinometers for global radius of curvature sensing. All measurements are sent to the SAMS computer where mirror motion corrections are calculated. In October 2000, a prototype SAMS was installed on a seven-segment cluster of the HET. Subsequent testing has shown that the SAMS concept and architecture are a viable practical approach to maintaining HET's primary mirror figure, or the figure of any large segmented telescope. This paper gives a functional description of the SAMS sub-array components and presents test data to characterize the performance of the sub-array SAMS.

Rakoczy, John↗