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INTRODUCTION Lunar dust exposure is an unavoidable hazard during lunar surface operations. Given the large number of surface EVAs expected to be performed during Artemis missions, it is critical that the incidence and extent of symptoms resulting from contact with lunar dust be fully understood in order to accurately predict the resources needed to treat Artemis astronauts. The purpose of this study will be to gather the latest data regarding the risk of and severity of symptoms associated with lunar dust exposure and refine the estimates of the impact of lunar dust on astronaut health for PRA models, both those in operational use and those currently being developed. METHODS The latest data on the pathophysiologic effects of lunar dust on humans will be gathered by querying the peer-reviewed literature as well as NASA technical documents. This data will be supplemented with discussions with hardware designers regarding methods used to mitigate exposure to lunar dust during lunar surface operations. Taken together, this data will be used to refine both the estimates for exposure to lunar dust for astronauts inside and outside lunar habitats, as well as provide evidence to guide estimates for the percentage of astronauts who are exposed to lunar dust who will be symptomatic. RESULTS Querying the peer-reviewed literature and NASA technical documents will begin in October of 2024, with the goal of codifying this information by the end of October. In parallel, discussions will begin with hardware engineering teams, also in October. Using the evidence found will help refine the estimate for resources needed to treat astronauts who exhibit symptoms from lunar dust exposure. DISCUSSION Lunar dust exposure is expected to be a major risk for upcoming exploration missions that include a lunar surface interval. Until recently, most of the information to inform the risk associated with lunar dust exposure has come from anecdotal evidence from Apollo astronauts about their symptoms while on the lunar surface; however, this evidence is sparse. Newer studies are now coming out, looking at the impact of lunar dust on human physiology, including studies on effects to the immune system. Additionally, there are new engineering efforts to attempt to mitigate the exposure to lunar dust from the space suits of astronauts returning to the lunar habitat after surface operations. Thus, developing an updated risk assessment, based on our current understanding of human physiology and our current resources for risk mitigation, is prudent to best estimate overall human health and performance risk for future Artemis missions. This project will lead to an updated and more accurate assessment of the risk of lunar dust exposure for exploration missions and will therefore allow mission planners to more accurately predict resources needed for these exploration-class missions.