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Search indexed NASA NTRS and DOE OSTI research on propulsion, heat transfer, battery materials and energy systems. Follow report and document links to the original sources.

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At least 127 records · Page 7
All sourcesNASA NTRSDOE OSTI
DOE OSTI2015

Proposed New Accelerator Design for Homeland Security X-Ray Applications

In the security and inspection market, there is a push towards highly mobile, reduced-dose active interrogation scanning and imaging systems to allow operation in urban environments. To achieve these goals, the accelerator system design needs to be smaller than existing systems. A smaller radiation exclusion zone may be accomplished through better beam collimation and an integrated, x-ray-source/detector-array assembly to allow feedback and control of an intensity-modulated x-ray source. A shaped low-Z target in the x-ray source can be used to generate a more forward peaked x-ray beam. Electron-beam steering can then be applied to direct the forward-peaked x rays toward areas in the cargo with high attenuation. This paper presents an exploratory study to identify components and upgrades that would be required to meet the desired specifications, as well as the best technical approach to design and build a prototype.

43 PARTICLE ACCELERATORS↗
DOE OSTI2019

Preliminary Evaluation of Fuel Management Strategies for the Versatile Test Reactor (VTR)

Different fuel management approaches have been investigated for the Versatile Test Reactor (VTR). The main design variables were the number of batches, the number of (orifice) zones, and the loading pattern within the core. The optimization criteria are maximizing the fast flux at the centermost position, minimizing the peak assembly power, and reducing fuel consumption. Design constraints were mainly driven by material limits such as peak clad temperature, and maximum fuel burnup. The exploratory study determined that active fuel shuffling only brought very limited benefits. A three-orifice region was found to provide enough flexibility to ensure thermal criteria were met. Lastly, a flexible batch loading termed ‘5-6-8’ was identified as a promising management strategy from a resource utilization standpoint.

22 GENERAL STUDIES OF NUCLEAR REACTORS↗
DOE OSTI2016

Spatially Resolved Thermal Transport Measurements in PyC Coated Fuel Particles

Self-regulating, low-power, compact, nuclear reactors are of immense interest to a community of sponsors who have power needs in space, underwater and in remote areas. Recent exploratory studies have provided valuable understanding into the underlying physics of self-regulation, including, how a material's self-regulation (or reactivity feedback) can be controlled by engineering its micro-scale and mesoscale properties. The approach being explored at Los Alamos National Laboratory involves a core matrix that is constructed of fuel kernels dispersed in a graphite matrix. The timing of the feedback is influenced by thermal properties of the fuel composite, which can be 'tuned' by micro-engineering. A pyrolytic carbon (PyC) layer coats the kernels to ensure that during a reactivity spike, the majority of the heat is trapped within the fuel kernel. The resulting precipitous temperature rise triggers a strong negative Doppler feedback. The ability to measure the local thermal properties of the individual materials that compose the fuel particle are crucial to fully understanding and controlling this feedback mechanism. The work covered in this presentation involves using laser-based thermal wave microscopy to measure the local thermal properties of the fuel particles. Specifically we measure the thermal conductivity and diffusivity of the fuel kernel and the PyC layer as well as the contact resistance between the kernel and the PyC layer. (authors)

21 SPECIFIC NUCLEAR REACTORS AND ASSOCIATED PLANTS↗
DOE OSTI2024

Drug providers’ perspectives on antibiotic misuse practices in eastern Ethiopia: a qualitative study

Objective Antibiotic misuse includes using them to treat colds and influenza, obtaining them without a prescription, not finishing the prescribed course and sharing them with others. Although drug providers are well positioned to advise clients on proper stewardship practices, antibiotic misuse continues to rise in Ethiopia. It necessitates an understanding of why drug providers failed to limit such risky behaviours. This study aimed to explore drug providers’ perspectives on antibiotic misuse practices in eastern Ethiopia. Setting The study was conducted in rural Haramaya district and Harar town, eastern Ethiopia. Design and participants An exploratory qualitative study was undertaken between March and June 2023, among the 15 drug providers. In-depth interviews were conducted using pilot-tested, semistructured questions. The interviews were transcribed verbatim, translated into English and analysed thematically. The analyses considered the entire dataset and field notes. Results The study identified self-medication pressures, non-prescribed dispensing motives, insufficient regulatory functions and a lack of specific antibiotic use policy as the key contributors to antibiotic misuse. We found previous usage experience, a desire to avoid extra costs and a lack of essential diagnostics and antibiotics in public institutions as the key drivers of non-prescribed antibiotic access from private drug suppliers. Non-prescribed antibiotic dispensing in pharmacies was driven by client satisfaction, financial gain, business survival and market competition from informal sellers. Antibiotic misuse in the setting has also been linked to traditional and ineffective dispensing audits, inadequate regulatory oversights and policy gaps. Conclusion This study highlights profits and oversimplified access to antibiotics as the main motivations for their misuse. It also identifies the traditional antibiotic dispensing audit as an inefficient regulatory operation. Hence, enforcing specific antibiotic usage policy guidance that entails an automated practice audit, a responsible office and insurance coverage for persons with financial limitations can help optimise antibiotic use while reducing resistance consequences.

General & Internal Medicine↗
DOE OSTI2024

Influence of Karen Immigrant Students on Teachers’ Instructional Decisions in the Rural United States

Across the United States, the number of classrooms welcoming young students who are new English language learners (ELL) is rapidly growing. Motivated by a dramatic increase in the number of Myanmar- and Burma-originating immigrants now attending English-speaking schools in the rural, upper midwestern United States, this study systematically considers how the presence of Karen immigrant students impacts the instructional decisions that K-12 classroom teachers make using an exploratory case study method. Several recurrent themes emerged, and findings can be used to help better prepare both pre-service and in-service teachers to meet the needs of their ELL students, as well as policy makers. These emergent themes include the following: (a) authentic teacher–family relationships are key; (b) visual/hands-on learning and the use of technology enhance student achievement; (c) student work must be completed during the school day in classrooms; (d) teachers’ purposeful use of parallel language is critical for learning; (e) rigor can be maintained, although quantity is often adjusted; and (f) targeted ESL/cultural training for pre-service and newly hired teachers is positively influential. Such informed training often seems to help teachers learn key cultural distinctions and become better able to identify the most effective ways to meet the needs of students.

99 GENERAL AND MISCELLANEOUS↗
DOE OSTI2013

Life-Cycle Assessment of Energy and Environmental Impacts of LED Lighting Products, Part 3: LED Environmental Testing

This report covers the third part of a larger U.S. Department of Energy (DOE) project to assess the life- cycle environmental and resource impacts associated with the manufacturing, transport, use, and disposal of light-emitting diode (LED) lighting products in relation to incumbent lighting technologies. All three reports are available on the DOE website (www.ssl.energy.gov/tech_reports.html). Part 1: Review of the Life-Cycle Energy Consumption of Incandescent, Compact Fluorescent and LED Lamps; Part 2: LED Manufacturing and Performance; Part 3: LED Environmental Testing. Parts 1 and 2 were published in February and June 2012, respectively. The Part 1 report included a summary of the life-cycle assessment (LCA) process and methodology, provided a literature review of more than 25 existing LCA studies of various lamp types, and performed a meta-analysis comparing LED lamps with incandescent and compact fluorescent lamps (CFLs). Drawing from the Part 1 findings, Part 2 performed a more detailed assessment of the LED manufacturing process and used these findings to provide a comparative LCA taking into consideration a wider range of environmental impacts. Both reports concluded that the life-cycle environmental impact of a given lamp is dominated by the energy used during lamp operation—the upstream generation of electricity drives the total environmental footprint of the product. However, a more detailed understanding of end-of-life disposal considerations for LED products has become increasingly important as their installation base has grown. The Part 3 study (reported herein) was undertaken to augment the LCA findings with chemical analysis of a variety of LED, CFL, and incandescent lamps using standard testing procedures. A total of 22 samples, representing 11 different models, were tested to determine whether any of 17 elements were present at levels exceeding California or Federal regulatory thresholds for hazardous waste. Notably, this type of testing does not provide an indication of product safety during use. Key findings include: • The selected models were generally found to be below thresholds for Federally regulated elements, although volatile mercury in the CFLs is presumed to have escaped detection; • Nearly all of the lamps (regardless of technology) exceeded at least one California threshold— typically for copper, zinc, antimony, or nickel; • The greatest contributors were the metal screw bases, drivers, ballasts, and wires or filaments— internal LED light sources generally did not cause LED lamps to exceed thresholds. This study was exploratory in nature and was not intended to provide a definitive indication of regulatory compliance for any specific lamp model or technology. Further study would be needed to more broadly characterize the various light source technologies; to more accurately and precisely characterize a specific model; or to determine whether product redesign would be appropriate. However, concentrations of regulated elements in LED lamps were found to be comparable to cell phones and other types of electronic devices, which like incandescent lamps and CFLs have also have been shown to exceed the stringent California thresholds for hazardous waste. Although LED lamps offer reduced life-cycle energy and environmental impacts when compared to CFLs and incandescent lamps, recycling will likely gain importance as consumer adoption of this emerging technology continues to increase.

bulb↗
DOE OSTI2018

Maternal and paternal serum concentrations of persistent organic pollutants and the secondary sex ratio: A population-based preconception cohort study

Highlights: • Recent declines in the SSR in some countries may be attributed to exposure to POPs. • Maternal PCB 128 and paternal HCB were associated with a female excess. • Maternal mirex and paternal PCB 128 and p,p′-DDE were associated with a male excess. • These findings await corroboration given the exploratory design of this study. Recent declines in the secondary sex ratio (SSR), defined as the ratio of males to females at birth, in some industrialized countries may be attributed to exposure to environmental toxicants such as persistent organic pollutants (POPs). This study aimed to evaluate the association of couples’ preconception exposure to POPs with the SSR. The study cohort comprised 235 couples who were enrolled in the Longitudinal Investigation of Fertility and the Environment (LIFE) Study between 2005 and 2009 prior to conception and prospectively followed through delivery of a singleton birth. Upon enrollment, couples’ serum concentrations (ng/g) were measured for 9 organochlorine pesticides, 1 polybrominated biphenyl, 10 polybrominated diphenyl ethers, and 36 polychlorinated biphenyls (PCBs). Birth outcome data including infant sex were collected upon delivery. Modified Poisson regression models were used to estimate the relative risks (RRs) and 95% confidence intervals (CIs) of a male birth for each chemical. Of the 56 POPs examined, maternal PCB 128 and paternal hexachlorobenzene were significantly associated with a female excess (RRs, 0.75 [95% CI, 0.60–0.94] and 0.81 [95% CI, 0.68–0.97] per 1 SD increase in log-transformed serum chemical concentrations, respectively), whereas maternal mirex and paternal PCB 128 and p,p′-dichlorodiphenyldichloroethylene were significantly associated with a male excess (RR range, 1.10–1.22 per 1 SD increase in log-transformed serum chemical concentrations). After adjusting for multiple comparisons, only maternal mirex remained significantly associated with the SSR. This exploratory study on multiple classes of POPs demonstrated no conclusive evidence on the association between parental preconception exposure to POPs and the SSR.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2014

A Phase 1/2 and Biomarker Study of Preoperative Short Course Chemoradiation With Proton Beam Therapy and Capecitabine Followed By Early Surgery for Resectable Pancreatic Ductal Adenocarcinoma

Purpose: To evaluate the safety, efficacy and biomarkers of short-course proton beam radiation and capecitabine, followed by pancreaticoduodenectomy in a phase 1/2 study in pancreatic ductal adenocarcinoma (PDAC) patients. Methods and Materials: Patients with radiographically resectable, biopsy-proven PDAC were treated with neoadjuvant short-course (2-week) proton-based radiation with capecitabine, followed by surgery and adjuvant gemcitabine. The primary objective was to demonstrate a rate of toxicity grade ≥3 of <20%. Exploratory biomarker studies were performed using surgical specimen tissues and peripheral blood. Results: The phase 2 dose was established at 5 daily doses of 5 GyE. Fifty patients were enrolled, of whom 35 patients were treated in the phase 2 portion. There were no grade 4 or 5 toxicities, and only 2 of 35 patients (4.1%) experienced a grade 3 toxicity event (chest wall pain grade 1, colitis grade 1). Of 48 patients eligible for analysis, 37 underwent pancreaticoduodenectomy. Thirty of 37 (81%) had positive nodes. Locoregional failure occurred in 6 of 37 resected patients (16.2%), and distant recurrence occurred in 35 of 48 patients (72.9%). With median follow-up of 38 months, the median progression-free survival for the entire group was 10 months, and overall survival was 17 months. Biomarker studies showed significant associations between worse survival outcomes and the KRAS point mutation change from glycine to aspartic acid at position 12, stromal CXCR7 expression, and circulating biomarkers CEA, CA19-9, and HGF (all, P<.05). Conclusions: This study met the primary endpoint by showing a rate of 4.1% grade 3 toxicity for neoadjuvant short-course proton-based chemoradiation. Treatment was associated with favorable local control. In exploratory analyses, KRAS{sup G12D} status and high CXCR7 expression and circulating CEA, CA19-9, and HGF levels were associated with poor survival.

62 RADIOLOGY AND NUCLEAR MEDICINE↗
DOE OSTI2016

Strategic Environmental Assessment practices in European small islands: Insights from Azores and Orkney islands

The literature concerning Strategic Environmental Assessment (SEA) often refers to the importance of context-specific approaches. However, there is a lack of systematised and consistent studies that enhance tailor-made SEA practices and procedures. Small islands are bounded units of study which may help explore SEA theory and practice in special territories. Small islands present particular features and unique values, such as, small size and population, geographic isolation, limited resources and vulnerable ecosystems. Hence, the main goal of this research was to profile SEA practices and procedures in European small islands and provide a background for future research aiming to improve context-specific SEA applications. To achieve this goal, an exploratory case study was developed using Azores (Portugal) and Orkney (Scotland) archipelagos. An analysis of the corresponding mainland was also carried out to contextualise both case studies. The data collection was achieved through a qualitative content analysis of 43 Environmental Reports. The research found that there is not an SEA context-specific approach used within these European small islands, including guidelines, assessment topics, assessment techniques, follow-up and stakeholders engagement. The debate concerning specific approaches to small islands must be re-focused on the enhancement of SEA capacity-building amongst different stakeholders (including decision-makers), on the development and implementation of collaborative approaches, and on the exchange of knowledge and experiences between small islands networks. - Highlights: • Reviewed the differences between the Portuguese and Scottish SEA system • Showed a low integration of SEA specific features in reports of European small islands • Provides background for future SEA research for small islands approaches.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2015

Application of electroretinography (ERG) in early drug development for assessing retinal toxicity in rats

Retinal ocular toxicity is among the leading causes of drug development attrition in the pharmaceutical industry. Electroretinography (ERG) is a non-invasive functional assay used to assess neuro-retinal physiological integrity by measuring the electrical responses. To directly assess the utility of ERG, a series of studies was conducted following intravitreal and/or iv administration of pan-cyclin-dependent kinase inhibitors: AG-012,986 and AG-024,322 in rats. Both compounds have previously shown to induce retinal toxicity. Retinal injury was evaluated by ERG, histopathology and TUNEL staining. Intravitreal injection of AG-012,986 at ≥ 10 μg/eye resulted in decreases (60%) in ERG b-wave and microscopic changes of mild to moderate retinal degeneration, and at 30 μg/eye led to additional ophthalmic findings. Intravenous administration of AG-012,986 daily at ≥ 5 mg/kg resulted in dose-related decreases (25 to 40%) in b-wave and sporadic to intense positive TUNEL staining. Intravitreal injection of AG-024,322 at 30 μg/eye also resulted in decreases (50 to 60%) in b-wave, mild to marked retinal degeneration and mild vitreous debris. These experiments demonstrate that ERG can be used as a sensitive and reliable functional tool to evaluate retinal toxicity induced by test compounds in rats complementing other classical ocular safety measurements. - Highlights: • There were strong correlations of ERG readouts to in vivo ophthalmic exams, TUNEL assay, and histopathology. • ERG appears to be more sensitive and can detect retinal functional changes at a very early stage of pathogenesis. • ERG can be incorporated into routine exploratory toxicity study to identify compound ocular safety issues. • In drug discovery, ERG is a quick, non-invasive, sensitive and reliable tool in retinal toxicity de-risking.

60 APPLIED LIFE SCIENCES↗
DOE OSTI2015

SMITHERS: An object-oriented modular mapping methodology for MCNP-based neutronic–thermal hydraulic multiphysics

A novel object-oriented modular mapping methodology for externally coupled neutronics–thermal hydraulics multiphysics simulations was developed. The Simulator using MCNP with Integrated Thermal-Hydraulics for Exploratory Reactor Studies (SMITHERS) code performs on-the-fly mapping of material-wise power distribution tallies implemented by MCNP-based neutron transport/depletion solvers for use in estimating coolant temperature and density distributions with a separate thermal-hydraulic solver. The key development of SMITHERS is that it reconstructs the hierarchical geometry structure of the material-wise power generation tallies from the depletion solver automatically, with only a modicum of additional information required from the user. In addition, it performs the basis mapping from the combinatorial geometry of the depletion solver to the required geometry of the thermal-hydraulic solver in a generalizable manner, such that it can transparently accommodate varying levels of thermal-hydraulic solver geometric fidelity, from the nodal geometry of multi-channel analysis solvers to the pin-cell level of discretization for sub-channel analysis solvers.

42 ENGINEERING↗
DOE OSTI2018

Mining project's economic impact on local communities, as a social determinant of health: A documentary analysis of environmental impact statements

Australian mining developments cause indirect economic impacts on nearby communities leading to poor health and wellbeing of local residents. Economic instability is a recognised social determinant of health (SDoH); however, SDoHs are rarely considered adequately in Environmental Impact Assessments (EIAs). This research aimed to determine the extent economic impacts as a SDoH are considered in three Environmental Impact Statements (EISs) of mining projects in the New South Wales, Australia. We adopted an exploratory case study design following Yin (2012). Three cases in New South Wales, Australia, were purposively sampled as being of concern to the local community who had sought legal advice about the content of the EIS (although not necessarily for health reasons). Two were open cut mines: Watermark located in the Liverpool Plains and Warkworth Continuation in the Hunter Valley Region. The third is a comparative case – the underground Mandalong Southern Extension located in Lake Macquarie. We adapted a health-focused EIA coding framework to investigate how economic indicators as SDoH were explicitly mentioned in EISs and applied this to the three cases. Economic indicators as SDoH were rarely considered. There was a greater focus on population characteristics rather than the potential economic impacts of the mining projects on the communities. Causal association of economic determinants and health outcomes were insufficiently reported compared to best practice, and health data were not used to inform assessments. Despite two EISs – Warkworth Continuation and Watermark – associating some economic indicators to health outcomes, impacts were not adequately discussed when compared to the known literature on economic impacts of mines. Our findings show that the three EISs were inadequately utilised to determine economic impacts of mining projects on the health and wellbeing of local communities. The evidence base linking economic impacts of mines to health is underdeveloped, which compromises assessing the quality of economic coverage in EISs. EIA scoping should enable sufficient inclusion of broader determinants of health using appropriate methodology, and the economic-focused content of EISs should be subject to rigorous peer-review process to fully inform government approvals for projects. Our methods lend themselves to research in other contexts to investigate the quality of EIAs.

54 ENVIRONMENTAL SCIENCES↗
DOE OSTI2013

Large High Resolution Displays for Co-Located Collaborative Sensemaking: Display Usage and Territoriality

Large, high-resolution vertical displays carry the potential to increase the accuracy of collaborative sensemaking, given correctly designed visual analytics tools. From an exploratory user study using a fictional textual intelligence analysis task, we investigated how users interact with the display to construct spatial schemas and externalize information, as well as how they establish shared and private territories. We investigated the space management strategies of users partitioned by type of tool philosophy followed (visualization- or text-centric). We classified the types of territorial behavior exhibited in terms of how the users interacted with information on the display (integrated or independent workspaces). Next, we examined how territorial behavior impacted the common ground between the pairs of users. Finally, we offer design suggestions for building future co-located collaborative visual analytics tools specifically for use on large, high-resolution vertical displays.

co-located collaborative sensemaking↗