Additional Capabilities of a Compact Neutron Scatter Camera: Active Interrogation Time-Correlated Pulse-Height Multiplication Measurements and Gamma Imaging.
Abstract not provided.
Goldsmith, John E. M.↗
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First Results from the Swift Gamma Ray Burst Mission
Swift is now in orbit after a beautiful launch on November 20, 2004. It is a multiwavelength observatory designed specifically to study the fascinating gamma-ray bursts. The goals are to determine the origin of bursts and use them to probe the early Universe. A new-technology wide-field gamma-ray camera detects more than a hundred bursts per year. Sensitive narrow-field X-ray and UV/optical telescopes are pointed at the burst location in 20 to 70 sec by an autonomously controlled "swift" spacecraft. For each burst, arcsec positions are determined and optical/UV/X-ray/gamma-ray spectrophotometry performed. Information is also rapidly sent to the ground to a team of more than 50 observers at telescopes around the world. First results from the mission will be presented, including observations of bright GRBs, faint GRBs, short GRBs and a super-giant flare from the soft gamma repeater SGRl806-20.
Gehreis, Neil↗
TH-CD-201-10: Highly Efficient Synchronized High-Speed Scintillation Camera System for Measuring Proton Range, SOBP and Dose Distributions in a 2D-Plane
Purpose: Proton therapy (PT) delivery is complex and extremely dynamic. Therefore, quality assurance testing is vital, but highly time-consuming. We have developed a High-Speed Scintillation-Camera-System (HS-SCS) for simultaneously measuring multiple beam characteristics. Methods: High-speed camera was placed in a light-tight housing and dual-layer neutron shield. HS-SCS is synchronized with a synchrocyclotron to capture individual proton-beam-pulses (PBPs) at ∼504 frames/sec. The PBPs from synchrocyclotron trigger the HS-SCS to open its shutter for programmed exposure-time. Light emissions within 30×30×5cm3 plastic-scintillator (BC-408) were captured by a CCD-camera as individual images revealing dose-deposition in a 2D-plane with a resolution of 0.7mm for range and SOBP measurements and 1.67mm for profiles. The CCD response as well as signal to noise ratio (SNR) was characterized for varying exposure times, gains for different light intensities using a TV-Optoliner system. Software tools were developed to analyze ∼5000 images to extract different beam parameters. Quenching correction-factors were established by comparing scintillation Bragg-Peaks with water scanned ionization-chamber measurements. Quenching corrected Bragg-peaks were integrated to ascertain proton-beam range (PBR), width of Spared-Out-Bragg-Peak (MOD) and distal.
07 ISOTOPE AND RADIATION SOURCES↗
Absorbed Doses and Risk Estimates of {sup 211}At-MX35 F(ab'){sub 2} in Intraperitoneal Therapy of Ovarian Cancer Patients
Purpose: Ovarian cancer is often diagnosed at an advanced stage with dissemination in the peritoneal cavity. Most patients achieve clinical remission after surgery and chemotherapy, but approximately 70% eventually experience recurrence, usually in the peritoneal cavity. To prevent recurrence, intraperitoneal (i.p.) targeted α therapy has been proposed as an adjuvant treatment for minimal residual disease after successful primary treatment. In the present study, we calculated absorbed and relative biological effect (RBE)-weighted (equivalent) doses in relevant normal tissues and estimated the effective dose associated with i.p. administration of {sup 211}At-MX35 F(ab'){sub 2}. Methods and Materials: Patients in clinical remission after salvage chemotherapy for peritoneal recurrence of ovarian cancer underwent i.p. infusion of {sup 211}At-MX35 F(ab'){sub 2}. Potassium perchlorate was given to block unwanted accumulation of {sup 211}At in thyroid and other NIS-containing tissues. Mean absorbed doses to normal tissues were calculated from clinical data, including blood and i.p. fluid samples, urine, γ-camera images, and single-photon emission computed tomography/computed tomography images. Extrapolation of preclinical biodistribution data combined with clinical blood activity data allowed us to estimate absorbed doses in additional tissues. The equivalent dose was calculated using an RBE of 5 and the effective dose using the recommended weight factor of 20. All doses were normalized to the initial activity concentration of the infused therapy solution. Results: The urinary bladder, thyroid, and kidneys (1.9, 1.8, and 1.7 mGy per MBq/L) received the 3 highest estimated absorbed doses. When the tissue-weighting factors were applied, the largest contributors to the effective dose were the lungs, stomach, and urinary bladder. Using 100 MBq/L, organ equivalent doses were less than 10% of the estimated tolerance dose. Conclusion: Intraperitoneal {sup 211}At-MX35 F(ab'){sub 2} treatment is potentially a well-tolerated therapy for locally confined microscopic ovarian cancer. Absorbed doses to normal organs are low, but because the effective dose potentially corresponds to a risk of treatment-induced carcinogenesis, optimization may still be valuable.
62 RADIOLOGY AND NUCLEAR MEDICINE↗
The effect of CT-based attenuation correction on the automatic perfusion score of myocardial perfusion imaging using a dedicated cardiac solid-state CZT SPECT/CT
Background: Data regarding cardiac cadmium-zinc-telluride (CZT)-specific augmented databases and their impact on CT-based attenuation correction (AC) perfusion scores in myocardial perfusion imaging (MPI) were obtained on a multiple-pinhole CZT SPECT/CT. Methods and Results: Summed stress (SSS) and rest scores (SRS) were measured using automated software in three independent patient groups: group 1 (n = 80) underwent MPI on both CZT and conventional sodium iodide (NaI) devices, group 2 (n = 80) with low coronary artery disease likelihood and normal MPI provided reference CZT databases; and group 3 (n = 152) served to compare AC and non-AC (NAC) scores on CZT. Group 1 CZT and NaI scores gave a significant 1:1 linear correlation for CZT scores referenced to the custom database vs NaI scores referenced to the default database, but these were not concordant when CZT scores were referenced to the default database. AC significantly decreased average SSS and SRS in men vs NAC, 4.29 ± 6.30 vs 5.37 ± 7.26 (P < 0.001) and 2.37 ± 4.72 vs 3.13 ± 5.85 (P < 0.001), but not in women, 2.28 ± 3.42 vs 2.28 ± 3.08 (p NS) and 0.46 ± 1.51 vs 0.61 ± 1.86, (p NS), respectively. Conclusions: Specifically designed databases for solid-state CZT cardiac SPECT provide accurate quantitation of perfusion scores concordant with those previously validated for conventional SPECT. AC and NAC CZT scores differed significantly, especially in men.
62 RADIOLOGY AND NUCLEAR MEDICINE↗
TH-C-BRD-01: Analytical Computation of Prompt Gamma Ray Emission and Detection for Proton Range Verification
Purpose: A prompt gamma (PG) slit camera prototype demonstrated that on-line range monitoring within 1–2 mm could be performed by comparing expected and measured PG detection profiles. Monte Carlo (MC) can simulate the expected PG profile but this would result in prohibitive computation time for a complete pencil beam treatment plan. We implemented a much faster method that is based on analytical processing of pre-computed MC data. Methods: The formation of the PG detection signal can be separated into: 1) production of PGs and 2) detection by the camera detectors after PG transport in geometry. For proton energies from 40 to 230 MeV, PG productions in depth were pre-computed by MC (PENH) for 12C, 14N, 16O, 31P and 40Ca. The PG production was then modeled analytically by adding the PG production for each element according to local proton energy and tissue composition.PG transport in the patient/camera geometries and the detector response were modeled by convolving the PG production profile with a transfer function. The latter is interpolated from a database of transfer functions fitted to pre-computed MC data (PENELOPE). The database was generated for a photon source in a cylindrical phantom with various radiuses and a camera placed at various positions.As a benchmark, the analytical model was compared to PENH for a water phantom, a phantom with different slabs (adipose, muscle, lung) and a thoracic CT. Results: Good agreement (within 5%) was observed between the analytical model and PENH for the PG production. Similar accuracy for detecting range shifts was also observed. Speed of around 250 ms per profile was achieved (single CPU) using a non-optimized MatLab implementation. Conclusion: We devised a fast analytical model for generating PG detection profiles. In the test cases considered in this study, similar accuracy than MC was achieved for detecting range shifts. This research is supported by IBA.
60 APPLIED LIFE SCIENCES↗
MINER - A Mobile Imager of Neutrons for Emergency Responders
We have developed a mobile fast neutron imaging platform to enhance the capabilities of emergency responders in the localization and characterization of special nuclear material. This mobile imager of neutrons for emergency responders (MINER) is based on the Neutron Scatter Camera, a large segmented imaging system that was optimized for large-area search applications. Due to the reduced size and power requirements of a man-portable system, MINER has been engineered to fit a much smaller form factor, and to be operated from either a battery or AC power. We chose a design that enabled omnidirectional (4π) imaging, with only a ~twofold decrease in sensitivity compared to the much larger neutron scatter cameras. The system was designed to optimize its performance for neutron imaging and spectroscopy, but it does also function as a Compton camera for gamma imaging. This document outlines the project activities, broadly characterized as system development, laboratory measurements, and deployments, and presents sample results in these areas. Additional information can be found in the documents that reside in WebPMIS.
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
Expanding the HAWC Observatory
The High Altitude Water Cherenkov Gamma-Ray Observatory is expanding its current array of 300 water tanks to include 350 outrigger tanks to increase sensitivity to gamma rays above 10 TeV. This involves creating and testing hardware with which to build the new tanks, including photomultiplier tubes, high voltage supply units, and flash analog to digital converters. My responsibilities this summer included preparing, testing and calibrating that equipment.
46 INSTRUMENTATION RELATED TO NUCLEAR SCIENCE AND ↗
A series approximation model for optical light transport and output intensity field distribution in large aspect ratio cylindrical scintillation crystals
A series approximation has been derived for the transport of optical photons within a cylindrically symmetric light pipe and applied to the task of evaluating both the origin and angular distribution of light reaching the output plane. This analytic expression finds particular utility in first-pass photonic design applications since it may be evaluated at a very modest computational cost and is readily parameterized for relevant design constraints. It has been applied toward quantitative exploration of various scintillation crystal preparations and their impact on both quantum efficiency and noise, reproducing sensible dependencies and providing physical justification for certain gamma ray camera design choices.
71 CLASSICAL AND QUANTUM MECHANICS, GENERAL PHYSIC↗
A parameterized ray-tracing model for evaluation of hemispherical lensing of a uniform, telecentric object aperture -- performance improvement estimates for segmented scintillators with miniature lens arrays
A parametric model describing the collimation of radiation from a uniform circular aperture by a hemispherical lens of the same radius has been developed for rapid estimation of the potential benefit of miniature dielectric lens arrays in lens-coupled gamma ray cameras (GRCs) with segmented scintillators. A simplified ray-tracing approach is adopted that makes use of small angle approximations relevant to GRCs used in nuclear science at Los Alamos National Laboratory and elsewhere. Application of this analysis technique in a first-pass design optimization process results in the optimistic estimate that miniature lenses fabricated from typical optical quality glass might boost optical coupling by as much as a factor of 4 (6 dB gain). However, this is not likely to be economically attractive compared to other techniques, such as reduction of the GRC lens f-number.
47 OTHER INSTRUMENTATION↗
Study for identification of beneficial uses of Space, phase 1. Volume 2, book 2: Technical report: results, conclusions and recommendations
A variety of technologies were investigated to determine the benefits to be derived from space activities. The subjects accepted for product development are: (1) eutectics for cold cathodes, (2) higher putiry fiber optics, (3) fluidic wafers, (4) large germanium wafers for gamma ray camera, (5) improved batteries and capacitors, (6) optical filters, (7) corrosion resistant electrodes, (8) high strength carbon-based filaments for plastic reinforcement, and (9) new antibiotics. In addition, three ideas for services, involving disposal of radioactive wastes, blood analysis, and enhanced solar insolation were proposed.
Source record↗
Coded-aperture imaging in nuclear medicine
Coded-aperture imaging is a technique for imaging sources that emit high-energy radiation. This type of imaging involves shadow casting and not reflection or refraction. High-energy sources exist in x ray and gamma-ray astronomy, nuclear reactor fuel-rod imaging, and nuclear medicine. Of these three areas nuclear medicine is perhaps the most challenging because of the limited amount of radiation available and because a three-dimensional source distribution is to be determined. In nuclear medicine a radioactive pharmaceutical is administered to a patient. The pharmaceutical is designed to be taken up by a particular organ of interest, and its distribution provides clinical information about the function of the organ, or the presence of lesions within the organ. This distribution is determined from spatial measurements of the radiation emitted by the radiopharmaceutical. The principles of imaging radiopharmaceutical distributions with coded apertures are reviewed. Included is a discussion of linear shift-variant projection operators and the associated inverse problem. A system developed at the University of Arizona in Tucson consisting of small modular gamma-ray cameras fitted with coded apertures is described.
Smith, Warren E.↗
The Swift MlDEX Mission
Swift is a NASA MIDEX mission that is in development for launch in 2004. It is a multiwavelength observatory for transient astronomy. The goals of the mission are to determine the origin of gamma-ray bursts and their afterglows and use bursts to probe the early Universe. The mission will also perform a hard x-ray survey at the 1 milliCrab level and will continuously monitor the sky for transients. A wide- field gamma-ray camera will detect more than a hundred GRBs per year to 3 times fainter than BATSE. Sensitive narrow-field X-ray and Uv/optical telescopes will be pointed at the burst location in 20 to 70 sec by an autonomously controlled "swift" spacecraft. For each burst, arcsec positions will be determined and optical/W/X-ray/gamma-ray spectrophotometry performed. The instrumentation is a combination of existing flight-spare hardware and design from XMM and Spectrum-X/JET-X contributed by collaborators in the UX and Italy and development of a coded-aperture camera with a large-area (-0.5 square meter) CdZnTe detector array. The ground station in Malindi is contributed by the Italian Space Agency. The instruments have now completed their fabrication phase and are currently being integrated on the observatory for final testing. up and outreach programs to engage the astronomical community and public in Swift.
Gehrels, Neil↗
The Swift Gamma Ray Burst Mission
Swift is an international mission managed by NASA as part of its MIDEX program. It is a multiwavelength transient observatory for GRB astronomy that will launch in 2004. The goals of the mission are to determine the origin of GRBs and their afterglows and use bursts to probe the early Universe. A wide field gamma-ray camera will detect more than a hundred GRBs per year to 2-5 times fainter than BATSE. Sensitive narrow-field X-ray, and UV/optical telescopes will be pointed at the burst location in 20 to 75 sec by an autonomously controlled 'swift' spacecraft. For each burst, arcsec positions will be determined and optical/UV/x-ray/gamma-ray spectrophotometry performed. Measurements of redshift will be made for many of the bursts. The instrumentation is a combination of superb existing flight-spare hardware and design from XMM and Spectrum-X/JET-X contributed by collaborators in the UK and Italy and development of a coded-aperture camera with a large-area (approx. 0.5 square meter) CdZnTe detector array. The instruments have now completed their fabrication phase and are integrated on the observatory for final testing. Key components of the mission are vigorous follow-up and outreach programs to engage the astronomical community and public in Swift. The talk will describe the mission and its status and give a summary of our plans for GRB operations.
Gehrels, Neil↗
The Swift GRB Mission
Swift is a MIDEX mission that is in development for launch in October 2004. It is a multiwavelength transient observatory for GRB astronomy. The goals of the mission are to determine the origin of GRBs and their afterglows and use bursts to probe the early Universe. A wide-field gamma-ray camera will detect mare than 100 GRBs per year to -3 times fainter than BATSE. Sensitive narrow-field X-ray and UV/optical telescopes will be pointed at the burst location in 20 to 75 sec by an autonomously controlled spacecraft. Far each burst, aresec positions will be determined and optical/UV/X-ray/gamma-say spectrophotometry performed. Measurements of redshift will be made for many burstes. The instrumentation is a combination of superb existing flight-spare hardware and design from XMM and Spectrum-X/JET-X contributed by collaborators in the UK and Italy and development of a coded-aperture camera with a large-area (approx. 0.5 square meter) CdZnTe detector array. Key components of the mission are vigorous follow-up and outreach programs to engage the astronomical community and public in Swift. The talk vi11 describe the mission statue and give a summary of plans for GRB operations. It is likely that Swift will have just been launched at the time of the conference.
Gehrels, Neil↗
The Imminent Swift MIDEX Mission
Swift is a NASA MIDEX mission that is in development for launch in Fall 2004. It is a multiwavelength observatory for transient astronomy. The goals of the mission are to determine the origin of gamma-ray bursts and their afterglows and use bursts to probe the early Universe. The mission will also perform a hard x-ray survey at the 1 milliCrab level and will continuously monitor the sky for transients. A wide-field gamma-ray camera will detect more than a hundred GRBs per year to 3 times fainter than BATSE. Sensitive narrow-field X-ray and UV/optical telescopes will be pointed at the burst. location in 20 to 70 sec by an autonomously controlled "swift" spacecraft. For each burst, arcsec positions will be determined and optical/UV/X-ray/gamma-ray spectrophotometry performed. The instrumentation is a combination of existing flight-spare hardware and design from XMM and Spectrum-X/JET-X contributed by collaborators in the UK and Italy and development of a coded-aperture camera with a large-area (approximately 0.5 square meter) CdZnTe detector array. The ground station in Malindi is contributed by the Italian Space Agency. The instruments have now completed their fabrication phase and are currently being integrated on the observatory for final testing. Key components of the mission are vigorous follow-up and outreach programs to engage the astronomical community and public in Swift.
Gehrels, Neil↗
The Swift Gamna-Ray Burst Mission
Swift is a NASA Explorer mission that will be launched in late 2004. It is a multiwavelength observatory for transient astronomy. The goals of the mission are to determine the origin of gamma-ray bursts and their afterglows and use bursts to probe the early Universe. The mission will also perform a hard x-ray survey at the 1 milliCrab level and will continuously monitor the sky for transients. A wide-field gamma-ray camera will detect more than a hundred GRBs per year to 3 times fainter than BATSE. Sensitive narrow-field X-ray and UV/optical telescopes will be pointed at the burst location in 20 to 70 sec by an autonomously controlled "swift" spacecraft. For each burst, arcsec positions will be determined and optical/UV/X-ray/gamma-ray spectrophotometry performed. The instrumentation is a combination of existing flight-spare hardware and design from XMM and Spectrum-X/JET-X contributed by collaborators in the UK and Italy and development of a coded-aperture camera with a large-area (-0.5 square meter) CdZnTe detector array. The ground station in Malindi is contributed by the Italian Space Agency. Key components of the mission are vigorous follow-up and outreach programs to engage the astronomical community and public in Swift.
Gehrels, Neil↗
Gamma Ray Burst Discoveries by the Swift Mission
Gamma-ray bursts are among the most fascinating occurrences in the cosmos. They are thought to be the birth cries of black holes throughout the universe. The NASA Swift mission is an innovative new multiwavelength observatory designed to determine the origin of bursts and use them to probe the early Universe. Swift is now in orbit after a beautiful launch on November 20, 2004. A new-technology wide-field gamma-ray camera detects more than a hundred bursts per year. Sensitive narrow-field X-ray and UV/optical telescopes, built in collaboration with UK and Italian partners, are pointed at the burst location in 20 to 70 sec by an autonomously controlled "swift" spacecraft. For each burst, arcsec positions are determined and optical/UV/X-ray/gamma-ray spectrophotometry performed. Information is also rapidly sent to the ground to a team of more than 50 observers at telescopes around the world. The first year of findings from the mission will be presented. The long-standing mystery of short GRBs has been solved, and the answer is the most interesting possible scenario. High redshift bursts have been detected leading to a better understanding of star formation rates and distant galaxy environments. GRBs have been found with giant X-ray flares occurring in their afterglow. These, and other topics, will be discussed.
Gehrels, Neil↗