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At least 127 records · Page 7

Test of the antiorthostatic suspension model on mice - Effects on the inflammatory cell response

The antiorthostatic suspension model was tested for use as a 1G model to study the effects of factors that will be encountered during space travel on inflammation. No differences were found in inflammatory cells induced in antiorthostatically suspended mice. However, the superoxide response (used for oxidative killing of bacteria such as S. aureus) was impaired in antiorthostatically oriented mice compared to control mice. Elevated corticosterone levels were found in antiorthostatically suspended mice, indicating that stress may be a factor in the model. If the stress factor of the model correlates with the physiological stress of space flight, antiorthostatic suspension may be an acceptable model for studying inflammatory responses in mice.

Rosenkrans, Charles F., Jr.↗

Differences in glycogen, lipids, and enzymes in livers from rats flown on Cosmos 2044

Livers from rats flown aboard Cosmos 2044 were analyzed for protein, carbohydrate (glycogen), and lipids as well as the activities of a number of key enzymes involved in metabolism of these compounds and xenobiotics. The major differences between the flight group and the synchronous control were elevations in microsomal protein, liver glycogen content, tyrosine aminotransferase, and tryptophan oxygenase and reductions in sphingolipids and the rate-limiting enzyme of heme biosynthesis delta-aminolevulinic acid synthase. These results provide further evidence that spaceflight has pronounced and diverse effects on liver function; however, some of the results with samples from Cosmos 2044 differed notably from those from previous spaceflights. This may be due to conditions of spaceflight and/or the postflight recovery period for Cosmos 2044.

Merrill, Alfred H., Jr.↗

Animal model of neuropathic tachycardia syndrome

Clinically relevant autonomic dysfunction can result from either complete or partial loss of sympathetic outflow to effector organs. Reported animal models of autonomic neuropathy have aimed to achieve complete lesions of sympathetic nerves, but incomplete lesions might be more relevant to certain clinical entities. We hypothesized that loss of sympathetic innervation would result in a predicted decrease in arterial pressure and a compensatory increase in heart rate. Increased heart rate due to loss of sympathetic innervation is seemingly paradoxical, but it provides a mechanistic explanation for clinical autonomic syndromes such as neuropathic postural tachycardia syndrome. Partially dysautonomic animals were generated by selectively lesioning postganglionic sympathetic neurons with 150 mg/kg 6-hydroxydopamine hydrobromide in male Sprague-Dawley rats. Blood pressure and heart rate were monitored using radiotelemetry. Systolic blood pressure decreased within hours postlesion (Delta>20 mm Hg). Within 4 days postlesion, heart rate rose and remained elevated above control levels. The severity of the lesion was determined functionally and pharmacologically by spectral analysis and responsiveness to tyramine. Low-frequency spectral power of systolic blood pressure was reduced postlesion and correlated with the diminished tyramine responsiveness (r=0.9572, P=0.0053). The tachycardia was abolished by treatment with the beta-antagonist propranolol, demonstrating that it was mediated by catecholamines acting on cardiac beta-receptors. Partial lesions of the autonomic nervous system have been hypothesized to underlie many disorders, including neuropathic postural tachycardia syndrome. This animal model may help us better understand the pathophysiology of autonomic dysfunction and lead to development of therapeutic interventions.

NASA Discipline Regulatory Physiology↗

Hormonal and electrolyte responses to acute isohemic volume expansion in unanesthetized rats

This study was undertaken to explore the time course of the metabolic response to isohemic blood volume expansion (30%) in normotensive, unanesthetized Sprague-Dawley rats. Whole blood, drawn from a femoral artery catheter of conscious donor rats, was infused into the jugular vein of recipient rats. Blood samples were drawn from a carotid artery of recipient rats at time points beginning immediately post-volume expansion (IPVE) up through 5 days post-volume expansion (PVE). To characterize the attendant compensatory mechanisms, the plasma concentrations of electrolytes and fluid regulatory hormones were determined. Hematocrit began to raise IPVE and was significantly elevated above control IPVE 20, 30, 40, 60, and 90 min, and 2, 4, 6, 8, 12, and 24 hr PVE. Consistent with our current understanding of the hormonal response to excess volume, atrial natriuretic factor was significantly increased above the prevolume expansion (control) values 0-30 min PVE. Surprisingly, plasma aldosterone levels were significantly increased above control at 20 and 30 min and 6 hr PVE, whereas plasma renin activity was significantly decreased 30-40 min PVE. Plasma sodium was not changed from control values except for a significant increase at 6 hr post-volume expansion. Plasma potassium, osmolality, and arginine vasopressin levels were not altered by the volume expansion. These studies delineate the physiologic time scheme operative in the regulation of fluid volume during acute ischemic volume expansion.

NASA Discipline Cardiopulmonary↗

Some Tests and Calculations Pertaining to the Dive Path and to Wing and Tail Loads in the Accident to Eastern Airlines C54B Airplane, NC-88814, Near Bainbridge, Maryland, May 30, 1947

Several dive paths were calculated for a C54 airplane starting from level flight at an altitude of 4000 feet and from an initial indicated airspeed of 200 miles per hour. The results show that, within the limits of the possible paths permitted by the evidence of the crash at Bainbridge, the speed of impact would be about 370 miles per hour and the time to crash would be between 12 1/2 and 15 1/2 seconds. Tail load calculations indicate that, with moderate negative acceleration of the airplane, the tail would fail near the end of the dive in a manner consistent in several important respects with the evidence. A number of tests were made of the elevator tab control system to determine whether the tab would move by an amount sufficient to have caused the observed dive if the stored energy in the tab control cable were suddenly released. The results of these tests indicated that the probable tab movement is such as to be capable of causing a dive similar to the one observed at Bainbridge.

Rhode, Richard V.↗

An Improved Formulation for Calorimetric Emittance Testing of Spacecraft Thermal Control Coatings

Spacecraft often really heavily on passive thermal control to maintain operating temperature. An important parameter in the spacecraft heat balance equation is the emittance of thermal control coatings as a function of coating temperature. One method for determining the emittance of spacecraft thermal control from elevated temperature to cryogenic temperatures relies on a calorimetric technique. The fundamental equation governing this test method can be found in numerous places in the literature and although it generally provides reasonable results, its formulation is based on a conceptual flaw that only becomes apparent when the sample temperature approaches the wall temperature during testing. This paper investigates the cause for this error and develops the correct formulation for calorimetric emittance testing. Experimental data will also be presented that illustrates the difference between the two formulations and the resulting difference in the calculated emittance.

Kauder, Lonny R.↗

Controlling Precision Stepper Motors in Flight Using (Almost) No Parts

This concept allows control of high-performance stepper motors with minimal parts count and minimal flight software complexity. Although it uses a small number of common flight-qualified parts and simple control algorithms, it is capable enough to meet demanding system requirements. Its programmable nature makes it trivial to implement changes to control algorithms both during integration & test and in flight. Enhancements such as microstepping, half stepping, back-emf compensation, and jitter reduction can be tailored to the requirements of a large variety of stepper motor based applications including filter wheels, focus mechanisms, antenna tracking subsystems, pointing and mobility. The hardware design (using an H-bridge motor controller IC) was adapted from JPL's MER mission, still operating on Mars. This concept has been fully developed and incorporated into the MCS instrument on MRO, currently operating in Mars orbit. It has been incorporated into the filter wheel mechanism and linear stage (focus) mechanism for the AMT instrument. On MCS/MRO, two of these circuits control the elevation and azimuth of the MCS telescope/radiometer assembly, allowing the instrument to continuously monitor the limb of the Martian atmosphere. Implementation on MCS/MRO resulted in a 4:1 reduction in the volume and mass required for the motor driver electronics (100:25 square inches of PCB space), producing a very compact instrument. In fact, all of the electronics for the MCS instrument are packaged within the movable instrument structure. It also saved approximately 3 Watts of power. Most importantly, the design enabled MCS to meet very its stringent maximum allowable torque disturbance requirements.

Randall, David↗

High Temperature Material Properties Measurement Capabilities of the MSFC Electrostatic Levitation (ESL) Laboratory

The NASA Marshall Space Flight Center (MSFC) electrostatic levitation (ESL) laboratory has a long history of providing materials research and thermophysical property data. The lab can measure thermophysical properties, such as density, surface tension, and viscosity of liquid materials, including elements, alloys, glasses, ceramics, and oxides. For improved measurement quality, the ESL lab also has an oxygen control system, which allows the oxygen partial pressure within the vacuum chamber to be measured and controlled, at elevated temperatures, over a wide range of partial pressures. The surface tension of metals is affected by even a small amount of adsorption of oxygen, and the presence of oxygen has been hypothesized as a likely cause for the large scatter seen in published surface tension data. This presentation will cover the MSFC ESL lab, its high temperature material properties measurement capabilities, and some information about measurements done on alloys relevant to additive manufacturing.

Michael SanSoucie↗

Topical: Recommendations for Fire Extinguisher Research for Crewed Missions

Fire extinguishers are a necessary component of crewed space missions, providing a measure of fire safety beyond material selection and other controls. The elevated oxygen levels and presence of reduced but significant buoyancy during proposed Lunar and Martian missions presents both elevated fire risk and challenges in understanding and designing for extinguisher performance. This white paper proposes experimental and modeling research into the performance of fire extinguishers in Lunar and Martian atmosphere and gravity environments, exploring the use of additives to water extinguishers and research into alternative extinguishing materials, and exploration into the use of Froude number scaling relationships, used in terrestrial water extinguishing research and design, in the Lunar and Martian environment.

Combustion↗

A flight investigation of the stability, control, and handling qualities of an augmented jet flap STOL airplane

The stability, control, and handling qualities of an augmented jet flap STOL airplane are presented. The airplane is an extensively modified de Havilland Buffalo military transport. The modified airplane has two fan-jet engines which provide vectorable thrust and compressed air for the augmentor jet flap and Boundary-Layer Control (BLC). The augmentor and BLC air is cross ducted to minimize asymmetric moments produced when one engine is inoperative. The modifications incorporated in the airplane include a Stability Augmentation System (SAS), a powered elevator, and a powered lateral control system. The test gross weight of the airplane was between 165,000 and 209,000 N (37,000 and 47,000 lb). Stability, control, and handling qualities are presented for the airspeed range of 40 to 180 knots. The lateral-directional handling qualities are considered satisfactory for the normal operating range of 65 to 160 knots airspeed when the SAS is functioning. With the SAS inoperative, poor turn coordination and spiral instability are primary deficiencies contributing to marginal handling qualities in the landing approach. The powered elevator control system enhanced the controllability in pitch, particularly in the landing flare and stall recovery.

Vomaske, R. F.↗

Vertical flight path steering system for aircraft

Disclosed is a vertical flight path angle steering system for aircraft, utilizing a digital flight control computer which processes pilot control inputs and aircraft response parameters into suitable elevator commands and control information for display to the pilot on a cathode ray tube. The system yields desirable airplane control handling qualities and responses as well as improvements in pilot workload and safety during airplane operation in the terminal area and under windshear conditions.

Lambregts, Antonius A.↗

Evaluation of the Global Multi-Resolution Terrain Elevation Data 2010 (GMTED2010) Using ICESat Geodetic Control

Supported by NASA's Earth Surface and Interior (ESI) Program, we are producing a global set of Ground Control Points (GCPs) derived from the Ice, Cloud and land Elevation Satellite (ICESat) altimetry data. From February of 2003, to October of 2009, ICESat obtained nearly global measurements of land topography (+/- 86deg latitudes) with unprecedented accuracy, sampling the Earth's surface at discrete approx.50 m diameter laser footprints spaced 170 m along the altimetry profiles. We apply stringent editing to select the highest quality elevations, and use these GCPs to characterize and quantify spatially varying elevation biases in Digital Elevation Models (DEMs). In this paper, we present an evaluation of the soon to be released Global Multi-resolution Terrain Elevation Data 2010 (GMTED2010). Elevation biases and error statistics have been analyzed as a function of land cover and relief. The GMTED2010 products are a large improvement over previous sources of elevation data at comparable resolutions. RMSEs for all products and terrain conditions are below 7 m and typically are about 4 m. The GMTED2010 products are biased upward with respect to the ICESat GCPs on average by approximately 3 m.

Carabajal, Claudia C.↗

ICESat Lidar and Global Digital Elevation Models: Application to DESDynI

Geodetic control is extremely important in the production and quality control of topographic data sets, enabling elevation results to be referenced to an absolute vertical datum. Global topographic data with improved geodetic accuracy achieved using global Ground Control Point (GCP) databases enable more accurate characterization of land topography and its change related to solid Earth processes, natural hazards and climate change. The multiple-beam lidar instrument that will be part of the NASA Deformation, Ecosystem Structure and Dynamics of Ice (DESDynI) mission will provide a comprehensive, global data set that can be used for geodetic control purposes. Here we illustrate that potential using data acquired by NASA's Ice, Cloud and land Elevation Satellite (ICEsat) that has acquired single-beam, globally distributed laser altimeter profiles (+/-86deg) since February of 2003 [1, 2]. The profiles provide a consistently referenced elevation data set with unprecedented accuracy and quantified measurement errors that can be used to generate GCPs with sub-decimeter vertical accuracy and better than 10 m horizontal accuracy. Like the planned capability for DESDynI, ICESat records a waveform that is the elevation distribution of energy reflected within the laser footprint from vegetation, where present, and the ground where illuminated through gaps in any vegetation cover [3]. The waveform enables assessment of Digital Elevation Models (DEMs) with respect to the highest, centroid, and lowest elevations observed by ICESat and in some cases with respect to the ground identified beneath vegetation cover. Using the ICESat altimetry data we are developing a comprehensive database of consistent, global, geodetic ground control that will enhance the quality of a variety of regional to global DEMs. Here we illustrate the accuracy assessment of the Shuttle Radar Topography Mission (SRTM) DEM produced for Australia, documenting spatially varying elevation biases of several meters in magnitude.

Carabajal, Claudia C.↗

Sleep-wake responses of squirrel monkeys exposed to hyperdynamic environments

This study examines the sleep responses of primates to acute 3 Gz environments. To investigate this question, loosely-restrained squirrel monkeys were exposed to 70 minutes of 3 Gz during the day. The animals' behavioral state was polygraphically monitored (EEG, EMG, EOG) along with video and deep body temperature. During the control period, animals exhibited slow wave sleep (SWS) napping behavior. SWS occurred during approximately 20 percent of the control period. Body temperature was maintained at 38.7 C. At 3 Gz, SWS was inhibited for 5 minutes, after which SWS occurred at levels 50 percent lower than in the control period. During the post-centrifugation period, SWS was elevated above the control (50 percent) and hyperdynamic (100 percent) levels. Body temperature was depressed 1.5 C when the animals were at 3 Gz. Thus, hyperdynamic environments are capable of modifying primate sleep behavior, at least as a result of acute exposure. Further, the increased arousal in the hyperdynamic environment is correlated with a lower body temperature. This negative correlation differs from the normal positive correlation of arousal and body temperature.

Fuller, C. A.↗

Real-Time Flight Envelope Monitoring System

The objective of this effort was to show that real-time aircraft control-surface hinge-moment information could be used to provide a robust and reliable prediction of vehicle performance and control authority degradation. For a given airfoil section with a control surface -- be it a wing with an aileron, rudder, or elevator -- the control-surface hinge moment is sensitive to the aerodynamic characteristics of the section. As a result, changes in the aerodynamics of the section due to angle-of-attack or environmental effects such as icing, heavy rain, surface contaminants, bird strikes, or battle damage will affect the control surface hinge moment. These changes include both the magnitude of the hinge moment and its sign in a time-averaged sense, and the variation of the hinge moment with time. The current program attempts to take the real-time hinge moment information from the aircraft control surfaces and develop a system to predict aircraft envelope boundaries across a range of conditions, alerting the flight crew to reductions in aircraft controllability and flight boundaries.

Kerho, Michael↗

Elevation scanning laser/multi-sensor hazard detection system controller and mirror/mast speed control components

The electro-mechanical and electronic systems involved with pointing a laser beam from a roving vehicle along a desired vector are described. A rotating 8 sided mirror, driven by a phase-locked dc motor servo system, and monitored by a precision optical shaft encoder is used. This upper assembly is then rotated about an orthogonal axis to allow scanning into all 360 deg around the vehicle. This axis is also driven by a phase locked dc motor servo-system, and monitored with an optical shaft encoder. The electronics are realized in standard TTL integrated circuits with UV-erasable proms used to store desired coordinates of laser fire. Related topics such as the interface to the existing test vehicle are discussed.

Craig, J.↗

A star camera aspect system suitable for use in balloon experiments

A balloon-borne experiment containing a star camera aspect system was designed, built, and flown. This system was designed to provide offset corrections to the magnetometer and inclinometer readings used to control an azimuth and elevation pointed experiment. The camera is controlled by a microprocessor, including commendable exposure and noise rejection threshold, as well as formatting the data for telemetry to the ground. As a background program, the microprocessor runs the aspect program to analyze a fraction of the pictures taken so that aspect information and offset corrections are available to the experiment in near real time. The analysis consists of pattern recognition of the star field with a star catalog in ROM memory and a least squares calculation. The performance of this system in ground based tests is described. It is part of the NASA/GSFC High Energy Gamma-Ray Balloon Instrument (2).

Hunter, S. D.↗