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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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118 records · Page 7
All sourcesNASA NTRSDOE OSTI
NASA NTRSDate not supplied

BLOOD-BASED MULTI-SCALE MODEL FOR CANCER RISK FROM GCR IN GENETICALLY DIVERSE POPULATIONS

OBJECTIVES AND METHODS This project addresses the challenge of understanding and predicting individual radiation sensitivity by integrating genetics, demographics and biomarker characteristics across species (mice and humans). We hypothesize that ex vivo DNA repair response to GCR components is a central determinant of cancer risk from space radiation and can serve as a biomarker of radiation risk in combination with genetics. Automated image quantification of 53BP1+ radiation-induced foci (RIF) during the first 4-48 h post-irradiation was performed as a function of dose and LET in non-immortalized primary skin fibroblasts derived from 76 mice across 15 strains (5 inbred reference strains and 10 collaborative-cross strains) exposed to X rays (0.1, 1 and 4 Gy), 350 MeV/n 40Ar and 600 MeV/n 56Fe (1.1 and 3 particles/100μm2), as well as in peripheral blood mononuclear cells (PBMCs) from 768 healthy donors (matched ethnicity, 50/50 male/female, 18-70 years old) exposed to gamma rays (0.1 and 1 Gy), 350 MeV/n 28Si, 350 MeV/n 40Ar and 600 MeV/n 56Fe (1.1 and 3 particles/100μm2). QUANTIFICATION OF 53BP1+ FOCI IN VITRO AND ASSOCIATIONS TO IN VIVO RADIATION SUSCEPTIBILITY IN 15 MOUSE STRAINS We reported in vitro repair kinetic and repairable fractions of RIF for the 15 mouse strains and introduced a mathematical model for RIF as a function of time, dose and LET. We noted that the metabolic activity of cells modulates the RIF response, and we introduced the open access tool terRIFic (Tool for Enhanced Results of RIF In Cells, https://radbiolab.shinyapps.io/terrific/) to correct for such bias using confluence level. Notably, at 4h post-irradiation, RIF/Gy decreased with dose or LET: as the dose or LET increases, so does the proximity of DNA double-strand-breaks (DSB) and our data suggest that proximal DSBs are brought together inside isolated RIF for repair. The RIF/Gy trend was inverted at 24h, suggesting RIF with high DSB content are more difficult to repair. We showed that in vitro metrics correlate with in vivo measurements in the same 15 mouse strains, such as survival levels of immune cells or spontaneous cancer incidence, suggesting a relationship between the efficiency of DSB repair and cancer risk or radiation toxicity. In addition to the efficiency of repair and persistent RIF, the amount of spontaneous foci before irradiation was also found to be strain dependent. Finally, we performed genome-wide association study in the same 15 mouse strains using all RIF phenotypes measured in vitro, identifying genes of interest and validating RIF as an ideal biomarker for individual radiation sensitivity. BASELINE 53BP1+ FOCI PREDICTS INDIVIDUAL HUMAN RESPONSE TO GCR COMPONENTS Based on the analysis of radiation responses of 576 donor PBMCs (using quantification of 53BP1+ foci, oxidative stress and cell death), we observed a wide variability of subject- and LET-dependent radiation responses, with radiation-induced DNA repair foci increasing with LET, though oxidative stress being notably reduced by high-LET irradiation, potentially due to a switch between hydrogen peroxide and oxygen radical-based mechanisms. We identified a relationship between few spontaneous DNA foci at baseline and increased DNA repair after irradiation, accompanied by an alteration in immunoregulatory cytokine secretion, which might be adapted as biomarkers to predict ionizing radiation sensitivity. Among demographic variables, only latent cytomegalovirus infection and age were predictive of high baseline foci formation. Finally, we have performed low-throughput whole genome sequencing of all samples and are currently in the process of identifying the genes and pathways associated with low and high-LET ionizing radiation sensitivity in humans.

53BP1↗
NASA NTRS2019

An Integrated Data Analytics Platform

An Integrated Science Data Analytics Platform is an environment that enables the confluence of resources for scientific investigation. It harmonizes data, tools and computational resources which subsequently enable the research community to focus on the investigation rather than spending time on security, data preparation, management, etc. OceanWorks is a NASA technology integration project to establish a cloud-based Integrated Ocean Science Data Analytics Platform at NASA’s Physical Oceanography Distributed Active Archive Center (PO.DAAC) for big ocean science. It focuses on advancement and maturity by bringing together several NASA open-source, big data projects for parallel analytics, anomaly detection, in-situ to satellite data matchup, quality-screened data subsetting, search relevancy, and data discovery. Our communities are relying on data distributed through data centers such as the PO.DAAC, COAPS, NCAR, and many others to conduct their research. In typical investigations, scientists would engage in: search for data, evaluate the relevance of that data, download it, and then apply algorithms to identify trends. Such workflow cannot scale if the research involves a massive amount of data or multi-variate measurements. NASA’s Surface Water and Ocean Topography (SWOT) mission is expected to produce massive amount of observational data during its 3-year nominal mission. Collections like SWOT challenges all existing Earth Science data archival, distribution and analysis paradigms. In this paper, we will discuss how OceanWorks enhances the analysis of physical ocean data where the computation is done on an elastic cloud platform next to the archive to deliver fast, web-accessible services for working with oceanographic measurements.

Yang, Chaowei↗
NASA NTRS2020

Intellectual Property and Licensing in the Commercial Space Age

The commercial space industry is undergoing a paradigm shift from the time when governments and very large space companies dominated the industry. A confluence of laws allowing commercial space companies to operate in unprecedented ways, new technologies enabling new commercial space applications, and an influx of risk capital has drastically changed the space industry landscape. As small and medium-sized companies enter the commercial space realm, they will seek a competitive advantage, and universities and the NASA space centers are positioned to offer such advantages. The commercial space industry has recently become an active area of technology partnering and licensing, even for technologies that have experienced poor licensing performance in the past. The Jet Propulsion Laboratory is seeing unprecedented technology transfer activity in the areas of spacecraft navigation, mission design, space antennas, thrusters, radio occultation, and specialized satellites. Intellectual property rights and partnering play a crucial role in the ability of the private sector to invest in these technologies and to drive space technologies forward. Participants in this burgeoning field seek the most cutting-edge innovations to attain a competitive advantage, and it is crucial for those in the university and public sector to gain an understanding of the market forces that are driving the commercial space business.

Broderick, Daniel↗
NASA NTRS2020

Intellectual Property and Licensing in the Commercial Space Age

The commercial space industry is undergoing a paradigm shift from the time when governments and very large space companies dominated the industry. A confluence of laws allowing commercial space companies to operate in unprecedented ways, new technologies enabling new commercial space applications, and an influx of risk capital has drastically changed the space industry landscape. As small and medium-sized companies enter the commercial space realm, they will seek a competitive advantage, and universities and the NASA space centers are positioned to offer such advantages. The commercial space industry has recently become an active area of technology partnering and licensing, even for technologies that have experienced poor licensing performance in the past. The Jet Propulsion Laboratory is seeing unprecedented technology transfer activity in the areas of spacecraft navigation, mission design, space antennas, thrusters, radio occultation, and specialized satellites. Intellectual property rights and partnering play a crucial role in the ability of the private sector to invest in these technologies and to drive space technologies forward. Participants in this burgeoning field seek the most cutting-edge innovations to attain a competitive advantage, and it is crucial for those in the university and public sector to gain an understanding of the market forces that are driving the commercial space business.

Broderick, Daniel↗
NASA NTRS2022

Using Sentinel-1 and GRACE Satellite Data to Monitor the Hydrological Variations Within the Tulare Basin, California

Subsidence induced by groundwater depletion is a grave problem in many regions around the world, leading to a permanent loss of groundwater storage within an aquifer and even producing structural damage at the Earth’s surface. California’s Tulare Basin is no exception, experiencing about a meter of subsidence between 2015 and 2020. However, understanding the relationship between changes in groundwater volumes and ground deformation has proven difficult. We employ surface displacement measurements from Interferometric Synthetic Aperture Radar (InSAR) and gravimetric estimates of terrestrial water storage from the Gravity Recovery and Climate Experiment (GRACE) satellite pair to characterize the hydrological dynamics within the Tulare basin. The removal of the long-term aquifer compaction from the InSAR time series reveals coherent short-term variations that correlate with hydrological features. For example, in the winter of 2018–2019 uplift is observed at the confluence of several rivers and streams that drain into the southeastern edge of the basin. These observations, combined with estimates of mass changes obtained from the orbiting GRACE satellites, form the basis for imaging the monthly spatial variations in water volumes. This approach facilitates the quick and effective synthesis of InSAR and gravimetric datasets and will aid efforts to improve our understanding and management of groundwater resources around the world.

Donald W. Vasco↗
NASA NTRS2024

Impact of Simulated Microgravity on Mesenchymal Stem Cell Proliferation

Background Long term exposure to microgravity has adverse effects on human body such as bone loss. Due to the vital role of mesenchymal stem cell (MSC) in bone regeneration, studying MSC under microgravity conditions has been of interest during the past decade. However, high cost and limited access to space flight can dampen enthusiasm of researchers. Microgravity simulators provide a way to investigate the effects of microgravity in human physiology. Methods In this study, we compared MSC cultures under simulated microgravity using random positioning machine (RPM) and Gravite 3D simulators. Two culture durations, 1 week and 2 weeks, were selected for MSC cultures without media change. To evaluate impact of simulated microgravity on cell proliferation, cell counting was performed using trypan blue exclusion assay. Additionally, RNA samples and conditioned media were collected for further analysis. Results After 1 week and 2 weeks, no cell morphology change was observed from RPM and Gravite cultures compared to control. Notably, distinct lower cell confluence at the edge of the flasks on the RPM was observed, which could be caused by fluid sheer forces. MSCs cultured on both microgravity simulators showed decreased cell proliferation after 1-week culture. After 2-week culture, cells grown on the RPM showed no significant difference in cell proliferation compared with control while cells cultured on the Gravite bioreactor showed significantly enhanced MSC proliferation. Conclusion Type of microgravity simulator and duration of culture significantly affect MSC proliferation. Further investigation into how simulated microgravity influences MSC gene expression and cytokine secretion related to bone loss is currently on going in our lab.

Cuiping Zhang↗
NASA NTRS2022

Gender Diversity in Heliophysics

Science is conducted by people. When those people do not feel safe in their workplace, they will struggle to produce quality science. The American scientific community has traditionally been dominated by cisgender white men–cisgender meaning that their gender aligns with the one assigned to them at birth. Individuals who are not part of this dominant demographic group have historically been excluded from scientific debate. However, the demographic landscape is changing rapidly [e.g., Jones (2022)], and organizations must ensure early career scientists of all identities feel accepted so they can achieve their goals in the field. Heliophysics describes the confluence and interaction of historically delineated scientific disciplines, including plasma, solar, and space physics. The scientific architecture of our field is founded on collaboration between people with diverse interests, backgrounds, skill sets, and ways of approaching problems. It should follow that the cohort of heliophysicists is at least as diverse as our research problems. A framing often referred to as “the business case” for diversity holds that perspectives different than our own enrich the ways in which we solve problems and communicates the positive outcomes for diverse working groups Starck et al. (2021). However, this rationale is insufficient in scope and uncompassionate in motivation; the safety of marginalized individuals is just as important as the achievements of a group. From the expectations that marginalized people outperform in order to prove themselves to the tokenization of their inclusion in an otherwise normative space, the “business case” for diversity is often harmful to historically marginalized individuals Haacker et al. (2022). The primary motivation for a diverse constituency of heliophysicists ought to be equity. Only by accepting the authentic selves of our fellow heliophysicists can we create an environment in which they have the mental and emotional safety necessary to do their best work. This white paper focuses on a particular axis of identity which the authors believe lacks visibility within heliophysics: gender expansion. It begins with definitions, explains the current landscape, and suggests actions toward a better future. The authors seek to shed light on these issues so that we can work together as a community to create a more inclusive, safe, and welcoming space for people of all identities.

M. Kenny↗
NASA NTRSDate not supplied

Monitoring and Assessing Heat Vulnerability to Identify Locations for Heat Mitigation Efforts in Sarasota, Florida

Located in the coastal subtropical region, Florida’s Sarasota County receives plenty of sunlight for more than half of the year. However, the ongoing rise in summer temperatures attributed to climate change poses an increasing vulnerability to extreme heat for the residents. Moreover, the area's high relative humidity exacerbates the discomfort of high temperatures, thereby intensifying the severity of heat events and elevating the risks of heat-related illnesses. Our collaborations with Sarasota County Sustainability underscore shared concerns about the impact of urban heat island (UHI) on the community. We utilized Earth observation data from NASA Landsat 8 and Landsat 9’s Thermal Infrared Sensors (TIRS) and the International Space Station’s Ecosystem Spaceborne Thermal Radiometer Experiment on Space Station (ECOSTRESS) to model UHI effects within the county during the summer from 2019 to 2023. By implementing the open-source Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) Urban Cooling software model, ArcGIS ModelBuilder, and principal component analysis, we identified the land surface temperature variance within the county and areas that are least capable of mitigating the effects of UHI. In addition, we use socioeconomic and demographic data as indicators to quantify vulnerability at the census tract level. The results revealed that heat intensity varies significantly across Sarasota County, with the highest temperatures being in the more developed western part of the region. We pinpointed that at least three vulnerable communities reside in high-heat regions: North Sarasota, Venice, and North Port. These areas demonstrate a confluence between socioeconomic sensitivity and environmental hazard, indicating a high priority in future heat mitigation efforts.

Theresia Phoa↗
NASA NTRS2018

Computer Programming Resources 2018

The document is a compilation of Computer Programming resources. It is geared toward front-end and back-end web development. It specializes on an ongoing project to create a website for the Safety and Mission Assurance Directorate. The Quality Assurance System (QAS) is intended to improve the overall quality and efficiency of communication among NASA Quality Assurance Engineers and Contractors. The use of QAS software will be limited to NASA Kennedy Space Center and Contractors. It is accessible through the KSC network.

Confluence↗