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At least 127 records · Page 7

Cardiovascular regulation in humans in response to oscillatory lower body negative pressure

The frequency response characteristics of human cardiovascular regulation during hypotensive stress have not been determined. We therefore exposed 10 male volunteers to seven frequencies (0.004-0.1 Hz) of oscillatory lower body negative pressure (OLBNP; 0-50 mmHg). Fourier spectra of arterial pressure (AP), central venous pressure (CVP), stroke volume (SV), cardiac output (CO), heart rate (HR), and total peripheral resistance (TPR) were determined and first harmonic mean, amplitude, and phase angles with respect to OLBNP are presented. AP was relatively well regulated as demonstrated by small oscillations in half amplitude (3.5 mmHg) that were independent of OLBNP frequency and similar to unstressed control spectra. Due to the biomechanics of the system, the magnitudes of oscillations in calf circumference (CC) and CVP decreased with increasing frequency; therefore, we normalized responses by these indexes of the fluid volume shifted. The ratios of oscillations in AP to oscillations in CC increased by an order of magnitude, whereas oscillations in CVP to oscillations in CC and oscillations in AP to oscillations in CVP both tripled between 0.004 and 0.1 Hz. Therefore, even though the amount of fluid shifted by OLBNP decreased with increasing frequency, the magnitude of both CVP and AP oscillations per volume of fluid shifted increased (peaking at 0.08 Hz). The phase relationships between variables, particularly the increasing lags in SV and TPR, but not CVP, indicated that efferent responses with lags of 5-6 s could account for the observed responses. We conclude that, at frequencies below 0.02 Hz, the neural system of humans functioned optimally in regulating AP; OLBNP-induced decreases in SV (by as much as 50%) were counteracted by appropriate oscillations in HR and TPR responses. As OLBNP frequency increased, SV, TPR, and HR oscillations increasingly lagged the input and became less optimally timed for AP regulation.

NASA Discipline Cardiopulmonary↗

Verifying Interfaces and Generating Interface Control Documents for the Alignment and Phasing Subsystem of the Thirty Meter Telescope from a System Model in SysML

This paper presents a novel method for verifying interfaces and generating interface control documents (ICDs) from a system model in SysMLTM. In systems and software engineering, ICDs are key artifacts that specify the interface(s) to a system or subsystem, and are used to control the documentation of these interfaces. ICDs enable independent teams to develop connecting systems that use the specified interfaces. In the context of the Thirty Meter Telescope (TMT), interface control documents also act as contracts for delivered subsystems. The Alignment and Phasing system (APS) is one such subsystem. APS is required to implement a particular interface, and formulates requirements for the interfaces to be provided by other components of TMT that interface with APS. As the design of APS matures, these interfaces are frequently refined, making it necessary for related ICDs to be updated. In current systems engineering practice, ICDs are maintained manually. This manual maintenance can lead to a loss in integrity and accuracy of the documents over time, resulting in the documents no longer reflecting the actual state of the interfaces of a system. We show how a system model in SysMLTM can be used to generate ICDs automatically. The method is demonstrated through application to interface control documents pertaining to APS. Specifically, we apply the method to the interface of APS to the primary mirror control system (M1CS) and of APS to the Telescope Control System (TCS). We evaluate the newly introduced method through application to two case studies.

Troy, Mitchell↗

Physical interaction of the activator protein-1 factors c-Fos and c-Jun with Cbfa1 for collagenase-3 promoter activation

Previously, we determined that the activator protein-1 (AP-1)-binding site and the runt domain (RD)-binding site and their binding proteins, c-Fos.c-Jun and Cbfa, regulate the collagenase-3 promoter in parathyroid hormone-treated and differentiating osteoblasts. Here we show that Cbfa1 and c-Fos.c-Jun appear to cooperatively bind the RD- and AP-1-binding sites and form ternary structures in vitro. Both in vitro and in vivo co-immunoprecipitation and yeast two-hybrid studies further demonstrate interaction between Cbfa1 with c-Fos and c-Jun in the absence of phosphorylation and without binding to DNA. Additionally, only the runt domain of Cbfa1 was required for interaction with c-Jun and c-Fos. In mammalian cells, overexpression of Cbfa1 enhanced c-Jun activation of AP-1-binding site promoter activity, demonstrating functional interaction. Finally, insertion of base pairs that disrupted the helical phasing between the AP-1- and RD-binding sites also inhibited collagenase-3 promoter activation. Thus, we provide direct evidence that Cbfa1 and c-Fos.c-Jun physically interact and cooperatively bind the AP-1- and RD-binding sites in the collagenase-3 promoter. Moreover, the AP-1- and RD-binding sites appear to be organized in a specific required helical arrangement that facilitates transcription factor interaction and enables promoter activation.

Non-NASA Center↗

Valorizing Hydrothermal liquefaction aqueous phase via nanofiltration: Enhancing biocrude production from algal biomass

The hydrothermal liquefaction aqueous phase (HTL-AP), a nutrient- and carbon-rich waste byproduct of the HTL process, can be recirculated to enhance biocrude production efficiency. To avoid dilution of the HTL feedstock and reduced fuel quality associated with recirculating untreated HTL-AP, this study investigated nanofiltration to concentrate organic compounds and separate nutrients from HTL-AP of three algal biomass sources: an algal wastewater treatment system and two from harmful algal blooms in lakes. Up to 99% of the organics were recovered in the concentrated HTL-AP (retentate), and significant increases in both permeate flux and permeation of nitrogenous compounds were achieved by increasing HTL-AP temperature to 45 °C and pH to 11. Recirculating the concentrated HTL-AP increased biocrude yield by 70%-116% and reduced biocrude nitrogen content by up to 12%. The carbon and energy capture in the biocrude also increased by 66% and 68%, respectively.

09 BIOMASS FUELS↗

Subtropical Jet Regulates Arabian Winter Precipitation: A Viable Mechanism

The present study explores the mechanism governing wintertime (November–April) precipitation over the Arabian Peninsula (AP) using a 17-yr-long (2002–18) high-resolution WRF simulation. The composite analysis of strong precipitation events suggests that the equatorward extension of the upper-level jet together with the embedded upper-level trough creates a positive (cyclonic) midlevel vorticity and subsequently generates an anomalous lower-level convergence through Ekman pumping. This leads to the development of an anomalous surface low, which is further enhanced in the presence of the existing Red Sea trough over the AP. This surface low weakens the persistent anticyclone over the AP, shifting it further eastward to the Arabian Sea. The eastward shift in the lower-level anticyclone contributes to the transport of warm, moist air from the Arabian Sea and the Red Sea toward the AP. This warm, moist air converges with the cold and dry air advected by the midlatitude jet and creates a moisture convergence zone, leading to the initiation of convection. We test the proposed mechanism through numerical experiments with modified upper-level wind and demonstrate that a strong, southward intrusion of the jet can indeed lead to precipitation over the AP. The above mechanism also explains the interannual variability of precipitation over the AP. During wet years, we notice approximately 3 m s -1 stronger jet core magnitude and about a 2° equatorward shift of the jet compared to dry years. While the equatorward extension of the jet explains about 21% of the interannual variability, the jet magnitude explains around 7% of the variability during wet years.

54 ENVIRONMENTAL SCIENCES↗

FY24 accomplishments in preparation for startup of Activated Materials Laboratory (AML)

The Activated Materials Laboratory (AML) will be a new radiological facility at the Advanced Photon Source (APS) in Argonne National Laboratory (ANL), adjacent to the high-energy x-ray microscopy (HEXM) beamline in the long beamline building (LBB) constructed under the APS-upgrade (APS-U) project. The AML is a centralized facility to facilitate the safe conduct of experiments on activated materials at the APS. This report provides an overview of the status of the AML as a Nuclear Science User Facilities (NSUF) partner user facility in preparation for the general user access in 2025 upon the commissioning of the APS-U beamlines. The AML's scope, functionality and components are detailed. The NSUF partner beamlines’ commissioning status in the post-APS-U era is provided, along with the AML’s operational updates and operational plan.

73 NUCLEAR PHYSICS AND RADIATION PHYSICS↗

Space shuttle low pressure auxiliary propulsion subsystem design definition: Design handbook

A detailed description of recommended low pressure auxiliary propulsion subsystems (APS) for a space shuttle orbiter and booster is presented. The APS designs are the product of a study to identify and evaluate APS concepts, and to perform in-depth design and performance analyses for the most attractive of these. Selected APS baselines use the main engine propellant tanks as low pressure gas accumulators. For the orbiter, propellants from separate liquid tanks are used for main engine tank resupply. Resupply propellants are first circulated through tubular, passive heat exchangers, where they are vaporized and superheated prior to injection into the main engine tanks. Warm propellant vapors from the main engine tanks are mixed with additional liquid propellants in a downstream liquid/vapor mixer and supplied to the engines at constant temperature and pressure (constant density). The booster APS requires no separate propellant storage, since propellant residuals, trapped in the main engine tanks following boost, are sufficient to meet APS propellant demands.

Bruns, A. E.↗

Relationship of area postrema to three putative measures of motion sickness

Although the rat has an incomplete emetic reflex, several species-specific responses to motion were proposed as measures of 'motion sickness' in rats. The purpose was to determine the dependence of these responses on one of several neural structures known to be essential to motion-induced vomiting in species with a complete emetic reflex. The Area Postrema (AP) was shown to play an important role in the production of motion sickness in vomiting species. The effects of thermo-cautery ablations of the AP on three different responses supposedly reflecting motion sickness in the rat were compared: conditioned taste aversion (CTA); drinking suppression; and fecal boli. Efficacy of the ablations was determined by subjecting ablated, sham-operated, and unoperated control animals to a CTA test which is known to require a functional AP. Animals with AP ablations failed to form CTA when 0.15 M LiCl was paired with a 10 percent sucrose solution, while sham-operated control subjects conditioned as well as the unoperated control subjects. The extent of the ablations was evaluated histologically at the end of the experiment. To determine the effects of the ablations on the measures of motion sickness, all animals were subjected to rotation for 30 min or 90 min on a platform displaced 20 deg from earth horizontal. Results indicate that ablation of AP in the rat has no effect on the formation of CTA to a 4 percent solution of cider paired with motion, on the suppression of drinking immediately after exposure to motion, or on the frequency of fecal boli during exposure to motion. This failure of AP ablations to eliminate the effects of motion on any of these responses discourages their use as equivalents of motion-induced vomiting. The appropriateness of other suggested measures, e.g., pica, remains untested but the dependence of such measures on stimulation more severe than commonly used in motion sickness research and the absence of a demonstration of their dependence on neural structures essential to motion sickness in vomiting species, suggest caution in the use of such responses. Further, until more is known about the neural structures underlying these putative measures, the rat will remain a questionable subject in which to study motion sickness.

R Sutton↗

Reassessment of area postrema's role in motion sickness and conditioned taste aversion

On the basis of classical studies on the role of the area psotrema (AP) in motion-induced emesis it was generally accepted that the AP is an essential structure for the production of vomiting in response to motion. However, in more recent studies it has been demonstrated that vomiting induced by motion can still occur in animals in which the AP has been destroyed bilaterally. It was inferred from some of these more recent studies that the AP plays no role in motion-induced emesis. From the standpoint of the current understanding of central nervous system (CNS) plasticity, redundancy, remodeling, unmasking, regeneration, and recovery of function, however, it is important to realize the limitations of using ablation procedures to determine the functional role of a given neural structure in a highly integrated, adaptable central nervous system (CNS). For example, the results of our recent investigations in cat and squirrel monkey on the role of the AP in emesis and conditioned taste aversion induced by motion indicate that while AP lesions do not prevent motion-induced emesis when animals are tested 30 days or more after surgery, the lesions do change the latency to emesis. Thus, contradictory findings from lesion studies must be evaluated not only in terms of species difference, differences in lesioning techniques and extent of lesions, and in stimulus parameters, but also in terms of duration of the recovery period, during which significant recovery of function may take place. In our judgment, inadequate consideration of the foregoing factors could lead to erroneous inferences about given structure's role in the behavior of the intact, nonablated animal.

N G Daunton↗

The Effect of Solid Constituent Particle Size Distributions on TP-H1148 Propellant Slag

Special aluminum and ammonium perchlorate (AP) particle size distributions were prepared for a matrix of five-inch diameter, center-perforated (CP) motor tests to measure the aluminum oxide slag response in Space Shuttle Reusable Solid Rocket Motor (RSRM) propellant. Previous tests of TP-H1148 propellant in five-inch CP spin motors have shown a correlation between aluminum particle size and generated slag. The motors for this study were cast from thirteen five-gallon propellant mixes which used five particle size levels of aluminum powder, five of unground AP and three of ground AP. Aluminum had the greatest effect on slag formation, the more coarse fractions causing greater slag quantities and larger slag particles. Unground AP had about half the effect of aluminum with the coarser fractions again producing more and larger sized slag particles. The variation in ground AP did not have a significant effect on slag formation. Quench bomb tests showed the same trends as the spin motors, that is, larger aluminum and AP particle size distributions generated larger slag particles leaving the propellant surface. Cured propellant mechanical properties were also impacted by particle size variation.

May, Douglas H.↗

Experimental and Numerical Study of Ammonium Perchlorate Counterflow Diffusion Flames

Many solid rocket propellants are based on a composite mixture of ammonium perchlorate (AP) oxidizer and polymeric binder fuels. In these propellants, complex three-dimensional diffusion flame structures between the AP and binder decomposition products, dependent upon the length scales of the heterogeneous mixture, drive the combustion via heat transfer back to the surface. Changing the AP crystal size changes the burn rate of such propellants. Large AP crystals are governed by the cooler AP self-deflagration flame and burn slowly, while small AP crystals are governed more by the hot diffusion flame with the binder and burn faster. This allows control of composite propellant ballistic properties via particle size variation. Previous measurements on these diffusion flames in the planar two-dimensional sandwich configuration yielded insight into controlling flame structure, but there are several drawbacks that make comparison with modeling difficult. First, the flames are two-dimensional and this makes modeling much more complex computationally than with one-dimensional problems, such as RDX self- and laser-supported deflagration. In addition, little is known about the nature, concentration, and evolution rates of the gaseous chemical species produced by the various binders as they decompose. This makes comparison with models quite difficult. Alternatively, counterflow flames provide an excellent geometric configuration within which AP/binder diffusion flames can be studied both experimentally and computationally.

Smooke, M. D.↗

Web Exploration Tools for a Fast Federated Optical Survey Database

We implemented several new web-based tools to improve the efficiency and versatility of access to the APS Catalog of the POSS I (Palomar Observatory-National Geographic Sky Survey) and its associated image database. The most important addition was a federated database system to link the APS Catalog and image database into one Internet-accessible database. With the FDBS, the queries and transactions on the integrated database are performed as if it were a single database. We installed Myriad the FDBS developed by Professor Jaideep Srivastava and members of his group in the University of Minnesota Computer Science Department. It is the first system to provide schema integration, query processing and optimization, and transaction management capabilities in a single framework. The attached figure illustrates the Myriad architecture. The FDBS permits horizontal access to the data, not just vertical. For example, for the APS, queries can be made not only by sky position, but also by any parameter present in either of the databases. APS users will be able to produce an image of all the blue galaxies and stellar sources for comparison with x-ray source error ellipses from AXAF (X Ray Astrophysics Facility) (Chandra) for example. The FDBS is now available as a beta release with the appropriate query forms at our web site. While much of our time was occupied with adapting Myriad to the APS environment, we also made major changes in Star Base, our DBMS for the Catalog, at the web interface to improve its efficiency for issuing and processing queries. Star Base is now three times faster for large queries. Improvements were also made at the web end of the image database for faster access; although work still needs to be done to the image database itself for more efficient return with the FDBS. During the past few years, we made several improvements to the database pipeline that creates the individual plate databases queries by StarBase. The changes include improved positions especially for galaxies, using a new median centroider and integrated magnitudes for galaxies with an improved density-to-intensity calibration with a "sky" background subtraction. In the original version of StarBase the object classification fainter than 19.5-20.0 mag., was an extrapolation of the networks trained on brighter objects. We have used a new catalog of galaxies at the NGP to train a neural network on objects fainter than 20th mag. This improved classification is used in the new version of StarBase. We have also added a FITS table option for the returned data from queries on the object catalog. The APS image database includes images in both colors so we have added a tool for querying the image database in both colors simultaneously. The images can be displayed in parallel or blinked for comparison.

Humphreys, Roberta M.↗

An Overview of Combustion Mechanisms and Flame Structures for Advanced Solid Propellants

Ammonium perchlorate (AP) and cyclotretamethylenetetranitramine (HMX) are two solid ingredients often used in modern solid propellants. Although these two ingredients have very similar burning rates as monopropellants, they lead to significantly different characteristics when combined with binders to form propellants. Part of the purpose of this paper is to relate the observed combustion characteristics to the postulated flame structures and mechanisms for AP and HMX propellants that apparently lead to these similarities and differences. For AP composite, the primary diffusion flame is more energetic than the monopropellant flame, leading to an increase in burning rate over the monopropellant rate. In contrast the HMX primary diffusion flame is less energetic than the HMX monopropellant flame and ultimately leads to a propellant rate significantly less than the monopropellant rate in composite propellants. During the past decade the search for more energetic propellants and more environmentally acceptable propellants is leading to the development of propellants based on ingredients other than AP and HMX. The objective of this paper is to utilize the more familiar combustion characteristics of AP and HMX containing propellants to project the combustion characteristics of propellants made up of more advanced ingredients. The principal conclusion reached is that most advanced ingredients appear to burn by combustion mechanisms similar to HMX containing propellants rather than AP propellants.

Beckstead, M. W.↗

Examples of Unsteady Combustion in Non-Metallized Propellants

For over thirty years the T-Burner has been the de facto standard for determining the unstable response of solid propellants. This paper reviews some of the different approaches that have been used, and briefly summarizes advantages and disadvantages of the different techniques. Data from a variety of sources have been reviewed and summarized showing the effect of various test conditions and propellant formulation variations. Much of the data taken in the 60's and early 70's were with so-called research propellants, with relatively low solids loading and usually monomodal AP as the oxidizer. Later data were obtained with propellants containing solids loading more typical and practical propellants. Several distinct differences were observed in the data for the different types of propellants. Data varying AP particle size distributions indicate that either additional fine AP or finer AP usually increases the propellant response. A significant reduction in the response can be achieved by reducing the amount of fine AP, while holding burning rate constant either by adding a catalyst or by varying the overall AP size distribution. A significant amount of data has been obtained for reduced smoke propellants containing stability additives. The data indicate that the additives provide significant particle damping, and most often, also reduce the propellant response. Data from double base propellants indicate a much broader response over a wide frequency range. This implies that double base propellants should be more unstable in tangential modes than composite propellants. This trend seems to be consistent with observed motor data. Measuring the response of metallized propellants has been a challenge due to the large damping due to metal oxide particles in the gas. Data from metallized propellants are not presented here, but will be summarized in a future paper.

Beckstead, M. W.↗

LabHEART: an interactive computer model of rabbit ventricular myocyte ion channels and Ca transport

An interactive computer program, LabHEART, was developed to simulate the action potential (AP), ionic currents, and Ca handling mechanisms in a rabbit ventricular myocyte. User-oriented, its design allows switching between voltage and current clamp and easy on-line manipulation of key parameters to change the original formulation. The model reproduces normal rabbit ventricular myocyte currents, Ca transients, and APs. We also changed parameters to simulate data from heart failure (HF) myocytes, including reduced transient outward (I(to)) and inward rectifying K currents (I(K1)), enhanced Na/Ca exchange expression, and reduced sarcoplasmic reticulum Ca-ATPase function, but unaltered Ca current density. These changes caused reduced Ca transient amplitude and increased AP duration (especially at lower frequency) as observed experimentally. The model shows that the increased Na/Ca exchange current (I(NaCa)) in HF lowers the intracellular [Ca] threshold for a triggered AP from 800 to 540 nM. Similarly, the decrease in I(K1) reduces the threshold to 600 nM. Changes in I(to) have no effect. Combining enhanced Na/Ca exchange with reduced I(K1) (as in HF) lowers the threshold to trigger an AP to 380 nM. These changes reproduce experimental results in HF, where the contributions of different factors are not readily distinguishable. We conclude that the triggered APs that contribute to nonreentrant ventricular tachycardia in HF are due approximately equally (and nearly additively) to alterations in I(NaCa) and I(K1). A free copy of this software can be obtained at http://www.meddean.luc.edu/lumen/DeptWebs/physio/bers.html.

NASA Discipline Cardiopulmonary↗

An Examination of Selected Geomagnetic Indices in Relation to the Sunspot Cycle

Previous studies have shown geomagnetic indices to be useful for providing early estimates for the size of the following sunspot cycle several years in advance. Examined this study are various precursor methods for predicting the minimum and maximum amplitude of the following sunspot cycle, these precursors based on the aa and Ap geomagnetic indices and the number of disturbed days (NDD), days when the daily Ap index equaled or exceeded 25. Also examined is the yearly peak of the daily Ap index (Apmax), the number of days when Ap greater than or equal to 100, cyclic averages of sunspot number R, aa, Ap, NDD, and the number of sudden storm commencements (NSSC), as well the cyclic sums of NDD and NSSC. The analysis yields 90-percent prediction intervals for both the minimum and maximum amplitudes for cycle 24, the next sunspot cycle. In terms of yearly averages, the best regressions give Rmin = 9.8+/-2.9 and Rmax = 153.8+/-24.7, equivalent to Rm = 8.8+/-2.8 and RM = 159+/-5.5, based on the 12-mo moving average (or smoothed monthly mean sunspot number). Hence, cycle 24 is expected to be above average in size, similar to cycles 21 and 22, producing more than 300 sudden storm commencements and more than 560 disturbed days, of which about 25 will be Ap greater than or equal to 100. On the basis of annual averages, the sunspot minimum year for cycle 24 will be either 2006 or 2007.

Wilson, Robert M.↗

Medical Decision Making in the Physician Hierarchy: A Pilot Pedagogical Evaluation

Context: Recently, The American College of Graduate Medical Education (ACGME) has included the medical decision making as a core competency in several specialties. To date, the ability to demonstrate and measure a pedagogical evolution of medical judgment in a medical education program has been limited. Objective: In this study we hope to examine differences in medical decision making ability of different physicians across their various stages of post-graduate hierarchy. Method: Physcians spanning a wide spectrum of scientific disciplines were recruited for three catagories: administrative physicians(AP) representing physcians with the most experience but mostly practice administratively; resident physicians completing their postgraduate medical training (RP) and seasoned attending physicians with mastery level experience (MP). Participants completed four medical simulations focused on abdominal pain: cholecystitis (CH) and renal colic(RC) and chest pain; Cardiac ischemia (STEMI) and pneumothorax (PX). Simulation were ordered randomly so that there was no systematic bias due to learning or to fatigue. The Medical judgment metric (MJM) was used to evaluate medical decision-making. Results: There were no significant differences between the AP, RP, and MP groups in the gender, race, ethnicity, education, and baseline heart rate. There was a significant (p=0.002) interaction effect for simulation time and RP group, 6.2 minutes (+/-1.58); MP group, 8.7 minutes (+/-2.46); and AP group, 10.3 minutes (+/-2.78). The RC MJM scores were significantly (P=0.10) worse in the AP group 12.3 (+/-2.66) then the RP 14.7(+/-1.15) and MP17.7 (+/-1.15) groups. In every simulation, the AP group MJM scores were worse on average (no significantly) compared to the MP and RP groups. The AP group was significantly (P=0.040) less likely to stabilize the subject in the RC simulation than MP and RP groups. Conclusion: There remains significant variability in the medical education and skill retention influences medical decision making throughout a physician's career.

Rosasco, John↗

Measurements of source emittance and beam coherence properties of the upgraded Advanced Photon Source

The Advanced Photon Source (APS) has been upgraded with a multi-bend achromat lattice, achieving significantly reduced electron beam emittance and enhanced X-ray coherence. Precise characterization of these properties is essential for optimizing beamline performance and enabling new experiments that take full advantage of the upgraded source. We report on measurements of source size and transverse coherence properties using grating interferometry at two beamlines: the APS 3-ID-B undulator beamline and the 1-BM-B bending magnet beamline. The results confirm the world-record horizontal emittance of the upgraded APS below 30 pm rad and validate the theoretical design parameters. We further investigate the impact of optical aberrations and mechanical vibrations at the 12-ID-C beamline on coherence preservation. These measurements establish a benchmark for future beamline enhancements and demonstrate the effectiveness of grating interferometry for high-precision beam characterization. Our findings provide critical insights into synchrotron beam dynamics, coherence degradation mechanisms, and strategies for optimizing beamline X-ray optics at next-generation light sources.

Advanced Photon Source↗